array:19 [
  "pii" => "13046510"
  "issn" => "15792129"
  "estado" => "S300"
  "fechaPublicacion" => "2003-07-01"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2003;39:327"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2452
    "formatos" => array:3 [
      "EPUB" => 108
      "HTML" => 1770
      "PDF" => 574
    ]
  ]
  "itemSiguiente" => array:15 [
    "pii" => "13046512"
    "issn" => "15792129"
    "estado" => "S300"
    "fechaPublicacion" => "2003-07-01"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2003;39:328"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2053
      "formatos" => array:3 [
        "EPUB" => 114
        "HTML" => 1400
        "PDF" => 539
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "Authors¿ reply"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:1 [
          "paginaInicial" => "328"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Respuesta de los autores"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "N Salord, R M Miralda, P Casan"
          "autores" => array:3 [
            0 => array:2 [
              "Iniciales" => "N"
              "apellidos" => "Salord"
            ]
            1 => array:2 [
              "Iniciales" => "R M"
              "apellidos" => "Miralda"
            ]
            2 => array:2 [
              "Iniciales" => "P"
              "apellidos" => "Casan"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13046512?idApp=UINPBA00003Z"
    "url" => "/15792129/0000003900000007/v0_201307090915/13046512/v0_201307090915/en/main.assets"
  ]
  "itemAnterior" => array:15 [
    "pii" => "13046511"
    "issn" => "15792129"
    "estado" => "S300"
    "fechaPublicacion" => "2003-07-01"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2003;39:327-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 5468
      "formatos" => array:3 [
        "EPUB" => 106
        "HTML" => 4773
        "PDF" => 589
      ]
    ]
    "en" => array:9 [
      "idiomaDefecto" => true
      "titulo" => "The progression of amyotrophic lateral sclerosis (ALS): respiratory function"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "327"
          "paginaFinal" => "328"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Evolución de la esclerosis lateral amiotrófica a través de la función pulmonar"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "S Mayoralas, M A Gómez, S Díaz"
          "autores" => array:3 [
            0 => array:2 [
              "Iniciales" => "S"
              "apellidos" => "Mayoralas"
            ]
            1 => array:2 [
              "Iniciales" => "M A"
              "apellidos" => "Gómez"
            ]
            2 => array:2 [
              "Iniciales" => "S"
              "apellidos" => "Díaz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13046511?idApp=UINPBA00003Z"
    "url" => "/15792129/0000003900000007/v0_201307090915/13046511/v0_201307090915/en/main.assets"
  ]
  "en" => array:10 [
    "idiomaDefecto" => true
    "titulo" => "Alveolar proteinosis or the importance of identifying concurrent infections"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:1 [
        "paginaInicial" => "327"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "S Mayoralas, L Gómez, S Díaz"
        "autores" => array:3 [
          0 => array:3 [
            "Iniciales" => "S"
            "apellidos" => "Mayoralas"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          1 => array:3 [
            "Iniciales" => "L"
            "apellidos" => "G&#243;mez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
          2 => array:3 [
            "Iniciales" => "S"
            "apellidos" => "D&#237;az"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "affa"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:3 [
            "entidad" => "Servicio de Neumología. Hospital Universitario La Paz. Madrid. Spain."
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "affa"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Proteinosis alveolar o la importancia de identificar infecciones sobrea&#241;adidas"
      ]
    ]
    "textoCompleto" => "<p class="elsevierStylePara"><span class="elsevierStyleBold"> To the Editor&#58;</span> Alveolar proteinosis &#40;AP&#41; is a rare disease which affects the lungs diffusely and is characterized by the deposition of protein-like material rich in phospholipids&#46; This material is characteristically PAS positive and does not cause interstitial alveolar inflammation&#59; thus the degree of fibrosis minimal<span class="elsevierStyleSup">1</span>&#46; Signs and symptoms are nonspecific and patients are generally asymptomatic before complications occur&#46; The main complication in AP is concurrent infection with unusual germs like <span class="elsevierStyleItalic">Aspergillus</span> sp&#46;<span class="elsevierStyleItalic">&#44; Nocardia</span> sp&#46;<span class="elsevierStyleItalic">&#44; Mycobacterium</span> sp&#46;<span class="elsevierStyleItalic">&#44; Cryptococcus neoformans&#44; Histoplasma capsulatum&#44; Pneumocystis carinii</span> and certain viruses<span class="elsevierStyleSup">2</span>&#46; We report the case of a woman diagnosed with AP after being infected with <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span>&#46;</p><p class="elsevierStylePara">The patient was a 41-year-old female who smoked 500 cigarettes per year and was a moderate drinker with no relevant medical or occupational history&#46; The patient complained of night sweats&#44; dyspnea upon moderate effort&#44; cough with abundant whitish sputum and wasting syndrome with loss of 6 to 7 kg in weight starting three months earlier&#46; She had presented bloody sputum on one occasion one week before admission&#46; Perihilar ground-glass opacities were observed in the chest radiograph&#46; Physical exploration showed no significant findings&#46; Relevant analytical findings were leukocytes&#44; 6550&#47;&#181;l &#40;neutrophiles 57&#37;&#44; lymphocytes 34&#37;&#41;&#59; hemoglobin&#44; 14 g&#47;dL&#59; hematocrit&#44; 38&#46;6&#37;&#59; platelets&#44; 212 000&#59; and erythrocyte sedimentation rate&#44; 10 mm&#47;h&#46; Biochemistry&#44; proteinogram&#44; coagulation and urine analyses were normal&#46; Nuclear antibodies&#44; anti-smooth muscle and rheumatoid factors were normal&#46; The angiotensin-converting enzyme level was 51 &#40;30-50&#41;&#46; The pneumonia panel was negative and no <span class="elsevierStyleItalic">Legionella</span> antigen was found in urine&#46; Lung function testing gave normal findings&#44; including a carbon monoxide diffusion capacity of 82&#46;3&#37;&#46; Resting arterial gases were measured&#44; pH being 7&#46;39&#44; PaO<span class="elsevierStyleInf">2</span> 68 mmHg and PaCO<span class="elsevierStyleInf">2</span> 41 mmHg&#46; A computed tomography scan of the thorax showed bilateral ground-glass opacities&#44; mainly in high and mid fields&#46; Bronchoscopy revealed no endobronchial lesions&#44; but PAS-positive material was detected in bronchial aspirate and bronchoalveolar lavage samples&#46; The L&#246;wenstein&#173;Jensen culture was positive for <span class="elsevierStyleItalic">M&#46; tuberculosis</span>&#46; A transbronchial biopsy gave no remarkable findings&#46; There was good response to treatment with isoniazid and rifampicin for six months and with pyrazinamide for the first two months&#46; The patient remained asymptomatic one year later&#46; A chest radiograph showed no changes&#44; pulmonary function tests were normal and the biopsy was still PAS positive&#46; L&#246;wenstein-Jensen cultures were negative&#46;</p><p class="elsevierStylePara">The clinical presentation of AP is variable and nonspecific&#46; The most frequent symptoms are dry cough and dyspnea&#46; Some patients present no symptoms before developing concurrent infections&#44; as in the case we report&#46; Although favorable results have been described after treatment with granulocytic-monocytic series colony stimulating factor<span class="elsevierStyleSup">3</span>&#44; the only treatment of proven efficacy is whole-lung lavage<span class="elsevierStyleSup">4</span>&#46; This treatment is only prescribed for patients with dyspnea or respiratory insufficency<span class="elsevierStyleSup">5&#44;6</span>&#46; Nevertheless&#44; before considering whole-lung lavage&#44; it is necessary to rule out specifically treatable concurrent infections&#46; Our patient experienced symptoms while the <span class="elsevierStyleItalic">M&#46; tuberculosis</span> infection persisted and remained asymptomatic after being treated&#59; therefore&#44; whole-lung lavage was not considered&#46; With the exception of patients with severe respiratory insufficiency&#44; identifying and treating concurrent infections is the best way to improve quality of life and prognosis for AP patients&#46; While these infections were the main cause of death in the past&#44; the prognosis has currently improved considerably with their appropriate treatment&#46;</p>"
    "pdfFichero" => "260v39n07a13046510pdf001.pdf"
    "tienePdf" => true
    "bibliografia" => array:2 [
      "titulo" => "Bibliography"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:6 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Update on the clinical diagnosis&#44; management and pathogenesis of pulmonary alveolar proteinosis&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Claypool WD"
                            1 => "Rogers RM"
                            2 => "Matuschak M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "85"
                        "paginaInicial" => "550"
                        "paginaFinal" => "8"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6368143"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Pulmonary alveolar proteinosis&#58; clinical aspects and current concepts on pathogenesis&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Shah PL"
                            1 => "Hansell D"
                            2 => "Lawson PR"
                            3 => "Reid KB&#46;N"
                            4 => "Morgan C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2000"
                        "volumen" => "55"
                        "paginaInicial" => "67"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10607805"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Eficacia del GM-CSF en la proteinosis alveolar pulmonar&#46;"
                      "idioma" => "es"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Acosta O"
                            1 => "Mara&#241;es I"
                            2 => "P&#233;rez A"
                            3 => "Hern&#225;ndez AI"
                            4 => "Bello MD"
                            5 => "L&#243;pez Y&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2002"
                        "volumen" => "38"
                        "paginaInicial" => "191"
                        "paginaFinal" => "3"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11953273"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Whole-lung lavage in alveolar proteinosis by a modified lavage technique&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Bingisser R"
                            1 => "Kaplan V"
                            2 => "Zollinger A"
                            3 => "Russi EW&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1998"
                        "volumen" => "113"
                        "paginaInicial" => "1718"
                        "paginaFinal" => "9"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9631820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Pulmonary alveolar proteinosis causing severe hypoxemic respiratory failure treated with sequential whole-lung lavage utilizing venovenous extracorporeal membrane oxygenation&#58; a case report and review&#46;"
                      "idioma" => "en"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Cohen ES"
                            1 => "Elpern E"
                            2 => "Silver MR&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2001"
                        "volumen" => "120"
                        "paginaInicial" => "1024"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11555544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Proteinosis alveolar&#46; Tratamiento mediante lavado pulmonar completo&#46;"
                      "idioma" => "es"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Mont&#243;n C"
                            1 => "Pe&#241;a R"
                            2 => "Mar&#237;n A&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2000"
                        "volumen" => "36"
                        "paginaInicial" => "291"
                        "paginaFinal" => "2"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10916671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000003900000007/v0_201307090915/13046510/v0_201307090915/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "14576"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Letters to the editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000003900000007/v0_201307090915/13046510/v0_201307090915/en/260v39n07a13046510pdf001.pdf?idApp=UINPBA00003Z&text.app=https://www.archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/13046510?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 39. Issue 7.
Pages 327 (July 2003)
Share
Share
Download PDF
More article options
Vol. 39. Issue 7.
Pages 327 (July 2003)
Full text access
Alveolar proteinosis or the importance of identifying concurrent infections
Proteinosis alveolar o la importancia de identificar infecciones sobreañadidas
Visits
4719
S. Mayoralasa, L. Gómeza, S. Díaza
a Servicio de Neumología. Hospital Universitario La Paz. Madrid. Spain.
This item has received
Article information
Full Text
Bibliography
Download PDF
Statistics
Full Text

To the Editor: Alveolar proteinosis (AP) is a rare disease which affects the lungs diffusely and is characterized by the deposition of protein-like material rich in phospholipids. This material is characteristically PAS positive and does not cause interstitial alveolar inflammation; thus the degree of fibrosis minimal1. Signs and symptoms are nonspecific and patients are generally asymptomatic before complications occur. The main complication in AP is concurrent infection with unusual germs like Aspergillus sp., Nocardia sp., Mycobacterium sp., Cryptococcus neoformans, Histoplasma capsulatum, Pneumocystis carinii and certain viruses2. We report the case of a woman diagnosed with AP after being infected with Mycobacterium tuberculosis.

The patient was a 41-year-old female who smoked 500 cigarettes per year and was a moderate drinker with no relevant medical or occupational history. The patient complained of night sweats, dyspnea upon moderate effort, cough with abundant whitish sputum and wasting syndrome with loss of 6 to 7 kg in weight starting three months earlier. She had presented bloody sputum on one occasion one week before admission. Perihilar ground-glass opacities were observed in the chest radiograph. Physical exploration showed no significant findings. Relevant analytical findings were leukocytes, 6550/µl (neutrophiles 57%, lymphocytes 34%); hemoglobin, 14 g/dL; hematocrit, 38.6%; platelets, 212 000; and erythrocyte sedimentation rate, 10 mm/h. Biochemistry, proteinogram, coagulation and urine analyses were normal. Nuclear antibodies, anti-smooth muscle and rheumatoid factors were normal. The angiotensin-converting enzyme level was 51 (30-50). The pneumonia panel was negative and no Legionella antigen was found in urine. Lung function testing gave normal findings, including a carbon monoxide diffusion capacity of 82.3%. Resting arterial gases were measured, pH being 7.39, PaO2 68 mmHg and PaCO2 41 mmHg. A computed tomography scan of the thorax showed bilateral ground-glass opacities, mainly in high and mid fields. Bronchoscopy revealed no endobronchial lesions, but PAS-positive material was detected in bronchial aspirate and bronchoalveolar lavage samples. The Löwenstein­Jensen culture was positive for M. tuberculosis. A transbronchial biopsy gave no remarkable findings. There was good response to treatment with isoniazid and rifampicin for six months and with pyrazinamide for the first two months. The patient remained asymptomatic one year later. A chest radiograph showed no changes, pulmonary function tests were normal and the biopsy was still PAS positive. Löwenstein-Jensen cultures were negative.

The clinical presentation of AP is variable and nonspecific. The most frequent symptoms are dry cough and dyspnea. Some patients present no symptoms before developing concurrent infections, as in the case we report. Although favorable results have been described after treatment with granulocytic-monocytic series colony stimulating factor3, the only treatment of proven efficacy is whole-lung lavage4. This treatment is only prescribed for patients with dyspnea or respiratory insufficency5,6. Nevertheless, before considering whole-lung lavage, it is necessary to rule out specifically treatable concurrent infections. Our patient experienced symptoms while the M. tuberculosis infection persisted and remained asymptomatic after being treated; therefore, whole-lung lavage was not considered. With the exception of patients with severe respiratory insufficiency, identifying and treating concurrent infections is the best way to improve quality of life and prognosis for AP patients. While these infections were the main cause of death in the past, the prognosis has currently improved considerably with their appropriate treatment.

Bibliography
[1]
Claypool WD, Rogers RM, Matuschak M..
Update on the clinical diagnosis, management and pathogenesis of pulmonary alveolar proteinosis..
Chest, 85 (1984), pp. 550-8
[2]
Shah PL, Hansell D, Lawson PR, Reid KB.N, Morgan C..
Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis..
Thorax, 55 (2000), pp. 67-77
[3]
Acosta O, Marañes I, Pérez A, Hernández AI, Bello MD, López Y..
Eficacia del GM-CSF en la proteinosis alveolar pulmonar..
Arch Bronconeumol, 38 (2002), pp. 191-3
[4]
Bingisser R, Kaplan V, Zollinger A, Russi EW..
Whole-lung lavage in alveolar proteinosis by a modified lavage technique..
Chest, 113 (1998), pp. 1718-9
[5]
Cohen ES, Elpern E, Silver MR..
Pulmonary alveolar proteinosis causing severe hypoxemic respiratory failure treated with sequential whole-lung lavage utilizing venovenous extracorporeal membrane oxygenation: a case report and review..
Chest, 120 (2001), pp. 1024-6
[6]
Montón C, Peña R, Marín A..
Proteinosis alveolar. Tratamiento mediante lavado pulmonar completo..
Arch Bronconeumol, 36 (2000), pp. 291-2
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?