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Here&#44; we began first-line treatment with a platinum and pemetrexed doublet&#44; and partial response according to RECIST criteria was recorded after 4 cycles&#44; with reduction of the pleural implants and effusion&#44; and low toxicity&#46; Given the clear clinical benefit&#44; treatment continued with single-agent pemetrexed as maintenance therapy with radiological follow-up every 3 months&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> The disease remained stable with optimal oncological control for 2&#46;5 years&#44; when the patient developed pain in the region of the left thigh&#46; Examination revealed increased consistency in the area&#44; which was hard and painful on palpation&#46; A magnetic resonance imaging study performed to rule out a neoplastic process in this region showed a soft tissue lesion involving the whole of the thigh&#44; extending to the gluteus&#46; Radiological characteristics were consistent with secondary involvement &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Given the rarity of the observation&#44; an ultrasound-guided biopsy was performed&#44; confirming metastatic malignant mesothelioma&#46; In view of our patient&#39;s prolonged oligometastatic disease&#44; local radiation therapy to the muscle lesion was proposed&#46; Moreover&#44; because he was clearly benefitting from systemic treatment and in view of the lack of second-line options&#44; he continued the same therapeutic regimen with oncological monitoring for another 12 months&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Our case is an example of the clinical and therapeutic management of long-term pleural malignant mesothelioma which raises 2 points of interest&#58; prolonged survival achieved with the treatment&#44; and the presence of secondary musculoskeletal involvement&#46; Malignant mesothelioma is a rare tumor that is characterized by involvement of the serous membranes&#44; most commonly the pleura&#46; It is traditionally associated with exposure to asbestos&#44; although other risk factors have been identified&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">2&#44;3</span></a> The initial clinical presentation is characterized by pleuritic pain and pleural effusion&#46; Diagnosis is difficult&#44; and depends in many cases on ruling out other entities&#46; Pleural biopsy is required for a definitive diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Most newly diagnosed pleural mesothelioma cannot be treated locally&#44; and require systemic treatment with chemotherapy&#44; but this tumor is largely chemo-resistant&#44; and therapeutic options are limited&#46; Indeed&#44; consistent data are only available on first-line treatment&#44; and options after progression are currently unclear&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">1&#44;4</span></a> Despite this being a highly aggressive tumor&#44; dissemination is generally local&#44; and symptoms caused by compression and direct invasion cause the patient to deteriorate rapidly&#46; Distant dissemination&#44; as observed in our patient&#44; is much more uncommon&#44; and the development of musculoskeletal metastasis despite control of the pulmonary disease is exceptional&#46; These events suggest that long-term tumors might disseminate atypically to the so-called &#8220;sanctuary organs&#8221;&#44; where the tumor can evade oncological control&#46; More food for thought is that in oligometastatic patients&#44; continuing systemic treatment while adding a local treatment appears to be a valid therapeutic option&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our case illustrates a pleural mesothelioma with an atypical course&#58; unusual features include the patient&#39;s long survival on oncological treatment &#40;36 months&#44; when mean survival is around 12 months&#41;&#44; and an exceptionally rare site of dissemination&#46;</p></span>"
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Scientific Letter
Muscle Involvement in Long-term Malignant Pleural Mesothelioma
Afectación muscular de un mesotelioma maligno pleural de larga evolución
Patricia Cruz Castellanos
Corresponding author
cruz.patricia@hotmail.com

Corresponding author.
, Teresa González Merino, Javier de Castro Carpeño
Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain
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Here&#44; we began first-line treatment with a platinum and pemetrexed doublet&#44; and partial response according to RECIST criteria was recorded after 4 cycles&#44; with reduction of the pleural implants and effusion&#44; and low toxicity&#46; Given the clear clinical benefit&#44; treatment continued with single-agent pemetrexed as maintenance therapy with radiological follow-up every 3 months&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> The disease remained stable with optimal oncological control for 2&#46;5 years&#44; when the patient developed pain in the region of the left thigh&#46; Examination revealed increased consistency in the area&#44; which was hard and painful on palpation&#46; A magnetic resonance imaging study performed to rule out a neoplastic process in this region showed a soft tissue lesion involving the whole of the thigh&#44; extending to the gluteus&#46; Radiological characteristics were consistent with secondary involvement &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Given the rarity of the observation&#44; an ultrasound-guided biopsy was performed&#44; confirming metastatic malignant mesothelioma&#46; In view of our patient&#39;s prolonged oligometastatic disease&#44; local radiation therapy to the muscle lesion was proposed&#46; Moreover&#44; because he was clearly benefitting from systemic treatment and in view of the lack of second-line options&#44; he continued the same therapeutic regimen with oncological monitoring for another 12 months&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Our case is an example of the clinical and therapeutic management of long-term pleural malignant mesothelioma which raises 2 points of interest&#58; prolonged survival achieved with the treatment&#44; and the presence of secondary musculoskeletal involvement&#46; Malignant mesothelioma is a rare tumor that is characterized by involvement of the serous membranes&#44; most commonly the pleura&#46; It is traditionally associated with exposure to asbestos&#44; although other risk factors have been identified&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">2&#44;3</span></a> The initial clinical presentation is characterized by pleuritic pain and pleural effusion&#46; Diagnosis is difficult&#44; and depends in many cases on ruling out other entities&#46; Pleural biopsy is required for a definitive diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">1</span></a> Most newly diagnosed pleural mesothelioma cannot be treated locally&#44; and require systemic treatment with chemotherapy&#44; but this tumor is largely chemo-resistant&#44; and therapeutic options are limited&#46; Indeed&#44; consistent data are only available on first-line treatment&#44; and options after progression are currently unclear&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">1&#44;4</span></a> Despite this being a highly aggressive tumor&#44; dissemination is generally local&#44; and symptoms caused by compression and direct invasion cause the patient to deteriorate rapidly&#46; Distant dissemination&#44; as observed in our patient&#44; is much more uncommon&#44; and the development of musculoskeletal metastasis despite control of the pulmonary disease is exceptional&#46; These events suggest that long-term tumors might disseminate atypically to the so-called &#8220;sanctuary organs&#8221;&#44; where the tumor can evade oncological control&#46; More food for thought is that in oligometastatic patients&#44; continuing systemic treatment while adding a local treatment appears to be a valid therapeutic option&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Our case illustrates a pleural mesothelioma with an atypical course&#58; unusual features include the patient&#39;s long survival on oncological treatment &#40;36 months&#44; when mean survival is around 12 months&#41;&#44; and an exceptionally rare site of dissemination&#46;</p></span>"
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            0 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;J&#46; Vogelzang"
                            1 => "J&#46;J&#46; Rusthoven"
                            2 => "J&#46; Symanowski"
                            3 => "C&#46; Denham"
                            4 => "E&#46; Kaukel"
                            5 => "P&#46; Ruffie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2003.11.136"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2003"
                        "volumen" => "21"
                        "paginaInicial" => "2636"
                        "paginaFinal" => "2644"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12860938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advances in malignant mesothelioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;W&#46; Robinson"
                            1 => "R&#46;A&#46; Lake"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra050152"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2005"
                        "volumen" => "353"
                        "paginaInicial" => "1591"
                        "paginaFinal" => "1603"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16221782"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current approach to malignant mesothelioma of the pleura"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Aisner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1995"
                        "volumen" => "107"
                        "numero" => "Suppl&#46;"
                        "paginaInicial" => "332S"
                        "paginaFinal" => "344S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7781415"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phase III trial of pemetrexed plus best supportive care compared with best supportive care in previously treated patients with advanced malignant pleural mesothelioma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jassem"
                            1 => "R&#46; Ramlau"
                            2 => "A&#46; Santoro"
                            3 => "W&#46; Schuette"
                            4 => "A&#46; Chemaissani"
                            5 => "S&#46; Hong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2006.09.9887"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "paginaInicial" => "1698"
                        "paginaFinal" => "1704"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18375898"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
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Article information
ISSN: 15792129
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