Publish in this journal
Journal Information
Vol. 51. Issue 10.
Pages 533 (October 2015)
Vol. 51. Issue 10.
Pages 533 (October 2015)
Letter to the Editor
DOI: 10.1016/j.arbr.2015.08.005
Full text access
Corrigendum: Consensus Document on the Diagnosis, Treatment and Prevention of Tuberculosis. Prothionamide and PAS Doses
Dosis de protionamida y PAS. Corrección al «Documento de Consenso sobre diagnóstico, tratamiento y prevención de la tuberculosis»
Visits
1495
José-María García-Garcíaa,1,
Corresponding author
josemaria.garciag@sespa.es

Corresponding author.
, Julià González-Martínb,1
a Unidad de Gestión Clínica de Neumología, Hospital San Agustín, Avilés, Spain
b Servei de Microbiologia, Hospital Clínic-ISGLOBAL, Universitat de Barcelona, Barcelona, Spain
This item has received
1495
Visits
Article information
Full Text
Bibliography
Download PDF
Statistics
Tables (1)
Table 1. Second-line drugs in the treatment of tuberculosis.
Full Text
To the Editor:

With regard to the “Consensus Document on the Diagnosis, Treatment and Prevention of Tuberculosis”, presented by the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) and the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), published simultaneously with exactly the same contents in the official journals of both societies, Archivos de Bronconeumología and Enfermedades Infecciosas y Microbiología Clínica,1,2 we, as authors of the consensus document, would like to make the following remarks:

  • 1.

    A mistake was detected in the list of recommended doses of para-aminosalicylic acid (PAS) and prothionamide. In Table 11 of the consensus, the doses of both drugs have been interchanged: the dose of prothionamide has been given for the PAS dose, while the dose of PAS has been given for the prothionamide dose.

  • 2.

    The PAS dose is 8–12g/day, split into 2–3 doses.

  • 3.

    The dose of prothionamide is 10–15mg/kg/day (in 2 doses).

Changes are given in the attached Table 1.

Table 1.

Second-line drugs in the treatment of tuberculosis.

Category  Drug  Dose in adults 
InjectablesAmikacin  15mg/kg/day (for all 3)
Capreomycina 
Kanamycin 
FluoroquinolonesMoxifloxacina  400mg/24
Levofloxacin  500mg/12
Ofloxacin  400mg/12
OtherCycloserine  15–20mg/kg/day (in 2–3 doses) 
PAS  8–12g/day (in 2–3 doses) 
Prothionamidea  10–15mg/kg/day (in 2 doses) 

This table corresponds to Table 11 in the “Consensus Document on the Diagnosis, Treatment and Prevention of Tuberculosis”.1,2

a

Drug of choice in each group.

Moreover, regarding the doses for medication used in the treatment of tuberculosis, we would like to recommend the handbooks published by the TB Alliance and the World Health Organization. Links are given below in references 3 and 4.

Thank you for your help in publishing this letter.

References
[1]
J. González-Martín, J.M. García-García, L. Anibarro, R. Vidal, J. Esteban, S. Moreno, et al.
Documento de consenso sobre diagnóstico, tratamiento y prevención de la tuberculosis.
Arch Bronconeumol, 46 (2010), pp. 255-274
[2]
J. González-Martín, J.M. García-García, L. Anibarro, R. Vidal, J. Esteban, S. Moreno, et al.
Documento de consenso sobre diagnóstico, tratamiento y prevención de la tuberculosis.
Enferm Infecc Microbiol Clin, 28 (2010),
[3]
Handbook of anti-tuberculosis agents.
Tuberculosis, 88 (2008), pp. 85-170
[4]
World Health Organization.
Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis. WHO/HTM/TB/2014.11.
(2014),

Consensus Coordinators representing SEPAR and SEIMC, respectively, on behalf of all authors.

Please cite this article as: García-García J-M, González-Martín J. Dosis de protionamida y PAS. Corrección al «Documento de Consenso sobre diagnóstico, tratamiento y prevención de la tuberculosis». Arch Bronconeumol. 2015;51:533.

Copyright © 2015. SEPAR
Idiomas
Archivos de Bronconeumología (English Edition)

Subscribe to our newsletter

Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.