Publish in this journal
Journal Information
Vol. 51. Issue 7.
Pages 364-365 (July 2015)
Vol. 51. Issue 7.
Pages 364-365 (July 2015)
Letter to the Editor
DOI: 10.1016/j.arbr.2015.04.020
Full text access
Occult Alveolar Hemorrhage in a Patient With Bronchopulmonary Kaposi Sarcoma
Hemorragia alveolar oculta en paciente con sarcoma de Kaposi broncopulmonar
Visits
2251
Ingrid Martinez Ramireza,
Corresponding author
ijmartinezr@unal.edu.co

Corresponding author.
, Adan Jose Luquezb, Plutarco Garcia Herrerosc
a Fellow de Neumología, Universidad Nacional de Colombia, Bogotá, Colombia
b Medicina Interna, Universidad Nacional de Colombia, Bogotá, Colombia
c Unidad de Neumología, Instituto Nacional de Cancerología, Bogotá, Colombia
Article information
Full Text
Bibliography
Download PDF
Statistics
Figures (1)
Full Text

We report the case of 23-year-old man with human immunodeficiency virus (HIV) infection and a history of Kaposi sarcoma of the palate, treated with radiation therapy and antiretrovirals 2 years previously. He presented due to the appearance of violaceous skin lesions on the face, dyspnea and pleuritic pain with a CD4 T-lymphocyte count of 149cells/mm3 and viral load of 52092copies/ml. High resolution computed tomography of the chest (Fig. 1) revealed bilateral nodules with irregular margins and ground glass opacities, peribronchial cuffing and left pleural effusion. Bronchoscopy showed a raised lesion in the mucous membrane of the apical segment of the right upper lobe. Abundant hemosiderophages were found in the bronchoalveolar lavage (BAL) fluid, confirming alveolar hemorrhage. Immunohistochemistry was positive for human herpesvirus 8 (HHV-8). Treatment began with liposomal doxorubicin and antiretroviral treatment was switched. The patient remains alive at 8 months.

Fig. 1.

High resolution computed tomography of the chest showing bilateral nodules with irregular margins, ground glass opacities and peribronchial cuffing.

(0.08MB).

Kaposi sarcoma involving the lung occurs in 6%–32% of patients with acquired immunodeficiency syndrome (AIDS). It presents with skin lesions,1,2 and in 47%–75% of patients it is diagnosed post-mortem.3 Lesions can appear in the pulmonary parenchyma, bronchial tree, pleura, chest wall, and mediastinal lymph nodes,1,3 and CD4 T-lymphocyte count is generally <100cells/mm.3 In 80% of cases, death is a result of co-infection, due to cytomegalovirus, Mycobacterium avium complex, Pneumocistis jirovecii, bacterial pneumonia and herpes simplex infection.1

Chest computed tomography reveals poorly defined bilateral nodules, distributed symmetrically around the bronchial vessels (flame-like lesions). Other findings include septal peribronchial and interlobar cuffing, progressive air space consolidation and ground glass opacities.3

Lesions on the palate are a strong predictor for bronchopulmonary involvement.1 Typical lesions observed on bronchoscopy are red or violaceous cherry-like plaques in the bronchial Tree.1 HHV-8 is detected in BAL, which is highly specific (95%–98.9%) with variable sensitivity (58%–100%).

Occult alveolar hemorrhage has been described in HIV-positive patients with respiratory symptoms and abnormal radiological findings in the absence of hemoptysis. In 35.6% of cases, bronchopulmonary Kaposi sarcoma was detected, and of these 60.5% had occult alveolar hemorrhage.4

Vincent et al.5 subsequently characterized the following risk factors for AIDS-related alveolar hemorrhage: Kaposi sarcoma (OR: 5.3; 95% CI: 1.8–16.7; P=.003); cytomegalovirus pneumonia (OR: 9.8; 95% CI: 1–100; P=.05); hydrostatic pulmonary edema (OR: 16.4; 95% CI: 1.8–142; P=.01) and platelet count <60000 (OR: 5.6; 95% CI: 1.5–20; P=.009).

In conclusion, bronchoscopy is a useful tool for the diagnosis of occult alveolar hemorrhage in patients with HIV infection and respiratory symptoms.

Funding

This report received no type of funding.

Acknowledgements

Our thanks go to Drs Edgar Sánchez and Alfredo Saavedra, Internists and Pulmonologists from the Pulmonology Unit, Instituto Nacional de Cancerología, Universidad Nacional de Colombia.

We also thank Dr Sonia Cuervo, Infectologist from the Instituto Nacional de Cancerología, Bogotá, Colombia.

References
[1]
R.J. Sullivan, L. Pantanowitz, C. Casper, J. Stebbing, B.J. Dezube.
HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpes virus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
Clin Infect Dis, 47 (2008), pp. S1209-S1215
[2]
C.S. Restrepo, S. Martínez, J.A. Lemos, J.A. Carrillo, D.F. Lemos, P. Ojeda, et al.
Imaging manifestations of Kaposi sarcoma.
Radiographics, 26 (2006), pp. S1169-S1185
[3]
T.L. Benfield, K.K. Dodt, J.D. Lundgren.
Human herpes virus-8 DNA in bronchoalveolar lavage samples from patients with AIDS-associated pulmonary Kaposi’ sarcoma.
Scand J Infect Dis, 29 (1997), pp. S13-S16
[4]
L. Hughes-Davies, G. Kocjan, M.F. Spittle, R.F. Miller.
Occult alveolar haemorrhage in bronchopulmonary Kaposi’ sarcoma.
J Clin Pathol, 45 (1992), pp. S536-S537
[5]
B. Vincent, A. Flahault, M. Antoine, M. Wislez, A. Parrot, C. Mayaud, et al.
AIDS-related alveolar hemorrhage: a prospective study of 273 BAL procedures.
Chest, 120 (2001), pp. S1078-S1084

Please cite this article as: Martinez Ramirez I, Luquez AJ, Garcia Herreros P. Hemorragia alveolar oculta en paciente con sarcoma de Kaposi broncopulmonar. Arch Bronconeumol. 2015;51:364–365.

Copyright © 2013. SEPAR
Idiomas
Archivos de Bronconeumología (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.