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Vol. 57. Issue 12.
Pages 771 (December 2021)
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Severe lung and pleural involvement due to osteosarcoma in a 24 year woman. The most aggressive visceral presentation of a bone tumor
Afectación pulmonar y pleural severa por osteosarcoma en mujer de 24 años. La manifestación visceral más agresiva de un tumor óseo
Katherin Martínez Barroso
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Corresponding author.
, Miguel Borregón Rivilla, Manuel Mazariegos Rubí, Javier Medina Martínez
Servicio de Oncología Médica, Hospital Virgen de la Salud, Toledo, Spain
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A young woman with no history of interest attended the emergency department complaining of a 5-day history of dyspnea, dry cough, and pleuritic pain in the left costal region. She also reported a 1-month history of right shoulder pain and slight weight loss.

Physical examination revealed tachypnea, chest indrawing, and absent breath sounds in the left hemitorax. Lactate dehydrogenase (LDH) and alkaline phosphatase (AP) were elevated.

Chest X-ray and computed tomography showed multiple bilateral lung and pleural masses containing calcium, left pleural effusion, and a blastic lesion on the right humeral head (Fig. 1). Pathology study of a lung mass biopsy confirmed the diagnosis of osteosarcoma metastases.

Fig. 1.

Plain PA chest X-ray (A) and chest-abdominal CT coronal slice (B) at diagnosis, showing massive left pleural effusion, right humeral head blastic lesion, and multiple calcium density images in bilateral pulmonary parenchyma and pleura. Chest CT axial slice (C1 and C2) after drainage of pleural effusion, significant for multiple bilateral metastases in lung parenchyma and pleura, and left pneumothorax. Plain PA and lateral chest X-rays (D.1 and D.2) at 10 months after diagnosis, showing an increase in the number and size of bilateral pulmonary and pleural nodules and masses, left pleural effusion, and an increase in the size of the primary lesion in the right humeral head.


She received doxorubicin and cisplatin and achieved a partial response. Thirteen months later, progression was observed and the patient presented with lower respiratory tract infection and partial respiratory failure, causing her death.

Primary bone tumors account for less than 0.2% of malignant neoplasms, most frequently osteosarcoma1. Lung metastases are the most common and, along with elevated LDH and AP, are indicators of poor prognosis. The aggressiveness of the lung involvement of this tumor is illustrated in this clinical image2.

Appendix A
Supplementary data

The following is Supplementary data to this article:

C.A. Stiller, A. Trama, D. Serraino.
Descriptive epidemiology of sarcomas in Europe: report from the RARECARE project.
Eur J Cancer, 49 (2013), pp. 684-695
S.S. Bielack, B. Kempf-Bielack, G. Delling, G.U. Exner, S. Flege, K. Helmke, et al.
Prognostic factors in high grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols.
J Clin Oncol, 20 (2002), pp. 776-790

Please cite this article as: Martínez Barroso K, Borregón Rivilla M, Mazariegos Rubí M, Medina Martínez J. Afectación pulmonar y pleural severa por osteosarcoma en mujer de 24 años. La manifestación visceral más agresiva de un tumor óseo. Arch Bronconeumol. 2021;57:771.

Copyright © 2021. SEPAR
Archivos de Bronconeumología

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