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Vol. 42. Issue 10.
Pages 509-515 (October 2006)
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Vol. 42. Issue 10.
Pages 509-515 (October 2006)
Original Articles
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Determination of Maximal Diaphragm Strength in Chronic Obstructive Pulmonary Disease: Cervical Magnetic Stimulation Versus Traditional Sniff Maneuver
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Juana Martínez-Llorensa,1,
Corresponding author
jmartinezl@imas.imim.es

Correspondence: Dra. J. Martínez-Llorens. Servei de Medicina Respiratòria. Hospital del Mar. Pg. Martítim, 27.08003 Barcelona, España
, Carlos Coronella, Alba Ramírez-Sarmientoa, Mauricio Orozco-Levia, Josep M. Espadalerb, Juan Bautista Gáldizc, Joaquim Geaa, on behalf of the ENIGMA COPD study group
a Servei de Medicina Respiratòria, Unitat de Recerca en Múscul i Aparell Respiratori (URMAR), Hospital del Mar-IMIM, Departament CEXS, Universital Pompeu Fabra, Barcelona, Spain
b Secció de Neurofisiologia, Unitat de Recerca en Múscul i Aparell Respiratori (URMAR), Hospital del Mar-IMIM, Departament CEXS, Universitat Pompeu Fabra, Barcelona, Spain
c cServicio de Neumología, Hospital de Cruces, Barakaldo, Vizcaya, Spain, Study supported by UE QLRT-2001, RTIC C03/11 (Red RespiralSCIII) and SOCAP 2002 and 2003 grants
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Objective

Magnetic stimulation of the diaphragm allows its strength to be assessed. The clinical applications of this technique are becoming more widespread given that the patient's cooperation is not required. The aim of the present study was to compare this inhalation technique with traditional voluntary forced inspiration (sniff test) in a group of patients with chronic obstructive pulmonary disease (COPD).

Patients and methods

Sixteen men with moderate-to-severe COPD were studied (mean [SD] forced expiratory volume in 1 second, 35% [15%] of the reference value). For all patients, the maximal transdiaphragmatic pressure (a measure of the contractility of the muscle) was determined at peak inspiration and during cervical magnetic stimulation.

Results

A moderate correlation between measurements with the 2 techniques was observed. The value obtained with stimulation was approximately 20% of that obtained with voluntary inhalation (22 [7] cm H2O vs 97 [27] cm H2O, respectively). The stimulation technique yielded an intraindividual coefficient of variation of 12% (7%) and an interindividual one of 33% (6%). Very similar values for these coefficients were obtained with forced inhalation. Qualitative analysis of the stimulation technique showed it to have a high sensitivity (89%) for diagnosing muscle weakness, with few fake negatives. In contrast, specificity was very low (43%), and false positives for muscle weakness were relatively common. The overall effectiveness of the prediction was acceptable (69%).

Conclusions

Cervical magnetic stimulation appears to be a good clinical option for ruling out diaphragm weakness. It is particularly indicated in patients with limited capacity for understanding instructions or those unable to cooperate.

Key words:
Respiratory muscles
Pulmonary disease
Transdiaphragmatic pressure
Muscle stimulation
Objetivo

La estimulación magnética del diafragma es una técnica que permite evaluar la fuerza de este músculo. Dado que obvia la necesidad de colaboración del paciente, va extendiendo progresivamente su aplicación clinica. El objetiyo del presente estudio ha sido comparar esta técnica de estimulación con la clásica de inhalación voluntaria forzada (sniff) en un grupo de pacientes con enfermedad pulmonar obstructive crónica (EPOC).

Pacientes y métodos

Se estudió a 16 pacientes varones con EPOC de moderada a grave (valor medio ± desviación estándar del volumen espiratorio forzado en el primer segundo del 35 ± 15% del valor de referencia). En todos ellos se obtuvo la presión máxima del diafragma (expresión de la fuerza contráctil del músculo) por maniobras de inhalación voluntaria máxima y de estimulación cervical magnética.

Resultados

Se observó una relación moderada entre ambas técnicas, siendo los valores obtenidos con estimulación de aproximadamente un 20% de los obtenidos con la maniobra voluntaria (97 ± 27 y 22 ± 7 cmH2O, respectivamente). La técnica de estimulación mostró unos coeficientes de variabilidad intraindividual del 12 ± 7%, e interindividual del 33 ± 6%, muy similares a los del método de inhalación. El análisis cualitativo de la técnica de estimulación para el diagnóstico de debilidad muscular mostró una elevada sensibilidad (89%), con escasos falsos negativos. Por el contrario, su especificidad fue muy baja (43%), con una tasa relativamente elevada de sobrediagnósticos. La eficacia de la predicción resultó globalmente aceptable (69%).

Conclusiones

La técnica de estimulación magnética cervical se muestra como una buena opción clínica para descartar debilidad del diafragma, con indicatión sobre todo en pacientes con poca capacidad de comprensión o incapacidad de colaboración.

Palabras clave:
Músculos respiratorios
Enfermedad pulmonar
Presión transdiafragmática
Estimulación muscular
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REFERENCES
[1]
Global Initiative for Chronic Obstructive Lung Disease NHLBI/WHO.
[2]
NM Siafakas, P Vermeire, NB Priede, P Paoletti, J Gibson, P Howard, et al.
Optimal assessment and manegement of chronic obstructive pulmonary disease (COPD). ERS consensus statement.
Eur Respir J, 8 (1995), pp. 1398-1420
[3]
American Thoracic Society.
Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 152 (1995), pp. S77-S120
[4]
JA Barbera, G Peces-Barba, AG Agustí, JL Izquierdo, E Monsó, T Montemayor, et al.
Guía clinica para el diagnóstico y tratamiento de la enfermedad pulmonar obstructiva crónica.
Arch Bronconeumol, 37 (2001), pp. 297-316
[5]
J Gea, E Barreiro, M Orozco-Levi.
Oxidative stress, cytokines and respiratory muscle dysfunction.
Clin Pulm Med, (2006),
[6]
American Thoracic Society and European Respiratory Society.
Skeletal muscle dysfunction in chronic obstructive pulmonary disease.
Am J Resp Crit Care Med, 159 (1999), pp. 1-40
[7]
J Gea, M Orozco-Levi, E Barreiro, A Ferrer, JM Broquetas.
Structural and functional changes in the skeletal muscles of COPD patients: the “compartments” theory.
Mon Arch Chest Dis, 56 (2001), pp. 214-224
[8]
AG Agustí, A Noguera, J Sauleda, C Miralles, S Batle, X Busquets.
Systemic inflammation in chronic respiratory diseases.
European Respiratory Monograph, 8 (2003), pp. 46-55
[9]
I Rahman, D Morrison, K Donaldson, W MacNee.
Systemic oxidative stress in asthma. COPD, and smokers.
Am J Respir Crit Care Med, 154 (1996), pp. 1055-1060
[10]
J Sauleda, FJ García-Palmer, G González, A Palou, AG Agustí.
The activity of cytochrome oxidase is increased in circulating lymphocytes of patients with chronic obstructive pulmonary disease, asthma, and chronic arthritis.
Am J Respir Crit Care Med, 161 (2000), pp. 32-35
[11]
A Noguera, X Busquets, J Sauleda, JM Villaverde, W MacNee, AG Agustí.
Expression of adhesion molecules and G proteins in circulating neutrophils in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 158 (1998), pp. 1664-1668
[12]
R Mathur, IJ Cox, A Oatridge, DT Shephard, RJ Shaw, SD Taylor-Robinson.
Cerebral bioenergetics in stable chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 160 (1999), pp. 1994-1999
[13]
RA Sharkey, EM Mulloy, IA Kilgallen, SJ Neill.
Renal functional reserve in patients with severe chronic obstructive pulmonary disease.
Thorax, 52 (1997), pp. 411-415
[14]
J Napal, Y Cuerno, JM Olmos, JA Riancho, JA Amado, J González Macías.
Cambios en la masa Ósea de pacientes con cirrosis hepática, enfermedad pulmonar obstructiva crónica, diabetes insulinodependiente e hiperparatiroidismo primario.
Med Clin (Barc), 100 (1993), pp. 576-579
[15]
K Marquis, R Debigare, Y Lacasse, P Blanc, J Jobin, G Carrier, et al.
Midthigh muscle cross-sectional area is a better predictor of mortality than body mass index in patients with chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 166 (2002), pp. 809-813
[16]
EF Wouters, EC Creutzberg, AM Schols.
Systemic effects in COPD.
Chest, 121 (2002), pp. 127-130
[17]
F Lótters, B van Tol, G Kwakkel, R Gosselink.
Effects of controlled inspiratory muscle training in patients with COPD: a metaanalysis.
Eur Respir J, 20 (2002), pp. 570-576
[18]
AD de Andrade, TN Silva, H Vasconcelos, M Marcelino, MG Rodrigues-Machado, VC Filho, et al.
Inspiratory muscular activation during threshold (R) therapy in elderly healthy and patients with COPD.
J Electromyogr Kinesiol, 15 (2005), pp. 631-639
[19]
X Aran, J Gea, R Guiu, MC Aguar, J Sauleda, JM Broquetas.
Comparación de tres maniobras diferentes para la obtención de la presión transdiafragmática máxima.
Arch Bronconeumol, 28 (1992), pp. 112-115
[20]
D Laporta, A Grassino.
Assessment of transdiaphragmatic pressure in humans.
J Appl Physiol, 58 (1985), pp. 1469-1476
[21]
J Gea, M Orozco-Levi, E Barreiro, AL Ramírez-Sarmiento, JB Gáldiz, E López de Santamaría.
Pruebas para el estudio de las enfermedades neuromusculares. Manual SEPAR de procedimientos. Módulo 4: Procedimientos de evaluación de la función pulmonar II, pp. 125
[22]
T Similowski, B Fleury, S Launois, HP Cathala, P Bouche, JP Derenne.
Cervical magnetic stimulation: a new painless method for bilateral phrenic nerve stimulation in conscious humans.
J Appl Physiol, 67 (1989), pp. 1311-1318
[23]
J Gea, JM Espadaler, R Guiu, X Aran, L Seoane, JM Broquetas.
Diaphragmatic activity induced by cortical stimulation: surface versus esophageal electrodes.
J Appl Physiol, 74 (1993), pp. 655-658
[24]
MI Polkey, D Kyroussis, SE Keilty, CH Hamnegard, GH Mills, M Green, et al.
Exhaustive treadmill exercise does not reduce twitch transdiaphragmatic pressure in patients with COPD.
Am J Respir Crit Care Med, 152 (1995), pp. 959-964
[25]
CH Hamnegard, S Wragg, D Kyroussis, GH Mills, MI Polkey, J Moran, et al.
Diaphragm fatigue following maximal ventilation in man.
Eur Respir J, 9 (1996), pp. 241-247
[26]
JB Gáldiz, V Bustamante, J Camino, V Cabriada.
Comparación de la presión en boca. twitch, tras estimulación magnética anterior frente a estimulación magnética posterior en sujetos sanos.
Arch Bronconeumol, 36 (2000), pp. 557-562
[27]
CH Hamnegard, B Bake, J Moxham, MI Polkey.
Does undernutrition contribute to diaphragm weakness in patients with severe COPD?.
Clin Nutr, 21 (2002), pp. 239-243
[28]
CH Hammegard, SD Wragg, GH Mills, D Kyroussis, MI Polkey, B Bake, et al.
Clinical assessment of diaphragm strength by cervical magnetic stimulation of the phrenic nerves.
Thorax, 51 (1996), pp. 123-142
[29]
DR el-Kabir, MI Polkey, RA Lyall, AJ Williams, J Moxham.
The effect of treatment on diaphragm contractility in obstructive sleep apnea syndrome.
Respir Med, 97 (2003), pp. 1021-1026
[30]
J Roca, J Sanchis, A Agustí-Vidal, F Segarra, D Navajas, R Rodríguez-Roisin, et al.
Spirometric reference values from Mediterranean population.
Bull Eur Physiopathol Respir, 22 (1986), pp. 217-224
[31]
J Roca, F Burgos, JA Barberá, J Sunyer, R Rodríguez-Roisín, J Castellsagué, et al.
Prediction equations for plethismografic lung volumes.
Respir Med, 92 (1998), pp. 454-460
[32]
J Roca, R Rodríguez-Roisín, E Cobo, F Burgos, J Pérez, JL Clausen.
Single breath carbon monoxide diffusing capacity prediction from a Mediterranean population.
Am Rev Respir Dis, 141 (1990), pp. 1026-1032
[33]
P Morales, J Sanchis, PJ Cordero, JL Dies.
Presiones respiratorias estáticas en adultos. Valores de referencia para población caucásica mediterránea.
Arch Bronconeumol, 33 (1997), pp. 213-219
[34]
YM Luo, N Hart, N Mustfa, WD Man, GF Rafferty, MI Polkey, et al.
Reproducibility of twitch and sniff transdiaphragmatic pressures.
Respir Physiol Neurobiol, 132 (2002), pp. 301-306
[35]
DF Rochester, NMT Braun, NS Arora.
Respiratory muscle strength in chronic obstructive pulmonary disease.
Am Rev Respir Dis, 119 (1979), pp. 151-154
[36]
T Similowsky, S Yan, AP Gauthier, PT Macklem.
Contractile properties of the human diaphragm.
N Engl J Med, 325 (1991), pp. 917-923
[37]
PT Macklem, DM Macklem, A de Troyer.
A model of inspiratory muscle mechanics.
J Appl Physiol, 55 (1983), pp. 547-557
[38]
M Orozco-Levi, J Gea.
El diafragma.
Arch Bronconeumol, 33 (1997), pp. 399-411
[39]
J Sánchez, G Medrano, B Debese, M Riquet, JP Derene.
Muscle fibre types in costal and crural diaphragm in normal men and in patients with moderate chronic respiratory disease.
Bull Eur Physiopathol Respir, 21 (1985), pp. 351-356
[40]
M Orozco-Levi, J Lloreta, J Minguella, S Serrano, JM Broquetas, J Gea.
Injury of the human diaphragm associated with exertion and chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 164 (2001), pp. 1734-1739
[41]
J Lloreta, M Orozco-Levi, J Gea, JM Corominas, S Serrano.
Selective diaphragmatic mitochondrial abnormalities in sever airflow obstruction.
Ultraestruct Pathol, 20 (1996), pp. 67-71
[42]
E Barreiro, B de la Puente, J Minguella, JM Corominas, S Serrano, SN Hussain, et al.
Oxidative stress and respiratory muscle dysfunction in severe chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 171 (2005), pp. 1116-1124
[43]
M Orozco-Levi, J Gea, JL Lloreta, M Félez, J Minguella, S Serrano, et al.
Subcellular adaptation of the human diaphragm in chronic obstructive pulmonary disease.
Eur Respir J, 13 (1999), pp. 371-378
[44]
S Levine, L Kaiser, J Leferovich, B Tikunov.
Cellular adaptations in the diaphragm in chronic obstructive pulmonary disease.
N Engl J Med, 337 (1997), pp. 1799-1806
[45]
PD Hughes, MI Polkey, D Kyroussis, CH Hamnegard, J Moxham, M Green.
Measurement of sniff nasal and diaphragm twitch mouth pressure in patients.
Thorax, 53 (1998), pp. 96-100
[46]
S Chieveley-Williams, L Dinner, A Puddicombe, D Field, AT Lovell, JC Goldstone.
Central venous and bladder pressure reflect transdiaphragmatic pressure during pressure support ventilation.
Chest, 121 (2002), pp. 533-538
[47]
MI Polkey, D Kyroussis, CH Hamnegard, GH Mills, M Green, J Moxham.
Diaphragm strength in chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 154 (1996), pp. 1310-1317
[48]
GH Mills, D Kyroussis, CH Humnegard, MI Polkey, M Green, J Moxham.
Bilateral magnetic stimulation of the phrenic nerves from an anterolateral approach.
Am J Respir Crit Care Med, 154 (1996), pp. 1099-1105
[49]
NS Hopkinson, WD Man, MJ Dayer, ET Ross, AH Nickol, N Hart, et al.
Acute effect of oral steroids on muscle function in chronic obstructive pulmonary disease.
Eur Respir J, 24 (2004), pp. 137-142
[50]
CH Hamnegard, SD Wragg, GH Mills, D Kyroussis, MI Polkey, B Bake, et al.
Clinical assessment of diaphragm strength by cervical magnetic stimulation of the phrenic nerves.
Thorax, 51 (1996), pp. 1239-1242
[51]
Z Luz, X Tang, X Huang.
Phrenic nerve conduction and diaphragmatic motor evoked potentials: evaluation of respiratory dysfunction.
Clin Med J, 111 (1998), pp. 496-499

Dr J. Martínez-Llorens received the SEPAR 2002 grant during the study period.

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