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Vol. 56. Issue 4.
Pages 251 (April 2020)
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Vol. 56. Issue 4.
Pages 251 (April 2020)
Clinical Image
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Endobronchial Diffuse Large B-cell Lymphoma
Localización endobronquial del linfoma difuso de células grandes tipo B
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Masahiro Yamasakia,
Corresponding author
myamasanjp@yahoo.co.jp

Corresponding author.
, Yu Matsumotob, Noboru Hattorib
a Department of Respiratory Medicine, Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital, Naka-ku, Hiroshima, Japan
b Department of Molecular and Internal Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan
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A 60-year-old woman with 35 pack-year smoking history presented with a primary complaint of productive cough. Haemoptysis was observed 2 months later. No systemic symptoms such as weight loss, fever, or night sweats occurred. Chest radiography and computed tomography were performed, and an intrabronchial lesion extending from the right main bronchus to lower bronchus (Fig. 1A, arrows) was detected. Subsequently, bronchoscopy was performed, which detected a protruding lesion with an irregular surface and necrosis in the endobronchial region (Fig. 1B). The biopsy specimen from the lesion was pathologically examined. Microscopic findings of diffuse proliferation of large neoplastic lymphoid cells with CD20 positivity led to a diagnosis of endobronchial diffuse large B-cell lymphoma (DLBCL). Further examinations showed no presence of distant metastasis, and chemotherapy was initiated.

Fig. 1.

(A) Computed tomography showing an intrabronchial lesion extending from the right main bronchus to the lower bronchus (arrows). (B) Bronchoscopic examination showing a protruding lesion with an irregular surface and necrosis, detected in the endobronchial region of the right main bronchus.

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Primary pulmonary lymphomas are rare entities, and among them, an endobronchial DLBCL is even rarer; therefore, the bronchoscopic findings of DLBCL are recognised insufficiently even by respiratory medicine specialists. Existing knowledge characterises the bronchoscopic findings of endobronchial lymphoma as multi-nodular, protruding lesions with a smooth surface.1 However, in aggressive lymphoma, the lesion usually shows an irregular surface and necrosis,2 resembling a carcinomatous lesion.

Acknowledgments

We would like to thank Editage (www.editage.jp) for English language editing.

References
[1]
M. Yamasaki, K. Funaishi, T. Muta, N. Matsumoto, M. Taniwaki, N. Hattori.
Endobronchial mucosa-associated lymphoid tissue (MALT) lymphoma.
[2]
M. Nakao, T. Oguri, M. Miyazaki, H. Hijikata, M. Yokoyama, E. Kunii, et al.
Transformed lymphoplasmacytic lymphoma involving the main carina: a case report.
Oncol Lett, 6 (2013), pp. 542-544
Copyright © 2019. SEPAR
Archivos de Bronconeumología

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