Journal Information
Vol. 41. Issue 7.
Pages 389-392 (July 2005)
Share
Share
Download PDF
More article options
Vol. 41. Issue 7.
Pages 389-392 (July 2005)
Review Article
Full text access
Endothelial Dysfunction in Pulmonary Hypertension
Visits
4832
J.C. Caraballo Fonseca, C.D. Martínez Balzano, R. Sánchez de León
Corresponding author
rsdl@telcel.net.ve

Correspondence: Dr. R. Sánchez de León. POBA international #1-20312, Miami, Florida 33102-5255, USA
Sección de Fisiología Respiratoria, Facultad de Medicina, Escuela de Medicina Luis Razetti, Universidad Central de Venezuela, Caracas, Venezuela
This item has received
Article information
Full text is only aviable in PDF
REFERENCES
[1]
J Barberà.
Nueva nomenclatura y clasificación de la hipertensión pulmonar.
Arch Bronconeumol, 38 (2002), pp. 3-9
[2]
Primary pulmonary hypertension. Executive summary from the World Symposium on Primary Pulmonary Hypertension,
[3]
E Yi, H Kim, H Ahn, J Strother, T Morris, E Masliah, et al.
Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension. A morphometric and immunohistochemical study.
Am J Respir Crit Care Med, 162 (2000), pp. 1577-1586
[4]
S Lee, K Shroyer, N Markham, C Cool, N Voelkel, R Tuder.
Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension.
J Clin Invest, 101 (1998), pp. 927-934
[5]
J Lloyd, M Butler, T Foroud, P Conneally, J Phillips, J Newman.
Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension.
Am J Respir Crit Care Med, 152 (1995), pp. 93-97
[6]
W Nichols, D Koller, B Slovis, T Foroud, V Terry, N Arnold, et al.
Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32.
Nat Genet, 15 (1997), pp. 277-280
[7]
J Morse, A Jones, R Barst, S Hodge, K Wilhelmsen, T Nygaard.
Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32.
Circulation, 95 (1997), pp. 2603-2606
[8]
J Newman, L Wheeler, K Lane, E Loyd, R Gaddipati, J Phillips, et al.
Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred.
N Engl J Med, 345 (2001), pp. 319-324
[9]
J Thomson, R Machado, M Pauciulo, N Morgan, M Humbert, G Elliott, et al.
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family.
J Med Genet, 37 (2000), pp. 741-745
[10]
N Morrell, X Yang, P Upton, K Jourdan, N Morgan, K Sheares, et al.
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta and bone morphogenetic proteins.
Circulation, 104 (2001), pp. 790-795
[11]
R Trembath, J Thomson, R Machado, N Morgan, C Atkinson, I Winship, et al.
Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia.
N Engl J Med, 345 (2001), pp. 325-334
[12]
M Yanagisawa, H Kurihara, S Kimura, K Goto, T Masaki.
A novel peptide vasoconstrictor, endothelin, is produced by vascular endothelium and modulates smooth muscle Ca2+ channels.
J Hypertens Suppl, 6 (1988), pp. 88-91
[13]
A Giaid, M Yanagisawa, D Langleben, R Michel, R Levy, H Shennib, et al.
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
N Engl J Med, 328 (1993), pp. 1732-1739
[14]
B Rondelet, R van Beneden, F Kerbaul, S Motte, P Fesler, K McEntee, et al.
Expression of the serotonin 1b receptor in experimental pulmonary hypertension.
Eur Respir J, 22 (2003), pp. 408-412
[15]
R Channick, G Simonneau, O Sitbon, I Robbins, A Frost, V Tapson, et al.
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study.
Lancet, 358 (2001), pp. 1119-1123
[16]
O Sitbon, D Badesch, R Channick, A Frost, I Robbins, G Simonneau, et al.
Effects of the dual endothelin receptor antagonist bosentan in patients with pulmonary arterial hypertension: a 1-year follow-up study.
Chest, 124 (2003), pp. 247-254
[17]
N Galie, A Hinderliter, A Torbicki, T Fourme, G Simonneau, T Pulido, et al.
Effects of the oral endothelin-receptor antagonist bosentan on echocardiographic and doppler measures in patients with pulmonary arterial hypertension.
J Am Coll Cardiol, 41 (2003), pp. 1380-1386
[18]
L Du, C Sullivan, D Chu, A Cho, M Kido, P Wolf, et al.
Signaling molecules in nonfamilial pulmonary hypertension.
N Engl J Med, 348 (2003), pp. 500-509
[19]
C Sullivan, L Du, D Chu, A Cho, M Kido, P Wolf, et al.
Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway.
Proc Natl Acad Sci USA, 100 (2003), pp. 12331-12336
[20]
A Dinh-Xuan, T Higenbottam, C Clelland, J Pepke-Zaba, G Cremona, A Butt, et al.
Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease.
N Engl J Med, 324 (1991), pp. 1539-1547
[21]
L Cea-Calvo, P Escribano, R Tello, M Gómez, J Delgado, C Sáenz.
Sildenafilo como sustituto de la prostaciclina subcutánea en la hipertensión pulmonar.
Arch Bronconeumol, 39 (2003), pp. 476-477
[22]
A Giaid, D Saleh.
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension.
N Engl J Med, 333 (1995), pp. 214-221
[23]
R Berger, R Geiger, J Hess, A Bogers, W Mooi.
Altered arterial expression patterns of inducible and endothelial nitric oxide synthase in pulmonary plexogenic arteriopathy caused by congenital heart disease.
Am J Respir Crit Care Med, 163 (2001), pp. 1493-1499
[24]
R Tuder, C Cool, M Geraci, J Wang, S Abman, L Wright, et al.
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension.
Am J Respir Crit Care Med, 159 (1999), pp. 1925-1932
[25]
V Roig, A Herrero, N de la Torre, E Hernández, J Aller, J Cabello.
Iloprost en la hipertensión pulmonar tromboembólica crónica.
Arch Bronconeumol, 40 (2004), pp. 326-328
[26]
J Yuan, A Aldinger, M Juhaszova, J Wang, J Conte, S Gaine, et al.
Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension.
Circulation, 98 (1998), pp. 1400-1406
[27]
C Cool, P Rai, M Yeager, D Hernández-Saavedra, A Serls, T Bull, et al.
Expression of human herpesvirus 8 in primary pulmonary hypertension.
N Engl J Med, 349 (2003), pp. 1113-1122
Copyright © 2005. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?