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Vol. 47. Issue 3.
Pages 134-137 (January 2011)
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Vol. 47. Issue 3.
Pages 134-137 (January 2011)
Original Article
DOI: 10.1016/S1579-2129(11)70032-5
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Surgery of female genital tract tumour lung metastases
Cirugía de las metástasis pulmonares de tumores del tracto genital femenino
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Guillermo González Casaurrána,??
Corresponding author
ggcasaurran@gmail.com

Corresponding author.
, Carlos Simón Adiegoa, Rafael Peñalver Pascuala,b, Nicolás Moreno Mataa, Miguel Ángel Lozano Barriusob, Federico González Aragonesesa
a Servicio de Cirugía Torácica, Hospital General Universitario Gregorio Marañón, Madrid, Spain
b Servicio de Oncología Radioterápica, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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Abstract
Introduction

Lung metastases originating from tumors of the female genital tract are rare. Due to this rarity and their variable histology, it has been difficult to compare different patient series.

Material and methods

A retrospective study of patients who underwent resection of lung metastases of female genital tract tumors (uterine, fallopian and cervical cancer) during the period from 01/01/1989 to 12/31/2006. Epidemiological, diagnostic and treatment data were collected. Non-parametric tests and the survival analysis were performed using the Kaplan-Meier curves and the log-rank test.

Results

During the study period, 27 underwent resection. Mean disease-free interval (DFI) from initial diagnosis to the diagnosis of metastasis was 58 months (1–195 months). Mean survival from the diagnosis of metastasis was 94 months. The overall 5-year survival after diagnosis of metastasis was 84.1%. A second surgery for metastasis was performed on 5 patients (18.5%). Survival after second surgery of metastases was 80.5 months. Five-year survivals from diagnosis of metastasis were: endometrial carcinoma 100%; cervical cancer 62.5%; uterine sarcoma 60%. Adjuvant hormone therapy was prescribed in15 out of 16 patients with endometrial carcinoma. There was a statistically significant difference in survival depending on the histological type and disease free interval.

Conclusion

Surgical treatment of lung metastases originating from female genital tract tumors (mainly endometrial carcinoma) is associated with a high long-term survival.

Keywords:
Drug therapy
Pulmonary metastases
Surgical procedures
Uterine neoplasms
Resumen
Introducción

Los tumores del tracto genital femenino constituyen una etiología poco frecuente de metástasis pulmonares. Debido a esto y a su variada histología, la comparación de resultados ha resultado complicada hasta la fecha.

Material y métodos

Estudio retrospectivo de pacientes intervenidos de metástasis pulmonares de tumores del tracto genital femenino (cuerpo, trompa y cuello de útero) en el periodo 01/01/1989-31/12/2006. Se recogen datos referentes a aspectos epidemiológicos, de diagnóstico y tratamiento. Se han utilizado tests no paramétricos, y el análisis de supervivencia se ha realizado con curvas de Kaplan-Meier y el log-ranktest.

Resultados

Durante el periodo descrito se ha intervenido a 27 pacientes. Intervalo libre de enfermedad (ILE) desde el diagnóstico inicial al de metástasis pulmonares 58 meses (1–195 meses). Mediana de supervivencia desde el diagnóstico de metástasis 94 meses. Supervivencia global tras diagnóstico de metástasis a 5 años: 84,1%. Segunda cirugía de metástasis: 5 pacientes (18,5%). Supervivencia tras segunda cirugía de metástasis: 80,5 meses. Supervivencia desde el diagnóstico de metástasis a 5 años: carcinoma de endometrio 100%; cáncer de cérvix 62,5%; sarcoma uterino 60%. Recibieron hormonoterapia adyuvante 15 de 16 pacientes con carcinoma de endometrio. Hallamos diferencias estadísticamente significativas en la supervivencia en función de: tipo histológico, e intervalo libre de enfermedad.

Conclusión

El tratamiento quirúrgico de las metástasis del tracto genital femenino (principalmente de las de carcinoma de endometrio) se asocia a una elevada supervivencia a largo plazo.

Palabras clave:
Tratamiento médico
Metástasis pulmonares
Procedimientos quirúrgicos
Neoplasias uterinas
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Copyright © 2011. Sociedad Española de Neumología y Cirugía Torácica
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