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Vol. 57. Issue 5.
Pages 330-337 (May 2021)
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Vol. 57. Issue 5.
Pages 330-337 (May 2021)
Original Article
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Threats and Interventions During the Treatment of Tuberculosis in an Inner-city District
Factores de riesgo e intervenciones durante el tratamiento de la tuberculosis en un barrio marginal
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Neus Jovéa,1, Eva Masdeub,1, Sílvia Bruguerasb,c,d, Joan-Pau Milletb,c,e,f,
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juampablomillet@gmail.com

Corresponding author.
, Jesús E. Ospinab,c, Àngels Orcaub,c,f, Cristina Riusb,c,d, Joan A. Caylàf, Francesca Sáncheza,c
a Unitat Clínica de Tuberculosis, Hospital del Mar, Barcelona, Spain
b Servicio de Epidemiología, Agència de Salut Pública de Barcelona, Barcelona, Spain
c Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain
d Departamento de Pediatría, Obstetricia y Ginecología y Medicina Preventiva, Facultad de Medicina, Universidad Autónoma de Barcelona (UAB), Barcelona, Spain
e Serveis Clínics, Barcelona, Spain
f Fundació de la Unitat d’Investigació en Tuberculosi (fuiTB), Barcelona, Spain
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Tables (4)
Table 1. Distribution of cases and incidence of tuberculosis per 100,000 inhabitants in the districts of Ciutat Vella, Sant Martí and Barcelona per year. Mar Hospital, Barcelona, 2013–2016.
Table 2. Comparison of socio demographic and clinical variables between Spanish-born and foreign-born patients with tuberculosis. Mar Hospital, Barcelona, 2013–2016.
Table 3. Comparison of threats-related variables between Spanish and foreign-born patients with tuberculosis. Mar Hospital, Barcelona, 2013–2016.
Table 4. Comparison of variables related to adherence strategies used for Spanish-born and foreign-born tuberculosis patients. Mar Hospital, Barcelona, 2013–2016.
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Abstract
Background

Since there are active drugs against tuberculosis (TB), the most effective control measures are to assure treatment adherence and to perform contact tracing. Given the long treatment duration and characteristics of some TB patients, threats that put at risk treatment adherence may appear. Identify and address them is essential to achieve the objectives of disease control.

Objectives

To identify the epidemiological characteristics of TB patients and the incidents and threats occurring during treatment, to describe the interventions performed to enhance treatment adherence and to determine if there are differences among native and foreign-born patients in the TB clinical unit of a referral hospital in the inner city of Barcelona.

Methods

A descriptive, observational, cross-sectional study was performed. We recorded information on sociodemographic and clinical characteristics, incidents and interventions during treatment in all patients with TB diagnosed between September 2013 and August 2016.

Results

172 patients were included, 62.2% were foreign-born. The most common incidents and threats were medication-related complications (43.0%), missed follow-up visits (34.3%), communication problems (25.6%), comorbidities complications (23.8%), trips (19.2%), fear of social rejection (16.9%) and change of address (14.5%). The adherence-promoting interventions were: follow-up calls, directly observed treatment, medical and humanitarian reports, extra visits and cultural mediation. Incidents and interventions were more frequent in foreign-born patients, however there were no differences in treatment success among Spanish and foreign-born.

Conclusion

In this inner city several incidents occurred during TB treatment that can threaten adherence and are more common among foreign-born patients. Coordination among professionals from different healthcare settings was able to overcome obstacles in most cases and achieve TB treatment completion.

Keywords:
Adherence
Coordination
Incidents
Interventions
Nursing
Tuberculosis
Abbreviations:
ASPB
CHW
DHI
DOT
HIV
IDU
IQR
PHN
PLHIV
TB
TBCU
TBPCP
WHO
Resumen
Antecedentes

Dado que existen medicamentos activos contra la tuberculosis (TB), las medidas de control más efectivas son asegurar la adherencia al tratamiento y realizar un seguimiento cercano. Debido a la larga duración del tratamiento y las características de algunos pacientes con TB, pueden entrar en juego ciertos factores que hacen peligrar la adherencia al tratamiento. Identificar estos factores y abordarlos es esencial para lograr los objetivos de control de la enfermedad.

Objetivos

Identificar las características epidemiológicas de los pacientes con TB y los incidentes y factores que tienen lugar durante el tratamiento, describir las intervenciones realizadas para mejorar la adherencia al tratamiento y determinar si existen diferencias entre los pacientes nativos y extranjeros en la Unidad Clínica de TB de un hospital de referencia en el centro de la ciudad de Barcelona.

Métodos

Se realizó un estudio descriptivo, observacional y transversal. Registramos las características sociodemográficas y clínicas de todos los pacientes con TB diagnosticados entre septiembre de 2013 y agosto de 2016, así como los incidentes y las intervenciones realizadas durante el tratamiento.

Resultados

Se incluyeron 172 pacientes, el 62,2% eran nacidos en el extranjero. Los incidentes y los factores de riesgo más comunes fueron: complicaciones relacionadas con la medicación (43,0%), visitas de seguimiento perdidas (34,3%), problemas de comunicación (25,6%), complicaciones de las comorbilidades (23,8%), viajes (19,2%), miedo al rechazo social (16,9%) y cambio de domicilio (14,5%). Las intervenciones para el fomento de la adherencia fueron: llamadas de seguimiento, tratamiento directamente observado, informes médicos y humanitarios, visitas adicionales y mediación cultural. Los incidentes e intervenciones fueron más frecuentes en pacientes nacidos en el extranjero; sin embargo, no hubo diferencias en el éxito del tratamiento entre españoles y nacidos en el extranjero.

Conclusión

En este barrio marginal ocurrieron varios incidentes durante el tratamiento de TB que pueden poner en peligro la adherencia y que son más frecuentes entre los pacientes nacidos en el extranjero. La coordinación entre profesionales de los diferentes entornos de atención médica fue capaz de superar los obstáculos en la mayoría de los casos y lograr la finalización del tratamiento de la TB.

Palabras clave:
Adherencia
Coordinación
Incidentes
Intervenciones
Enfermería
Tuberculosis
Full Text
Introduction

Tuberculosis (TB) continues to be a global public health problem worldwide. According to the World Health Organization (WHO) report of 2017, 10.4 million cases were diagnosed worldwide in 2016. A total of 65% of cases occurred in men, 10% in persons living with HIV (PLHIV), and 56% were concentrated in 5 countries: India, Indonesia, China, the Philippines and Pakistan. In all, 3% of cases (290,000 cases) occurred in Europe, with an incidence of 32 cases/100,000 inhabitants.1 In the same period, the incidence of notified cases was 10.7 and 13.3 cases/100,000 inhabitants in Spain as a whole and in Catalonia, respectively and was 16.6 cases/100,000 inhabitants in the city of Barcelona.2,3

Since active drugs against Mycobacterium tuberculosis became available, the most effective measures for TB control and treatment success are early diagnoses and adherence to anti-TB therapy. Given that treatments are long, even those shortened to 6 months, treatment adherence is essential to achieve TB control targets. Indeed, as observed with other chronic transmissible infections such as PLHIV, non-adherence to treatment has a human, economic and very important social cost. Treatment discontinuation reduces its effectiveness, increases transmission, and causes drug resistance, thus increasing morbidity, mortality and more widespread infection. These diseases mainly affect economically and socially disadvantaged groups and may require complex treatment regimens. They are thus a public health priority.4

According to the WHO report on long-term treatment adherence, adherence can be defined as the extent to which a person's behavior corresponds to the recommendations agreed with the health provider. The patient's context is determined by factors related to his or her socioeconomic status, the healthcare team or health system, the disease, treatment, and individual characteristics. Consequently, these factors need to be targeted in interventions to prevent treatment discontinuation.5

The Barcelona TB prevention and control program (TBPCP) was created in 1987, and public health nurses (PHN) played an essential role in following-up TB cases and conducting contact tracing. In its early beginnings, the program encouraged directly observed treatment (DOT) for homeless persons with TB in the inner city (Ciutat Vella) and progressively guaranteed community- or hospital-based DOT for patients showing poor adherence.6 Community health workers (CHW) were incorporated in 2003 because of the increase in immigration from countries with a high TB burden, and their role was to support public health nurses and act as cultural mediators and translators.7 Later, five TB clinical units (TBCU) were created, located at the four large hospitals in Barcelona and in a specialist TB outpatient unit. A key figure in these units is the nurse case manager, who follows up TB patients, performs contact tracing, and supervises treatments always in coordination with public health nurses from TBPCP as well as with other professionals.8 Therefore, this has made it possible to increase TB treatment adherence until 88.5%.3

The aim of this study was to identify the sociodemographic and epidemiological characteristics of TB cases, the incidents occurring during treatment that could influence treatment adherence and contact tracing, the interventions performed to promote adherence comparing foreign-born and Spanish-born patients in a hospital from the inner city of Barcelona with a TBCU, the Mar Hospital, with a population reference of 336,900 inhabitants living in the districts of Sant Martí and Ciutat Vella in Barcelona.

Materials and methodsDesign

A population based observational descriptive cross-sectional study in a multidisciplinary specialist TBCU in Mar Hospital in Barcelona from September 1, 2013 to August 31, 2016 was performed. Follow-up of cases was closed in April 2018.

Setting

The TBCU has three medical specialties (pneumology, infectious diseases and pediatrics), a nurse case manager and an administrative assistant. The unit is part of a university referral hospital for the districts of Ciutat Vella and Sant Martí where there is very important immigration from countries with a high TB burden (the percentage of the foreign-born population registered in the districts being 45% and 16.5%, respectively, during the study period). The day to day work is coordinated by the TBPCP of Barcelona. These programs are composed of PHN, CHW, DOT teams and a specialized center for long-term inpatient care of TB patients.

Study participants

This study included all patients with TB diagnosed and under follow-up by the TBCU of the hospital and notified to the Epidemiology Service of the Barcelona Public Health Agency (ASPB) through the circuits established for reporting notifiable diseases. TB cases were defined as patients with a clinical and/or microbiological diagnosis of TB starting treatment within the study period.9

Data collection

A data collection form was designed for the registration of the various threats that could jeopardize treatment adherence and patient and contact follow-up, as well as the strategies applied to maintain adherence. This form was complemented by an epidemiological survey of the Barcelona TBPCP, collected by PHN from the Epidemiology Service of ASPB for each TB patient, obtaining sociodemographic, clinical–epidemiological, microbiological treatment variables and data on contact tracing. To complete all the information, the patients’ clinical records, the follow-up forms of the public health nurses and those of the CHW were also consulted.

Definitions

Homeless: persons living on the street or in municipal facilities, centers or shelters (with no fixed abode) and who could be at risk of rooflessness at any moment.

Disposable household income (DHI) index: variable constructed by the Statistics Department of the Barcelona City Council to determine the socioeconomic position of TB patients based on the postal address gathered in the survey, bearing in mind various indicators.10

TB risk factors: the following risk factors were collected in the epidemiological survey of the Barcelona TB program: diabetes, silicosis, renal insufficiency, pregnancy, immunosuppressive therapy, gastrectomy, injecting drug use, HIV/AIDS infection, alcohol abuse, tobacco use, homelessness, and problems with the law or prison.

Threat: event occurring during the treatment of TB that could jeopardize their treatment adherence, follow-up or contact tracing.

Perception and fear of social rejection: includes the perception reported by patients themselves and the variables “does not want to tell co-habitants of his/her diagnosis”, “does not want people at work to know of his/her diagnosis” and “refuses DOT”.

Extra visit: a nurse or physician visit scheduled before the routine follow-up visit (30 days in our TBCU).

Extra report: a medical and/or social report containing an up-to-date summary of the patient's clinical and/or social situation and which is not a discharge report. These reports include humanitarian reports, which are medical reports specifying the patient's disease and stating that treatment cannot be ensured in his or her country of origin.

Successful treatment: according to WHO definition, a cured patient was a patient whose sputum smear or culture was positive at the beginning of the treatment but who was smear- or culture-negative in the last month of treatment and on at least one previous occasion. Patients who completed treatment but who did not have a negative sputum smear or culture result in the last month of treatment and on at least one previous occasion were classified as having “completed treatment”. These two categories were considered as treatment success in this study.11 Therefore successful treatment are cured TB patients plus patients that completed TB treatment.

Ethical considerations

In agreement with the ethical principles of the Declaration of Helsinki12 on the autonomy and voluntary participation of human research subjects, an informed consent form was signed by all patients and the anonymity and confidentiality of the data were maintained, in accordance with the Spanish Data Protection Law 3/201813 and the General Data Protection Regulation (EU) 2016/679.14 The project was approved by the Clinical Research Ethics Committee of Parc de Salut Mar (number 2014/5840/I).

Data analysis

A descriptive analysis of the data was performed. The median and interquartile range (IQR) were calculated for quantitative variables, as they did not follow a normal distribution, while proportions were calculated for categorical variables. To compare foreign with native-born patients, in the bivariate analysis, categorical variables were compared with the chi-square test or the corresponding non-parametric tests. We calculated 95% confidence intervals (CI) and statistical significance was set at 5% (p-value<0.05).

The percentage of patients attended in Mar Hospital from the catchment areas of Ciutat Vella and Sant Martí was calculated and the number of cases treated in the hospital was compared with the total number of cases in the two districts and the number of new TB cases in the city of Barcelona during the study period. The statistical analysis was conducted using the SPSS 20.0 statistical package.

Validity and reliability

Based on the patients’ clinical records, a data collection form was designed specifically for the study, which helped to ensure the rigor of the registry and coherence of the information. In addition, the information from the TB program was also used as a data source. This program has more than 30 years of experience in TB control and surveillance. From the initiation of the program, information reaching it is validated and contrasted throughout treatment by experienced epidemiologists.

Results

During the study period, 172 TB cases were treated in the TBCU of Mar Hospital. A total of 40% and 55% occurred among residents of Ciutat Vella and Sant Martí districts, respectively. The distribution of cases and incidence of TB according to district are presented in Table 1. The table shows a higher incidence of tuberculosis in Ciutat Vella in relation to Sant Marti and Barcelona.

Table 1.

Distribution of cases and incidence of tuberculosis per 100,000 inhabitants in the districts of Ciutat Vella, Sant Martí and Barcelona per year. Mar Hospital, Barcelona, 2013–2016.

Year  Ciutat VellaSant MartíBarcelona
  Cases Mar Hospital  Total cases  Incidence  Cases Mar Hospital  Total cases  Incidence  Cases Mar Hospital  Total cases  Incidence 
2013  8  78  67.0  8  48  21.6  17  329  20.4 
2014  33  62  60.5  20  43  17.2  59  300  18.6 
2015  27  58  58.7  18  44  19.6  54  280  17.4 
2016  20  42  43.8  8  25  10.5  30  260  16.2 

Ref: Programa de Prevenció i Control de la Tuberculosi de Barcelona. La Tuberculosi a Barcelona. Informe. Barcelona: Agència de Salut Pública de Barcelona (2013–2016).

Cases per 100,000 inhabitants.

Study period: September 1, 2013–December 31, 2013 and January 1, 2016–August 31, 2016.

Of the 172 patients included, 106 (61.6%) were men. The median age was 43 years (IQR: 32.2–56). A total of 107 (62.2%) were foreign-born, of which 54 (31.3%) were born in the Indian subcontinent, 12 (6.9%) in Latin America, and 12 (6.9%) in Eastern Europe, while 9 patients were born in Morocco and 9 in the Philippines. Table 2 compares socio-demographic characteristics and clinical variables among Spanish and foreign-born patients.

Table 2.

Comparison of socio demographic and clinical variables between Spanish-born and foreign-born patients with tuberculosis. Mar Hospital, Barcelona, 2013–2016.

Variables  Categories  Spanish-born (N=65)N (%)  Foreign-born (N=107)N (%)  Total(N=172)N (%)  p-Value 
SexMale  38 (58.5)  68 (63.6)  106 (61.6)   
Female  27 (41.5)  39 (36.4)  66 (38.4)  0.506 
Age  Median (IQR)  54 (42.5–72.5)  38 (29–49)  43 (32.25–56)  <0.001 
Age groups**0–14  5 (7.7)  2 (1.9)  7 (4.1)  0.106* 
15–24  1 (1.5)  12 (11.2)  13 (7.6)  0.019* 
25–39  5 (7.7)  45 (42.1)  50 (29.1)  <0.001 
40–64  33 (50.8)  44 (41.1)  77 (44.8)  0.217 
>64  21 (32.3)  4 (3.7)  25 (14.5)  <0.001* 
Income according to DHI**Low  26 (43.3)  68 (70.8)  94 (54.7)  0.003 
Low-medium  21 (35.0)  19 (19.8)  40 (23.3)  0.029 
Medium-high  10 (16.7)  7 (7.3)  17 (9.9)  0.060 
High-very high  3 (5.0)  2 (2.1)  5 (2.9)  0.367 
Employment groups**Unemployed  10 (16.7)  42 (39.6)  52 (30.2)  0.001 
Student  2 (3.3)  7 (6.6)  9 (5.2)  0.486 
Retired  16 (26.7)  2 (1.9)  18 (10.5)  <0.001 
Employed  29 (48.3)  52 (49.1)  81 (47.1)  0.612 
Not known  3 (5.0)  3 (2.8)  6 (3.5)  0.674 
Tobacco useYes  30 (46.2)  36 (33.6)  66 (38.4)   
No  35 (53.8)  71 (66.4)  106 (61.6)  0.102 
Alcohol abuseYes  8 (12.3)  10 (9.3)  18 (10.5)   
No  57 (87.7)  97 (90.7)  154 (89.5)  0.538 
IDUYes  2 (3.1)  5 (4.7)  7 (4.1)   
No  63 (96.9)  102 (95.3)  165 (95.9)  0.711* 
HomelessnessYes  4 (6.2)  14 (13.1)  18 (10.5)   
No  61 (93.8)  93 (86.9)  154 (89.5)  0.15 
HIVYes  5 (7.7)  6 (5.6)  11 (6.4)   
No  60 (92.3)  101 (94.4)  161 (93.6)  0.749* 
Immunosuppressive therapyYes  8 (12.3)  5 (4.7)  13 (7.6)   
No  57 (87.7)  102 (95.3)  159 (92.4)  0.079* 
DiabetesYes  9 (13.8)  10 (9.3)  19 (11.0)   
No  56 (86.2)  97 (90.7)  153 (89.0)  0.361 
TB localizationPulmonary  46 (70.8)  54 (50.5)  100 (58.1)   
Extra pulmonary  19 (29.2)  53 (49.5)  72 (41.9)  0.009 
1st line drug resistance$Yes  5 (7.7)  7 (6.5)  12 (7.0)   
No  40 (61.5)  61 (57.0)  101 (58.7)   
Unknown  20 (30.8)  39 (36.4)  59 (34.3)  0.741* 
Prison or problems with the lawYes  1 (1.5)  4 (3.7)  5 (2.9)   
No  64 (98.5)  103 (96.3)  167 (97.1)  0.651* 
Treatment outcome**Treatment success  56 (86.2)  93 (86.9)  149 (86.6)  0.887 
TB death  2 (3.1)  0 (0.0)  2 (1.2)  0.141 
Other causes death  7 (10.8)  4 (3.7)  11 (6.4)  0.105 
Prolonged treatment  0 (0.0)  1 (0.9)  1 (0.6)  1.000 
Transfer  0 (0.0)  5 (4.7)  5 (2.9)  0.158 
Lost to follow-up  0 (0.0)  4 (3.7)  4 (2.3)  0.299 
Risk factorsYes  44 (67.7)  59 (55.1)  103 (59.9)   
No  21 (32.3)  48 (44.9)  69 (40.1)  0.103 

IQR: interquartile range; DHI: disposable household income index; IDU: intravenous drug use; HIV: human immunodeficiency virus; TB: tuberculosis.

Median test (for two independent samples).

*

Fisher's exact test.

$

Any kind of 1st line drug resistance.

Risk factors: diabetes, silicosis, renal insufficiency, pregnancy, immunosuppressive therapy, gastrectomy, intravenous drug use, HIV/AIDS infection, risky alcohol use, smoking, homelessness, and problems with the law or having had a prison sentence.

**

Age groups: global p-value <0.001. Income according to DHI: global p-value=0.008. Employment groups: global p-value <0.001. Treatment conclusion: global p-value <0.029.

In all, 134 patients (78.0%) lived in low- or low-medium income neighborhoods and 81 (47.1%) were employed. At least one risk factor for TB was present in 103 patients (59.9%). Disease localization was pulmonary or mixed in 100 patients (58.1%) and resistance to anti-TB drugs was detected in 12 patients (7%), one of whom showed multiresistance. Treatment success was achieved in 150 patients (86.6%), 5 (2.9%) moved to other autonomous communities of Spain or abroad, 4 (2.3%) were lost to follow-up, and 13 (7.5%) died (2 due to TB) (see Table 2).

Comparison of data from foreign and native-born patients revealed statistically significant differences: foreign-born patients contracted TB at younger ages, lived in neighborhoods with lower incomes, and a higher percentage were unemployed. A larger proportion of native-born patients were pensioners. Pulmonary localization was more common among native-born patients. There were no differences in treatment conclusion between the two groups. A comparison of sociodemographic, clinical and epidemiological factors between foreign and native-born patients is shown in Table 2.

Incidents occurred during follow-up in 151 patients (87.8%) with a median of 2 incidents per patient (IQR: 0–7). Medication-related complications occurred in 74 patients (43%), and exacerbation of comorbidities in 41 (23.8%).59 patients (34.3%) failed to attend follow-up visits in at least one occasion, and 33 patients (19.2%) reported traveling abroad during treatment (see Table 3).

Table 3.

Comparison of threats-related variables between Spanish and foreign-born patients with tuberculosis. Mar Hospital, Barcelona, 2013–2016.

Variables  Categories  Spanish-born(N=65)N (%)  Foreign-born(N=107)N (%)  Total(N=172)N (%)  p-Value 
Number of threats  Median (IQR)  1 (0–2)  3 (2–4)  2 (1–4)  <0.001 
ThreatsNone  19 (29.2)  2 (1.9)  21 (12.2)   
One or more  46 (70.8)  105 (98.1)  151 (87.8)  <0.001 
Medication-related complicationsYes  30 (46.2)  44 (41.1)  74 (43.0)   
No  35 (53.8)  63 (58.9)  98 (57.0)  0.518 
Type of medication-related complications (N=74)Side effects or intolerance  16 (53.3)  23 (52.3)  39 (52.7)   
Treatment prolongation  14 (46.7)  21 (47.7)  35 (47.3)  0.929 
Complication of comorbiditiesYes  20 (30.8)  21 (19.6)  41 (23.8)   
No  45 (69.2)  86 (80.4)  131 (76.2)  0.096 
Missing in some follow-up visitYes  11 (16.9)  48 (44.9)  59 (34.3)   
No  54 (83.1)  59 (55.1)  113 (65.7)  <0.001 
TravelYes  2 (3.1)  31 (29.0)  33 (19.2)   
No  63 (96.9)  76 (71.0)  139 (80.8)  <0.001 
Communication problemsYes  1 (1.5)  43 (40.2)  44 (25.60)   
No  64 (98.5)  64 (59.8)  128 (74.4)  <0.001 
Change of addressYes  6 (9.2)  19 (17.8)  25 (14.5)   
No  59 (90.8)  88 (82.2)  147 (85.5)  0.124 
Job lossYes  1 (1.5)  2 (1.9)  3 (1.7)   
No  64 (98.5)  105 (98.1)  169 (98.3)  1* 
Perception and fear of social rejectionYes  15 (23.1)  14 (13.1)  29 (16.9)   
No  50 (76.9)  93 (86.9)  143 (83.1)  0.090 
Problems of unstable housingYes  1 (1.5)  14 (13.1)  15 (8.70)   
No  64 (98.5)  93 (86.9)  157 (91.3)  0.009 
Health cardYes  65 (100)  95 (88.8)  160 (93.00)   
No  0 (0.0)  12 (11.2)  12 (7.0)  0.004* 

IQR: interquartile range.

Median test (for two independent samples).

*

Fisher's exact test.

Communication problems were detected in 44 patients (25.6%) and 25 patients (14.5%) changed address; of these, 19 (76%) had pulmonary TB. Another effect of TB diagnosis was stigmatization: 3 patients (1.7%) lost their jobs, 29 (16.9%) showed attitudes influenced by fear of social rejection (not mentioning their diagnosis to cohabitants or at work, not accepting DOT due to fear of rejection by neighbors and/or discrimination in their environment). Compared with Spanish-born, foreign-born patients showed a higher number of threats during treatment, traveled more often, missed more follow-up visits, and had more problems of unstable housing (p<0.05). A comparison of incidents during treatment between native and foreign-born patients is shown in Table 3.

Various strategies were used to maintain adherence. DOT was conducted in a specialized intermediate care center in 82 patients (47.7%), either as long term inpatients or community based DOT outpatients. Extra reports were issued for 85 patients (49.4%), and additional visits were scheduled for 41 (23.8%). Cultural mediation during hospital visits was provided for 27 patients (15.7%), while CHW from the ASPB intervened in 40 patients (13.3%). The PHN and the hospital-based nurse case manager made follow-up telephone calls and coordinated with different healthcare levels in 112 patients (65.1%). Contact tracing was conducted in 79 patients with pulmonary TB (79%) and in 36 with non-pulmonary TB (50%). Eight patients lived alone (4.7%) and 13 refused contact tracing (7.6%) (see Table 4).

Table 4.

Comparison of variables related to adherence strategies used for Spanish-born and foreign-born tuberculosis patients. Mar Hospital, Barcelona, 2013–2016.

Variables  Categories  Spanish-born(N=65)N (%)  Foreign-born(N=107)N (%)  Total(N=172)N (%)  p-Value 
Contact tracing*Conducted  40 (61.5)  75 (70.1)  115 (66.9)  0.248 
Refused  2 (3.1)  11 (10.3)  13 (7.6)  0.135 
Live alone  5 (7.7)  3 (2.8)  8 (4.7)  0.156 
Not come  18 (27.7)  18 (16.8)  36 (20.9)  0.089 
DOTYes  25 (38.5)  57 (53.3)  82 (47.7)  0.059
No  40 (61.5)  50 (46.7)  90 (52.3) 
Extra visitsYes  18 (27.7)  23 (21.5)  41 (23.8)  0.355
No  47 (72.3)  84 (78.5)  131 (76.2) 
Extra reportsYes  17 (26.2)  68 (63.6)  85 (49.4)  <0.001
No  48 (73.8)  39 (36.4)  87 (50.6) 
Cultural mediationYes  0 (0.0)  27 (25.2)  27 (15.7)  <0.001
No  65 (100.0)  80 (74.8)  145 (84.3) 
CHW interventionYes  3 (4.6)  37 (34.6)  40 (23.3)  <0.001
No  62 (95.4)  70 (65.4)  132 (76.7) 
Follow-up callsYes  33 (50.8)  79 (73.8)  112 (65.1)  0.002
No  32 (49.2)  28 (26.2)  60 (34.9) 

DOT: directly observed treatment; CHW: Community health workers; TB: tuberculosis.

*

Contact tracing: global p-value=0.056.

Foreign-born required more reports, additional visits and telephone calls and were also more frequently referred to DOT centers. There was no statistical differences between Spanish-born and foreign-born patients regarding to contact tracing coverage. The strategies used to maintain adherence by country of origin (native or foreign-born) are shown in Table 4.

Discussion

The profile of persons diagnosed in this study corresponded to young adults (median age, 43 years), from countries with a high TB burden, especially the Indian subcontinent, of working age and living in low-income neighborhoods. As in other countries in the European Union, these patients had other risk factors in addition to being immigrants, such as immunosuppression, alcohol abuse, tobacco use, psychoactive substance use and, sometimes, problems with the law.15 Other risk factors were social vulnerability, low socioeconomic position, precarious employment not covering basic needs, unhealthy lifestyles and low individual perception of risk, with little appreciation of the personal and community effects of the disease.16 This at-risk population is most numerous in Ciutat Vella,17 an inner city district of Barcelona that, as in London18 or Rotterdam,19 is characterized by being situated in the city center, with a large socially deprived population and an incidence of TB three times higher than that of the city as a whole. Moreover, in Ciutat Vella, there is a higher percentage of those foreign-born compared to the city of Barcelona, as well as a higher incidence of TB due to the high burden of disease in the foreign-born population.2,3,7,17

In this study, we found that a lot and different social, economic and treatment-related threats usually happen during the long treatment period required in TB patients. In agreement with the findings of studies conducted in other countries with a high TB burden such as Colombia and Peru, medication-related complications (side effects) and the presence of comorbidities concurrent with TB were highly common incidents that could provoke treatment withdrawal.20,21 Adverse reactions were also associated with having stopped treatment in a low incidence setting.22 Another common threat was missing follow-up visits. Factors related to this finding in other European cities were a lower perception of risk and suboptimal working conditions.15

Communication problems frequently occurred, due both to patients’ language barriers and to the complexity of healthcare-related information, which, as shown by the literature poses a major threat to adherence in different settings.23–25 Therefore, understanding health information is a requisite for correctly following treatment. Effective communication is essential for patients to take informed decisions and participate in health-promoting processes. As was already described among foreign-born TB patients in Barcelona,7 CHW strategy contributed to minimize this problem also for TB patients for this hospital. Another obstacle identified during TB treatment follow-up was traveling. Foreign-born move aboard more often than the Spanish-born population. Patients usually travel to their country of origin, which can lead to losses to follow-up and TB treatment discontinuation.26–28

Nevertheless, the most important data in our study were those related to the social discrimination affecting TB patients. These findings prompt reflection on the fact that, despite all the knowledge accumulated over the years, TB patients continue to experience perception of social rejection.16 Factors detected in this study were patients not mentioning their diagnosis to cohabitants or in the workplace, not accepting supervised treatment for fear of rejection in their environment, losing their Jobs or being at risk of having to change address because of their diagnosis. These factors directly impacted the therapeutic process and contact tracing. A study conducted in India, the country of origin of many of the patients in this study, supports this reflection and stresses that a substantial proportion of opinion leaders and social representatives show discriminatory behavior toward people who have had TB.29 Another study from Colombia revealed that health professionals, despite having sufficient knowledge of the disease, hold mistaken beliefs leading to discrimination against specific social groups.30 Among countries with a low TB burden, studies have been performed in the USA, Canada, the United Kingdom, Europe and Australia that mention the association between TB, stigma and immigrant communities and demonstrate the interaction between social and cultural determinants and stigma.31 Therefore, a negative social response to TB is universal. While global investigation is focused on treatment and diagnostic tools simplification, the available literature shows insufficient data on research, interventions and recommendations on this topic.32,33

Numerous strategies have been reported in the literature to enhance treatment adherence and contact tracing, including reminders and food vouchers, adherence agreements, intensive patient supervision and social support, the use of new technologies such as an ingestible sensor-based system, video-calls, video DOT etc., which seem to have some potential.34,35 However, broad consensus in the literature is reserved for multi-pronged approaches known as “intervention packages”. This approach is based on patients’ needs and is effective in enhancing adherence.5,36–41 The combined use of all the strategies employed in this study—follow-up calls and liaison between healthcare levels, medical and humanitarian reports, DOT, extra visits, cultural mediation and CHW—allowed completion of most anti-TB treatments and contact tracing. The work performed in a network consisting of healthcare and non-healthcare professionals was essential to carry out these activities. Among other elements, key factors configuring the strategy implemented by the Barcelona TB Program are TB units with nurse case managers, public health teams, DOT teams, CHW, primary care and methadone maintenance programs.7,42,43 As in other countries such as the United Kingdom, the cornerstones of this strategy are flexible healthcare, multidisciplinary teams, and the assignment of a health professional as a key worker to each patient with TB.44

This study found that, compared with Spanish-born, foreign-born patients showed a higher number of threats and incidents during treatment. However, foreign-born required more interventions and finally had similar treatment evolution than Spanish-born patients. Therefore, we can assume that the greater number of interventions in the group with more incidents would be the cause of the similar final evolution.

One of the strengths of this study is that it provides an overall view of the context of patients treated in a referral hospital in Barcelona. The Spanish health system provides universal and for-free coverage. Moreover, the Barcelona TB Program has broad experience and there is clear coordination between the various stakeholders involved in the management and control of TB. The study designed a specific data collection form, favoring rigor in registering data and coherence of the information. In addition, various data sources were used, ensuring the veracity of the data. On the other hand, this study has the limitations characteristic of observational designs such us little control of confounding factors. Moreover, under-registering of the activities reported by the professionals involved in patient follow-up was possible. Another limitation was the small number of cases, which did not allow for more complex statistical analyzes.

Conclusion

Identifying the context and incidents occurring during TB treatment allows the implementation of measures to enhance patients’ adherence. Moreover, coordinated interventions between professionals from different health fields allow to complete treatment: interventions aiming to reduce stigma, improve the administrative situation of the patients, and ensure adequate treatment during trips. The most effective strategy is combining a package of multidisciplinary interventions responding to the particular needs of each patient.

Authors’ contributions

All authors were involved in the conception or design of the work; the acquisition, analysis and interpretation of data; the drafting of the work and revising it critically; the final approval; and agree to be accountable for all aspects of the work.

Competing interests

The authors declare that they have no competing interests.

Funding

No additional funding was required.

Ethics approval and consent to participate

The project was approved by the Clinical Research Ethics Committee of Parc de Salut Mar (number 2014/5840/I).

Acknowledgments

The authors would like to thank all the public health nurses, CHW and committed team of the Barcelona Public Health Agency, the TB Clinic (Serveis Clínics) staff, the social workers and the Mar Hospital team for their support and contributions to this study.

References
[1]
World Health Organization (WHO). Global TB report 2017 [Internet]. WHO Geneva, editor; 2017. Available from: https://extranet.who.int/tme.
[2]
A. Rodés Monegal, M. López Espinilla, M. García Lebrón.
Informe anual 2016.
Situació epidemiològica i tendència de l’endèmia tuberculosa a Catalunya [Internet], (2018),
[3]
À. Orcau, J.A. Caylà, C. Rius.
La Tuberculosi a Barcelona. Informe 2016.
Serv d’Epidemiologia Agència Salut Pública Barcelona [Internet], (2018),
[4]
S. Munro, S. Lewin, T. Swart, J. Volmink.
A review of health behaviour theories: how useful are these for developing interventions to promote long-term medication adherence for TB and HIV/AIDS?.
BMC Public Health, 7 (2007), pp. 1-16
[5]
World Health Organization (WHO).
Adherence to long-term therapies: evidence for action.
WHO, (2003), pp. 199-229
[6]
E. Diez, J. Claveria, T. Serra, J.A. Caylà, J.M. Jansà, R. Pedro, et al.
Evalution of a social health intervention among homeless tuberculosis patients.
Tuber Lung Dis [Internet], 77 (1996), pp. 420-424
[7]
J.E. Ospina, A. Orcau, J.-P. Millet, F. Sánchez, M. Casals, J.A. Caylà.
Community health workers improve contact tracing among immigrants with tuberculosis in Barcelona.
BMC Public Health [Internet], 12 (2012), pp. 158
[8]
Consorci Sanitari de Barcelona. Guia i proposta d’organització per a la prevenció i control de la tuberculosi a a la Regió Sanitària Barcelona. Generalitat de Catalunya. Departament de Salut. Consorci Sanit Barcelona [Internet]; 2008. Available from: https://www.aspb.cat/wp-content/uploads/2016/10/guiaorganitzacio_TB.pdf.
[9]
Departament de Salut. Direcció General de Salut Pública. Definició de cas de les Malalties de Declaració Obligatòria. Barcelona Dir Gen Salut Pública [Internet]; 2006. Available from: http://canalsalut.gencat.cat/web/.content/80_Professionals/Vigilancia_epidemiologica/documents/arxius/spdefimdo.pdf [cited 08.05.19].
[10]
C. Martí, E. Casas, A. Jorge Juan, J. Martí, J. Conde, G. Figuerola.
Distribució territorial de la Renda Familiar per càpita a Barcelona.
Barcelona Ajunt Barcelona [Internet], (2007),
[11]
World Health Organization (WHO).
Treatment of tuberculosis guidelines.
4th edition, World Heal Organization, (2010),
[12]
Declaración de Helsinki de la AMM. Principios éticos para las investigaciones médicas en seres humanos. Asoc Médica Mund [Internet]; 2013; Available from: http://www.isciii.es/ISCIII/es/contenidos/fd-investigacion/fd-evaluacion/fd-evaluacion-etica-investigacion/Declaracion-Helsinki-2013-Esp.pdf.
[13]
Ley Orgánica 3/2018, de 5 de diciembre, de Protección de Datos Personales y garantía de los derechos digitales [Internet]. Madrid: Noticias jurídicas BOE núm. 294; 2018. Available from: http://noticias.juridicas.com/base_datos/Laboral/632849-lo-3-2018-de-5-dic-proteccion-de-datos-personales-y-garantia-de-los-derechos.html [cited 18.04.19].
[14]
Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC [Internet]. Official Journal of the European Union, vol. L119; 2016. p. 1–88. Available from: https://publications.europa.eu/en/publication-detail/-/publication/3e485e15-11bd-11e6-ba9a-01aa75ed71a1/language-en [cited 18.04.19].
[15]
N.A. van Hest, R.W. Aldridge, G. de Vries, A. Sandgren, B. Hauer, A. Hayward, et al.
Tuberculosis control in big cities and urban risk groups in the European Union: a consensus statement.
Eurosurveillance [Internet], 19 (2014),
[16]
P. Salas Abarca, H. Chamizo García.
Determinantes sociales de la adherencia al tratamiento de la tuberculosis: una discusión desde la perspectiva heurística del riesgo.
Rev Ciencias Adm y Financ la Segur Soc [Internet], 10 (2002), pp. 67-78
[17]
A. Novoa, M. Rodriguez-Sanz, A. Sentis, A. Espelt, A. Orcau, P. Garcia de Olalla.
La salut als districtes 2015: Ciutat Vella.
Barcelona Agència Salut Pública Barcelona [Internet], (2016),
[18]
Public Health England.
Tuberculosis in London annual review (2016 data).
Public Heal England, (2017), pp. 1-47
[19]
A. Sandgren, N.A. van Hest, R.W. Aldridge, G. de Vries, J.A. Caylà, W.H. Haas, et al.
Epidemiology of tuberculosis in big cities of the European Union and European Economic Area countries.
Eurosurveillance, 19 (2014), pp. 1-8
[20]
C. Navarro Quintero, J. Rueda Rincón, J. Mendoza Ojeda.
Factores asociados al abandono del tratamiento antituberculoso en pacientes con TB.
Rev Cienc y Cuid, 10 (2013), pp. 19-27
[21]
D.R. Culqui, E.C.V. Munayco, C.G. Grijalva, J.A. Cayla, O. Horna-Campos, K. Alva Ch, et al.
Factores asociados al abandono de tratamiento antituberculoso convencional en Perú.
Arch Bronconeumol, 48 (2012), pp. 150-155
[22]
D. Antoine, C.E. French, J. Jones, J.M. Watson.
Tuberculosis treatment outcome monitoring in England, Wales and Northern Ireland for cases reported in 2001.
J Epidemiol Community Health, 61 (2007), pp. 302-307
[23]
S. Thiam, A.M. LeFevre, F. Hane, A. Ndiaye, F. Ba, K.L. Fielding, et al.
Effectiveness of a strategy to improve adherence to tuberculosis treatment in a resource-poor setting.
[24]
S. Iribarren, S. Beck, P.F. Pearce, C. Chirico, M. Etchevarria, D. Cardinale, et al.
TextTB: a mixed method pilot study evaluating acceptance, feasibility, and exploring initial efficacy of a text messaging intervention to support TB treatment adherence.
Tuberc Res Treat, (2013), pp. 1-12
[25]
D.A. Bukstein.
Patient adherence and effective communication.
Ann Allergy Asthma Immunol [Internet], 117 (2016), pp. 613-619
[26]
B. Sanz Barbero, T. Blasco Hernández, S. Galindo Carretero.
Abandono del tratamiento antituberculoso en la población inmigrante: la movilidad y la falta de apoyo familiar.
[27]
J.A. Caylà, J.A. Caminero, R. Rey, N. Lara, X. Vallés, H. Galdós-Tangüis.
Current status of treatment completion and fatality among tuberculosis patients in Spain.
Int J Tuberc Lung Dis, 8 (2004), pp. 458-464
[28]
K.C. Cummings, J. Mohle-Boetani, S.E. Royce, D.P. Chin.
Movement of tuberculosis patients and the failure to complete antituberculosis treatment.
Am J Respir Crit Care Med, 157 (1998), pp. 1249-1252
[29]
N. Wilson, S. Chadha, K. Sagili, S. Satyanarayana, G. Sharma, S. Mohanty.
Knowledge, attitude and practice about Tuberculosis in India. A midline survey, 2013.
Int Union Against Tuberc Lung Dis [Internet], (2013),
[30]
R. Carvajal Barona, P.A. Hoyos Hernández, M.T. Varela Arévalo, E.S. Angulo Valencia, C. Duarte Alarcón, Y. Estigma.
Discriminación Ante La Tuberculosis Por Profesionales De La Salud De La Costa Pacífica Colombiana.
Hacia la promoción la salud [Internet], 23 (2018), pp. 13-25
[31]
G.M. Craig, A. Daftary, N. Engel, S. O’Driscoll, A. Ioannaki.
Tuberculosis stigma as a social determinant of health: a systematic mapping review of research in low incidence countries.
Int J Infect Dis [Internet], 56 (2017), pp. 90-100
[32]
K. Macintyre, M.I. Bakker, S. Bergson, R. Bhavaraju, V. Bond, J. Chikovore, et al.
Defining the research agenda to measure and reduce tuberculosis stigmas.
Int J Tuberc Lung Dis, 21 (2017), pp. 87-96
[33]
A. Daftary, M. Frick, N. Venkatesan, M. Pai, T.B. Fighting.
stigma: we need to apply lessons learnt from HIV activism.
BMJ Glob Heal, 2 (2017), pp. e000515
[34]
CDC.
Manejo de pacientes con tuberculosis y mejora de la adherencia al tratamiento. Módulos autoaprendizaje sobre Tuberc.
(2014), pp. 98
[35]
R. Belknap, S. Weis, A. Brookens, K.Y. Au-Yeung, G. Moon, L. DiCarlo, et al.
Feasibility of an ingestible sensor-based system for monitoring adherence to tuberculosis therapy.
PLoS One, 8 (2013), pp. 8-12
[36]
V.T. Guerra Guerrero, A.E. Díaz Mujica, K. Vidal Albornoz.
La educación como estrategia para mejorar la adherencia de los pacientes en terapia dialítica Education as a.
Rev Cuba Enfermer, 26 (2010), pp. 52-62
[37]
J. Puig Junoy.
Lecciones de la revisión de los experimentos para mejorar la adherencia.
Gestión Clínica y Sanit, 19 (2017), pp. 94-95
[38]
N. Alipanah, L. Jarlsberg, C. Miller, N.N. Linh, D. Falzon, E. Jaramillo, et al.
Adherence interventions and outcomes of tuberculosis treatment: a systematic review and meta-analysis of trials and observational studies.
PLoS Med, 15 (2018), pp. 1-44
[39]
World Health Organization (WHO).
A patient-centred approach to TB care.
World Heal Organization, (2018),
[40]
R. Haynes, H. McDonald, A. Garg, P. Montague.
Interventions for helping patients to follow prescriptions for medications.
Cochrane Database Syst Rev, (2003),
[41]
N. Jansen-Aaldring, S. van de Berg, S. van den Hof.
Patient support during treatment for active tuberculosis and for latent tuberculosis infection: policies and practices in European low-incidence countries.
J Adv Nurs, 74 (2018), pp. 2755-2765
[42]
S. Brugueras, À. Orcau, J.-P. Millet, L. Espinosa, A. de Andrés, P. Gorrindo, et al.
Tuberculosis clinical units improve contact tracing.
Int J Tuberc Lung Dis [Internet], 20 (2016), pp. 1572-1579
[43]
E.M. Guix-Comellas, L. Rozas-Quesada, E. Velasco-Arnaiz, A. Ferrés-Canals, J.M. Estrada-Masllorens, E. Force-Sanmartín, et al.
Impact of nursing interventions on adherence to treatment with antituberculosis drugs in children and young people: a nonrandomized controlled trial.
J Adv Nurs, 74 (2018), pp. 1819-1830
[44]
I. Abubakar, S. Anderson, H. Hirani, I. Kar-Purkayastha, L. Thomas, L. Weil, et al.
Collaborative tuberculosis strategy for England 2015–2020.
Public Heal Engl, (2015),

These authors should be considered joint first author.

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