Article information
Resumen
Se provocó una peritonitis fecal por perforación del ciego en parejas de ratas anestesiadas mediante inyección de Ketolar. Los animales fueron sacrificados a distintas horas a partir de la inducción de la peritonitis, con objeto de estudiar las lesiones al microscopio electrónico.
En especial, los hallazgos sugieren que en las alteraciones producidas intervienen los leucocitos polimorfonucleares, lo que apoyaría el papel terapéutico de los corticoides y acetil-salicilato de Usina en el pulmón de shock y spesis.
Summary
Peritonitis was experimentally induced by perforating the cecum in rats previously anesthesized by Ketolar injection.
The animáis were sacrificed at different intervals after induction of the peritonitis and the lesions studied with electrón microscope.
The findings suggested that polymorphonuclear leukocytes played a role in producing alterations thus confirming the therapeutic valué of corticosteroids and lysine acetilsalycilate for the treatment of pulmonary shock and sepsis.
Full text is only aviable in PDF
Bibliografia
[1.]
G.H.A. Clowes Jr..
Pulmonary abnormalities in sepsis.
Surg Clin North Am, 54 (1974), pp. 991-1011
[2.]
G.H.A. Clowes Jr., E.M.F. Hirsh, L. Williams.
Septic lung and shock lung in man.
Ann Surg, 181 (1975), pp. 681-686
[3.]
L. Vito, R.C. Dennis, R.D. Weisel, H.B. Hechtman.
Sepsis presenting as acute respiratory insuficiency.
Surg Gynecol Obstet, 138 (1974), pp. 896-900
[4.]
E.H. Bergofsky.
The adult respiratory acute inssuficiency syndrome following non-thoracic trauma: the lung in shock.
Am J Cardiol, 26 (1970), pp. 619-626
[5.]
Petty TL, Ashbaugh DG. The adult respiratory distress syndrome. Chest 191; 60: 323-330.
[6.]
G.H.A. Clowes Jr., W. Zuscheid, M. Turner, G. Blenburn, J. Rbien, P. Toala, G. Creen.
Observations on the pathogenesis of neumonitis associated with sever infections in other parts of the body.
Ann Surg, 167 (1968), pp. 630-645
[7.]
M.J. Cledes, D. Bony, M.M. Emeriau, L. Potaux.
Le poumon des peritonites.
Bord Med, 116 (1972), pp. 1989-1991
[9.]
D.G. Mc Kay, W. Margaretten, I. Csavossy.
An electron microscope study of the effecs of bacterial endotoxin on the blood-vascular system.
Lab Invest, 15 (1966), pp. 1815-1829
[10.]
A.A. Brown, D.A. Willonghby.
Alteraciones estructurales en el pulmón de la rata consecutivas a tres tipos de shock.
pp. 21-35
[11.]
R.G. De Palma, J. Coil, J.H. Dais, W.D. Holden.
Cellular and ultrastructural changes in edotoxemia; a light electron microscopy study.
Surgery, 62 (1972), pp. 505-515
[12.]
W.E. Stehbens, M. Kostianovsky, A.C. Sonnenwirth.
Ultrastructure of the pulmonary microcirculation in experimental streptococcal bacteraemia.
Quart J Exp Physiol, 54 (1969), pp. 432-441
[13.]
L.H. Harrison, L.B. Hinshaw, J.J. Coalson, L.J. Greenfield.
Effects of live E Coli bacteremic shock on pulmonary hemodynamics and capillary permeability.
J. Thorac Cardiovasc Surg, 61 (1971), pp. 795-803
[14.]
D.G. Mc Kay, W. Margaretten, I. Csavossy.
An electron microscope estudy of endotoxin shock in Rhesus monkeys.
Surg Gynecol Obstet, 125 (1967), pp. 825-832
[15.]
J.J. Coalson, L.B. Hinshaw, C.A. Fuenter.
The pulmonary ultrastructure in septic shock.
Exp Molec Pathol, 12 (1970), pp. 84-103
[16.]
J.L. Ratliff, J.R. Fletcher, E.F. Hirsh, C.J. Kopriva.
The mecanism of the «lung lession» in shock.
Adv Exp Med Biol, 23 (1971), pp. 203-211
[17.]
Y. Peloux.
Bacteriological studies of peritonitis.
Ann Anaesthesiol, 19 (1978), pp. 895-902
[18.]
P. Cuevas, L.M. de la Maza, J. Gibbert, J. Fine.
The lung lession in four different types of shock in rabits.
Arch Surg, 104 (1972), pp. 319-322
[19.]
M. Bachofen, E.R. Weibel.
Alterations of the gasechange apparatus in adult respiratory insufficiency associated with septicaemia.
Am Rev Respir Dis, 116 (1977), pp. 589-615
[20.]
A. Almazán Enríquez, A. Gómez Alonso, J. García García, J.L. del Villar, A. Henarejos López.
Valor del uso profiláctico de un corticoide y una droga antinflamatoria no esteroidea en la peritonitis experimental endógena.
Rev Esp Enf Ap Digest, 58 (1980), pp. 367-372
[21.]
A. Almazán Enríquez, M. Ramon Boyero, F. Lozano Sánchez, A. Gómez Alonso.
Profilaxis de las alteraciones estructurales pulmonares en la peritonitis experimental.
Rev Esp Enf Ap Digest, (1982),
[22.]
H.E. Karrer.
The ultrastructure of mouse lung General architecture of capillary and alveolar walls.
J. Biophysic Biochem Cytol, 2 (1956), pp. 241-252
[24.]
K.L. Brigham, W.C. Woolverton, L.H. Blake, N.C. Staub.
Increased sheep lung vascular permeability caused by pseudomonas bacteria.
J. Clin Invest, 54 (1974), pp. 792-800
[25.]
E.E. Schneeberger.
Ultrastructural basis for alveolarcapillary permeability to protein.
Elsevier, Excerpta Médica, (1976), pp. p3
[26.]
T.S. Leeson, C.R. Leeson.
A ligth and electron microscope study of developping respiratory tissue in the rat.
J Anat, 98 (1964), pp. 183-197
[27.]
C.B. Carrington, T.J. Green.
Granular neumocytes in early repair of diffuse alveolar injury.
Arch Intern Med, 126 (1970), pp. 464-470
[28.]
M. Bachofen, E.R. Wibel.
Basic pattern of tissue repair in human lungs following unespecific injury.
Chest, 1 (1974), pp. 14-20
[29.]
H.J. Robb.
The role ot microembolism in the production of irreversible shock.
Ann Surg, 158 (1963), pp. 685-691
[30.]
K. Radegram.
Circulatory and respiratory effects of induced platelet agregation.
Acta Chir Scand, 420 (1971), pp. 9-15
[31.]
I.R. Berman, V.S. Gutiérrez, E.L. Burran, R.D. Boatrich.
Intravascular microagregation in young men with combat trauma.
Surg Forum, 20 (1969), pp. 14-20
[32.]
I.R. Berman.
The lung lesion in shock.
Adv Esp Med Biol, 23 (1971), pp. 51-65
[33.]
N.B. Ratliff, J.W. Wilson, E. Mikat.
Alterd leucocytes in pulmonary vessels of dogs in hemorrhagic shock.
Microvasc Res, 2 (1970), pp. 7-19
[34.]
N.B. Ratliff, J.W. Wilson, E. Mikat, D.B. Hackel, T.C. Graham.
The lung in hemorrhagic shock IV: The role of the neutrophilic polymorphonuclear leucocytes.
Am J Path, 65 (1971), pp. 325-334
[35.]
A.Z. Cohn, J.G. Hirsch.
The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes.
J Explt Med, 112 (1960), pp. 938-989
[36.]
G.P. Gladstone.
General pathology.
Ed. Lord Florey, (1970),
[37.]
G. Weissman, L. Thomas.
On a mechanism of tissue damage bu bacterial endotoxin. En Bacterial Endotoxins.
Rutgers Univ Press New Brunswick, (1964), pp. 602-609
[38.]
A. Almazán Enríquez.
Alteraciones estructurales pulmonares en la peritonitis experimental. Tesis doctoral.
Univ. de Salamanca, (1979), pp. 78-79
[39.]
W.S. Miller, J.H. Smith Jr..
Effect of acetylsalicytic acid on lysosomes.
Proc Soc Exp Biol Med, 122 (1966), pp. 634-639
[40.]
N. Al-Kaisi, J.R. Parrat, H.H. Siddiqui, I.J. Zeintlin.
Feline endotoxin shock: effect of methylprednisolone on kininogen depletion, on pulmonary circulation and on survival.
Br J. Pharmacol, 60 (1977), pp. 471-477
Copyright © 1982. Sociedad Española de Neumología y Cirugía Torácica
