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Vol. 38. Issue 10.
Pages 495-498 (October 2002)
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Vol. 38. Issue 10.
Pages 495-498 (October 2002)
DOI: 10.1016/S0300-2896(02)75273-3
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Síndrome antisintetasa y afección pulmonar intersticial. Descripción de 6 casos
Antisynthetase syndrome and interstitial lung involvement. Report of 6 cases
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R. Santiago Villalobos??
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rsantiago_villalobos@hotmail.com

Correspondencia: Bami, 27, 4° D. 41013 Sevilla
, J.L. López-Campos Bodineau, E. Rodríguez Becerra, E. Laserna Martínez, E. Luque Crespo, G. Borja Urbano
Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Hospital Universitario Virgen del Rocío. Sevilla
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Presentamos los casos de 6 pacientes, 4 varones y 2 mujeres, diagnosticados de síndrome antisintetasa con afección pulmonar. La edad media era de 60 años. El síntoma guía desde el punto de vista respiratorio fue la disnea progresiva, presente en 4 pacientes. De los otros dos pacientes, uno tenía hemoptisis y el otro estaba asintomático. Respecto a la clínica sistémica, 2 pacientes presentaban fenómeno de Raynaud, 3 artritis de manos y 4 afección muscular. La radiografía del tórax revelaba la presencia de infiltrados intersticiales lineales de distinto grado en todos los casos menos en un paciente, quien además padecía una silicosis. La exploración funcional respiratoria demostró una alteración ventilatoria restrictiva en 4 casos, de carácter obstructivo en un paciente afectado de EPOC y normal en otro. El anticuerpo antisintetasa (ACAS) detectado fue el anti-Jo1 en 4 casos y el anti-PL12 en otro. En el sexto caso no se determinó la naturaleza del ACAS. La evolución de los enfermos fue favorable en todos los casos menos en uno. La determinación de los ACAS es de utilidad dentro del estudio de las neumopatías intersticiales idiopáticas

Palabras clave:
Enfermedad pulmonar intersticial
Síndrome antisintetasa
Enfermedad sistémica

The cases of 6 patients (4 men, 2 women) with antisynthetase syndrome are reported. The mean age was 60 years and the most frequent symptom was increasing dyspnea (4 patients). One of the remaining 2 patients had hemoptysis and the last was asymptomatic. Systemic symptoms included Raynaud's phenomenon (2 patients), arthritis in hands (3) and muscle impairment (4). Chest films showed linear interstitial infiltrates of varying severity in 5 patients; the patient without such infiltrates also suffered silicosis. Functional assessment showed restrictive impairment in 4 patients; of the remaining 2 patients, 1 had chronic obstructive pulmonary disease and 1 had normal function. The antisynthetase antibody (ASAB) detected was anti-Jo-1 in 4 cases, anti-PL-12 in 1 case, and unidentified in 1 case. The course of disease was satisfactory for 5 patients. ASAB analysis is useful for studying idiopathic interstitial lung disease

Keywords:
Interstitial lung disease
Antisynthetase syndrome
Systemic disease
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Copyright © 2002. Sociedad Española de Neumología y Cirugía Torácica
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