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Los valores de p se calcularon con la prueba de U de Mann-Whitney.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Laura Gonzalez-Lopez, Alberto D. Rocha-Muñoz, Eva M. Olivas-Flores, Araceli Garcia-Gonzalez, Ana R. Peguero-Gómez, Juan Flores-Navarro, Alberto I. Villa-Manzano, Soraya A. Zavaleta-Muñiz, Mario Salazar-Paramo, Mayra Mejía, Pablo Juárez-Contreras, Monica Vazquez-del Mercado, Ernesto G. Cardona-Muñoz, Benjamin Trujillo-Hernández, Arnulfo H. Nava-Zavala, Jorge I. Gamez-Nava" "autores" => array:16 [ 0 => array:2 [ "nombre" => "Laura" "apellidos" => "Gonzalez-Lopez" ] 1 => array:2 [ "nombre" => "Alberto D." "apellidos" => "Rocha-Muñoz" ] 2 => array:2 [ "nombre" => "Eva M." "apellidos" => "Olivas-Flores" ] 3 => array:2 [ "nombre" => "Araceli" "apellidos" => "Garcia-Gonzalez" ] 4 => array:2 [ "nombre" => "Ana R." "apellidos" => "Peguero-Gómez" ] 5 => array:2 [ "nombre" => "Juan" "apellidos" => "Flores-Navarro" ] 6 => array:2 [ "nombre" => "Alberto I." 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"apellidos" => "Gamez-Nava" "email" => array:1 [ 0 => "drivangamez@prodigy.net.mx" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:10 [ 0 => array:3 [ "entidad" => "Departamento de Medicina Interna-Reumatología y Neumología, Hospital General Regional 110, IMSS, Guadalajara, Mexico" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Programa Postdoctoral, Consejo Nacional de Ciencia y Tecnología (CONACYT), Mexico City, Mexico" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Hospital General Regional 180, IMSS, Tlajomulco, Mexico" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Symptoms Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Unidad de Investigación en Epidemiología Clínica, Departamento de Radiodiagnóstico y División de Investigación, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Mexico" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Unidad de Medicina Familiar y Cirugía Ambulatoria no. 52 IMSS, Guadalajara, Mexico" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Unidad de Investigación y Epidemiología Clínica, Hospital General de Zona y Medicina Familiar No. 1, Instituto Mexicano del Seguro Social (IMSS), Colima, Mexico" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, Guadalajara, Mexico" "etiqueta" => "j" "identificador" => "aff0050" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Niveles de propéptido aminoterminal de procolágeno tipos <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">iii</span> y gravedad de la enfermedad pulmonar intersticial en mujeres mexicanas con esclerosis sistémica progresiva" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1390 "Ancho" => 2347 "Tamanyo" => 123403 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">(a) Comparison of antitopoisomerase I antibody titers in patients with systemic sclerosis without interstitial lung disease (SSc-no ILD) and patients with systemic sclerosis with interstitial lung disease (SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD). (b) Comparison of anticentromere antibody titers in SSc-no ILD patients and SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients. <span class="elsevierStyleItalic">P</span>-values were calculated with the Mann–Whitney <span class="elsevierStyleItalic">U</span> test.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Progressive systemic sclerosis (SSc) is characterized by the excessive accumulation of collagen in tissues such as the skin, subcutaneous tissues, the lungs, and other internal organs.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a> Interstitial lung disease (ILD) is a common complication of SSc that occurs in 25%–90% of cases, depending on the method used for diagnosis.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">2</span></a> As ILD progresses, abnormalities develop in excellular matrix remodeling processes. ILD is similar to idiopathic pulmonary fibrosis: common manifestations include fibroblast proliferation, excessive collagen deposits and, in the early stages, abundant myofibroblasts.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">3</span></a> These myofibroblasts have been shown in in vitro studies to increase the synthesis of type I collagen.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Pulmonary fibrosis is one of the most common causes of death in SSc. Nagy and Czirják,<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a> in a prospective cohort study, found that increased procollagen type III aminoterminal propeptide (PIIINP) levels were associated with poor SSc prognosis, and lung involvement was associated with poor prognosis in the Kaplan–Meier analysis. Increased collagen synthesis is associated with high levels of PIIINP and procollagen type I aminoterminal propeptide (PINP) that are released into the bloodstream in SSc associated with ILD. Of these biomarkers, PIIINP has received most attention to date.<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">6–8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Findings regarding PINP levels in SSc are contradictory, and some authors have reported no changes, or normal values.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9,10</span></a> A systematic review concluded that current evidence is insufficient for supporting the use of serum markers associated with collagen turnover in the evaluation of disease activity or SSc severity. The authors underlined the need for performing standardized evaluations in future studies.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">11</span></a> Moreover, the utility of these potential markers must be determined in specific types of SSc. It is not yet known if serum levels of procollagen type I and III propeptides are correlated with SSc severity when this entity is complicated by ILD. Thus, the objective of this study was to determine if procollagen type I and III propeptide levels in serum correlate with the clinical characteristics, patterns of ILD involvement detected on high-resolution computed tomography (HRCT) and pulmonary function tests.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Material and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Patients and Study Design</span><p id="par0020" class="elsevierStylePara elsevierViewall">Women with SSc attending a rheumatology outpatient clinic in Guadalajara, Mexico, were consecutively screened for inclusion in this cross-sectional study. To be eligible, patients had to be at least 18 years old and meet the American College of Rheumatology criteria for SSc (1980).<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a> Patients with localized scleroderma or overlap syndrome, a history of hepatic or cardiac disease, active respiratory infection or asthma were excluded. Pregnant patients were also excluded. Patients with SSc were then divided into two subgroups: those with normal results on lung HRCT were included in the “no interstitial lung disease” group (SSc-no ILD, n=14) and those with conclusive findings of ILD on HRCT formed the SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD group (n=19).</p><p id="par0025" class="elsevierStylePara elsevierViewall">A control group was also included, comprising of women blood donors of the same age without infections or indicators of systemic rheumatic disease or other autoimmune disorders. The same exclusion criteria described for patients with SSc were also applied to the selection of control group, which included 45 women.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Clinical Evaluation of Systemic Sclerosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">All patients completed a structured questionnaire, evaluating the demographic and clinical variables related with rheumatic disease, including disease duration, time of rheumatological control, comorbidities and medication history. Clinical evaluation was performed by a rheumatologist and SSc subtypes were classified according to the definitions of LeRoy et al.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">13</span></a> Parameters included skin thickness, according to the modified Rodnan index (mRSS),<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> maximum mouth opening, finger-palm distance, visual analog scale (VAS) for evaluating disease severity as perceived by the patient and function according to the Health Assessment Questionnaire-Disability Index HAQ-DI, validated for SSc.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">15</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Quality of Life in Systemic Sclerosis Patients</span><p id="par0035" class="elsevierStylePara elsevierViewall">Three indices were used to evaluate the impact of ILD on the cardiopulmonary system. The first was a Spanish version of the Saint George Respiratory Questionnaire (SGRQ), a specific health-related quality of life (HRQoL) index for patients with chronic lung disease. This 50-item questionnaire evaluates three HRQoL-related domains: symptoms, activity and disease impact, which are summarized in an overall score.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">16</span></a> The second index was the 6-min walk test (6MWT), used to evaluate cardiopulmonary function, according to the guidelines of the American Thoracic Society.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> The third instrument was the modified Borg scale for evaluating dyspnea and fatigue (ATS guidelines).<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Respiratory Function Test Screening</span><p id="par0040" class="elsevierStylePara elsevierViewall">The three groups (SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD, SSc-no ILD and controls) performed spirometric testing with a portable SpiroPro spirometer (SensorMedics version 2.0) according to the recommendations of the American Thoracic Society and the European Respiratory Society (2005).<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> Forced expiratory volume in 1<span class="elsevierStyleHsp" style=""></span>s (FEV<span class="elsevierStyleInf">1</span>), forced vital capacity (FVC) and FEV<span class="elsevierStyleInf">1</span>/FVC ratio were determined in three measurements taken during the same evaluation to confirm a restrictive ventilatory pattern. Values obtained were expressed as percentages of the predicted value for subjects of the same sex, age, weight and height. The restrictive pattern was defined from the results of the respiratory function tests, when FVC<80 and FEV<span class="elsevierStyleInf">1</span>/FVC>80%.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with overlap syndrome, pregnancy, active infection, grade III or IV heart failure, chronic obstructive lung disease, asthma or pulmonary tuberculosis were excluded.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">High-Resolution Computed Tomography</span><p id="par0050" class="elsevierStylePara elsevierViewall">HRCT was performed in all patients using the same scanner (fourth generation SOMATOM AR.T., Siemens<span class="elsevierStyleSup">®</span>). Slices of 1–2<span class="elsevierStyleHsp" style=""></span>mm (10<span class="elsevierStyleHsp" style=""></span>mm intervals) were obtained with the patient in a prone position. Images were reconstructed using a high-resolution algorithm, bone filter and standard lung window (WL-700, WW 1.000–1.500<span class="elsevierStyleHsp" style=""></span>HU). Criteria for classifying ILD were determined prospectively in consensus by 2 pulmonologists (JP, MM), 2 rheumatologists (LGL, JIGN) and a radiologist (JFN). The definitive diagnosis of SSc associated with ILD (SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD) required the observation on HRCT of defined bilateral peripheral reticular opacities, with or without subpleural honeycomb pattern or evidence of ground glass opacities. As mentioned above, patients with SSc were divided into two groups, depending on HRCT results: group 1, SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD, and group 2, SSc-no ILD.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Using the method put forward by Kazerooni et al.,<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a> the presence or absence of two characteristics was recorded on a standardized form: (a) ground glass opacity (operatively equivalent to alveolar score), defined as a more attenuated area; and (b) honeycomb pattern (operatively equivalent to interstitial score), defined as clustered subpleural cystic air spaces with defined walls of 3–25<span class="elsevierStyleHsp" style=""></span>mm in diameter. The three lobes of both lungs were scored on a scale of 0–5, as follows: for the alveolar scale, no evidence of alveolar involvement<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0; ground glass opacities in <5% of the lobe<span class="elsevierStyleHsp" style=""></span>=1; in >25%=2; in 50%–75%=4; in >75% of the lobe<span class="elsevierStyleHsp" style=""></span>=5. The sum for each pattern was calculated from the score of the sections evaluated. Operatively, the total HRCT score was calculated by adding the alveolar and interstitial scores and dividing by 2.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Evaluation of Pulmonary Arterial Pressure by Echocardiography</span><p id="par0060" class="elsevierStylePara elsevierViewall">An experienced cardiologist and echocardiographer, blinded to the clinical characteristics and laboratory test results of the patients, performed an echocardiogram in all participants using a Philips 7500 device with a 2.5<span class="elsevierStyleHsp" style=""></span>MHz transducer. Tricuspid regurgitation was studied using color Doppler and the regurgitation jet was recorded using continuous wave Doppler. Regurgitation peak velocity was used to calculate transvalvular pressure gradient with the modified Bernoulli equation (4V2). Right atrium pressure was estimated using the maximum diameter of the inferior vena cava, as described by Denton et al.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> Finally, systolic pulmonary arterial pressure (SPAP) was taken as the sum of the pressure gradient through the tricuspid valve plus right atrium pressure.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Serum Markers</span><p id="par0065" class="elsevierStylePara elsevierViewall">Venous blood samples were obtained at the time of the clinical evaluation. Serum was collected in a cold tube (4<span class="elsevierStyleHsp" style=""></span>°C) after whole blood was centrifuged at 2000<span class="elsevierStyleHsp" style=""></span>rpm for 15<span class="elsevierStyleHsp" style=""></span>min at 4<span class="elsevierStyleHsp" style=""></span>°C. Serum aliquots were stored at −20<span class="elsevierStyleHsp" style=""></span>°C for up to 5 months. These samples were used for determination of PINP and PIIINP by radioimmunoassay, using the Risteli technique in commercially-available kits.<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">21,22</span></a> Levels of PINP and PIIINP, expressed as μg/dl, were determined in the controls. Technicians performing the tests were blinded to the clinical data of the patients.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Statistical Analysis</span><p id="par0070" class="elsevierStylePara elsevierViewall">Quantitative variables are expressed as mean and standard deviation and qualitative variables as frequencies and percentages. The Student's <span class="elsevierStyleItalic">t</span>-test was used for comparing quantitative variables between SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients and SSc-no ILD patients. Qualitative variables between these groups were compared using the Chi-squared test (or Fisher's exact test, if necessary). Correlations between alveolar and interstitial scores and total HRCT scores and clinical characteristics, HRQoL, cardiopulmonary indices, and PINP and PIIINP levels were analyzed using the Pearson <span class="elsevierStyleItalic">r</span> test. Multivariate regression analysis was conducted to identify factors associated with the ILD score on HRCT, and variables included in this analysis were selected according to two criteria: (a) if they were statistically significant on the univariate analysis, and (b) if they were considered confounding factors. After attempting several models, the following variables were included in the final model: age, duration of disease, PINP and PIIINP levels, and antitopoisomerase antibody titers. A logistic regression analysis was also performed using the presence of ILD with SSc as a dependent variable, and sex, age, disease duration and PINP and PIIINP levels as covariables. Statistical significance was set a 0.05. All analyses were performed using SPSS version 8.0.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Ethics</span><p id="par0075" class="elsevierStylePara elsevierViewall">The study was approved by the Hospital Institutional Review Board of the Instituto Mexicano del Seguro Social (IMSS) (authorization number IMSS R-2005-1303-93). All participants gave their informed consent in writing.</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Results</span><p id="par0080" class="elsevierStylePara elsevierViewall">There were no differences between patients with SSc (n=33) and the healthy control group (n=45) in terms of age (52.55<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.48 vs 49.47<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>7.25, respectively, <span class="elsevierStyleItalic">P</span>=.15), frequency of exposure to solvents (15.2% vs 8.9%, respectively, <span class="elsevierStyleItalic">P</span>=.48), exposure to smoke (45.5% vs 26.7%, respectively, <span class="elsevierStyleItalic">P</span>=.98), smoking history (24.4% vs 15.6%, respectively, <span class="elsevierStyleItalic">P</span>=.39), use of alcohol (3.0% vs 2.2%, respectively, <span class="elsevierStyleItalic">P</span>=1.00) or contraceptives (39.4% vs 44.4%, respectively, <span class="elsevierStyleItalic">P</span>=.13). Differences between patients and controls were found in all pulmonary function test parameters evaluated (FVC%, FEV<span class="elsevierStyleInf">1</span>, FEV<span class="elsevierStyleInf">1</span>/FVC) (<span class="elsevierStyleItalic">P</span><.001). Mean 6MWT was significantly lower in the SSc group compared to the controls (372.87<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>112.14 vs 563.84<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>131.34, respectively, <span class="elsevierStyleItalic">P</span><.001). PINP serum levels were significant higher in the SSc group compared to the control group (PINP, 42.0 vs 26.58, respectively, <span class="elsevierStyleItalic">P</span>=.001). Similarly, PIIINP levels were significantly higher in the SSc group than in the controls (3.67 vs 2.32, respectively, <span class="elsevierStyleItalic">P</span><.001).</p><p id="par0085" class="elsevierStylePara elsevierViewall">Four of the controls were active smokers (8.9%). Patients with SSc reported pulmonary symptoms as follows: cough (n=15, 45.5%), phlegm (n=10, 30.3%), wheezing (n=3, 9.1%), bilateral crackles on inhalation and exhalation (n=23, 69.7%) and dyspnea (n=15, 45.5%). Moreover, 22 (66.7%) patients with SSc showed a restrictive pattern on their pulmonary function tests (PFTs). Modified Borg scale results before 6MWT showed significant worsening in the SSc group compared to the control group (1.17 vs 0, respectively, <span class="elsevierStyleItalic">P</span><.001). A similar difference in Borg scale values after 6MWT was seen between the SSc group and the controls (2.62 vs 0, respectively, <span class="elsevierStyleItalic">P</span><.001). SGRQ scores in each domain were also significantly higher in patients with SSc compared to controls, indicating poorer symptom-related quality of life (15.42 vs 0, respectively, <span class="elsevierStyleItalic">P</span><.001), activity (17.67 vs 0, respectively, <span class="elsevierStyleItalic">P</span><.001), and impact (10.39 vs 0, respectively, <span class="elsevierStyleItalic">P</span><.001).</p><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Serum Marker Levels</span><p id="par0090" class="elsevierStylePara elsevierViewall">PINP and PIIINP levels in controls, SSc-no ILD and SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. SSc-no ILD and SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD groups had higher PINP levels (Mann–Whitney <span class="elsevierStyleItalic">U</span> test) than the control group (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a, with <span class="elsevierStyleItalic">P</span><.001 for both comparisons). Higher PIIINP levels were also found in SSc-no ILD (<span class="elsevierStyleItalic">P</span>=.003) and SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients compared to the control group (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>b). In a subanalysis not shown in this figure, mean PINP and PIIINP levels were compared among the three study groups: SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients had significantly higher PINP levels than the control group (49.28<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>28.63 vs 26.58<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.12, respectively, <span class="elsevierStyleItalic">P</span><.001), although there were no differences in PINP levels between the SSc-no ILD group and the control group (32.12<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>18.59 vs 26.58<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.12, respectively, <span class="elsevierStyleItalic">P</span>=.061). Moreover, SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients had significantly higher levels of PIIINP than controls (4.33<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.03 vs 2.32<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.04, respectively, <span class="elsevierStyleItalic">P</span><.001), while there were no differences in PIIINP levels between the SSc-no ILD group and the control group (2.67<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.26 vs 2.32<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.04, respectively, <span class="elsevierStyleItalic">P</span>=.058). Antitopoisomerase I and anticentromere antibodies levels in SSc-no ILD and SSC<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients are compared in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>. SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients had significantly higher antitopoisomerase antibody levels than those without ILD (<span class="elsevierStyleItalic">P</span><.001; <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>a), but no differences were found in anticentromere antibody titers between the two groups (<span class="elsevierStyleItalic">P</span>=.25; <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>b).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Differences in median PINP and PIIINP levels were compared between SSc-no ILD and SSC<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients, although the data are not shown in the tables (Mann–Whitney <span class="elsevierStyleItalic">U</span> test). Significant differences in PINP levels were found between both SSc groups compared to the control group (<span class="elsevierStyleItalic">P</span><.001 for both groups), and this was also the case for PIIINP (<span class="elsevierStyleItalic">P</span>=.003 and <span class="elsevierStyleItalic">P</span><.001 in SSc-no ILD). SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients had significantly higher levels of antitopoisomerase levels than SSc-no ILD patients (<span class="elsevierStyleItalic">P</span><.001), but no differences in anticentromere antibody levels were observed between SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD and SSc-no ILD groups (<span class="elsevierStyleItalic">P</span>=.25).</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Comparison Between the two SSc Groups: SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD vs SSc-no ILD</span><p id="par0100" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the comparison between the HRCT results of the SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD and the SSc-no ILD groups in terms of clinical characteristics, cardiopulmonary index scores, FVC results, propeptide serum levels and frequency of positive antinuclear, antitopoisomerase I and anticentromere antibody results. SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients had had the disease for a longer time (<span class="elsevierStyleItalic">P</span>=.005), presented a higher rate of diffuse SSc (<span class="elsevierStyleItalic">P</span>=.03) and had higher mRSS scores (<span class="elsevierStyleItalic">P</span><.01) in the HAQ-DI (<span class="elsevierStyleItalic">P</span><.001). As expected, FVC was significantly lower in patients with SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD compared with those who did not have ILD (<span class="elsevierStyleItalic">P</span><.001).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0105" class="elsevierStylePara elsevierViewall">The correlation between ILD severity scores on HRCT and series of selected characteristics in 33 patients with SSc is shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>. The total HRCT score was correlated with age (<span class="elsevierStyleItalic">P</span>=.03), disease duration (<span class="elsevierStyleItalic">P</span><.001), mRSS score (<span class="elsevierStyleItalic">P</span><.001), finger–palm distance (<span class="elsevierStyleItalic">P</span>=.04), mouth-opening (negative correlation, <span class="elsevierStyleItalic">P</span>=.02), HAQ-DI score (<span class="elsevierStyleItalic">P</span><.001), all SGRQ domains (<span class="elsevierStyleItalic">P</span><.001), 6MWT (negative correlation, <span class="elsevierStyleItalic">P</span>=.01), modified Borg scale before 6MWT (<span class="elsevierStyleItalic">P</span>=.03), modified Borg scale after 6MWT (<span class="elsevierStyleItalic">P</span>=.001), PINP (<span class="elsevierStyleItalic">P</span>=.03) and PIIINP levels (<span class="elsevierStyleItalic">P</span><.001). SPAP correlated significantly with PINP (<span class="elsevierStyleItalic">r</span>=0.422, <span class="elsevierStyleItalic">P</span>=.014) and PIIINP levels (<span class="elsevierStyleItalic">r</span>=0.476, <span class="elsevierStyleItalic">P</span>=.005). These data are not shown in the table.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Results from the multivariate linear regression analysis including variables associated with alveolar, interstitial and total HRCT scores from 33 patients with SSc are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>. After adjusting for age and disease duration, variables associated with a higher alveolar score were PINP (<span class="elsevierStyleItalic">P</span>=.029), PIIINP (<span class="elsevierStyleItalic">P</span>=.050) and antitopoisomerase antibodies (<span class="elsevierStyleItalic">P</span>=.023). No significant associations were identified for interstitial score. Total HRCT score was associated with disease duration (<span class="elsevierStyleItalic">P</span>=.037), PIIINP levels (<span class="elsevierStyleItalic">P</span>=.038), and antitopoisomerase antibody levels (<span class="elsevierStyleItalic">P</span>=.045). A log regression analysis was performed to evaluate if PINP and PIIINP levels were associated with SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD. After adjusting for age and disease duration, PIIINP levels were still significantly associated (OR=9.74, 95% CI: 1.20–78.78, <span class="elsevierStyleItalic">P</span>=.03), while PINP levels were no longer significant in this model (data not shown in the table).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">In this study, patients with ILD associated with SSc had higher concentrations of PINP and PIIINP compared to those with SSc with no lung involvement. Increased PIIINP was correlated with severity and extent of alveolar and interstitial damage and with the total HRCT score, while PINP levels were only correlated with interstitial involvement and total HRCT severity score.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Procollagen types I and III aminoterminal propeptides are an indication of the formation of collagen, and as such, are a useful marker of fibrogenesis in many organs. The fibrotic process that occurs in skin and other organs in SSc increases type I collagen production, causing high PINP levels in blood. In this study, we found that PINP serum levels were significantly higher in patients than in controls, a finding that differs from those of some other authors.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> High quantities of type III collagen are found in the architecture of the lung under normal conditions, and PIIINP levels reflect type III collagen production in the lungs and other organs. In lung diseases, increased PIIINP can be found in the presence of alveolar and interstitial damage, and is associated with active type III collagen production. Thus, increased serum levels of PIIINP may be an indication of the excessive type III collagen formation that has previously been described in SSc.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> Increased PIIINP has also been associated with poor prognosis in SSc patients.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">To date, the utility of PINP serum levels in the evaluation of the organ involvement of SSc has not been as widely evaluated as PIIINP. Diot et al.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">23</span></a> reported that high PIIINP levels were associated with lung involvement in SSc, but could not identify any correlation with severity. Scheja et al.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> showed that higher levels of PIIINP in SSc were associated with a loss of carbon monoxide diffusion capacity, but these authors did not perform any radiological studies to determine ILD.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Increased PIIINP serum levels have been related with the development of alveolitis, a condition that can lead to pulmonary fibrosis. Lammi et al.<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">24</span></a> found increased PIIINP in the bronchoalveolar lavage of 18 patients with fibrosing alveolitis of different origins, mainly idiopathic. This supports the notion that PIIINP is a potential marker of active ILD. Lee et al.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a> found that patients with SSc and FVC<80% had higher PIIINP levels, suggesting that this biomarker could be used to identify patients with a restrictive pattern on pulmonary function tests.</p><p id="par0135" class="elsevierStylePara elsevierViewall">To our knowledge, no other study has examined the correlation between ILD severity, according to HRCT results in SSc patients, and serum levels of PINP and PIIINP. We are equally unaware of any multivariate analysis exploring the association of these propeptides with ILD severity and patterns. We found that more severe ILD on HRCT is correlated with higher PIIINP levels, and that these levels are associated with greater interstitial and alveolar involvement. These data support the role of PIIINP not only in the detection of SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD, but also as a biomarker for determining the severity of lung involvement. Hunzelmann et al.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">10</span></a> evaluated PINP serum levels in patients with SSc, but did not find any correlation between the skin score and levels of this biomarker. In contrast, we found that patients with ILD had significantly higher levels of PINP, compared to healthy controls. Furthermore, Scheja et al.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">9</span></a> found a correlation between PINP levels and vital capacity on spirometry.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Pulmonary hypertension (PH) is a significant complication of SSc. Echocardiography can be used to detect PH, and SPAP can often be estimated by Doppler echocardiography. In this study, SPAP was seen to correlate significantly with PINP (<span class="elsevierStyleItalic">r</span>=0.422, <span class="elsevierStyleItalic">P</span>=.014) and PIIINP levels (<span class="elsevierStyleItalic">r</span>=0.476, <span class="elsevierStyleItalic">P</span>=.005). Denton et al.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> reported a correlation between Doppler echocardiography and right heart catheterization.</p><p id="par0145" class="elsevierStylePara elsevierViewall">One limitation of our study is that, although our patients with severe ILD had higher PIIINP levels, we were not able to determine if these patients have an increased risk of poor prognosis. For example, Nagy and Czirják<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">5</span></a> found that patients with higher PIIINP levels were more likely to have a poor prognosis. Another limitation is that no men with SSc were included in our series. The reason for this is that the population of men with this disease in our clinic is so small that the sample would be insufficient for statistical analysis. This limitation means that our results can only be generalized to women with SSc, and future studies should be designed to confirm our findings in a series that includes both sexes. Yet another limitation of our study is that there is no statistical association in the linear regression analysis between PINP or PIIINP and reticular pattern findings. This may be partially explained by the limited precision of our HRCT score for identifying some of the less severe cases of ILD (false negatives) that may have been wrongly classified. These problems must be taken into account in future studies, and a combination of diagnostic methods should be used for better detection of interstitial involvement, to increase the sensitivity of the ILD diagnosis. Another limitation is that these propeptides cannot be considered highly specific ILD markers; other disease characteristics and comorbidities are associated with increased serum levels of PINP and PIIINP and these must be taken into account. Other diseases associated with higher PINP levels include osteoporosis,<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">26,27</span></a> systemic lupus erythematosus,<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">28</span></a> breast cancer bone metastases<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">29</span></a> and chronic renal failure.<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">30</span></a> Moreover, increased levels of both PINP and PIIINP are associated with acute respiratory failure.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a> To minimize possible confounding factors, we excluded patients with overlap syndrome, localized scleroderma and history of cardiac or hepatic disease, all of which are associated with increased levels of these propeptides. However, our patients did not undergo a formal evaluation of osteoporosis with bone density studies, so this must be considered another limitation of our study, particularly in the case of PINP levels. None of our patients had creatinine serum levels >1.5<span class="elsevierStyleHsp" style=""></span>mg/dl, so this variable probably did not affect the PINP and PIIINP increases in serum found in patients with SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD. Although chronic renal failure was not a confounding factor in our study, PINP or PIIINP level as markers for SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD may be less useful in patients with significant renal impairment. Finally, a well-founded evaluation of the correlation between pulmonary function tests and PINP or PIIINP level in serum was not possible with the methodology used to explore lung function in our study.</p><p id="par0150" class="elsevierStylePara elsevierViewall">One of the strengths of our study is that the methodology used for evaluating lung involvement in SSc was based on a validated definition of ILD findings on HRCT and a validated index of the severity of the involvement. The main contribution of this study is not only that SSc complicated by ILD is associated with propeptide serum levels, but also that these levels increase in line with the severity of the lung involvement on the HRCT score. Another strength of this study that that the multivariate analysis was performed adjusting for confounding factors, and PIIINP levels were maintained as a factor associated with ILD severity. Our study was not designed to evaluate the role of PINP or PIIINP concentrations as an indication of prognosis in these patients. Nonetheless, the results from some patients in whom these biomarkers were increased, even in the absence of ILD as a complication, suggest that there is a need for longitudinal studies to determine if there are any clinically significant differences in disease course that can be predicted by propeptide levels.</p><p id="par0155" class="elsevierStylePara elsevierViewall">In conclusion, we provide evidence that PINP and PIIINP are markers of ILD severity in SSc, and that these markers are correlated with changes in HRCT scores of these patients. PIIINP is also associated with interstitial and alveolar involvement in ILD, supporting the suggestion that this marker may be useful in evaluating disease severity. Further studies in well-controlled cohorts are required to explore these findings in greater depth.</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0160" class="elsevierStylePara elsevierViewall">This project was co-funded by two research grants: the <span class="elsevierStyleGrantSponsor" id="gs1">Mexican Social Security Institute IMSS</span><span class="elsevierStyleGrantNumber" refid="gs1">FOFOI-2005/1/I/065</span>, and the <span class="elsevierStyleGrantSponsor" id="gs2">National Science and Technology Council (CONACYT)</span> mixed funds, <span class="elsevierStyleGrantSponsor" id="gs3">Government of the State of Michoacán</span>, <span class="elsevierStyleGrantNumber" refid="gs3">MICH-2003 C01-12442</span>.</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Contributions of the Authors</span><p id="par0165" class="elsevierStylePara elsevierViewall">Concept and design: Laura Gonzalez-Lopez, Araceli Garcia-Gonzalez, Alberto D. Rocha-Muñoz, Jorge I. Gámez-Nava.</p><p id="par0170" class="elsevierStylePara elsevierViewall">Data analysis and interpretation: Laura Gonzalez-Lopez, Alberto D. Rocha-Muñoz, Arnulfo H. Nava-Zavala, Jorge I. Gámez-Nava, Eva M Olivas-Flores.</p><p id="par0175" class="elsevierStylePara elsevierViewall">Manuscript preparation: Jorge I. Gamez-Nava, Alberto D. Rocha-Muñoz, Eva M Olivas-Flores, Laura Gonzalez-Lopez, Mayra Mejía, Soraya A Zavaleta-Muñiz, Mónica Vázquez-del Mercado, Ernesto G. Cardona-Muñoz, Benjamín Trujillo-Hernández.</p><p id="par0180" class="elsevierStylePara elsevierViewall">Critical review of the important intellectual content of the article: Araceli Garcia-Gonzalez, Arnulfo H. Nava-Zavala, Alberto I. Villa-Manzano, Soraya A. Zavaleta-Múñiz, Mónica Vázquez-del Mercado, Ernesto G. Cardona-Muñoz, Benjamín Trujillo-Hernández, Mario Salazar-Paramo, Ana Peguero.</p><p id="par0185" class="elsevierStylePara elsevierViewall">Supply of study patients or materials: Laura González-López, Juan Flores-Navarro, Alberto I. Villa-Manzano, Pablo Juárez-Contreras.</p><p id="par0190" class="elsevierStylePara elsevierViewall">Administrative, technical or logistical support: Mario Salazar-Paramo, Ana Peguero, Juan Flores-Navarro, Pablo Juárez-Contreras, Mayra Mejía.</p><p id="par0195" class="elsevierStylePara elsevierViewall">Final approval of the article: Laura González-López, Alberto D. Rocha-Muñoz, Eva M. Olivas-Flores, Araceli García-Gonzalez, Ana Peguero, Juan Flores-Navarro, Alberto I. Villa-Manzano, Soraya A. Zavaleta-Muñiz, Mario Salazar-Paramo, Mayra Mejía, Pablo Juárez-Contreras, Mónica Vázquez-del Mercado, Ernesto G. Cardona-Muñoz, Benjamín Trujillo-Hernández, Arnulfo Nava, Jorge I. Gámez-Nava.</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Conflict of Interests</span><p id="par0200" class="elsevierStylePara elsevierViewall">All authors declare that they have no conflict of interests with regard to the publication of this article.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres549655" "titulo" => "Abstract" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec567250" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres549656" "titulo" => "Resumen" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec567251" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Material and Methods" "secciones" => array:9 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patients and Study Design" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Clinical Evaluation of Systemic Sclerosis" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Quality of Life in Systemic Sclerosis Patients" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Respiratory Function Test Screening" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "High-Resolution Computed Tomography" ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Evaluation of Pulmonary Arterial Pressure by Echocardiography" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Serum Markers" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Statistical Analysis" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Ethics" ] ] ] 6 => array:3 [ "identificador" => "sec0060" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0065" "titulo" => "Serum Marker Levels" ] 1 => array:2 [ "identificador" => "sec0070" "titulo" => "Comparison Between the two SSc Groups: SSc + ILD vs SSc-no ILD" ] ] ] 7 => array:2 [ "identificador" => "sec0075" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0080" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0085" "titulo" => "Contributions of the Authors" ] 10 => array:2 [ "identificador" => "sec0090" "titulo" => "Conflict of Interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-02-01" "fechaAceptado" => "2014-06-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec567250" "palabras" => array:5 [ 0 => "Progressive systemic sclerosis" 1 => "Interstitial lung disease" 2 => "Procollagen type I aminoterminal propeptide" 3 => "Procollagen type III aminoterminal propeptide" 4 => "High-resolution computed tomography" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec567251" "palabras" => array:5 [ 0 => "Esclerosis sistémica progresiva" 1 => "Enfermedad pulmonar intersticial" 2 => "Propéptido aminoterminal de procolágeno tipo <span class="elsevierStyleSmallCaps">i</span>" 3 => "Propéptido aminoterminal de procolágeno tipo <span class="elsevierStyleSmallCaps">iii</span>" 4 => "Tomografía computarizada de alta resolución" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Interstitial lung disease (ILD) is a frequent complication in progressive systemic sclerosis (SSc), being present in 25% to 90% of cases.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate whether serum levels of procollagen type I and <span class="elsevierStyleSmallCaps">III</span> aminoterminal propeptide (PINP and PIIINP) correlate with severity and patterns of ILD in Mexican women with SSc.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Thirty-three SSc patients were assessed for disease characteristics and anti-topoisomerase antibodies (topo I), and also underwent pulmonary function tests and high-resolution computed tomography (HRCT). Nineteen patients had ILD<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>SSc, and 14 had no lung involvement (no ILD-SSc); data were compared with those from 45 healthy controls. PINP and PIIINP were assessed in all 3 groups.</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients with SSc had higher PINP and PIIINP vs controls (<span class="elsevierStyleItalic">P</span>=.001, <span class="elsevierStyleItalic">P</span><.001, respectively). Compared to no ILD-SSc patients, those with ILD<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>SSc had longer disease duration in years (<span class="elsevierStyleItalic">P</span>=.005), higher modified Rodnan skin score (<span class="elsevierStyleItalic">P</span><.001), higher Health Assessment Questionnaire-Disability Index scores (<span class="elsevierStyleItalic">P</span><.001), higher topo I U/mL (<span class="elsevierStyleItalic">P</span><.001), PINP (49.28<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>28.63 vs 32.12<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>18.58<span class="elsevierStyleHsp" style=""></span>μg/L, <span class="elsevierStyleItalic">P</span>=.05), and PIIINP (4.33<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.03 vs 2.67<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.26<span class="elsevierStyleHsp" style=""></span>μg/L, <span class="elsevierStyleItalic">P</span><.001) levels. ILD severity based on total HRCT correlated with PINP (<span class="elsevierStyleItalic">r</span>=.388, <span class="elsevierStyleItalic">P</span>=.03) and PIIINP (<span class="elsevierStyleItalic">P</span>=.594, <span class="elsevierStyleItalic">P</span><.001). On adjusted analysis, ILD severity was associated with disease duration (<span class="elsevierStyleItalic">P</span>=.037), PIIINP (<span class="elsevierStyleItalic">P</span>=.038), and topo I (<span class="elsevierStyleItalic">P</span>=.045).</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">PINP and PIIINP are useful markers for severe ILD<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>SSc, suggesting they could play a role in the follow-up of this complication in SSc.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Background" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Objectives" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Methods" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Results" ] 4 => array:2 [ "identificador" => "abst0025" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La enfermedad pulmonar intersticial (EPI) es una complicación frecuente en la esclerosis sistémica (ES) progresiva, presente en el 25–90% de los pacientes.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar si los niveles séricos de propéptido aminoterminal de procolágeno tipos<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">iii</span> (PINP y PIIINP) se correlacionan con la gravedad de la EPI en mujeres mexicanas con ES.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En 33 pacientes con ES se evaluaron las características de la enfermedad, anticuerpos antitopoisomerasa (topo<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">i</span>), pruebas de función pulmonar y tomografía computarizada de alta resolución (TCAR). Diecinueve pacientes tenían ES<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>EPI y 14 no presentaban afectación pulmonar (ES sin EPI). Se compararon con 45 controles sanos. Se evaluaron PINP y PIIINP en los 3 grupos.</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El grupo ES tuvo mayores niveles de PINP y PIIINP que el control (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001 y p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001, respectivamente). Las pacientes ES<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>EPI habían presentado la enfermedad más años que las ES sin EPI (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,005), tenían mayor puntuación en el índice modificado de Rodnan (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001), puntuación alta en el índice de evaluación de discapacidad (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001), mayores niveles de antitopoisomerasa <span class="elsevierStyleSmallCaps">i</span> (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001), PINP (49,28<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>28,63 vs. 32,12<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>18,58<span class="elsevierStyleHsp" style=""></span>μg/l, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,05), y PIIINP (4,33<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,03 vs. 2,67<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1,26<span class="elsevierStyleHsp" style=""></span>μg/l, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001). La gravedad de la EPI en TACAR se correlacionó con los niveles de PINP (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,388, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,03) y PIIINP (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,594, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001). En el análisis ajustado, la gravedad de la EPI se asoció con la duración de la enfermedad (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,037) y con los niveles de PIIINP (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,038) y de antitopoisomerasa<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSmallCaps">i</span> (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,045).</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">El PINP y el PIIINP son marcadores útiles para la ES<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>EPI grave. Esto apoya su uso clínico para el seguimiento de esta complicación.</p></span>" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "abst0030" "titulo" => "Antecedentes" ] 1 => array:2 [ "identificador" => "abst0035" "titulo" => "Objetivo" ] 2 => array:2 [ "identificador" => "abst0040" "titulo" => "Métodos" ] 3 => array:2 [ "identificador" => "abst0045" "titulo" => "Resultados" ] 4 => array:2 [ "identificador" => "abst0050" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Gonzalez-Lopez L, Rocha-Muñoz AD, Olivas-Flores EM, Garcia-Gonzalez A, Peguero-Gómez AR, Flores-Navarro J, et al. Niveles de propéptido aminoterminal de procolágeno tipos <span class="elsevierStyleSmallCaps">i</span> y <span class="elsevierStyleSmallCaps">iii</span> y gravedad de la enfermedad pulmonar intersticial en mujeres mexicanas con esclerosis sistémica progresiva. Arch Bronconeumol. 2015;51:440–448.</p>" ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1256 "Ancho" => 2561 "Tamanyo" => 143265 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Comparison of PINP and PIIINP levels between groups. (a) Comparison of procollagen type I propeptide (PINP) in healthy controls, in patients with systemic sclerosis without interstitial lung disease (SSc-no ILD) and in patients with systemic sclerosis with interstitial lung disease (SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD). (b) Comparison of serum levels of procollagen type III propeptide (PINP) in healthy controls, in SSc-no ILD patients and SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients. <span class="elsevierStyleItalic">P</span>-values were calculated with the Mann–Whitney <span class="elsevierStyleItalic">U</span> test.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1390 "Ancho" => 2347 "Tamanyo" => 123403 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">(a) Comparison of antitopoisomerase I antibody titers in patients with systemic sclerosis without interstitial lung disease (SSc-no ILD) and patients with systemic sclerosis with interstitial lung disease (SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD). (b) Comparison of anticentromere antibody titers in SSc-no ILD patients and SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD patients. <span class="elsevierStyleItalic">P</span>-values were calculated with the Mann–Whitney <span class="elsevierStyleItalic">U</span> test.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">6MWT, 6<span class="elsevierStyleHsp" style=""></span>min walk test; FVC, forced vital capacity; HAQ-DI, Health Assessment Questionnaire-Disability Index; PIIINP, procollagen III animoterminal propeptide; PINP, procollagen I animoterminal propeptide; SGRQ, Saint George Respiratory Questionnaire; VAS, visual analog scale.</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Qualitative variables are expressed in frequency (%); quantitative variables are expressed as mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation. Proportions were compared with the Chi-squared test or Fisher's exact test. Means were compared with the unpaired Student <span class="elsevierStyleItalic">t</span>-test.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SSc-no ILD (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">SSc<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>ILD (n<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>19) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Clinical characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46.64<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>8.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">56.89<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.06 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Exposure to solvents, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (14.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (15.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Exposure to smoke, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (50.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (42.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.73 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Pulmonary symptoms</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Bilateral crackles on inhalation and exhalation, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (42.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 (89.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dyspnea, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (73.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">SSc characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Disease duration, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.50<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>4.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11.21<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>4.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">SSc subtype</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Limited, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (42.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Diffuse, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (57.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (94.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Modified Rodnan index (units) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11.29<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">22.68<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>HAQ-DI index (units) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.41<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.43<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>0.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Systolic pulmonary arterial pressure, mmHg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">34.29<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">43.53<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pulmonary hypertension (≥40<span class="elsevierStyleHsp" style=""></span>mmHg), n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (7.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15 (93.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Pulmonary function</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>FVC (% predicted) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">78.14<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>7.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">65.68<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>6.91 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Restricted pattern, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (28.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (94.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Cardiopulmonary indices</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6MWT, meters \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">431.1<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>97.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">324.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>101.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Modified Borg scale VAS before 6MWT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.54<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.64<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.02 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Modified Borg scale VAS after 6MWT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.99<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.96<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dyspnea after 6MWT, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (21.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (52.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.14 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">SGRQ, %</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.79<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>10.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">21.79<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>15.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Activity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.43<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24.47<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>14.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Impact \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.07<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>6.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15.05<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8.71<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>11.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">25.32<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>15.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Collagen metabolism markers</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PINP (μg/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">32.12<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>18.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">49.28<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>28.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.05 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PIIINP (μg/l) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.67<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.33<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Autoantibody profile</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Antinuclear antibodies, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (85.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (94.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.56 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Antitopoisomerase antibodies, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (21.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">18 (94.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anticentromere antibodies, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (28.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (10.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.36 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Treatment</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>D-penicillamine, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (64.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (73.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.71 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Azathioprine, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (42.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (57.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.49 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Colchicine, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (42.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (36.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chloroquine, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (21.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (21.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.00 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Use of corticosteroids, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 (42.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14 (73.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab887961.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparison of Selected Characteristics Between Patients With Progressive Systemic Sclerosis (SSc) With Associated Interstitial Lung Disease (SSc+ILD) vs Patients With SSc Without ILD (SSc-no ILD).</p>" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">6MWT, 6<span class="elsevierStyleHsp" style=""></span>min walk test; FVC, forced vital capacity; HAQ-DI, Health Assessment Questionnaire-Disability Index; PIIINP, procollagen III animoterminal propeptide; PINP, procollagen I animoterminal propeptide; SGRQ, Saint George Respiratory Questionnaire; VAS, visual analog scale.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Alveolar score</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Interstitial score</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Total HRCT score</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">R</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Age, years</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.341 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.362 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.373 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Disease duration, years</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.582 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.653 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.665 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">SSc characteristics</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Modified Rodnan index (units) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.866 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.850 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.922 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Finger-palm distance (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.236 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.460 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.368 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.04 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mouth-opening (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.283 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.110 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.502 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.410 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.02 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>HAQ-DI score (units) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.665 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.723 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.743 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">Pulmonary function</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>FVC (% predicted) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.858 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.851 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.914 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">Health-related quality of life</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SGRQ, Symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.749 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.830 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.840 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SGRQ, Activity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.617 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.752 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.723 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SGRQ, Impact \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.663 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.773 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.764 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SGRQ, Total \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.611 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.775 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.713 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">Cardiopulmonary indices</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Modified Borg scale VAS before 6MWT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.383 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.302 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.372 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6MWT, meters \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.469 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.376 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.453 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.01 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Modified Borg scale VAS after 6MWT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.556 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.519 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.572 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="7" align="left" valign="top"><span class="elsevierStyleItalic">Collagen markers</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.550 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.388 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PIIINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.521 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.582 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.594 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab887963.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Correlation Between Interstitial Lung Disease Severity Scores on High-Resolution Computed Tomography (HRCT) and Selected Characteristics of Women With Progressive Systemic Sclerosis (SSc).</p>" ] ] 4 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="spar0095" class="elsevierStyleSimplePara elsevierViewall">HRCT, high-resolution computed tomography; PIIINP, procollagen III animoterminal propeptide; PINP, procollagen I animoterminal propeptide.</p><p id="spar0100" class="elsevierStyleSimplePara elsevierViewall">Multivariate regression analysis of interstitial lung disease severity according to HRCT markers with clinical and procollagen aminoterminal propeptides in women with progressive systemic sclerosis. Beta values are non-standardized coefficients. <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> is the total variance explained in the model.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">β Coefficient \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Partial <span class="elsevierStyleItalic">R</span><span class="elsevierStyleSup">2</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Alveolar score</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.090 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.116 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.538 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Disease duration, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.752 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.340 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.074 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.143 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.347 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.029 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PIIINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.983 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.487 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.050 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anti-topoisomerase antibodies (U/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.085 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.578 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.023 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Interstitial score</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.057 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.131 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.675 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Disease duration, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.689 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.430 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.076 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.054 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.505 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.350 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PIIINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.976 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.599 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.060 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anti-topoisomerase antibodies (U/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.034 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.615 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.298 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Total HRCT score</span></td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.067 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.139 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.587 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Disease duration, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.748 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.445 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.037 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.053 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.452 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.321 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PIIINP (μg/dl) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.531 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.038 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Anti-topoisomerase antibodies (U/ml) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.062 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.647 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">.045 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab887962.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Factors Determining Interstitial Lung Disease (ILD) in Multivariate Regression Analysis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:31 [ 0 => array:3 [ "identificador" => "bib0160" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis and staging of scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.K. Winkelmann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "1976" "volumen" => "56" "paginaInicial" => "83" "paginaFinal" => "92" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/58529" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0165" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interstitial lung disease in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. White" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rheum Dis Clin North Am" "fecha" => "2003" "volumen" => "29" "paginaInicial" => "371" "paginaFinal" => "390" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12841300" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0170" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "American Thoracic Society; European Respiratory Society; American College of Chest Physicians" "etal" => false "autores" => array:3 [ 0 => "M. Selman" 1 => "T.E. King" 2 => "A. Pardo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2001" "volumen" => "134" "paginaInicial" => "136" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11177318" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0175" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histopathology and bronchoalveolar lavage" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.M. Silver" 1 => "A.U. Wells" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2008" "volumen" => "47" "paginaInicial" => "v62" "paginaFinal" => "v64" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0180" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased levels of amino terminal propeptide of type III procollagen are an unfavourable predictor of survival in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Z. Nagy" 1 => "L. Czirják" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "165" "paginaFinal" => "172" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15895885" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0185" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prognostic markers for systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "O. Meyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jbspin.2006.01.022" "Revista" => array:6 [ "tituloSerie" => "Joint Bone Spine" "fecha" => "2006" "volumen" => "73" "paginaInicial" => "490" "paginaFinal" => "494" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16798048" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0190" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of serologic markers for collagen synthesis and degradation in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Heickendorff" 1 => "H. Zachariae" 2 => "P. Bjerring" 3 => "L. Halkier-Sorensen" 4 => "K. Sondergaard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1995" "volumen" => "32" "paginaInicial" => "584" "paginaFinal" => "588" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7896946" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0195" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum levels of aminoterminal type <span class="elsevierStyleSmallCaps">III</span> procollagen peptide and hyaluronan predict mortality in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Scheja" 1 => "A. Akesson" 2 => "K. Hørslev-Petersen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1992" "volumen" => "21" "paginaInicial" => "5" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1570489" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0200" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Circulating collagen metabolites in systemic sclerosis. Differences between limited and diffuse form and relationship with pulmonary involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Scheja" 1 => "M. Wildt" 2 => "F.A. Wollheim" 3 => "A. Akesson" 4 => "T. Saxne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2000" "volumen" => "39" "paginaInicial" => "1110" "paginaFinal" => "1113" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0205" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Circulating type <span class="elsevierStyleSmallCaps">I</span> collagen degradation products: a new serum marker for clinical severity in patients with scleroderma?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Hunzelmann" 1 => "J. Risteli" 2 => "L. Risteli" 3 => "C. Sacher" 4 => "R. Vancheeswaran" 5 => "C. Black" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "1998" "volumen" => "139" "paginaInicial" => "1020" "paginaFinal" => "1025" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9990365" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0210" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serological assessment of type <span class="elsevierStyleSmallCaps">I</span> collagen burden in scleroderma spectrum disorders: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Dziadzio" 1 => "R.E. Smith" 2 => "D.J. Abraham" 3 => "R.J. Stratton" 4 => "A. Gabrielli" 5 => "C.M. Black" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2004" "volumen" => "22" "paginaInicial" => "356" "paginaFinal" => "367" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15144134" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0215" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee" ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1980" "volumen" => "23" "paginaInicial" => "581" "paginaFinal" => "590" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7378088" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0220" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleroderma (systemic sclerosis): classification, subsets and pathogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.C. LeRoy" 1 => "C. Black" 2 => "R. Fleischmajer" 3 => "S. Jablonska" 4 => "T. Krieg" 5 => "T.A. Medsger Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1988" "volumen" => "15" "paginaInicial" => "202" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3361530" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0225" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Clements" 1 => "P. Lachenbruch" 2 => "J. Siebold" 3 => "B. White" 4 => "S. Weiner" 5 => "R. Martin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1995" "volumen" => "22" "paginaInicial" => "1281" "paginaFinal" => "1285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7562759" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0230" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Concurrent validity of the Health Assessment Questionnaire Disability Index in scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.L. Poole" 1 => "C.A. Williams" 2 => "D.A. Bloch" 3 => "B. Hollak" 4 => "P. Spitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Care Res" "fecha" => "1995" "volumen" => "8" "paginaInicial" => "189" "paginaFinal" => "193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7654804" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0235" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validity of the Saint George's Respiratory Questionnaire in the evaluation of the health-related quality of life in patients with interstitial lung disease secondary to systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Beretta" 1 => "A. Santaniello" 2 => "A. Lemos" 3 => "M. Masciocchi" 4 => "R. Scorza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "296" "paginaFinal" => "301" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0240" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ATS statement: guidelines for the six-minute walk test" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.166.1.at1102" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "166" "paginaInicial" => "111" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12091180" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0245" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ATS/ERS task force standardisation of spirometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Miller" 1 => "J. Hankinson" 2 => "V. Brusasco" 3 => "F. Burgos" 4 => "R. Casaburi" 5 => "A. Coates" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.05.00034805" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "319" "paginaFinal" => "338" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055882" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0250" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thin-section CT obtained at 10-mm increments versus limited three-level thin-section CT for idiopathic pulmonary fibrosis: correlation with pathologic scoring" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.A. Kazerooni" 1 => "F.J. Martinez" 2 => "A. Flint" 3 => "D.A. Jamadar" 4 => "B.H. Gross" 5 => "D.L. Spizarny" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Roentgenol" "fecha" => "1997" "volumen" => "169" "paginaInicial" => "977" "paginaFinal" => "983" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0255" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.P. Denton" 1 => "J.B. Cailes" 2 => "G.D. Phillips" 3 => "A.U. Wells" 4 => "C.M. Black" 5 => "R.M. Bois" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Rheumatol" "fecha" => "1997" "volumen" => "36" "paginaInicial" => "239" "paginaFinal" => "243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9133938" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0260" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunoassay for intact amino-terminal propeptide of human type <span class="elsevierStyleSmallCaps">i</span> procollagen" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Melkko" 1 => "S. Kauppila" 2 => "S. Niemi" 3 => "L. Risteli" 4 => "K. Haukipuro" 5 => "A. Jukkola" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1996" "volumen" => "42" "paginaInicial" => "947" "paginaFinal" => "954" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8665688" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0265" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type <span class="elsevierStyleSmallCaps">III</span> procollagen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Risteli" 1 => "S. Niemi" 2 => "P. Trivedi" 3 => "O. Maentausta" 4 => "A.P. Mowat" 5 => "L. Risteli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Chem" "fecha" => "1988" "volumen" => "34" "paginaInicial" => "715" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3359606" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0270" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictive value of serum <span class="elsevierStyleSmallCaps">III</span> procollagen for diagnosis of pulmonary involvement in patients with scleroderma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Diot" 1 => "P. Diot" 2 => "C. Valat" 3 => "E. Boissinot" 4 => "E. Asquier" 5 => "E. Lemarie" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1995" "volumen" => "8" "paginaInicial" => "1559" "paginaFinal" => "1565" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8575585" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0275" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Type <span class="elsevierStyleSmallCaps">III</span> and type <span class="elsevierStyleSmallCaps">I</span> procollagen markers in fibrosing alveolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Lammi" 1 => "L. Ryhanen" 2 => "E. Lakari" 3 => "J. Risteli" 4 => "P. Paakko" 5 => "K. Kahlos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.159.3.9805060" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1999" "volumen" => "159" "paginaInicial" => "818" "paginaFinal" => "823" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10051256" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0280" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Type <span class="elsevierStyleSmallCaps">III</span> procollagen N-terminal propeptide, soluble interleukin-2 receptor, and von Willebrand factor in systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Y.J. Lee" 1 => "K.C. Shin" 2 => "S.W. Kang" 3 => "E.B. Lee" 4 => "H.A. Kim" 5 => "Y.W. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "69" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11247328" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0285" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current recommendations for laboratory testing and use of bone turnover markers in management of osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Lee" 1 => "S. Vasikaran" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3343/alm.2012.32.2.105" "Revista" => array:6 [ "tituloSerie" => "Ann Lab Med" "fecha" => "2012" "volumen" => "32" "paginaInicial" => "105" "paginaFinal" => "112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22389876" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0290" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PINP as a biological response marker during teriparatide treatment for osteoporosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.H. Krege" 1 => "N.E. Lane" 2 => "J.M. Harris" 3 => "P.D. Miller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00198-014-2646-0" "Revista" => array:6 [ "tituloSerie" => "Osteoporos Int" "fecha" => "2014" "volumen" => "25" "paginaInicial" => "2159" "paginaFinal" => "2171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24599274" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0295" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of resistin as a marker of inflammation in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Almehed" 1 => "H.F. d’Elia" 2 => "M. Bokarewa" 3 => "H. Carlsten" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar2366" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2008" "volumen" => "10" "paginaInicial" => "R15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18234104" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0300" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of total and intact aminoterminal propeptide of type <span class="elsevierStyleSmallCaps">i</span> procollagen assays in patients with breast cancer with or without bone metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Marin" 1 => "M.K. Koivula" 2 => "A. Jukkola-Vuorinen" 3 => "A. Leino" 4 => "J. Risteli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1258/acb.2011.011040" "Revista" => array:7 [ "tituloSerie" => "Ann Clin Biochem" "fecha" => "2011" "volumen" => "48" "numero" => "Pt 5" "paginaInicial" => "447" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21733929" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0305" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Difference between total and intact assays for N-terminal propeptide of type <span class="elsevierStyleSmallCaps">I</span> procollagen reflects degradation of pN-collagen rather than denaturation of intact propeptide" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.K. Koivula" 1 => "V. Ruotsalainen" 2 => "M. Björkman" 3 => "S. Nurmenniemi" 4 => "R. Ikäheimo" 5 => "K. Savolainen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1258/acb.2009.009110" "Revista" => array:7 [ "tituloSerie" => "Ann Clin Biochem" "fecha" => "2010" "volumen" => "47" "numero" => "Pt 1" "paginaInicial" => "67" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19940208" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0310" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serum markers of collagen synthesis and degradation in acute respiratory failure patients" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Finnali Study Group" "etal" => true "autores" => array:6 [ 0 => "M. Okkonen" 1 => "F. Gäddnäs" 2 => "V. Pettilä" 3 => "J. Laurila" 4 => "P. Ohtonen" 5 => "J. Risteli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/aas.12182" "Revista" => array:6 [ "tituloSerie" => "Acta Anaesthesiol Scand" "fecha" => "2013" "volumen" => "57" "paginaInicial" => "1193" "paginaFinal" => "1200" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24011286" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005100000009/v2_201509070947/S1579212915002165/v2_201509070947/en/main.assets" "Apartado" => array:4 [ "identificador" => "9374" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005100000009/v2_201509070947/S1579212915002165/v2_201509070947/en/main.pdf?idApp=UINPBA00003Z&text.app=https://www.archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915002165?idApp=UINPBA00003Z" ]
Year/Month | Html | Total | |
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2024 October | 27 | 22 | 49 |
2024 September | 50 | 15 | 65 |
2024 August | 72 | 41 | 113 |
2024 July | 44 | 21 | 65 |
2024 June | 53 | 26 | 79 |
2024 May | 116 | 29 | 145 |
2024 April | 43 | 26 | 69 |
2024 March | 49 | 24 | 73 |
2024 February | 36 | 28 | 64 |
2023 March | 13 | 1 | 14 |
2023 February | 65 | 25 | 90 |
2023 January | 42 | 50 | 92 |
2022 December | 65 | 41 | 106 |
2022 November | 80 | 49 | 129 |
2022 October | 78 | 39 | 117 |
2022 September | 49 | 38 | 87 |
2022 August | 69 | 42 | 111 |
2022 July | 56 | 42 | 98 |
2022 June | 69 | 36 | 105 |
2022 May | 70 | 53 | 123 |
2022 April | 48 | 33 | 81 |
2022 March | 48 | 44 | 92 |
2022 February | 54 | 36 | 90 |
2022 January | 59 | 44 | 103 |
2021 December | 59 | 36 | 95 |
2021 November | 61 | 51 | 112 |
2021 October | 58 | 55 | 113 |
2021 September | 36 | 56 | 92 |
2021 August | 42 | 34 | 76 |
2021 July | 29 | 32 | 61 |
2021 June | 39 | 48 | 87 |
2021 May | 31 | 28 | 59 |
2021 April | 59 | 79 | 138 |
2021 March | 59 | 23 | 82 |
2021 February | 23 | 23 | 46 |
2021 January | 32 | 23 | 55 |
2020 December | 31 | 24 | 55 |
2020 November | 34 | 19 | 53 |
2020 October | 31 | 11 | 42 |
2020 September | 34 | 13 | 47 |
2020 August | 34 | 15 | 49 |
2020 July | 38 | 25 | 63 |
2020 June | 43 | 13 | 56 |
2020 May | 43 | 16 | 59 |
2020 April | 60 | 33 | 93 |
2020 March | 54 | 16 | 70 |
2020 February | 47 | 29 | 76 |
2020 January | 39 | 22 | 61 |
2019 December | 69 | 27 | 96 |
2019 November | 37 | 29 | 66 |
2019 October | 27 | 10 | 37 |
2019 September | 46 | 12 | 58 |
2019 August | 38 | 20 | 58 |
2019 July | 51 | 30 | 81 |
2019 June | 32 | 20 | 52 |
2019 May | 45 | 13 | 58 |
2019 April | 63 | 13 | 76 |
2019 March | 47 | 17 | 64 |
2019 February | 49 | 27 | 76 |
2019 January | 41 | 20 | 61 |
2018 December | 45 | 21 | 66 |
2018 November | 89 | 23 | 112 |
2018 October | 200 | 23 | 223 |
2018 September | 60 | 8 | 68 |
2018 May | 10 | 0 | 10 |
2018 April | 23 | 4 | 27 |
2018 March | 21 | 6 | 27 |
2018 February | 27 | 6 | 33 |
2018 January | 13 | 7 | 20 |
2017 December | 41 | 7 | 48 |
2017 November | 27 | 6 | 33 |
2017 October | 28 | 10 | 38 |
2017 September | 21 | 10 | 31 |
2017 August | 18 | 9 | 27 |
2017 July | 16 | 7 | 23 |
2017 June | 38 | 10 | 48 |
2017 May | 34 | 4 | 38 |
2017 April | 23 | 25 | 48 |
2017 March | 28 | 21 | 49 |
2017 February | 12 | 5 | 17 |
2017 January | 25 | 10 | 35 |
2016 December | 44 | 5 | 49 |
2016 November | 64 | 17 | 81 |
2016 October | 65 | 22 | 87 |
2016 September | 56 | 17 | 73 |
2016 August | 48 | 18 | 66 |
2016 July | 42 | 17 | 59 |
2016 March | 2 | 0 | 2 |
2015 December | 2 | 0 | 2 |
2015 September | 0 | 1 | 1 |