Pathogenic Mechanisms in Chronic Obstructive Pulmonary Disease Due to Biomass Smoke Exposure

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El estrés oxidativo generado por los ERO del humo de biomasa puede dañar de forma directa macromoléculas celulares como proteínas o lípidos, así como representar un factor genotóxico capaz de provocar lesiones en el ADN. El potencial de membrana mitocondrial también puede verse alterado por lesiones oxidativas, lo que se traduce en un incremento de la producción de ERO por parte de estos orgánulos. Algunos autores<a class="elsevierStyleCrossRef" href="#bib0305">61</a> han propuesto que las PM secuestran el hierro de las células pulmonares, afectando a la homeostasis de este metal. Cuando las células detectan una deficiencia de hierro, intentan restablecer su disponibilidad generando ERO para reducirlo e incrementando la expresión de importadores del hierro como el DMT1. Como consecuencia del aumento de la concentración del hierro intracelular, se incrementa la cantidad de ferritina. Por otro lado, se conoce que estas moléculas oxidantes pueden activar factores de transcripción pro-inflamatorios como el NF-κβ. Finalmente, las células inflamatorias activadas por el humo de biomasa constituyen otra fuente de ERO. DMT1: transportador de metales divalentes1; ERO: especies reactivas del oxígeno; NF-κβ: factor nuclear potenciador de las cadenas ligeras kappa de las célulasB activadas." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rafael Silva, Manuel Oyarzún, Jordi Olloquequi" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Rafael" "apellidos" => "Silva" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Oyarzún" ] 2 => array:2 [ "nombre" => "Jordi" "apellidos" => "Olloquequi" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212915001068" "doi" => "10.1016/j.arbr.2015.04.013" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212915001068?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289614004359?idApp=UINPBA00003Z" "url" => "/03002896/0000005100000006/v1_201505280239/S0300289614004359/v1_201505280239/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1579212915000701" "issn" => "15792129" "doi" => "10.1016/j.arbr.2015.03.005" "estado" => "S300" "fechaPublicacion" => "2015-06-01" "aid" => "1053" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2015;51:293-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3636 "formatos" => array:3 [ "EPUB" => 162 "HTML" => 2603 "PDF" => 871 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Special article" "titulo" => "Use of Computational Fluid Dynamics in Respiratory Medicine" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "293" "paginaFinal" => "298" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aplicaciones de la dinámica de fluidos computacional a la neumología" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 2463 "Ancho" => 1618 "Tamanyo" => 361645 ] ] "descripcion" => array:1 [ "en" => "Deposited fraction in the airway model (DF) for particles 1, 5, 10, 15 and 20μm in diameter, using inhalation flows of 15, 30 and 75l/min. 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J′awNO vs CANO scatterplot. Normal J′awNO<1470 (pl/s) and normal CANO<4.5 (ppb) (in purple). Type I (circle): Normal J′awNO and CANO; Type II (x): elevated J′awNO and normal CANO; Type III (cross): elevated J′awNO and CANO; Type IV (triangle): normal J′awNO and elevated CANO." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Paula Corcuera-Elosegui, Olaia Sardón-Prado, Ane Aldasoro-Ruiz, Javier Korta-Murua, Javier Mintegui-Aramburu, José I. Emparanza-Knorr, Eduardo G. Pérez-Yarza" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Paula" "apellidos" => "Corcuera-Elosegui" ] 1 => array:2 [ "nombre" => "Olaia" "apellidos" => "Sardón-Prado" ] 2 => array:2 [ "nombre" => "Ane" "apellidos" => "Aldasoro-Ruiz" ] 3 => array:2 [ "nombre" => "Javier" "apellidos" => "Korta-Murua" ] 4 => array:2 [ "nombre" => "Javier" "apellidos" => "Mintegui-Aramburu" ] 5 => array:2 [ "nombre" => "José I." "apellidos" => "Emparanza-Knorr" ] 6 => array:2 [ "nombre" => "Eduardo G." 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PM-stimulated cells generate numerous inflammatory mediators, including IL-6, IL-8, TNF-α, MCP-1, MIP2α and GROα. These can generate a second wave of mediators that include enzymes, such as MMP-9 and MMP-12, involved in tissue remodeling typical of COPD. It has been suggested that TRP ion channels in various lung cells can be activated by PMs in biomass smoke. This would lead to increased cytoplasmic Ca2+ and an intracellular signaling cascade that would increase the production of these pro-inflammatory mediators. The biological material in biomass smoke PMs (e.g., endotoxin) may also activate pro-inflammatory transcription factors AP-1 y NF-κβ via signaling initiated in the TLR receptors. These receptors and agents causing intracellular damage, such as ROS, can also activate inflammasome NLRP3, thereby constituting another possible pro-inflammatory pathway triggered by biomass smoke. AP-1: activating protein-1; GROα: growth-related oncogen α; ROS: reactive oxygen species; IL-6: interleukin-6; IL-8: interleukin-8; MCP-1: monocyte chemoattractant protein 1; MIP2α: macrophage inflammatory protein 2α; MMP-9: matrix metalloproteinase 9; MMP-12: matrix metalloproteinase 12; NF-κβ: nuclear factor kappa-light-chain-enhancer of activated B cells; PMs: respirable particulate matter; TLR4: Toll-like receptor 4; TNF-α: Tumor necrosis factor-α; TRP1: Transient Potential Receptor 1 ion channel." ] ] ] "textoCompleto" => "IntroductionChronic obstructive pulmonary disease (COPD) is a slow, progressive process, characterized by permanent, not fully reversible, airflow obstruction in the bronchioles and by destruction of the pulmonary parenchyma, known as emphysema.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> The onset of COPD is associated with chronic exposure to toxic gases and particles, in particular tobacco smoke, that triggers an abnormal inflammatory pulmonary and systemic response.<a class="elsevierStyleCrossRefs" href="#bib0010">2–5</a> However, the causes of the disease are multifactorial, and both genetic disorders and environmental factors may be involved.<a class="elsevierStyleCrossRef" href="#bib0005">1</a>Although tobacco smoke is still considered the primary risk factor for developing COPD,<a class="elsevierStyleCrossRef" href="#bib0030">6</a> a growing body of evidence indicates that between a quarter and a third of COPD cases are diagnosed in non-smokers.<a class="elsevierStyleCrossRef" href="#bib0035">7</a> Estimates based on Global Initiative for Lung Disease (GOLD) spirometric criteria suggest that 17%–38.8% of COPD patients worldwide are non-smokers.<a class="elsevierStyleCrossRef" href="#bib0035">7</a> In the United States, the United Kingdom, and Spain, rates of COPD in non-smokers are 23%,<a class="elsevierStyleCrossRef" href="#bib0040">8</a> 22.9%,<a class="elsevierStyleCrossRef" href="#bib0045">9</a> and 23.4%,<a class="elsevierStyleCrossRef" href="#bib0050">10</a> respectively. Epidemiological studies conducted in developing countries have also revealed a high prevalence of COPD among non-smokers. In the PLATINO study,<a class="elsevierStyleCrossRef" href="#bib0055">11</a> conducted in five cities in Latin America, 26% of all subjects with irreversible airflow obstruction were non-smokers. However, a study conducted in China using similar methodology found an overall prevalence of COPD of only 5.2% among non-smokers.<a class="elsevierStyleCrossRef" href="#bib0060">12</a>The most important risk factors that may contribute to the development of COPD in these subjects include genetic predisposition, occupational exposure to dust and chemicals, diet, recurrent respiratory infections in childhood, and air pollution, both indoors and outdoors.<a class="elsevierStyleCrossRef" href="#bib0065">13</a> In the latter group, there has been a recent surge of interest in biomass smoke as a significant pollutant in the pathogenesis of COPD.<a class="elsevierStyleCrossRef" href="#bib0065">13</a>Biomass Smoke as a PollutantBiomass smoke as a source of energy is defined as all organic material from animals or vegetable matter that can be used as fuel. This definition covers a wide range of materials, the most common being wood, agricultural residue, such as branches and dried grass, animal dung, and charcoal.<a class="elsevierStyleCrossRef" href="#bib0070">14</a> These materials are generally burnt in poorly-ventilated fireplaces and stoves, and generate substantial amounts of harmful pollutants that can reach exposure levels of between 10 and 20 times those recommended by the World Health Organization (WHO).<a class="elsevierStyleCrossRef" href="#bib0075">15</a>Smoke from burning biomasses contains more than 250 organic compounds that can vary depending on the type of material and combustion conditions.<a class="elsevierStyleCrossRef" href="#bib0080">16</a> A wide range of gaseous pollutants can be generated, including carbon monoxide, ammonia, hydrocyanic acid, formaldehyde, nitrogen oxides and sulfur, and volatile organic compounds, such as benzene and polycyclic aromatic hydrocarbons (PAH), like benzopyrene. The latter two are potent carcinogens in humans.<a class="elsevierStyleCrossRefs" href="#bib0085">17,18</a> Moreover, biomass smoke contains a mixture of solid and liquid particles that vary in concentration, size, surface and chemical composition, known as particulate matter (PM).<a class="elsevierStyleCrossRef" href="#bib0090">18</a> Some particles are respirable and are classified according to their aerodynamic diameter as PM10 (coarse particles with an aerodynamic diameter of 10μm or less), PM2.5 (fine particles with an aerodynamic diameter of 2.5μm or less) and PM0.1 (ultrafine particles with an aerodynamic diameter of 0.1μm or less). PM10 particles are generally composed of minerals with crystalline or amorphous components and elements absorbed from diverse sources, such as fungi, bacteria or endotoxins.<a class="elsevierStyleCrossRef" href="#bib0095">19</a> The high transition metal content of PM2.5 particles, which generally consist of a carbon nucleus with surface absorption of organic and inorganic components,<a class="elsevierStyleCrossRef" href="#bib0100">20</a> enhances their oxidative stress-generating potential. Ultrafine PM0.1 particles, meanwhile, with their high PAH content, are also powerful oxidative stress inducers.<a class="elsevierStyleCrossRefs" href="#bib0100">20,21</a>Many studies support the hypothesis that inhalation of these pollutants is harmful to the health and constitutes a risk factor not only for COPD, but also for respiratory infections, asthma, lung cancer, cardiovascular disorders, cataracts, cerebrovascular accidents or even adverse effects on neonatal development.<a class="elsevierStyleCrossRef" href="#bib0110">22</a>Risk PopulationAt present, around 50% of the world's population and 90% of homes in rural areas burn biomass as their main source of energy in the home, for cooking or heating.<a class="elsevierStyleCrossRef" href="#bib0115">23</a> Over 80% of homes in China, India and sub-Saharan Africa use biomass for fuel, while in rural areas in Latin America, the proportion ranges between 30% and 70%.<a class="elsevierStyleCrossRef" href="#bib0120">24</a> Although the use of biomass fuel is particularly extensive in developing countries, the rising cost of fossil fuel, such as petroleum products or natural gas, along with environmental concerns about CO2 emissions, have also led to an increase in the use of biomass as fuel in developed countries, such as Germany, Finland, Canada, Australia or the United States.<a class="elsevierStyleCrossRefs" href="#bib0120">24–27</a>Around 3 billion people worldwide are exposed to biomass smoke, compared to 1 billion tobacco smokers, suggesting that biomass smoke may be a more significant risk factor for developing COPD than tobacco smoke on a worldwide basis.<a class="elsevierStyleCrossRef" href="#bib0070">14</a> Moreover, for sociocultural reasons, women and children form the main population groups exposed to this pollutant, which is thought to contribute to the death of 2 million women and children globally every year.<a class="elsevierStyleCrossRef" href="#bib0140">28</a> This is because in many developing countries, it is common for women and children to remain at home for long periods, cooking or in close proximity to stoves.In these settings, women are thought to spend on average over 60000h of their life cooking on a biomass stove, during which time they inhale over 25 million liters of polluted air.<a class="elsevierStyleCrossRef" href="#bib0115">23</a> These data are significant, since it has been shown that respiratory symptoms and airflow limitation increase in line with exposure to biomass smoke.<a class="elsevierStyleCrossRefs" href="#bib0145">29,30</a> Consequently, several studies have shown that women who use biomass as fuel for cooking have a higher prevalence of respiratory symptoms of COPD than those who do not use this type of fuel.<a class="elsevierStyleCrossRefs" href="#bib0155">31–39</a> Indeed, 50% of deaths due to COPD in developing countries are attributable to biomass smoke, and 75% of these are in women.<a class="elsevierStyleCrossRef" href="#bib0200">40</a>Although COPD mainly affects adults, several studies have shown that many chronic diseases may originate in the development of the fetus and the early years of life.<a class="elsevierStyleCrossRef" href="#bib0205">41</a> In a recent study, Epstein et al.<a class="elsevierStyleCrossRef" href="#bib0210">42</a> found the children of mothers using biomass in their homes had a lower birth weight than those whose of mothers using other fuel sources. These results are relevant, since low birth weight, being associated with defective lung development and function during childhood and adulthood, is known to be an independent risk factor for the development of COPD.<a class="elsevierStyleCrossRef" href="#bib0215">43</a> Another study performed in a rural area in India found that forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were significantly lower in schoolchildren from homes burning biomass fuel than in those from homes using liquefied petroleum gas.<a class="elsevierStyleCrossRef" href="#bib0220">44</a> Biomass smoke in indoor environments also increases the risk of respiratory infections.<a class="elsevierStyleCrossRefs" href="#bib0225">45–47</a> This factor should also be taken into account, since infections in childhood can predispose an individual to developing COPD in adulthood.<a class="elsevierStyleCrossRef" href="#bib0120">24</a>Although women and children are most exposed to biomass smoke, a recent study in 922 COPD patients in 7 cities in Asia found that 31% of men had also been exposed to this pollutant.<a class="elsevierStyleCrossRef" href="#bib0240">48</a> Although the percentage is lower than in women (44.8%), the figure is significant. The results of a meta-analysis in Asian and non-Asian subjects revealed that individuals exposed to biomass smoke have a 2.44-fold greater risk of developing COPD than the unexposed population.<a class="elsevierStyleCrossRef" href="#bib0245">49</a> Exposure was identified as a risk factor in both men (OR: 4.30; 95% CI: 1.85–10.01) and women (OR: 2.73; 95% CI: 2.28–3.28).<a class="elsevierStyleCrossRef" href="#bib0245">49</a> Data from another recent study confirm the association between airflow obstruction in non-smokers and cooking with charcoal in both sexes.<a class="elsevierStyleCrossRef" href="#bib0250">50</a>Pathogenic Mechanisms of Biomass Smoke in Chronic Obstructive Pulmonary DiseaseBiomass smoke contains many compounds similar to those in tobacco smoke,<a class="elsevierStyleCrossRef" href="#bib0255">51</a> therefore, COPD caused by both types of smoke might be expected to present similar clinical and radiological characteristics.<a class="elsevierStyleCrossRefs" href="#bib0260">52,53</a> However, some differences are observed between COPD from biomass smoke and COPD from tobacco smoke<a class="elsevierStyleCrossRefs" href="#bib0265">53–60</a> (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). From a histopathological point of view, for example, patients with biomass COPD have more bronchiolitis, more anthracosis and pulmonary fibrosis, and more airway wall thickening than smokers with COPD, who present with more pulmonary emphysema.<a class="elsevierStyleCrossRefs" href="#bib0275">55,57–59</a> A recent paper published by Krimmer et al.<a class="elsevierStyleCrossRef" href="#bib0305">61</a> showed that fibroblasts exposed in vitro to biomass smoke increased their production of fibronectin.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Despite epidemiological evidence relating biomass smoke with COPD, little is known about the cell and molecular mechanisms that cause exposure to this type of pollutant to be harmful to health. It has been recently suggested that biomass smoke may contribute to the onset of COPD by fostering a pulmonary and systemic inflammatory state, and by increasing the genotoxic effect of oxidative stress, among other mechanisms of cell damage (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia>Pro-inflammatory MechanismsAbundant evidence is available to demonstrate that exposure to biomass smoke causes lung inflammation. Women exposed to biomass smoke have higher alveolar levels of neutrophils, eosinophils, monocytes, mastocytes, lymphocytes and macrophages, as well as higher sputum levels of interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α than those who use other types of fuel.<a class="elsevierStyleCrossRefs" href="#bib0310">62–64</a> Gene expression of some of these pro-inflammatory mediators, such as IL-8, TNF-α, matrix metalloproteinase (MMP)-9 and MMP-12, increases in parallel with exposure to biomass smoke, as recently demonstrated by Guarnieri et al.,<a class="elsevierStyleCrossRef" href="#bib0325">65</a> while another study shows that this pollutant alters the expression of genes associated with CD8+ T-cell activation.<a class="elsevierStyleCrossRef" href="#bib0330">66</a> The pro-inflammatory effects of biomass smoke are not restricted to the lung, since increases have been reported in CD8+ T-cells, natural killer (NK) cells, IL-6, IL-8, TNF-α, C-reactive protein (CRP) and monocyte chemoattractant protein (MCP)-1 in the blood of exposed individuals.<a class="elsevierStyleCrossRefs" href="#bib0335">67–69</a> Studies performed in samples of induced sputum, bronchoalveolar lavage (BAL) fluid and blood show that COPD patients exposed to biomass smoke have higher levels of inflammatory cells (neutrophils and eosinophils), IL-8, CRP and MMP-12, and increased MMP-9 activity, compared to control subjects.<a class="elsevierStyleCrossRefs" href="#bib0115">23,70,71</a>It has been suggested that biomass smoke may induce an inflammatory response via the Transient Potential Receptor (TRP) ion channels of the lung cells<a class="elsevierStyleCrossRef" href="#bib0360">72</a> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). These channels can be activated by a wide range of stimuli, including PM, meaning that the cells are responsive to changes in their environment. When a TRP channel is activated, it mediates Na+ and Ca2+ flow across the plasma membrane to the cytoplasma, stimulating other voltage-dependent channels and influencing cell events, such as transcription, transduction, contraction and migration.<a class="elsevierStyleCrossRefs" href="#bib0365">73,74</a> The TRP channel superfamily is divided into seven subfamilies, of which TRPA1, V1, V4 and M8 receptors have shown capacity for regulating inflammatory responses.<a class="elsevierStyleCrossRef" href="#bib0360">72</a> TRPA1 receptors, found in airway C-fibers, bronchiolar epithelial cells, fibroblasts and smooth muscle cells, may induce IL-6 and IL-8 production and increase bronchiolar macrophage inflammatory protein (MIP) 2α and growth-related oncogene (GRO)α cytosine expression after exposure to biomass smoke.<a class="elsevierStyleCrossRefs" href="#bib0370">74–78</a>Another pro-inflammatory mechanism proposed for biomass smoke is the activation of toll-like receptors (TLR) on airway macrophages and epithelial cells, which would in turn activate the nuclear factor kappa-light-chain-enhancers of activated B cells (NF-κβ) and activator protein-1 (AP-1) activity<a class="elsevierStyleCrossRef" href="#bib0100">20</a> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). According to this hypothesis, these pathways may be activated by the small amounts of biological material (e.g., endotoxin, fungal spores, etc.) present in the PM. Becker et al.<a class="elsevierStyleCrossRef" href="#bib0395">79</a> showed that IL-6 and IL-8 production in alveolar macrophages and epithelial cells exposed to PM could be inhibited by TLR4 and TLR2 antagonists or blocking antibodies. In another study, TLR4 and TLR2-deficient mouse macrophages produced less TNF-α and IL-6 after exposure to PM.<a class="elsevierStyleCrossRef" href="#bib0400">80</a>In another recent study, Hirota et al.<a class="elsevierStyleCrossRef" href="#bib0405">81</a> put forward inflammasome NLRP3, a protein complex that can initiate an inflammatory response to agents causing cell damage, as another key molecular mechanism in the PM-induced inflammatory response (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). These authors reported in vivo and in vitro evidence of increased IL-1β production and neutrophilia in airways when this molecular complex was activated after exposure to PM.Kido et al.<a class="elsevierStyleCrossRef" href="#bib0410">82</a> determined the link between pulmonary and systemic inflammation and biomass smoke. In another study in mice, they showed that pro-inflammatory mediators, such as IL-6, pass from the lungs to the bloodstream after exposure to PM10.Oxidative Mechanisms and GenotoxicitySeveral studies conducted in sputum and blood samples of women and children chronically exposed to biomass smoke showed an increase in the production of reactive oxygen species (ROS) and a decrease in antioxidant mechanisms such as superoxide dismutase (SOD), glutathione (GSH) and ascorbic acid.<a class="elsevierStyleCrossRefs" href="#bib0315">63,64,69,83–85</a> Other studies reported an increase in lipid peroxidation products, such as malondialdehyde (MDA) in the blood of subjects exposed to biomass smoke,<a class="elsevierStyleCrossRefs" href="#bib0425">85–88</a> and a correlation between the levels of this compound and reduced VEF1/CVF.<a class="elsevierStyleCrossRef" href="#bib0415">83</a> Increases in oxidative stress markers in DNA in sputum samples<a class="elsevierStyleCrossRef" href="#bib0445">89</a> and peripheral blood mononuclear cells (PBMC)<a class="elsevierStyleCrossRefs" href="#bib0435">87,90</a> have also been described in subjects chronically exposed to biomass smoke. Diminished capacity to repair cell damage has also been reported in these subjects.<a class="elsevierStyleCrossRefs" href="#bib0310">62,85,90</a> These results are supported by several studies in animal models<a class="elsevierStyleCrossRefs" href="#bib0455">91–94</a> or in vitro cell lines<a class="elsevierStyleCrossRefs" href="#bib0445">89,95–104</a> that found increased production of ROS, cytokines, lipid peroxidation products and oxidative DNA damage or impaired antioxidant mechanisms after exposure to biomass smoke. Oxidative stress, then, appears have a significant role in activating the harmful effects of this pollutant.ROS and reactive nitrogen species (RNS) may contribute to the pathogenesis of COPD and other lung diseases, such as asthma or bronchiectasis<a class="elsevierStyleCrossRefs" href="#bib0525">105–107</a> by oxidizing proteins, lipids, carbohydrates and DNA.<a class="elsevierStyleCrossRef" href="#bib0540">108</a> Some of the components of biomass smoke, such as PM, can induce oxidative stress via several mechanisms: directly, by the ROS-generating effect of the physicochemical characteristics of the particles or the effect of soluble components (e.g., organic compounds or transition metals), or indirectly, by activation of inflammatory cells that can lead to generation of ROS or RNS.<a class="elsevierStyleCrossRefs" href="#bib0100">20,64,96</a>Some authors have suggested that one of the most significant oxidative mechanisms of biomass smoke is the disturbance of iron homeostasis in lung cells<a class="elsevierStyleCrossRef" href="#bib0360">72</a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). When PMs become lodged in the lower respiratory tract, they sequester iron from the tissues, diminishing the amount of iron available to the cells. Attempts by the cells to reestablish the availability of the metal lead to increased iron importation and reduction through the Fenton reaction (Fe2++H2O2→Fe3++•OH+OH−), generating ROS in the process.<a class="elsevierStyleCrossRefs" href="#bib0360">72,109,110</a> ROS derived from these reactions are also known to activate transcription factors, such as NF-κβ, increasing the production of pro-inflammatory mediators.<a class="elsevierStyleCrossRef" href="#bib0555">111</a> Moreover, damage caused by mitochondrial oxidation may affect the membrane potential of these organelles, thereby increasing ROS production<a class="elsevierStyleCrossRef" href="#bib0560">112</a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).This hypothesis is supported by evidence of increased numbers of iron-laden macrophages (siderophages) in the sputum of women exposed to biomass smoke,<a class="elsevierStyleCrossRef" href="#bib0315">63</a> and increased expression of divalent metal transporter-1 (DMT1, one of the main iron importers) and ferritin levels in epithelial cells exposed to this pollutant.<a class="elsevierStyleCrossRef" href="#bib0360">72</a>ConclusionsBiomass may be a source of renewable and sustainable energy, but its combustion is one of the major sources of pollution, both indoors and outdoors. Abundant epidemiological, clinical and experimental evidence has shown that exposure to biomass smoke is harmful to health and predisposes individuals to a range of diseases, including COPD.The pathogenic mechanisms considered to date include increased pulmonary and systemic inflammation, and promotion of an oxidative stress state that may cause macromolecular cell damage, including DNA changes.Efforts must be made to increase awareness of the risk of exposure to biomass smoke. Significant data are available on the benefits of reducing exposure this pollutant by replacing biomass with biogas or by improving combustion systems and ventilation of stoves and kitchens.<a class="elsevierStyleCrossRefs" href="#bib0565">113–116</a> A report on the HUMAN platform initiative<a class="elsevierStyleCrossRef" href="#bib0585">117</a> found that the construction of kitchens to reduce smoke pollution in the homes of risk populations is feasible and inexpensive. Promoting the use of cleaner energy sources, such as electric, by way of incentives, particularly in more deprived populations in developing countries during the winter months, may also be an effective measure.AuthorshipDr Rafael Silva and Dr Miguel Oyarzún made a critical review of the manuscript. Dr Jordi Olloquequi conceived and produced the paper.Conflict of interestsThe authors state that they have no conflict of interests." "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres516633" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec537550" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres516632" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec537551" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Biomass Smoke as a Pollutant" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Risk Population" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Pathogenic Mechanisms of Biomass Smoke in Chronic Obstructive Pulmonary Disease" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Pro-inflammatory Mechanisms" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Oxidative Mechanisms and Genotoxicity" ] ] ] 8 => array:2 [ "identificador" => "sec0035" "titulo" => "Conclusions" ] 9 => array:2 [ "identificador" => "sec0040" "titulo" => "Authorship" ] 10 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflict of interests" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-08-11" "fechaAceptado" => "2014-10-14" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec537550" "palabras" => array:5 [ 0 => "Chronic obstructive pulmonary disease" 1 => "Biomass smoke" 2 => "Pathogenesis" 3 => "Inflammation" 4 => "Genotoxicity" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec537551" "palabras" => array:5 [ 0 => "Enfermedad pulmonar obstructiva crónica" 1 => "Humo de biomasa" 2 => "Patogenia" 3 => "Inflamación" 4 => "Genotoxicidad" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Chronic obstructive pulmonary disease (COPD) mortality and morbidity have increased significantly worldwide in recent decades. Although cigarette smoke is still considered the main risk factor for the development of the disease, estimates suggest that between 25% and 33% of COPD patients are non-smokers. Among the factors that may increase the risk of developing COPD, biomass smoke has been proposed as one of the most important, affecting especially women and children in developing countries.Despite the epidemiological evidence linking exposure to biomass smoke with adverse health effects, the specific cellular and molecular mechanisms by which this pollutant can be harmful for the respiratory and cardiovascular systems remain unclear. In this article we review the main pathogenic mechanisms proposed to date that make biomass smoke one of the major risk factors for COPD." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Las tasas de mortalidad y morbilidad de la enfermedad pulmonar obstructiva crónica (EPOC) han aumentado mundialmente de forma significativa durante las últimas décadas. A pesar de que el humo de tabaco se sigue considerando el principal factor etiopatogénico para el desarrollo de la enfermedad, se estima que entre una tercera y una cuarta parte de los pacientes con EPOC son no fumadores. De todos los factores de riesgo que pueden incrementar la probabilidad de sufrir EPOC en estos sujetos se ha propuesto al humo de biomasa como uno de los más importantes, afectando sobre todo a mujeres y a niños de países emergentes.Aunque existen numerosas evidencias epidemiológicas que relacionan la exposición al humo de biomasa con efectos nocivos para la salud, todavía no se conocen bien los mecanismos celulares y moleculares específicos mediante los cuales este contaminante puede suponer una noxa para los sistemas respiratorio y cardiovascular. En esta revisión se recogen los mecanismos patogénicos propuestos hasta la fecha que sitúan al humo de biomasa como uno de los principales factores de riesgo para la EPOC." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Silva R, Oyarzún M, Olloquequi J. Mecanismos patogénicos en la enfermedad pulmonar obstructiva crónica causada por exposición a humo de biomasa. Arch Bronconeumol. 2015;51:285-292." ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2121 "Ancho" => 2833 "Tamanyo" => 342309 ] ] "descripcion" => array:1 [ "en" => "Pro-inflammatory mechanisms of biomass smoke. PM-stimulated cells generate numerous inflammatory mediators, including IL-6, IL-8, TNF-α, MCP-1, MIP2α and GROα. These can generate a second wave of mediators that include enzymes, such as MMP-9 and MMP-12, involved in tissue remodeling typical of COPD. It has been suggested that TRP ion channels in various lung cells can be activated by PMs in biomass smoke. This would lead to increased cytoplasmic Ca2+ and an intracellular signaling cascade that would increase the production of these pro-inflammatory mediators. The biological material in biomass smoke PMs (e.g., endotoxin) may also activate pro-inflammatory transcription factors AP-1 y NF-κβ via signaling initiated in the TLR receptors. These receptors and agents causing intracellular damage, such as ROS, can also activate inflammasome NLRP3, thereby constituting another possible pro-inflammatory pathway triggered by biomass smoke. AP-1: activating protein-1; GROα: growth-related oncogen α; ROS: reactive oxygen species; IL-6: interleukin-6; IL-8: interleukin-8; MCP-1: monocyte chemoattractant protein 1; MIP2α: macrophage inflammatory protein 2α; MMP-9: matrix metalloproteinase 9; MMP-12: matrix metalloproteinase 12; NF-κβ: nuclear factor kappa-light-chain-enhancer of activated B cells; PMs: respirable particulate matter; TLR4: Toll-like receptor 4; TNF-α: Tumor necrosis factor-α; TRP1: Transient Potential Receptor 1 ion channel." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2050 "Ancho" => 2809 "Tamanyo" => 351116 ] ] "descripcion" => array:1 [ "en" => "Biomass smoke oxidative mechanisms and genotoxicity. Oxidative stress generated by biomass smoke ROS can cause direct damage to cell macromolecules, such as proteins or lipids, and can act as a genotoxic factor in producing DNA lesions. Mitochondrial membrane potential can also be affected by oxidative damage, resulting in increased ROS production in these organelles. Some authors<a class="elsevierStyleCrossRef" href="#bib0305">61</a> have proposed that PMs sequester iron from the lung cells, affecting iron homeostasis. When cells detect iron deficiency, they try to reestablish availability of this metal by generating ROS to decrease it and promoting the expression of iron importers such as DMT1. As a result of the increased intracellular iron levels, the amount of ferritin increases. However, these oxidizing molecules are known to activate pro-inflammatory transcription factors, such as NF-κβ. Finally, inflammatory cells activated by biomass smoke are another source of ROS. DMT1: divalent metal transporter 1; NF-κβ: nuclear factor kappa-light-chain-enhancer of activated B cells; ROS: reactive oxygen species." ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "COPD: chronic obstructive pulmonary disease; DLCO: diffusion lung capacity for carbon monoxide." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristic \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Biomass smoke COPD \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tobacco smoke COPD \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Reference \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Reduced DLCO \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0270">54</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Oxygen saturation at rest and during exercise \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0275">55</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Bronchial hyperreactivity on methacoline challenge \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0280">56</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Goblet-form cell hyperplasia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0285">57</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Emphysema \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRefs" href="#bib0275">55–60</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Airway wall thickening \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0285">57</a>, <a class="elsevierStyleCrossRef" href="#bib0290">58</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Anthracosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0285">57</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Pulmonary artery intimal hyperplasia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+++ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0285">57</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab833841.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Characteristics Differentiating Chronic Obstructive Pulmonary Disease (COPD) Caused by Tobacco Smoke and by Biomass Smoke." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:117 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2014. Available from <a href="http://www.goldcopd.org/">http://www.goldcopd.org/</a> [accesss 16.07.14]" ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung CD57+ cell density is increased in very severe COPD" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Histol Histopathol" "fecha" => "2012" "volumen" => "27" "paginaInicial" => "39" "paginaFinal" => "47" "link" => array:1 [ …1] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00201509" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2011" "volumen" => "37" "paginaInicial" => "289" "paginaFinal" => "298" "link" => array:1 [ …1] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential lymphocyte infiltration in small airways and lung parenchyma in COPD patients" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2010.03.002" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2010" "volumen" => "104" "paginaInicial" => "1310" "paginaFinal" => "1318" "link" => array:1 [ …1] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cellular and molecular mechanisms of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ccm.2013.10.004" "Revista" => array:6 [ "tituloSerie" => "Clin Chest Med" "fecha" => "2014" "volumen" => "35" "paginaInicial" => "71" "paginaFinal" => "86" "link" => array:1 [ …1] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201204-0596PP" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2013" "volumen" => "187" "paginaInicial" => "347" "paginaFinal" => "365" "link" => array:1 [ …1] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-smoking-related chronic obstructive pulmonary disease: a neglected entity" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1440-1843.2012.02152.x" "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2012" "volumen" => "17" "paginaInicial" => "908" "paginaFinal" => "912" "link" => array:1 [ …1] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airway obstruction in never smokers: results from the third national health and nutrition examination survey" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjmed.2005.06.041" "Revista" => array:7 [ "tituloSerie" => "Am J Med" "fecha" => "2005" "volumen" => "118" "paginaInicial" => "1364" "paginaFinal" => "1372" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical, radiologic, and induced sputum features of chronic obstructive pulmonary disease in nonsmokers: a descriptive study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2002" "volumen" => "166" "paginaInicial" => "1078" "paginaFinal" => "1083" "link" => array:1 [ …1] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographic variations in prevalence and underdiagnosis of COPD: results of the IBERPOC multicentre epidemiological study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "981" "paginaFinal" => "989" "link" => array:1 [ …1] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airflow obstruction in never smokers in five Latin American cities: the PLATINO study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arcmed.2012.03.007" "Revista" => array:6 [ "tituloSerie" => "Arch Med Res" "fecha" => "2012" "volumen" => "43" "paginaInicial" => "159" "paginaFinal" => "165" "link" => array:1 [ …1] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200612-1749OC" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2007" "volumen" => "176" "paginaInicial" => "753" "paginaFinal" => "760" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An official American Thoracic Society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200811-1757ST" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2010" "volumen" => "182" "paginaInicial" => "693" "paginaFinal" => "718" "link" => array:1 [ …1] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is exposure to biomass smoke the biggest risk factor for COPD globally" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.10-0645" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2010" "volumen" => "138" "paginaInicial" => "3" "paginaFinal" => "6" "link" => array:1 [ …1] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung function and symptoms among indigenous Mayan women exposed to high levels of indoor air pollution" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2007" "volumen" => "11" "paginaInicial" => "1372" "paginaFinal" => "1379" "link" => array:1 [ …1] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Woodsmoke health effects: a review" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/08958370701493456" "Revista" => array:6 [ "tituloSerie" => "Inhal Toxicol" "fecha" => "2007" "volumen" => "19" "paginaInicial" => "67" "paginaFinal" => "106" "link" => array:1 [ …1] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "National burden of disease in India from indoor air pollution" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.97.24.13286" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "2000" "volumen" => "97" "paginaInicial" => "13286" "paginaFinal" => "13293" "link" => array:1 [ …1] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pollutants from the combustion of solid biomass fuels" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Prog Energy Combust Sci" "fecha" => "2012" "volumen" => "38" "paginaInicial" => "113" "paginaFinal" => "137" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relations between PM10 composition and cell toxicity: a multivariate and graphical approach" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.chemosphere.2006.10.078" "Revista" => array:6 [ "tituloSerie" => "Chemosphere" "fecha" => "2007" "volumen" => "67" "paginaInicial" => "1218" "paginaFinal" => "1228" "link" => array:1 [ …1] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.taap.2011.09.007" "Revista" => array:6 [ "tituloSerie" => "Toxicol Appl Pharmacol" "fecha" => "2011" "volumen" => "257" "paginaInicial" => "209" "paginaFinal" => "226" "link" => array:1 [ …1] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polycyclic aromatic hydrocarbon-induced oxidative stress, antioxidant capacity, and the risk of lung cancer: a pilot nested case-control study" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Anticancer Res" "fecha" => "2013" "volumen" => "33" "paginaInicial" => "3089" "paginaFinal" => "3097" "link" => array:1 [ …1] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of diseases associated with household air pollution due to the use of biomass fuels" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhazmat.2011.05.087" "Revista" => array:6 [ "tituloSerie" => "J Hazard Mater" "fecha" => "2011" "volumen" => "192" "paginaInicial" => "425" "paginaFinal" => "431" "link" => array:1 [ …1] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposure to biomass smoke as a cause for airway disease in women and children" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACI.0b013e32834ecb65" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2012" "volumen" => "12" "paginaInicial" => "82" "paginaFinal" => "90" "link" => array:1 [ …1] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic obstructive pulmonary disease in non-smokers" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)61303-9" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "374" "paginaInicial" => "733" "paginaFinal" => "743" "link" => array:1 [ …1] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characterisation of particulates and carcinogenic polycyclic aromatic hydrocarbons in wintertime wood-fired heating in residential areas" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Atmos Environ" "fecha" => "2011" "volumen" => "45" "paginaInicial" => "7627" "paginaFinal" => "7634" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of combustion condition on cytotoxic and inflammatory activity of residential wood combustion particles" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Atmos Environ" "fecha" => "2010" "volumen" => "44" "paginaInicial" => "1691" "paginaFinal" => "1698" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wood smoke-associated chronic obstructive pulmonary disease (COPD)—underappreciated in the United States?" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2009" "volumen" => "179" "paginaInicial" => "A4742" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Of dung and dynein arms: understanding COPD in nonsmokers" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.02334" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2013" "volumen" => "58" "paginaInicial" => "543" "paginaFinal" => "545" "link" => array:1 [ …1] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of biomass burning on respiratory symptoms and lung function in rural Mexican women" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200503-479OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2006" "volumen" => "174" "paginaInicial" => "901" "paginaFinal" => "905" "link" => array:1 [ …1] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of COPD in five Colombian cities situated at low, medium, and high altitude (PREPOCOL study)" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-1361" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2008" "volumen" => "133" "paginaInicial" => "343" "paginaFinal" => "349" "link" => array:1 [ …1] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of indoor air pollution on the respiratory system of women using different fuels for cooking in an urban slum of Pondicherry" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Natl Med J India" "fecha" => "1996" "volumen" => "9" "paginaInicial" => "113" "paginaFinal" => "117" "link" => array:1 [ …1] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ventilatory function in nonsmoking rural Indian women using different cooking fuels" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respiration" "fecha" => "1994" "volumen" => "61" "paginaInicial" => "89" "paginaFinal" => "92" "link" => array:1 [ …1] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sister-chromatid exchange frequency in women who were exposed to biomass in a village in central Anatolia" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Turkish Respir J" "fecha" => "2001" "volumen" => "2" "paginaInicial" => "26" "paginaFinal" => "28" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional and radiological impairment in women highly exposed to indoor biomass fuels" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2001" "volumen" => "6" "paginaInicial" => "255" "paginaFinal" => "258" "link" => array:1 [ …1] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of pulmonary changes due to biomass fuels using high-resolution computed tomography" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00330-003-1925-5" "Revista" => array:6 [ "tituloSerie" => "Eur Radiol" "fecha" => "2003" "volumen" => "13" "paginaInicial" => "2372" "paginaFinal" => "2377" "link" => array:1 [ …1] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic pulmonary disease in rural women exposed to biomass fumes" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Invest Med" "fecha" => "2003" "volumen" => "26" "paginaInicial" => "243" "paginaFinal" => "248" "link" => array:1 [ …1] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Domestic smoke pollution and chronic bronchitis in a rural community of the hill region of Nepal" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "1984" "volumen" => "39" "paginaInicial" => "337" "paginaFinal" => "339" "link" => array:1 [ …1] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic bronchitis in women using solid biomass fuel in rural Peshawar, Pakistan" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.06-2529" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2007" "volumen" => "132" "paginaInicial" => "1472" "paginaFinal" => "1475" "link" => array:1 [ …1] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of clinical and functional parameters in female subjects with biomass smoke exposure" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4187/respcare.01772" "Revista" => array:6 [ "tituloSerie" => "Respir Care" "fecha" => "2013" "volumen" => "58" "paginaInicial" => "424" "paginaFinal" => "430" "link" => array:1 [ …1] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0200" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global burden of disease and risk factors" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "2006" "editorial" => "World Bank" "editorialLocalizacion" => "Washington, DC" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0205" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early origins of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.siny.2012.01.002" "Revista" => array:6 [ "tituloSerie" => "Semin Fetal Neonatal Med" "fecha" => "2012" "volumen" => "17" "paginaInicial" => "112" "paginaFinal" => "118" "link" => array:1 [ …1] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0210" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Household fuels, low birth weight, and neonatal death in India: the separate impacts of biomass, kerosene, and coal" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijheh.2012.12.006" "Revista" => array:6 [ "tituloSerie" => "Int J Hyg Environ Health" "fecha" => "2013" "volumen" => "216" "paginaInicial" => "523" "paginaFinal" => "532" "link" => array:1 [ …1] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0215" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations between birth weight, early childhood weight gain and adult lung function" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2008.103978" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2009" "volumen" => "64" "paginaInicial" => "228" "paginaFinal" => "232" "link" => array:1 [ …1] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0220" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Domestic fuels, indoor air pollution, and children's health" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1196/annals.1454.015" "Revista" => array:6 [ "tituloSerie" => "Ann N Y Acad Sci" "fecha" => "2008" "volumen" => "1140" "paginaInicial" => "209" "paginaFinal" => "217" "link" => array:1 [ …1] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0225" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Air pollution and child respiratory health: a case-crossover study in Australia and New Zealand" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200411-1586OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2005" "volumen" => "171" "paginaInicial" => "1272" "paginaFinal" => "1278" "link" => array:1 [ …1] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0230" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indoor air pollution from unprocessed solid fuel use and pneumonia risk in children aged under five years: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Bull World Health Organ" "fecha" => "2008" "volumen" => "86" "paginaInicial" => "390" "paginaFinal" => "398" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0235" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of biomass smoke on pulmonary host defence mechanisms" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.prrv.2007.07.010" "Revista" => array:6 [ "tituloSerie" => "Paediatr Respir Rev" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "287" "paginaFinal" => "291" "link" => array:1 [ …1] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0240" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Chron Obstruct Pulmon Dis" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "31" "paginaFinal" => "39" "link" => array:1 [ …1] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0245" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk of COPD from exposure to biomass smoke: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.08-2114" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2010" "volumen" => "138" "paginaInicial" => "20" "paginaFinal" => "31" "link" => array:1 [ …1] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0250" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and correlates of airflow obstruction in ∼317,000 never-smokers in China" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00152413" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2014" "volumen" => "44" "paginaInicial" => "66" "paginaFinal" => "77" "link" => array:1 [ …1] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0255" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive lung disease and exposure to burning biomass fuel in the indoor environment" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gheart.2012.06.016" "Revista" => array:6 [ "tituloSerie" => "Glob Heart" "fecha" => "2012" "volumen" => "7" "paginaInicial" => "265" "paginaFinal" => "270" "link" => array:1 [ …1] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0260" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Survival of patients with chronic obstructive pulmonary disease due to biomass smoke and tobacco" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200504-568OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2006" "volumen" => "173" "paginaInicial" => "393" "paginaFinal" => "397" "link" => array:1 [ …1] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0265" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wood smoke-associated lung disease: a clinical, functional, radiological and pathological description" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2008" "volumen" => "12" "paginaInicial" => "1092" "paginaFinal" => "1098" "link" => array:1 [ …1] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0270" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory health effects of indoor air pollution" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int Tuberc Lung Dis" "fecha" => "2010" "volumen" => "14" "paginaInicial" => "1079" "paginaFinal" => "1086" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0275" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00206112" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2014" "volumen" => "43" "paginaInicial" => "725" "paginaFinal" => "734" "link" => array:1 [ …1] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0280" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airway hyper-responsiveness in wood smoke COPD" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Chest" "fecha" => "2003" "volumen" => "124" "paginaInicial" => "168S" "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0285" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of lung morphology in COPD secondary to cigarette and biomass smoke" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "2008" "volumen" => "12" "paginaInicial" => "972" "paginaFinal" => "977" "link" => array:1 [ …1] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0290" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pseudophysiologic emphysema in women with wood smoke COPD in Bogota (2600m)" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2004" "volumen" => "40" "paginaInicial" => "31" "paginaFinal" => "36" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0295" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary changes on HRCT scans in nonsmoking females with COPD due to wood smoke exposure" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bras Pneumol" "fecha" => "2013" "volumen" => "39" "paginaInicial" => "155" "paginaFinal" => "163" "link" => array:1 [ …1] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0300" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad pulmonar obstructiva crónica (EPOC) por humo de leña en mujeres: comparación con la EPOC por tabaquismo" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Acta Med Colomb" "fecha" => "2004" "volumen" => "29" "paginaInicial" => "17" "paginaFinal" => "25" ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0305" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposure to biomass smoke extract enhances fibronectin release from fibroblasts" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0083938" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2013" "volumen" => "8" "paginaInicial" => "e83938" "link" => array:1 [ …1] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0310" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of DNA damage by comet assay and fast halo assay in buccal epithelial cells of Indian women chronically exposed to biomass smoke" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijheh.2011.04.003" "Revista" => array:6 [ "tituloSerie" => "Int J Hyg Environ Health" "fecha" => "2011" "volumen" => "214" "paginaInicial" => "311" "paginaFinal" => "318" "link" => array:1 [ …1] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0315" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in sputum cytology, airway inflammation and oxidative stress due to chronic inhalation of biomass smoke during cooking in premenopausal rural Indian women" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijheh.2012.05.005" "Revista" => array:6 [ "tituloSerie" => "Int J Hyg Environ Health" "fecha" => "2013" "volumen" => "216" "paginaInicial" => "301" "paginaFinal" => "308" "link" => array:1 [ …1] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0320" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neutrophilic inflammatory response and oxidative stress in premenopausal women chronically exposed to indoor air pollution from biomass burning" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10753-011-9360-2" "Revista" => array:7 [ "tituloSerie" => "Inflammation" "fecha" => "2012" "volumen" => "35" "paginaInicial" => "671" "paginaFinal" => "683" "link" => array:1 [ …1] "itemHostRev" => array:3 [ …3] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0325" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0088455" "Revista" => array:5 [ "tituloSerie" => "PLoS ONE" "fecha" => "2014" "volumen" => "9" "paginaInicial" => "e88455" "link" => array:1 [ …1] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0330" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhanced acute responses in an experimental exposure model to biomass smoke inhalation in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/01902140802322256" "Revista" => array:6 [ "tituloSerie" => "Exp Lung Res" "fecha" => "2008" "volumen" => "34" "paginaInicial" => "631" "paginaFinal" => "662" "link" => array:1 [ …1] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0335" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00097707" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2008" "volumen" => "32" "paginaInicial" => "129" "paginaFinal" => "138" "link" => array:1 [ …1] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0340" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immune cells and cardiovascular health in premenopausal women of rural India chronically exposed to biomass smoke during daily household cooking" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.scitotenv.2012.08.065" "Revista" => array:6 [ "tituloSerie" => "Sci Total Environ" "fecha" => "2012" "volumen" => "438" "paginaInicial" => "293" "paginaFinal" => "298" "link" => array:1 [ …1] ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0345" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic inflammatory changes and increased oxidative stress in rural Indian women cooking with biomass fuels" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.taap.2012.04.004" "Revista" => array:6 [ "tituloSerie" => "Toxicol Appl Pharmacol" "fecha" => "2012" "volumen" => "261" "paginaInicial" => "255" "paginaFinal" => "262" "link" => array:1 [ …1] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0350" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Matrix metalloproteinases activity in COPD associated with wood smoke" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2004" "volumen" => "125" "paginaInicial" => "466" "paginaFinal" => "472" "link" => array:1 [ …1] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0355" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C-reactive protein levels are raised in stable chronic obstructive pulmonary disease patients independent of smoking behavior and biomass exposure" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3978/j.issn.2072-1439.2013.06.27" "Revista" => array:6 [ "tituloSerie" => "J Thorac Dis" "fecha" => "2013" "volumen" => "5" "paginaInicial" => "414" "paginaFinal" => "421" "link" => array:1 [ …1] ] ] ] ] ] ] 71 => array:3 [ "identificador" => "bib0360" "etiqueta" => "72" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emerging mechanistic targets in lung injury induced by combustion-generated particles" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/toxsci/kft001" "Revista" => array:6 [ "tituloSerie" => "Toxicol Sci" "fecha" => "2013" "volumen" => "132" "paginaInicial" => "253" "paginaFinal" => "267" "link" => array:1 [ …1] ] ] ] ] ] ] 72 => array:3 [ "identificador" => "bib0365" "etiqueta" => "73" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TRP channels" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1146/annurev.biochem.75.103004.142819" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Biochem" "fecha" => "2007" "volumen" => "76" "paginaInicial" => "387" "paginaFinal" => "417" "link" => array:1 [ …1] ] ] ] ] ] ] 73 => array:3 [ "identificador" => "bib0370" "etiqueta" => "74" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Introduction to TRP channels: structure, function, and regulation" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/978-1-60761-500-2_6" "Revista" => array:6 [ "tituloSerie" => "Adv Exp Med Biol" "fecha" => "2010" "volumen" => "661" "paginaInicial" => "99" "paginaFinal" => "108" "link" => array:1 [ …1] ] ] ] ] ] ] 74 => array:3 [ "identificador" => "bib0375" "etiqueta" => "75" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1124/mol.111.076067" "Revista" => array:6 [ "tituloSerie" => "Mol Pharmacol" "fecha" => "2012" "volumen" => "81" "paginaInicial" => "411" "paginaFinal" => "419" "link" => array:1 [ …1] ] ] ] ] ] ] 75 => array:3 [ "identificador" => "bib0380" "etiqueta" => "76" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells" "autores" => array:1 [ 0 => array:2 [ …2] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/10799893.2011.602413" "Revista" => array:7 [ "tituloSerie" => "J Recept Signal Transduct Res" …6 ] ] ] ] ] ] 76 => array:3 [ "identificador" => "bib0385" "etiqueta" => "77" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0042454" "Revista" => array:5 [ …5] ] ] ] ] ] 77 => array:3 [ "identificador" => "bib0390" 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air particulate matter" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1189/jlb.1008587" "Revista" => array:6 [ …6] ] ] ] ] ] 80 => array:3 [ "identificador" => "bib0405" "etiqueta" => "81" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2011.11.033" "Revista" => array:7 [ …7] ] ] ] ] ] 81 => array:3 [ "identificador" => "bib0410" "etiqueta" => "82" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Particulate matter induces translocation of IL-6 from the lung to the systemic circulation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.2009-0427OC" "Revista" => array:7 [ …7] ] ] ] ] ] 82 => array:3 [ "identificador" => "bib0415" "etiqueta" => "83" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of biomass combustion smoke on hematological and antioxidant profile among children (8–13 years) in India" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/08958370802448961" "Revista" => array:6 [ …6] ] ] ] ] ] 83 => array:3 [ "identificador" => "bib0420" "etiqueta" => "84" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activation of protein kinase B (PKB/Akt) and risk of lung cancer among rural women in India who cook with biomass fuel" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.taap.2011.12.002" "Revista" => array:6 [ …6] ] ] ] ] ] 84 => array:3 [ "identificador" => "bib0425" "etiqueta" => "85" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of DNA mismatch repair protein expression in airway epithelial cells of premenopausal women chronically exposed to biomass smoke" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11356-013-2218-4" "Revista" => array:6 [ …6] ] ] ] ] ] 85 => array:3 [ "identificador" => "bib0430" "etiqueta" => "86" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between household air pollution from biomass smoke exposure, and pulmonary dysfunction, oxidant-antioxidant imbalance and systemic inflammation in rural women and children in Nigeria" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5539/gjhs.v5n4p28" "Revista" => array:6 [ …6] ] ] ] ] ] 86 => array:3 [ "identificador" => "bib0435" "etiqueta" => "87" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2005.10.011" "Revista" => array:6 [ …6] ] ] ] ] ] 87 => array:3 [ "identificador" => "bib0440" "etiqueta" => "88" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Experimental exposure to wood smoke: effects on airway inflammation and oxidative stress" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/oem.2006.032458" "Revista" => array:6 [ …6] ] ] ] ] ] 88 => array:3 [ "identificador" => "bib0445" "etiqueta" => "89" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic inhalation of biomass smoke is associated with DNA damage in airway cells: involvement of particulate pollutants and benzene" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jat.1748" "Revista" => array:6 [ …6] ] ] ] ] ] 89 => array:3 [ "identificador" => "bib0450" "etiqueta" => "90" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Micronucleus formation, DNA damage and repair in premenopausal women chronically exposed to high level of indoor air pollution from biomass fuel use in rural India" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mrgentox.2010.02.006" "Revista" => array:6 [ …6] ] ] ] ] ] 90 => array:3 [ "identificador" => "bib0455" "etiqueta" => "91" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCRESAHA.110.237560" "Revista" => array:6 [ …6] ] ] ] ] ] 91 => array:3 [ "identificador" => "bib0460" "etiqueta" => "92" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/toxsci/kfq290" "Revista" => array:6 [ …6] ] ] ] ] ] 92 => array:3 [ "identificador" => "bib0465" "etiqueta" => "93" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development and systematic oxidative stress of a rat model of chronic bronchitis and emphysema induced by biomass smoke" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/01902148.2013.797521" "Revista" => array:6 [ …6] ] ] ] ] ] 93 => array:3 [ "identificador" => "bib0470" "etiqueta" => "94" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of cigarette and biomass smoke exposure on oxidant-antioxidant status in rabbits" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 94 => array:3 [ "identificador" => "bib0475" "etiqueta" => "95" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron, as a function of particle size and source of coal" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 95 => array:3 [ "identificador" => "bib0480" "etiqueta" => "96" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1021/tx100407m" "Revista" => array:6 [ …6] ] ] ] ] ] 96 => array:3 [ "identificador" => "bib0485" "etiqueta" => "97" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wood smoke particles generate free radicals and cause lipid peroxidation, DNA, damage, NFkappaB activation and TNF-alpha release in macrophages" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 97 => array:3 [ "identificador" => "bib0490" "etiqueta" => "98" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Particle size-dependent radical generation from wildland fire smoke" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tox.2007.04.008" "Revista" => array:6 [ …6] ] ] ] ] ] 98 => array:3 [ "identificador" => "bib0495" "etiqueta" => "99" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of genotoxic and inflammatory effects of particles generated by wood combustion, a road simulator and collected from street and subway" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.toxlet.2006.04.003" "Revista" => array:6 [ …6] ] ] ] ] ] 99 => array:3 [ "identificador" => "bib0500" "etiqueta" => "100" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pro-inflammatory potential of wood smoke and traffic-derived particles in a monocytic cell line" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tox.2008.02.014" "Revista" => array:6 [ …6] ] ] ] ] ] 100 => array:3 [ "identificador" => "bib0505" "etiqueta" => "101" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.toxlet.2011.12.003" "Revista" => array:6 [ …6] ] ] ] ] ] 101 => array:3 [ "identificador" => "bib0510" "etiqueta" => "102" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of wood smoke PM2.5 obtained from the combustion of FIR and beech pellets on inflammation and DNA damage in A549 and THP-1 human cell lines" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00204-013-1071-z" "Revista" => array:6 [ …6] ] ] ] ] ] 102 => array:3 [ "identificador" => "bib0515" "etiqueta" => "103" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative damage to DNA and repair induced by Norwegian wood smoke particles in human A549 and THP-1 cell lines" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mrgentox.2008.10.014" "Revista" => array:6 [ …6] ] ] ] ] ] 103 => array:3 [ "identificador" => "bib0520" "etiqueta" => "104" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wood smoke extract induces oxidative stress-mediated caspase-independent apoptosis in human lung endothelial cells: Role of AIF and EndoG" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajplung.00099.2005" "Revista" => array:6 [ …6] ] ] ] ] ] 104 => array:3 [ "identificador" => "bib0525" "etiqueta" => "105" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reactive oxygen species and airway inflammation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 105 => array:3 [ "identificador" => "bib0530" "etiqueta" => "106" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic oxidative stress in asthma, COPD, and smokers" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.154.4.8887607" "Revista" => array:6 [ …6] ] ] ] ] ] 106 => array:3 [ "identificador" => "bib0535" "etiqueta" => "107" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.156.2.9611013" "Revista" => array:6 [ …6] ] ] ] ] ] 107 => array:3 [ "identificador" => "bib0540" "etiqueta" => "108" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative stress in COPD" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.12-2664" "Revista" => array:6 [ …6] ] ] ] ] ] 108 => array:3 [ "identificador" => "bib0545" "etiqueta" => "109" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ferruginous bodies: implications in the mechanism of fiber and particle toxicity" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/01926230490885733" "Revista" => array:6 [ …6] ] ] ] ] ] 109 => array:3 [ "identificador" => "bib0550" "etiqueta" => "110" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The endocytosis of asbestos by mouse peritoneal macrophages and its long-term effect on iron accumulation and labyrinth formation" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 110 => array:3 [ "identificador" => "bib0555" "etiqueta" => "111" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic effects of oil fly ash" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ …6] ] ] ] ] ] 111 => array:3 [ "identificador" => "bib0560" "etiqueta" => "112" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Particulate matter induces alveolar epithelial cell DNA damage and apoptosis: role of free radicals and the mitochondria" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1165/rcmb.2002-0269OC" "Revista" => array:6 [ …6] ] ] ] ] ] 112 => array:3 [ "identificador" => "bib0565" "etiqueta" => "113" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung function and incidence of chronic obstructive pulmonary disease after improved cooking fuels and kitchen ventilation: a 9-year prospective cohort study" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pmed.1001621" "Revista" => array:5 [ …5] ] ] ] ] ] 113 => array:3 [ "identificador" => "bib0570" "etiqueta" => "114" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of interventions to reduce air pollution from biomass smoke on mortality in Launceston, Australia: Retrospective analysis of daily mortality, 1994–2007" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ …5] ] ] ] ] ] 114 => array:3 [ "identificador" => "bib0575" "etiqueta" => "115" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Improved biomass stove intervention in rural Mexico: impact on the respiratory health of women" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200810-1556OC" "Revista" => array:6 [ …6] ] ] ] ] ] 115 => array:3 [ "identificador" => "bib0580" "etiqueta" => "116" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of reducing indoor air pollution on women's respiratory symptoms and lung function: the RESPIRE Randomized Trial, Guatemala" "autores" => array:1 [ …1] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/aje/kwp100" "Revista" => array:7 [ …7] ] ] ] ] ] 116 => array:3 [ "identificador" => "bib0585" "etiqueta" => "117" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ramirez-Sarmiento A, Ancochea J, Ramirez C, Sarmiento C, Orozco-Levi M. Construcción de las Cocinas HUMAN para disminuir la contaminación domiciliaria por Humo de Leña (Plataforma HUMAN, SEPAR Solidaria). Available from: <a href="http://www.separ.es/solidaridad/human-platform">http://www.separ.es/solidaridad/human-platform</a> [accessed 26.09.14]." ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:3 [ "titulo" => "Acknowledgement" "texto" => "The authors thank Ms Carmen Gloria Muñoz Pincheira for her administrative support in the generation of this review article." 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Pathogenic Mechanisms in Chronic Obstructive Pulmonary Disease Due to Biomass Smoke Exposure

Mecanismos patogénicos en la enfermedad pulmonar obstructiva crónica causada por exposición a humo de biomasa

Rafael Silvaa, Manuel Oyarzúnb, Jordi Olloquequia,

Corresponding author

jordiog82@gmail.com

Corresponding author.

a Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile

b Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile

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spirometric criteria suggest that 17&#37;&#8211;38&#46;8&#37; of COPD patients worldwide are non-smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In the United States&#44; the United Kingdom&#44; and Spain&#44; rates of COPD in non-smokers are 23&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> 22&#46;9&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> and 23&#46;4&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> respectively&#46; Epidemiological studies conducted in developing countries have also revealed a high prevalence of COPD among non-smokers&#46; In the PLATINO study&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> conducted in five cities in Latin America&#44; 26&#37; of all subjects with irreversible airflow obstruction were non-smokers&#46; However&#44; a study conducted in China using similar methodology found an overall prevalence of COPD of only 5&#46;2&#37; among non-smokers&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The most important risk factors that may contribute to the development of COPD in these subjects include genetic predisposition&#44; occupational exposure to dust and chemicals&#44; diet&#44; recurrent respiratory infections in childhood&#44; and air pollution&#44; both indoors and outdoors&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> In the latter group&#44; there has been a recent surge of interest in biomass smoke as a significant pollutant in the pathogenesis of COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Biomass Smoke as a Pollutant</span><p id="par0020" class="elsevierStylePara elsevierViewall">Biomass smoke as a source of energy is defined as all organic material from animals or vegetable matter that can be used as fuel&#46; This definition covers a wide range of materials&#44; the most common being wood&#44; agricultural residue&#44; such as branches and dried grass&#44; animal dung&#44; and charcoal&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> These materials are generally burnt in poorly-ventilated fireplaces and stoves&#44; and generate substantial amounts of harmful pollutants that can reach exposure levels of between 10 and 20 times those recommended by the World Health Organization &#40;WHO&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Smoke from burning biomasses contains more than 250 organic compounds that can vary depending on the type of material and combustion conditions&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> A wide range of gaseous pollutants can be generated&#44; including carbon monoxide&#44; ammonia&#44; hydrocyanic acid&#44; formaldehyde&#44; nitrogen oxides and sulfur&#44; and volatile organic compounds&#44; such as benzene and polycyclic aromatic hydrocarbons &#40;PAH&#41;&#44; like benzopyrene&#46; The latter two are potent carcinogens in humans&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17&#44;18</span></a> Moreover&#44; biomass smoke contains a mixture of solid and liquid particles that vary in concentration&#44; size&#44; surface and chemical composition&#44; known as particulate matter &#40;PM&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> Some particles are respirable and are classified according to their aerodynamic diameter as PM<span class="elsevierStyleInf">10</span> &#40;coarse particles with an aerodynamic diameter of 10<span class="elsevierStyleHsp" style=""></span>&#956;m or less&#41;&#44; PM<span class="elsevierStyleInf">2&#46;5</span> &#40;fine particles with an aerodynamic diameter of 2&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;m or less&#41; and PM<span class="elsevierStyleInf">0&#46;1</span> &#40;ultrafine particles with an aerodynamic diameter of 0&#46;1<span class="elsevierStyleHsp" style=""></span>&#956;m or less&#41;&#46; PM<span class="elsevierStyleInf">10</span> particles are generally composed of minerals with crystalline or amorphous components and elements absorbed from diverse sources&#44; such as fungi&#44; bacteria or endotoxins&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> The high transition metal content of PM<span class="elsevierStyleInf">2&#46;5</span> particles&#44; which generally consist of a carbon nucleus with surface absorption of organic and inorganic components&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> enhances their oxidative stress-generating potential&#46; Ultrafine PM<span class="elsevierStyleInf">0&#46;1</span> particles&#44; meanwhile&#44; with their high PAH content&#44; are also powerful oxidative stress inducers&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Many studies support the hypothesis that inhalation of these pollutants is harmful to the health and constitutes a risk factor not only for COPD&#44; but also for respiratory infections&#44; asthma&#44; lung cancer&#44; cardiovascular disorders&#44; cataracts&#44; cerebrovascular accidents or even adverse effects on neonatal development&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Risk Population</span><p id="par0035" class="elsevierStylePara elsevierViewall">At present&#44; around 50&#37; of the world&#39;s population and 90&#37; of homes in rural areas burn biomass as their main source of energy in the home&#44; for cooking or heating&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> Over 80&#37; of homes in China&#44; India and sub-Saharan Africa use biomass for fuel&#44; while in rural areas in Latin America&#44; the proportion ranges between 30&#37; and 70&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> Although the use of biomass fuel is particularly extensive in developing countries&#44; the rising cost of fossil fuel&#44; such as petroleum products or natural gas&#44; along with environmental concerns about CO<span class="elsevierStyleInf">2</span> emissions&#44; have also led to an increase in the use of biomass as fuel in developed countries&#44; such as Germany&#44; Finland&#44; Canada&#44; Australia or the United States&#46;<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24&#8211;27</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Around 3 billion people worldwide are exposed to biomass smoke&#44; compared to 1 billion tobacco smokers&#44; suggesting that biomass smoke may be a more significant risk factor for developing COPD than tobacco smoke on a worldwide basis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Moreover&#44; for sociocultural reasons&#44; women and children form the main population groups exposed to this pollutant&#44; which is thought to contribute to the death of 2 million women and children globally every year&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> This is because in many developing countries&#44; it is common for women and children to remain at home for long periods&#44; cooking or in close proximity to stoves&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In these settings&#44; women are thought to spend on average over 60<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>h of their life cooking on a biomass stove&#44; during which time they inhale over 25 million liters of polluted air&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> These data are significant&#44; since it has been shown that respiratory symptoms and airflow limitation increase in line with exposure to biomass smoke&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29&#44;30</span></a> Consequently&#44; several studies have shown that women who use biomass as fuel for cooking have a higher prevalence of respiratory symptoms of COPD than those who do not use this type of fuel&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#8211;39</span></a> Indeed&#44; 50&#37; of deaths due to COPD in developing countries are attributable to biomass smoke&#44; and 75&#37; of these are in women&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">40</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although COPD mainly affects adults&#44; several studies have shown that many chronic diseases may originate in the development of the fetus and the early years of life&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> In a recent study&#44; Epstein et al&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a> found the children of mothers using biomass in their homes had a lower birth weight than those whose of mothers using other fuel sources&#46; These results are relevant&#44; since low birth weight&#44; being associated with defective lung development and function during childhood and adulthood&#44; is known to be an independent risk factor for the development of COPD&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">43</span></a> Another study performed in a rural area in India found that forced expiratory volume in 1 second &#40;FEV<span class="elsevierStyleInf">1</span>&#41; and forced vital capacity &#40;FVC&#41; were significantly lower in schoolchildren from homes burning biomass fuel than in those from homes using liquefied petroleum gas&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">44</span></a> Biomass smoke in indoor environments also increases the risk of respiratory infections&#46;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">45&#8211;47</span></a> This factor should also be taken into account&#44; since infections in childhood can predispose an individual to developing COPD in adulthood&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Although women and children are most exposed to biomass smoke&#44; a recent study in 922 COPD patients in 7 cities in Asia found that 31&#37; of men had also been exposed to this pollutant&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">48</span></a> Although the percentage is lower than in women &#40;44&#46;8&#37;&#41;&#44; the figure is significant&#46; The results of a meta-analysis in Asian and non-Asian subjects revealed that individuals exposed to biomass smoke have a 2&#46;44-fold greater risk of developing COPD than the unexposed population&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Exposure was identified as a risk factor in both men &#40;OR&#58; 4&#46;30&#59; 95&#37; CI&#58; 1&#46;85&#8211;10&#46;01&#41; and women &#40;OR&#58; 2&#46;73&#59; 95&#37; CI&#58; 2&#46;28&#8211;3&#46;28&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">49</span></a> Data from another recent study confirm the association between airflow obstruction in non-smokers and cooking with charcoal in both sexes&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">50</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pathogenic Mechanisms of Biomass Smoke in Chronic Obstructive Pulmonary Disease</span><p id="par0060" class="elsevierStylePara elsevierViewall">Biomass smoke contains many compounds similar to those in tobacco smoke&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">51</span></a> therefore&#44; COPD caused by both types of smoke might be expected to present similar clinical and radiological characteristics&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">52&#44;53</span></a> However&#44; some differences are observed between COPD from biomass smoke and COPD from tobacco smoke<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">53&#8211;60</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; From a histopathological point of view&#44; for example&#44; patients with biomass COPD have more bronchiolitis&#44; more anthracosis and pulmonary fibrosis&#44; and more airway wall thickening than smokers with COPD&#44; who present with more pulmonary emphysema&#46;<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">55&#44;57&#8211;59</span></a> A recent paper published by Krimmer et al&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> showed that fibroblasts exposed in vitro to biomass smoke increased their production of fibronectin&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Despite epidemiological evidence relating biomass smoke with COPD&#44; little is known about the cell and molecular mechanisms that cause exposure to this type of pollutant to be harmful to health&#46; It has been recently suggested that biomass smoke may contribute to the onset of COPD by fostering a pulmonary and systemic inflammatory state&#44; and by increasing the genotoxic effect of oxidative stress&#44; among other mechanisms of cell damage &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Pro-inflammatory Mechanisms</span><p id="par0070" class="elsevierStylePara elsevierViewall">Abundant evidence is available to demonstrate that exposure to biomass smoke causes lung inflammation&#46; Women exposed to biomass smoke have higher alveolar levels of neutrophils&#44; eosinophils&#44; monocytes&#44; mastocytes&#44; lymphocytes and macrophages&#44; as well as higher sputum levels of interleukin &#40;IL&#41;-6&#44; IL-8 and tumor necrosis factor &#40;TNF&#41;-&#945; than those who use other types of fuel&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">62&#8211;64</span></a> Gene expression of some of these pro-inflammatory mediators&#44; such as IL-8&#44; TNF-&#945;&#44; matrix metalloproteinase &#40;MMP&#41;-9 and MMP-12&#44; increases in parallel with exposure to biomass smoke&#44; as recently demonstrated by Guarnieri et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">65</span></a> while another study shows that this pollutant alters the expression of genes associated with CD8<span class="elsevierStyleSup">&#43;</span> T-cell activation&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">66</span></a> The pro-inflammatory effects of biomass smoke are not restricted to the lung&#44; since increases have been reported in CD8<span class="elsevierStyleSup">&#43;</span> T-cells&#44; natural killer &#40;NK&#41; cells&#44; IL-6&#44; IL-8&#44; TNF-&#945;&#44; C-reactive protein &#40;CRP&#41; and monocyte chemoattractant protein &#40;MCP&#41;-1 in the blood of exposed individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">67&#8211;69</span></a> Studies performed in samples of induced sputum&#44; bronchoalveolar lavage &#40;BAL&#41; fluid and blood show that COPD patients exposed to biomass smoke have higher levels of inflammatory cells &#40;neutrophils and eosinophils&#41;&#44; IL-8&#44; CRP and MMP-12&#44; and increased MMP-9 activity&#44; compared to control subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23&#44;70&#44;71</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">It has been suggested that biomass smoke may induce an inflammatory response via the Transient Potential Receptor &#40;TRP&#41; ion channels of the lung cells<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These channels can be activated by a wide range of stimuli&#44; including PM&#44; meaning that the cells are responsive to changes in their environment&#46; When a TRP channel is activated&#44; it mediates Na<span class="elsevierStyleSup">&#43;</span> and Ca<span class="elsevierStyleSup">2&#43;</span> flow across the plasma membrane to the cytoplasma&#44; stimulating other voltage-dependent channels and influencing cell events&#44; such as transcription&#44; transduction&#44; contraction and migration&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">73&#44;74</span></a> The TRP channel superfamily is divided into seven subfamilies&#44; of which TRPA1&#44; V1&#44; V4 and M8 receptors have shown capacity for regulating inflammatory responses&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> TRPA1 receptors&#44; found in airway C-fibers&#44; bronchiolar epithelial cells&#44; fibroblasts and smooth muscle cells&#44; may induce IL-6 and IL-8 production and increase bronchiolar macrophage inflammatory protein &#40;MIP&#41; 2&#945; and growth-related oncogene &#40;GRO&#41;&#945; cytosine expression after exposure to biomass smoke&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">74&#8211;78</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Another pro-inflammatory mechanism proposed for biomass smoke is the activation of toll-like receptors &#40;TLR&#41; on airway macrophages and epithelial cells&#44; which would in turn activate the nuclear factor kappa-light-chain-enhancers of activated B cells &#40;NF-&#954;&#946;&#41; and activator protein-1 &#40;AP-1&#41; activity<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; According to this hypothesis&#44; these pathways may be activated by the small amounts of biological material &#40;e&#46;g&#46;&#44; endotoxin&#44; fungal spores&#44; etc&#46;&#41; present in the PM&#46; Becker et al&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">79</span></a> showed that IL-6 and IL-8 production in alveolar macrophages and epithelial cells exposed to PM could be inhibited by TLR4 and TLR2 antagonists or blocking antibodies&#46; In another study&#44; TLR4 and TLR2-deficient mouse macrophages produced less TNF-&#945; and IL-6 after exposure to PM&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">80</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">In another recent study&#44; Hirota et al&#46;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">81</span></a> put forward inflammasome NLRP3&#44; a protein complex that can initiate an inflammatory response to agents causing cell damage&#44; as another key molecular mechanism in the PM-induced inflammatory response &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These authors reported in vivo and in vitro evidence of increased IL-1&#946; production and neutrophilia in airways when this molecular complex was activated after exposure to PM&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Kido et al&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">82</span></a> determined the link between pulmonary and systemic inflammation and biomass smoke&#46; In another study in mice&#44; they showed that pro-inflammatory mediators&#44; such as IL-6&#44; pass from the lungs to the bloodstream after exposure to PM<span class="elsevierStyleInf">10</span>&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Oxidative Mechanisms and Genotoxicity</span><p id="par0095" class="elsevierStylePara elsevierViewall">Several studies conducted in sputum and blood samples of women and children chronically exposed to biomass smoke showed an increase in the production of reactive oxygen species &#40;ROS&#41; and a decrease in antioxidant mechanisms such as superoxide dismutase &#40;SOD&#41;&#44; glutathione &#40;GSH&#41; and ascorbic acid&#46;<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">63&#44;64&#44;69&#44;83&#8211;85</span></a> Other studies reported an increase in lipid peroxidation products&#44; such as malondialdehyde &#40;MDA&#41; in the blood of subjects exposed to biomass smoke&#44;<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">85&#8211;88</span></a> and a correlation between the levels of this compound and reduced VEF<span class="elsevierStyleInf">1</span>&#47;CVF&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">83</span></a> Increases in oxidative stress markers in DNA in sputum samples<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">89</span></a> and peripheral blood mononuclear cells &#40;PBMC&#41;<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">87&#44;90</span></a> have also been described in subjects chronically exposed to biomass smoke&#46; Diminished capacity to repair cell damage has also been reported in these subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">62&#44;85&#44;90</span></a> These results are supported by several studies in animal models<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">91&#8211;94</span></a> or in vitro cell lines<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">89&#44;95&#8211;104</span></a> that found increased production of ROS&#44; cytokines&#44; lipid peroxidation products and oxidative DNA damage or impaired antioxidant mechanisms after exposure to biomass smoke&#46; Oxidative stress&#44; then&#44; appears have a significant role in activating the harmful effects of this pollutant&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">ROS and reactive nitrogen species &#40;RNS&#41; may contribute to the pathogenesis of COPD and other lung diseases&#44; such as asthma or bronchiectasis<a class="elsevierStyleCrossRefs" href="#bib0525"><span class="elsevierStyleSup">105&#8211;107</span></a> by oxidizing proteins&#44; lipids&#44; carbohydrates and DNA&#46;<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">108</span></a> Some of the components of biomass smoke&#44; such as PM&#44; can induce oxidative stress via several mechanisms&#58; directly&#44; by the ROS-generating effect of the physicochemical characteristics of the particles or the effect of soluble components &#40;e&#46;g&#46;&#44; organic compounds or transition metals&#41;&#44; or indirectly&#44; by activation of inflammatory cells that can lead to generation of ROS or RNS&#46;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;64&#44;96</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Some authors have suggested that one of the most significant oxidative mechanisms of biomass smoke is the disturbance of iron homeostasis in lung cells<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; When PMs become lodged in the lower respiratory tract&#44; they sequester iron from the tissues&#44; diminishing the amount of iron available to the cells&#46; Attempts by the cells to reestablish the availability of the metal lead to increased iron importation and reduction through the Fenton reaction &#40;Fe<span class="elsevierStyleSup">2&#43;</span><span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>H<span class="elsevierStyleInf">2</span>O<span class="elsevierStyleInf">2</span><span class="elsevierStyleHsp" style=""></span>&#8594;<span class="elsevierStyleHsp" style=""></span>Fe<span class="elsevierStyleSup">3&#43;</span><span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleSup">&#8226;</span>OH<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>OH<span class="elsevierStyleSup">&#8722;</span>&#41;&#44; generating ROS in the process&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">72&#44;109&#44;110</span></a> ROS derived from these reactions are also known to activate transcription factors&#44; such as NF-&#954;&#946;&#44; increasing the production of pro-inflammatory mediators&#46;<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">111</span></a> Moreover&#44; damage caused by mitochondrial oxidation may affect the membrane potential of these organelles&#44; thereby increasing ROS production<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">112</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">This hypothesis is supported by evidence of increased numbers of iron-laden macrophages &#40;siderophages&#41; in the sputum of women exposed to biomass smoke&#44;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">63</span></a> and increased expression of divalent metal transporter-1 &#40;DMT1&#44; one of the main iron importers&#41; and ferritin levels in epithelial cells exposed to this pollutant&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">72</span></a></p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="par0115" class="elsevierStylePara elsevierViewall">Biomass may be a source of renewable and sustainable energy&#44; but its combustion is one of the major sources of pollution&#44; both indoors and outdoors&#46; Abundant epidemiological&#44; clinical and experimental evidence has shown that exposure to biomass smoke is harmful to health and predisposes individuals to a range of diseases&#44; including COPD&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The pathogenic mechanisms considered to date include increased pulmonary and systemic inflammation&#44; and promotion of an oxidative stress state that may cause macromolecular cell damage&#44; including DNA changes&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Efforts must be made to increase awareness of the risk of exposure to biomass smoke&#46; Significant data are available on the benefits of reducing exposure this pollutant by replacing biomass with biogas or by improving combustion systems and ventilation of stoves and kitchens&#46;<a class="elsevierStyleCrossRefs" href="#bib0565"><span class="elsevierStyleSup">113&#8211;116</span></a> A report on the HUMAN platform initiative<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">117</span></a> found that the construction of kitchens to reduce smoke pollution in the homes of risk populations is feasible and inexpensive&#46; Promoting the use of cleaner energy sources&#44; such as electric&#44; by way of incentives&#44; particularly in more deprived populations in developing countries during the winter months&#44; may also be an effective measure&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Authorship</span><p id="par0130" class="elsevierStylePara elsevierViewall">Dr Rafael Silva and Dr Miguel Oyarz&#250;n made a critical review of the manuscript&#46; Dr Jordi Olloquequi conceived and produced the paper&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interests</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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          "identificador" => "sec0005"
          "titulo" => "Introduction"
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        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Biomass Smoke as a Pollutant"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Risk Population"
        ]
        7 => array:3 [
          "identificador" => "sec0020"
          "titulo" => "Pathogenic Mechanisms of Biomass Smoke in Chronic Obstructive Pulmonary Disease"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Pro-inflammatory Mechanisms"
            ]
            1 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Oxidative Mechanisms and Genotoxicity"
            ]
          ]
        ]
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          "titulo" => "Conclusions"
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          "titulo" => "Authorship"
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          "identificador" => "sec0045"
          "titulo" => "Conflict of interests"
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          "titulo" => "References"
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      ]
    ]
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    "fechaRecibido" => "2014-08-11"
    "fechaAceptado" => "2014-10-14"
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec537550"
          "palabras" => array:5 [
            0 => "Chronic obstructive pulmonary disease"
            1 => "Biomass smoke"
            2 => "Pathogenesis"
            3 => "Inflammation"
            4 => "Genotoxicity"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec537551"
          "palabras" => array:5 [
            0 => "Enfermedad pulmonar obstructiva cr&#243;nica"
            1 => "Humo de biomasa"
            2 => "Patogenia"
            3 => "Inflamaci&#243;n"
            4 => "Genotoxicidad"
          ]
        ]
      ]
    ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chronic obstructive pulmonary disease &#40;COPD&#41; mortality and morbidity have increased significantly worldwide in recent decades&#46; Although cigarette smoke is still considered the main risk factor for the development of the disease&#44; estimates suggest that between 25&#37; and 33&#37; of COPD patients are non-smokers&#46; Among the factors that may increase the risk of developing COPD&#44; biomass smoke has been proposed as one of the most important&#44; affecting especially women and children in developing countries&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Despite the epidemiological evidence linking exposure to biomass smoke with adverse health effects&#44; the specific cellular and molecular mechanisms by which this pollutant can be harmful for the respiratory and cardiovascular systems remain unclear&#46; In this article we review the main pathogenic mechanisms proposed to date that make biomass smoke one of the major risk factors for COPD&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las tasas de mortalidad y morbilidad de la enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; han aumentado mundialmente de forma significativa durante las &#250;ltimas d&#233;cadas&#46; A pesar de que el humo de tabaco se sigue considerando el principal factor etiopatog&#233;nico para el desarrollo de la enfermedad&#44; se estima que entre una tercera y una cuarta parte de los pacientes con EPOC son no fumadores&#46; De todos los factores de riesgo que pueden incrementar la probabilidad de sufrir EPOC en estos sujetos se ha propuesto al humo de biomasa como uno de los m&#225;s importantes&#44; afectando sobre todo a mujeres y a ni&#241;os de pa&#237;ses emergentes&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Aunque existen numerosas evidencias epidemiol&#243;gicas que relacionan la exposici&#243;n al humo de biomasa con efectos nocivos para la salud&#44; todav&#237;a no se conocen bien los mecanismos celulares y moleculares espec&#237;ficos mediante los cuales este contaminante puede suponer una noxa para los sistemas respiratorio y cardiovascular&#46; En esta revisi&#243;n se recogen los mecanismos patog&#233;nicos propuestos hasta la fecha que sit&#250;an al humo de biomasa como uno de los principales factores de riesgo para la EPOC&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Silva R&#44; Oyarz&#250;n M&#44; Olloquequi J&#46; Mecanismos patog&#233;nicos en la enfermedad pulmonar obstructiva cr&#243;nica causada por exposici&#243;n a humo de biomasa&#46; Arch Bronconeumol&#46; 2015&#59;51&#58;285-292&#46;</p>"
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Pro-inflammatory mechanisms of biomass smoke&#46; PM-stimulated cells generate numerous inflammatory mediators&#44; including IL-6&#44; IL-8&#44; TNF-&#945;&#44; MCP-1&#44; MIP2&#945; and GRO&#945;&#46; These can generate a second wave of mediators that include enzymes&#44; such as MMP-9 and MMP-12&#44; involved in tissue remodeling typical of COPD&#46; It has been suggested that TRP ion channels in various lung cells can be activated by PMs in biomass smoke&#46; This would lead to increased cytoplasmic Ca<span class="elsevierStyleSup">2&#43;</span> and an intracellular signaling cascade that would increase the production of these pro-inflammatory mediators&#46; The biological material in biomass smoke PMs &#40;e&#46;g&#46;&#44; endotoxin&#41; may also activate pro-inflammatory transcription factors AP-1 y NF-&#954;&#946; via signaling initiated in the TLR receptors&#46; These receptors and agents causing intracellular damage&#44; such as ROS&#44; can also activate inflammasome NLRP3&#44; thereby constituting another possible pro-inflammatory pathway triggered by biomass smoke&#46;</p> <p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">AP-1&#58; activating protein-1&#59; GRO&#945;&#58; growth-related oncogen &#945;&#59; ROS&#58; reactive oxygen species&#59; IL-6&#58; interleukin-6&#59; IL-8&#58; interleukin-8&#59; MCP-1&#58; monocyte chemoattractant protein 1&#59; MIP2&#945;&#58; macrophage inflammatory protein 2&#945;&#59; MMP-9&#58; matrix metalloproteinase 9&#59; MMP-12&#58; matrix metalloproteinase 12&#59; NF-&#954;&#946;&#58; nuclear factor kappa-light-chain-enhancer of activated B cells&#59; PMs&#58; respirable particulate matter&#59; TLR4&#58; Toll-like receptor 4&#59; TNF-&#945;&#58; Tumor necrosis factor-&#945;&#59; TRP1&#58; Transient Potential Receptor 1 ion channel&#46;</p>"
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          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Biomass smoke oxidative mechanisms and genotoxicity&#46; Oxidative stress generated by biomass smoke ROS can cause direct damage to cell macromolecules&#44; such as proteins or lipids&#44; and can act as a genotoxic factor in producing DNA lesions&#46; Mitochondrial membrane potential can also be affected by oxidative damage&#44; resulting in increased ROS production in these organelles&#46; Some authors<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">61</span></a> have proposed that PMs sequester iron from the lung cells&#44; affecting iron homeostasis&#46; When cells detect iron deficiency&#44; they try to reestablish availability of this metal by generating ROS to decrease it and promoting the expression of iron importers such as DMT1&#46; As a result of the increased intracellular iron levels&#44; the amount of ferritin increases&#46; However&#44; these oxidizing molecules are known to activate pro-inflammatory transcription factors&#44; such as NF-&#954;&#946;&#46; Finally&#44; inflammatory cells activated by biomass smoke are another source of ROS&#46;</p> <p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">DMT1&#58; divalent metal transporter 1&#59; NF-&#954;&#946;&#58; nuclear factor kappa-light-chain-enhancer of activated B cells&#59; ROS&#58; reactive oxygen species&#46;</p>"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">COPD&#58; chronic obstructive pulmonary disease&#59; DLCO&#58; diffusion lung capacity for carbon monoxide&#46;</p>"
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Reduced DLCO&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Oxygen saturation at rest and during exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0275">55</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&#43;&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRefs" href="#bib0275">55&#8211;60</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><a class="elsevierStyleCrossRef" href="#bib0285">57</a>&#44; <a class="elsevierStyleCrossRef" href="#bib0290">58</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Anthracosis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="left" valign="top">Pulmonary artery intimal hyperplasia&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Characteristics Differentiating Chronic Obstructive Pulmonary Disease &#40;COPD&#41; Caused by Tobacco Smoke and by Biomass Smoke&#46;</p>"
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      "titulo" => "References"
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                0 => array:1 [
                  "referenciaCompleta" => "Global Strategy for the Diagnosis&#44; Management and Prevention of COPD&#44; Global Initiative for Chronic Obstructive Lung Disease &#40;GOLD&#41; 2014&#46; Available from <a href="http://www.goldcopd.org/">http&#58;&#47;&#47;www&#46;goldcopd&#46;org&#47;</a> &#91;accesss 16&#46;07&#46;14&#93;"
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              "identificador" => "bib0010"
              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung CD57<span class="elsevierStyleSup">&#43;</span> cell density is increased in very severe COPD"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Histol Histopathol"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "39"
                        "paginaFinal" => "47"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Significant increase of CD57<span class="elsevierStyleSup">&#43;</span> cells in pulmonary lymphoid follicles of COPD patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00201509"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2011"
                        "volumen" => "37"
                        "paginaInicial" => "289"
                        "paginaFinal" => "298"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential lymphocyte infiltration in small airways and lung parenchyma in COPD patients"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2010.03.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Med"
                        "fecha" => "2010"
                        "volumen" => "104"
                        "paginaInicial" => "1310"
                        "paginaFinal" => "1318"
                        "link" => array:1 [ …1]
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              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cellular and molecular mechanisms of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ccm.2013.10.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "2014"
                        "volumen" => "35"
                        "paginaInicial" => "71"
                        "paginaFinal" => "86"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global strategy for the diagnosis&#44; management&#44; and prevention of chronic obstructive pulmonary disease&#58; GOLD executive summary"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201204-0596PP"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2013"
                        "volumen" => "187"
                        "paginaInicial" => "347"
                        "paginaFinal" => "365"
                        "link" => array:1 [ …1]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Non-smoking-related chronic obstructive pulmonary disease&#58; a neglected entity"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1440-1843.2012.02152.x"
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                        "fecha" => "2012"
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              "identificador" => "bib0040"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway obstruction in never smokers&#58; results from the third national health and nutrition examination survey"
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                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.amjmed.2005.06.041"
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                        "tituloSerie" => "Am J Med"
                        "fecha" => "2005"
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                        "paginaInicial" => "1364"
                        "paginaFinal" => "1372"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
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            8 => array:3 [
              "identificador" => "bib0045"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical&#44; radiologic&#44; and induced sputum features of chronic obstructive pulmonary disease in nonsmokers&#58; a descriptive study"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "166"
                        "paginaInicial" => "1078"
                        "paginaFinal" => "1083"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Geographic variations in prevalence and underdiagnosis of COPD&#58; results of the IBERPOC multicentre epidemiological study"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2000"
                        "volumen" => "118"
                        "paginaInicial" => "981"
                        "paginaFinal" => "989"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airflow obstruction in never smokers in five Latin American cities&#58; the PLATINO study"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arcmed.2012.03.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Med Res"
                        "fecha" => "2012"
                        "volumen" => "43"
                        "paginaInicial" => "159"
                        "paginaFinal" => "165"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of chronic obstructive pulmonary disease in China&#58; a large&#44; population-based survey"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200612-1749OC"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2007"
                        "volumen" => "176"
                        "paginaInicial" => "753"
                        "paginaFinal" => "760"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An official American Thoracic Society public policy statement&#58; novel risk factors and the global burden of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200811-1757ST"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "182"
                        "paginaInicial" => "693"
                        "paginaFinal" => "718"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is exposure to biomass smoke the biggest risk factor for COPD globally"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.10-0645"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2010"
                        "volumen" => "138"
                        "paginaInicial" => "3"
                        "paginaFinal" => "6"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung function and symptoms among indigenous Mayan women exposed to high levels of indoor air pollution"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "2007"
                        "volumen" => "11"
                        "paginaInicial" => "1372"
                        "paginaFinal" => "1379"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Woodsmoke health effects&#58; a review"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/08958370701493456"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inhal Toxicol"
                        "fecha" => "2007"
                        "volumen" => "19"
                        "paginaInicial" => "67"
                        "paginaFinal" => "106"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "National burden of disease in India from indoor air pollution"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.97.24.13286"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "2000"
                        "volumen" => "97"
                        "paginaInicial" => "13286"
                        "paginaFinal" => "13293"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pollutants from the combustion of solid biomass fuels"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Prog Energy Combust Sci"
                        "fecha" => "2012"
                        "volumen" => "38"
                        "paginaInicial" => "113"
                        "paginaFinal" => "137"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relations between PM10 composition and cell toxicity&#58; a multivariate and graphical approach"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.chemosphere.2006.10.078"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chemosphere"
                        "fecha" => "2007"
                        "volumen" => "67"
                        "paginaInicial" => "1218"
                        "paginaFinal" => "1228"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.taap.2011.09.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol Appl Pharmacol"
                        "fecha" => "2011"
                        "volumen" => "257"
                        "paginaInicial" => "209"
                        "paginaFinal" => "226"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polycyclic aromatic hydrocarbon-induced oxidative stress&#44; antioxidant capacity&#44; and the risk of lung cancer&#58; a pilot nested case-control study"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Anticancer Res"
                        "fecha" => "2013"
                        "volumen" => "33"
                        "paginaInicial" => "3089"
                        "paginaFinal" => "3097"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A review of diseases associated with household air pollution due to the use of biomass fuels"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhazmat.2011.05.087"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hazard Mater"
                        "fecha" => "2011"
                        "volumen" => "192"
                        "paginaInicial" => "425"
                        "paginaFinal" => "431"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exposure to biomass smoke as a cause for airway disease in women and children"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/ACI.0b013e32834ecb65"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Allergy Clin Immunol"
                        "fecha" => "2012"
                        "volumen" => "12"
                        "paginaInicial" => "82"
                        "paginaFinal" => "90"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic obstructive pulmonary disease in non-smokers"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(09)61303-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2009"
                        "volumen" => "374"
                        "paginaInicial" => "733"
                        "paginaFinal" => "743"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterisation of particulates and carcinogenic polycyclic aromatic hydrocarbons in wintertime wood-fired heating in residential areas"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Atmos Environ"
                        "fecha" => "2011"
                        "volumen" => "45"
                        "paginaInicial" => "7627"
                        "paginaFinal" => "7634"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of combustion condition on cytotoxic and inflammatory activity of residential wood combustion particles"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Atmos Environ"
                        "fecha" => "2010"
                        "volumen" => "44"
                        "paginaInicial" => "1691"
                        "paginaFinal" => "1698"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Wood smoke-associated chronic obstructive pulmonary disease &#40;COPD&#41;&#8212;underappreciated in the United States&#63;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2009"
                        "volumen" => "179"
                        "paginaInicial" => "A4742"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Of dung and dynein arms&#58; understanding COPD in nonsmokers"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4187/respcare.02334"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2013"
                        "volumen" => "58"
                        "paginaInicial" => "543"
                        "paginaFinal" => "545"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of biomass burning on respiratory symptoms and lung function in rural Mexican women"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200503-479OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "174"
                        "paginaInicial" => "901"
                        "paginaFinal" => "905"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of COPD in five Colombian cities situated at low&#44; medium&#44; and high altitude &#40;PREPOCOL study&#41;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.07-1361"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2008"
                        "volumen" => "133"
                        "paginaInicial" => "343"
                        "paginaFinal" => "349"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of indoor air pollution on the respiratory system of women using different fuels for cooking in an urban slum of Pondicherry"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Natl Med J India"
                        "fecha" => "1996"
                        "volumen" => "9"
                        "paginaInicial" => "113"
                        "paginaFinal" => "117"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventilatory function in nonsmoking rural Indian women using different cooking fuels"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "1994"
                        "volumen" => "61"
                        "paginaInicial" => "89"
                        "paginaFinal" => "92"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sister-chromatid exchange frequency in women who were exposed to biomass in a village in central Anatolia"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Turkish Respir J"
                        "fecha" => "2001"
                        "volumen" => "2"
                        "paginaInicial" => "26"
                        "paginaFinal" => "28"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional and radiological impairment in women highly exposed to indoor biomass fuels"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Respirology"
                        "fecha" => "2001"
                        "volumen" => "6"
                        "paginaInicial" => "255"
                        "paginaFinal" => "258"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of pulmonary changes due to biomass fuels using high-resolution computed tomography"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00330-003-1925-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2003"
                        "volumen" => "13"
                        "paginaInicial" => "2372"
                        "paginaFinal" => "2377"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic pulmonary disease in rural women exposed to biomass fumes"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Invest Med"
                        "fecha" => "2003"
                        "volumen" => "26"
                        "paginaInicial" => "243"
                        "paginaFinal" => "248"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Domestic smoke pollution and chronic bronchitis in a rural community of the hill region of Nepal"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1984"
                        "volumen" => "39"
                        "paginaInicial" => "337"
                        "paginaFinal" => "339"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic bronchitis in women using solid biomass fuel in rural Peshawar&#44; Pakistan"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.06-2529"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2007"
                        "volumen" => "132"
                        "paginaInicial" => "1472"
                        "paginaFinal" => "1475"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of clinical and functional parameters in female subjects with biomass smoke exposure"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4187/respcare.01772"
                      "Revista" => array:6 [
                        "tituloSerie" => "Respir Care"
                        "fecha" => "2013"
                        "volumen" => "58"
                        "paginaInicial" => "424"
                        "paginaFinal" => "430"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global burden of disease and risk factors"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "2006"
                        "editorial" => "World Bank"
                        "editorialLocalizacion" => "Washington&#44; DC"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0205"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early origins of chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.siny.2012.01.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Fetal Neonatal Med"
                        "fecha" => "2012"
                        "volumen" => "17"
                        "paginaInicial" => "112"
                        "paginaFinal" => "118"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Household fuels&#44; low birth weight&#44; and neonatal death in India&#58; the separate impacts of biomass&#44; kerosene&#44; and coal"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijheh.2012.12.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Hyg Environ Health"
                        "fecha" => "2013"
                        "volumen" => "216"
                        "paginaInicial" => "523"
                        "paginaFinal" => "532"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations between birth weight&#44; early childhood weight gain and adult lung function"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2008.103978"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2009"
                        "volumen" => "64"
                        "paginaInicial" => "228"
                        "paginaFinal" => "232"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Domestic fuels&#44; indoor air pollution&#44; and children&#39;s health"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1196/annals.1454.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann N Y Acad Sci"
                        "fecha" => "2008"
                        "volumen" => "1140"
                        "paginaInicial" => "209"
                        "paginaFinal" => "217"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Air pollution and child respiratory health&#58; a case-crossover study in Australia and New Zealand"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200411-1586OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "1272"
                        "paginaFinal" => "1278"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Indoor air pollution from unprocessed solid fuel use and pneumonia risk in children aged under five years&#58; a systematic review and meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Bull World Health Organ"
                        "fecha" => "2008"
                        "volumen" => "86"
                        "paginaInicial" => "390"
                        "paginaFinal" => "398"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of biomass smoke on pulmonary host defence mechanisms"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.prrv.2007.07.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Paediatr Respir Rev"
                        "fecha" => "2007"
                        "volumen" => "8"
                        "paginaInicial" => "287"
                        "paginaFinal" => "291"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characteristics of stable chronic obstructive pulmonary disease patients in the pulmonology clinics of seven Asian cities"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "31"
                        "paginaFinal" => "39"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk of COPD from exposure to biomass smoke&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.08-2114"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2010"
                        "volumen" => "138"
                        "paginaInicial" => "20"
                        "paginaFinal" => "31"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence and correlates of airflow obstruction in &#8764;317&#44;000 never-smokers in China"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00152413"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2014"
                        "volumen" => "44"
                        "paginaInicial" => "66"
                        "paginaFinal" => "77"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obstructive lung disease and exposure to burning biomass fuel in the indoor environment"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.gheart.2012.06.016"
                      "Revista" => array:6 [
                        "tituloSerie" => "Glob Heart"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "265"
                        "paginaFinal" => "270"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Survival of patients with chronic obstructive pulmonary disease due to biomass smoke and tobacco"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200504-568OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2006"
                        "volumen" => "173"
                        "paginaInicial" => "393"
                        "paginaFinal" => "397"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Wood smoke-associated lung disease&#58; a clinical&#44; functional&#44; radiological and pathological description"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "2008"
                        "volumen" => "12"
                        "paginaInicial" => "1092"
                        "paginaFinal" => "1098"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory health effects of indoor air pollution"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int Tuberc Lung Dis"
                        "fecha" => "2010"
                        "volumen" => "14"
                        "paginaInicial" => "1079"
                        "paginaFinal" => "1086"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00206112"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2014"
                        "volumen" => "43"
                        "paginaInicial" => "725"
                        "paginaFinal" => "734"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Airway hyper-responsiveness in wood smoke COPD"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "168S"
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of lung morphology in COPD secondary to cigarette and biomass smoke"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "2008"
                        "volumen" => "12"
                        "paginaInicial" => "972"
                        "paginaFinal" => "977"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pseudophysiologic emphysema in women with wood smoke COPD in Bogota &#40;2600<span class="elsevierStyleHsp" style=""></span>m&#41;"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2004"
                        "volumen" => "40"
                        "paginaInicial" => "31"
                        "paginaFinal" => "36"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary changes on HRCT scans in nonsmoking females with COPD due to wood smoke exposure"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bras Pneumol"
                        "fecha" => "2013"
                        "volumen" => "39"
                        "paginaInicial" => "155"
                        "paginaFinal" => "163"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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            59 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enfermedad pulmonar obstructiva cr&#243;nica &#40;EPOC&#41; por humo de le&#241;a en mujeres&#58; comparaci&#243;n con la EPOC por tabaquismo"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Acta Med Colomb"
                        "fecha" => "2004"
                        "volumen" => "29"
                        "paginaInicial" => "17"
                        "paginaFinal" => "25"
                      ]
                    ]
                  ]
                ]
              ]
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            60 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Exposure to biomass smoke extract enhances fibronectin release from fibroblasts"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0083938"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2013"
                        "volumen" => "8"
                        "paginaInicial" => "e83938"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of DNA damage by comet assay and fast halo assay in buccal epithelial cells of Indian women chronically exposed to biomass smoke"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijheh.2011.04.003"
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                        "tituloSerie" => "Int J Hyg Environ Health"
                        "fecha" => "2011"
                        "volumen" => "214"
                        "paginaInicial" => "311"
                        "paginaFinal" => "318"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
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            62 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in sputum cytology&#44; airway inflammation and oxidative stress due to chronic inhalation of biomass smoke during cooking in premenopausal rural Indian women"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijheh.2012.05.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Hyg Environ Health"
                        "fecha" => "2013"
                        "volumen" => "216"
                        "paginaInicial" => "301"
                        "paginaFinal" => "308"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neutrophilic inflammatory response and oxidative stress in premenopausal women chronically exposed to indoor air pollution from biomass burning"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10753-011-9360-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Inflammation"
                        "fecha" => "2012"
                        "volumen" => "35"
                        "paginaInicial" => "671"
                        "paginaFinal" => "683"
                        "link" => array:1 [ …1]
                        "itemHostRev" => array:3 [ …3]
                      ]
                    ]
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                ]
              ]
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            64 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0088455"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "paginaInicial" => "e88455"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
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            65 => array:3 [
              "identificador" => "bib0330"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enhanced acute responses in an experimental exposure model to biomass smoke inhalation in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/01902140802322256"
                      "Revista" => array:6 [
                        "tituloSerie" => "Exp Lung Res"
                        "fecha" => "2008"
                        "volumen" => "34"
                        "paginaInicial" => "631"
                        "paginaFinal" => "662"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00097707"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2008"
                        "volumen" => "32"
                        "paginaInicial" => "129"
                        "paginaFinal" => "138"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immune cells and cardiovascular health in premenopausal women of rural India chronically exposed to biomass smoke during daily household cooking"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.scitotenv.2012.08.065"
                      "Revista" => array:6 [
                        "tituloSerie" => "Sci Total Environ"
                        "fecha" => "2012"
                        "volumen" => "438"
                        "paginaInicial" => "293"
                        "paginaFinal" => "298"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic inflammatory changes and increased oxidative stress in rural Indian women cooking with biomass fuels"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.taap.2012.04.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol Appl Pharmacol"
                        "fecha" => "2012"
                        "volumen" => "261"
                        "paginaInicial" => "255"
                        "paginaFinal" => "262"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Matrix metalloproteinases activity in COPD associated with wood smoke"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2004"
                        "volumen" => "125"
                        "paginaInicial" => "466"
                        "paginaFinal" => "472"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "C-reactive protein levels are raised in stable chronic obstructive pulmonary disease patients independent of smoking behavior and biomass exposure"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3978/j.issn.2072-1439.2013.06.27"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Dis"
                        "fecha" => "2013"
                        "volumen" => "5"
                        "paginaInicial" => "414"
                        "paginaFinal" => "421"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            71 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "72"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Emerging mechanistic targets in lung injury induced by combustion-generated particles"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/toxsci/kft001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Toxicol Sci"
                        "fecha" => "2013"
                        "volumen" => "132"
                        "paginaInicial" => "253"
                        "paginaFinal" => "267"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            72 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "73"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TRP channels"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1146/annurev.biochem.75.103004.142819"
                      "Revista" => array:6 [
                        "tituloSerie" => "Annu Rev Biochem"
                        "fecha" => "2007"
                        "volumen" => "76"
                        "paginaInicial" => "387"
                        "paginaFinal" => "417"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            73 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "74"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Introduction to TRP channels&#58; structure&#44; function&#44; and regulation"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/978-1-60761-500-2_6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Exp Med Biol"
                        "fecha" => "2010"
                        "volumen" => "661"
                        "paginaInicial" => "99"
                        "paginaFinal" => "108"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            74 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "75"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transient receptor potential vanilloid-1 &#40;TRPV1&#41; is a mediator of lung toxicity for coal fly ash particulate material"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1124/mol.111.076067"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Pharmacol"
                        "fecha" => "2012"
                        "volumen" => "81"
                        "paginaInicial" => "411"
                        "paginaFinal" => "419"
                        "link" => array:1 [ …1]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            75 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "76"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells"
                      "autores" => array:1 [
                        0 => array:2 [ …2]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/10799893.2011.602413"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Recept Signal Transduct Res"
                         …6
                      ]
                    ]
                  ]
                ]
              ]
            ]
            76 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "77"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0042454"
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            77 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "78"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of transient receptor potential ankyrin-1 &#40;TRPA1&#41; in lung cells by wood smoke particulate material"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1021/tx400024h"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            78 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "79"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TLR-2 is involved in airway epithelial cell response to air pollution particles"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.taap.2004.07.007"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            79 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "80"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1189/jlb.1008587"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            80 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "81"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaci.2011.11.033"
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
            ]
            81 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "82"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Particulate matter induces translocation of IL-6 from the lung to the systemic circulation"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2009-0427OC"
                      "Revista" => array:7 [ …7]
                    ]
                  ]
                ]
              ]
            ]
            82 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "83"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of biomass combustion smoke on hematological and antioxidant profile among children &#40;8&#8211;13 years&#41; in India"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/08958370802448961"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            83 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "84"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Activation of protein kinase B &#40;PKB&#47;Akt&#41; and risk of lung cancer among rural women in India who cook with biomass fuel"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.taap.2011.12.002"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            84 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "85"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduction of DNA mismatch repair protein expression in airway epithelial cells of premenopausal women chronically exposed to biomass smoke"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11356-013-2218-4"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            85 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "86"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between household air pollution from biomass smoke exposure&#44; and pulmonary dysfunction&#44; oxidant-antioxidant imbalance and systemic inflammation in rural women and children in Nigeria"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5539/gjhs.v5n4p28"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            86 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "87"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rmed.2005.10.011"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            87 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "88"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experimental exposure to wood smoke&#58; effects on airway inflammation and oxidative stress"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/oem.2006.032458"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            88 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "89"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic inhalation of biomass smoke is associated with DNA damage in airway cells&#58; involvement of particulate pollutants and benzene"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jat.1748"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            89 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "90"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Micronucleus formation&#44; DNA damage and repair in premenopausal women chronically exposed to high level of indoor air pollution from biomass fuel use in rural India"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mrgentox.2010.02.006"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            90 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "91"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIRCRESAHA.110.237560"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            91 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "92"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxidative stress&#44; inflammation&#44; and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/toxsci/kfq290"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            92 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "93"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development and systematic oxidative stress of a rat model of chronic bronchitis and emphysema induced by biomass smoke"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/01902148.2013.797521"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            93 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "94"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of cigarette and biomass smoke exposure on oxidant-antioxidant status in rabbits"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [ …5]
                    ]
                  ]
                ]
              ]
            ]
            94 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "95"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-8 levels in human lung epithelial cells are increased in response to coal fly ash and vary with the bioavailability of iron&#44; as a function of particle size and source of coal"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            95 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "96"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oxidative stress&#44; DNA damage&#44; and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1021/tx100407m"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            96 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "97"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Wood smoke particles generate free radicals and cause lipid peroxidation&#44; DNA&#44; damage&#44; NFkappaB activation and TNF-alpha release in macrophages"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            97 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "98"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Particle size-dependent radical generation from wildland fire smoke"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.tox.2007.04.008"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            98 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "99"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of genotoxic and inflammatory effects of particles generated by wood combustion&#44; a road simulator and collected from street and subway"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.toxlet.2006.04.003"
                      "Revista" => array:6 [ …6]
                    ]
                  ]
                ]
              ]
            ]
            99 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "100"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pro-inflammatory potential of wood smoke and traffic-derived particles in a monocytic cell line"
                      "autores" => array:1 [ …1]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                    0 => array:2 [
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
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                    0 => array:2 [
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                      "titulo" => "Oxidative stress in COPD"
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                    0 => array:2 [
                      "doi" => "10.1378/chest.12-2664"
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                      "doi" => "10.1080/01926230490885733"
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                      "titulo" => "The endocytosis of asbestos by mouse peritoneal macrophages and its long-term effect on iron accumulation and labyrinth formation"
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                  "host" => array:1 [
                    0 => array:1 [
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pmed.1001621"
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                0 => array:2 [
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                      "doi" => "10.1164/rccm.200810-1556OC"
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Article information

ISSN: 15792129
Original language: English

DOI:10.1016/j.arbr.2015.04.013

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2022 July	55	41	96
2022 June	61	52	113
2022 May	53	51	104
2022 April	78	55	133
2022 March	69	61	130
2022 February	70	40	110
2022 January	74	43	117
2021 December	72	56	128
2021 November	61	53	114
2021 October	139	62	201
2021 September	79	58	137
2021 August	112	44	156
2021 July	90	30	120
2021 June	89	30	119
2021 May	83	57	140
2021 April	105	64	169
2021 March	82	37	119
2021 February	75	28	103
2021 January	225	29	254
2020 December	45	25	70
2020 November	62	27	89
2020 October	69	30	99
2020 September	44	24	68
2020 August	53	29	82
2020 July	36	27	63
2020 June	78	30	108
2020 May	104	27	131
2020 April	143	33	176
2020 March	197	34	231
2020 February	132	39	171
2020 January	151	30	181
2019 December	171	23	194
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2019 September	145	15	160
2019 August	106	24	130
2019 July	62	27	89
2019 June	60	27	87
2019 May	103	30	133
2019 April	91	35	126
2019 March	69	37	106
2019 February	61	27	88
2019 January	119	31	150
2018 December	55	34	89
2018 November	131	54	185
2018 October	107	35	142
2018 September	55	17	72
2018 May	40	0	40
2018 April	83	13	96
2018 March	90	11	101
2018 February	65	22	87
2018 January	417	9	426
2017 December	511	8	519
2017 November	83	17	100
2017 October	65	13	78
2017 September	58	35	93
2017 August	70	20	90
2017 July	72	19	91
2017 June	92	27	119
2017 May	100	23	123
2017 April	58	26	84
2017 March	68	40	108
2017 February	143	20	163
2017 January	46	22	68
2016 December	53	20	73
2016 November	112	24	136
2016 October	142	27	169
2016 September	130	42	172
2016 August	71	35	106
2016 July	52	42	94
2016 March	3	0	3
2016 February	1	0	1
2015 December	3	0	3
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