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                        "paginaFinal" => "1143"
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                          0 => array:2 [
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                      "titulo" => "Pulmonary changes during treatment of Parkinson&#39;s disease with long-acting ergot derivative&#44; cabergoline"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; Frans"
                            1 => "R&#46; Dom"
                            2 => "M&#46; Demedts"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1992"
                        "volumen" => "5"
                        "paginaInicial" => "263"
                        "paginaFinal" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1348483"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low dose cabergoline induced interstitial pneumonitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "W&#46; Frank"
                            1 => "R&#46; Moritz"
                            2 => "B&#46; Becke"
                            3 => "R&#46; Pauli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1999"
                        "volumen" => "14"
                        "paginaInicial" => "968"
                        "paginaFinal" => "970"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10573251"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Constrictive pericarditis and pleuropulmonary fibrosis secondary to cabergoline treatment in Parkinson&#39;s disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Townsend"
                            1 => "D&#46;H&#46; Maclver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Heart"
                        "fecha" => "2004"
                        "volumen" => "90"
                        "paginaInicial" => "47"
                        "paginaFinal" => "48"
                        "itemHostRev" => array:3 [
                          "pii" => "S0300893211005239"
                          "estado" => "S300"
                          "issn" => "03008932"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Drugs and the pleura"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;Y&#46; Morelock"
                            1 => "S&#46;A&#46; Sahn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1999"
                        "volumen" => "116"
                        "paginaInicial" => "212"
                        "paginaFinal" => "221"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10424528"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normativa SEPAR&#58; diagn&#243;stico y tratamiento del derrame pleural"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Villena"
                            1 => "J&#46; Ferrer"
                            2 => "L&#46; Hern&#225;ndez"
                            3 => "A&#46; de Pablo"
                            4 => "E&#46; P&#233;rez"
                            5 => "F&#46; Rodr&#237;guez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2006"
                        "volumen" => "42"
                        "paginaInicial" => "349"
                        "paginaFinal" => "372"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16945266"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor&#46; III&#46; Agonist and antagonist properties at serotonin&#44; 5-HT&#40;1&#41; and 5-HT&#40;2&#41;&#44; receptor subtypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Newman-Tancredi"
                            1 => "D&#46; Cussac"
                            2 => "Y&#46; Quentric"
                            3 => "M&#46; Touzard"
                            4 => "L&#46; Verri&#232;le"
                            5 => "N&#46; Carpentier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1124/jpet.102.039883"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pharmacol Exp Ther"
                        "fecha" => "2002"
                        "volumen" => "303"
                        "paginaInicial" => "815"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12388668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dopamine agonists and the risk of cardiac-valve regurgitation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Schade"
                            1 => "F&#46; Andersohn"
                            2 => "S&#46; Suissa"
                            3 => "W&#46; Haverkamp"
                            4 => "E&#46; Garbe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa062222"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2007"
                        "volumen" => "356"
                        "paginaInicial" => "29"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17202453"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary hypertension as a result of drug therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Higenbottam"
                            1 => "L&#46; Laude"
                            2 => "C&#46; Emery"
                            3 => "M&#46; Essener"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0272-5231(03)00133-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "123"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15062604"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#191;De qu&#233; nos informa el l&#237;quido pleural&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "V&#46; Villena"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "paginaInicial" => "193"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12749800"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
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Vol. 45. Issue 2.
Pages 100-102 (February 2009)
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Vol. 45. Issue 2.
Pages 100-102 (February 2009)
Case report
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Pleural Effusion and Pulmonary Hypertension in a Patient With Parkinson Disease Treated With Cabergoline
Derrame pleural e hipertensión pulmonar en un paciente con enfermedad de Parkinson en tratamiento con cabergolina
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Manuel Haro-Estarriola,
Corresponding author
mip.mharo@htrueta.scs.es

Corresponding author.
, Gladis Sabater-Talaveranoa, Francisco Rodríguez-Jereza, Anton Obrador-Lagaresa, David Genís-Batlleb, Salvi Sendra-Salillasa
a Servicio de Neumología, Hospital Universitario de Girona Doctor Josep Trueta, Girona, Spain
b Servicio de Neurología, Hospital Universitario de Girona Doctor Josep Trueta, Girona, Spain
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Abstract

Cabergoline is a synthetic dopamine agonist used to treat Parkinson disease. The drug occasionally induces pleuropulmonary adverse effects, which manifest as pleural thickening or effusion, interstitial pneumonitis, pulmonary infiltrates, or fibrosis. We report a rare case of pleural effusion and severe pulmonary hypertension in a 79-year-old man with Parkinson disease who had been treated with cabergoline for 1 year. The symptoms disappeared 10 months after the drug was discontinued.

Keywords:
Cabergoline
Parkinson disease
Pleural effusion
Pulmonary hypertension
Resumen

La cabergolina es un fármaco sintético dopaminérgico, que se utiliza en el tratamiento de la enfermedad de Parkinson y que rara vez produce efectos adversos pleuropulmonares, los cuales se manifiestan como engrosamiento o derrame pleurales, neumonitis intersticial, infiltrados pulmonares o fibrosis. Presentamos un caso excepcional en un varón de 79 años con enfermedad de Parkinson, tratado con cabergolina durante un año, que presentó un derrame pleural y grave hipertensión pulmonar, que desaparecieron a los 10 meses de la retirada de este fármaco.

Palabras clave:
Cabergolina
Enfermedad de Parkinson
Derrame pleural
Hipertensión pulmonar
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References
[1.]
J.G. Nutt, G.F. Wooten.
Diagnosis and initial management of Parkinson's disease.
N Engl J Med, 353 (2005), pp. 1021-1027
[2.]
A.E. Lang, A.M. Lozano.
Parkinson's disease. Second of two parts.
N Engl J Med, 339 (1998), pp. 1130-1143
[3.]
A.D. Korczyn, M. Nussbaum.
Emerging therapies in the pharmacological treatment of Parkinson's disease.
Drugs, 62 (2002), pp. 775-786
[4.]
C. Villavicencio, A. Ramírez, A. Gayete, S. Grau, M. Orozco.
Toxicidad pleuropulmonar precoz asociada al tratamiento con cabergolina, un fármaco antiparkinsoniano.
Arch Bronconeumol, 43 (2007), pp. 519-522
[5.]
J.A. Cooper, D.A. White, R.A. Matthay.
Drug-induced pulmonary disease (part 2). Noncytotoxic drugs.
Am Rev Respir Dis, 133 (1986), pp. 488-505
[6.]
M. Haro, M. Rubio, J. Puig.
Enfermedad pulmonar asociada a la administración de fluoxetina.
Arch Bronconeumol, 38 (2002), pp. 153
[7.]
P. Pfitzenmeyer, P. Foucher, G. Dennewald, B. Chevalon, D. Debieuvre, P. Bensa, et al.
Pleuropulmonary changes induced by ergoline drugs.
Eur Respir J, 9 (1996), pp. 1013-1019
[8.]
M.P. Curran, C.M. Perry.
Cabergoline. A review of its use in the treatment of Parkinson's disease.
Drugs, 64 (2004), pp. 2125-2141
[9.]
E. Frans, R. Dom, M. Demedts.
Pulmonary changes during treatment of Parkinson's disease with long-acting ergot derivative, cabergoline.
Eur Respir J, 5 (1992), pp. 263-265
[10.]
W. Frank, R. Moritz, B. Becke, R. Pauli.
Low dose cabergoline induced interstitial pneumonitis.
Eur Respir J, 14 (1999), pp. 968-970
[11.]
M. Townsend, D.H. Maclver.
Constrictive pericarditis and pleuropulmonary fibrosis secondary to cabergoline treatment in Parkinson's disease.
Heart, 90 (2004), pp. 47-48
[12.]
S.Y. Morelock, S.A. Sahn.
Drugs and the pleura.
Chest, 116 (1999), pp. 212-221
[13.]
V. Villena, J. Ferrer, L. Hernández, A. de Pablo, E. Pérez, F. Rodríguez, et al.
Normativa SEPAR: diagnóstico y tratamiento del derrame pleural.
Arch Bronconeumol, 42 (2006), pp. 349-372
[14.]
A. Newman-Tancredi, D. Cussac, Y. Quentric, M. Touzard, L. Verrièle, N. Carpentier, et al.
Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes.
J Pharmacol Exp Ther, 303 (2002), pp. 815-822
[15.]
R. Schade, F. Andersohn, S. Suissa, W. Haverkamp, E. Garbe.
Dopamine agonists and the risk of cardiac-valve regurgitation.
N Engl J Med, 356 (2007), pp. 29-38
[16.]
T. Higenbottam, L. Laude, C. Emery, M. Essener.
Pulmonary hypertension as a result of drug therapy.
Clin Chest Med, 25 (2004), pp. 123-131
[17.]
V. Villena.
¿De qué nos informa el líquido pleural?.
Arch Bronconeumol, 39 (2003), pp. 193-194
Copyright © 2009. Sociedad Española de Neumología y Cirugía Torácica
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