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Vol. 62. Issue 4.
Pages 211-286 (April 2026)
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Vol. 62. Issue 4.
Pages 211-286 (April 2026)
Editorial

Central Sleep Apnea in Heart Failure: What Now?

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Shahrokh Javaheria,
Corresponding author
shahrokhjavaheri@icloud.com

Corresponding author.
, Winfried J. Randerathb, Alberto Giannonic,d
a Bethesda North Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, United States
b Institute of Pneumologie at the University of Cologne, Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany
c Health Science Interdisciplinary Center, Scuola Superiore Sant’Anna, Pisa, Italy
d Cardiovascular Medicine Division, Fondazione Monasterio, Pisa, Italy
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References
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S. Javaheri, S.M. Badr.
Central sleep apnea: pathophysiologic classification.
Sleep, 46 (2023), pp. 1-14
[2]
S. Javaheri, A. Giannoni, V.K. Somers, A. Malhotra, M. Emdin, M.R. Costanzo.
Central sleep apnea and cardiovascular disease state-of-the-art.
[3]
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Research priorities for patients with heart failure and central sleep apnea. An Official American Thoracic Society Research Statement.
Am J Respir Crit Care Med, 203 (2021), pp. e11-e24
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[7]
S. Javaheri, D.M. Rapoport, A.R. Schwartz.
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[8]
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Positive airway pressure therapy with adaptive servo-ventilation: part II: clinical applications.
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Adaptive servo-ventilation for central sleep apnea in systolic heart failure.
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Nocturnal hypoxaemia is associated with increased mortality in stable heart failure patients.
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CON: persistent central sleep apnea/Hunter-Cheyne-Stokes breathing despite best guideline-based therapy of heart failure with reduced ejection fraction, is not a compensatory mechanism and should be suppressed.
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Nocturnal oxygen therapy for central sleep apnea in patients with heart failure: the LOFT-HF trial.
Ann Am Thorac Soc, (2025),
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