Journal Information
Vol. 53. Issue 5.
Pages 273 (May 2017)
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A Case of Angioinvasive Aspergillosis
Un caso de aspergilosis angioinvasiva
Víctor Vázquez Sáncheza,
Corresponding author

Corresponding author.
, Armando Gózalo Garcíab, Fermín Sáez Garmendiab
a Servicio de Radiodiagnóstico, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Tenerife, Spain
b Sección de Radiología Pediátrica, Hospital de Cruces, Barakaldo, Vizcaya, Spain
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We present the case of a 13-year-old female with febrile neutropenia in the context of medullary aplasia secondary to chemotherapy treatment for acute lymphocytic leukemia. An opportunistic infection was suspected and Galactomannan test was performed with a positive result.

A CT-scan performed to evaluate any possible lung involvement, revealed multiple solid pulmonary nodules with bilateral distribution and upper-lobe predominance. These nodules showed ill-defined margins and exhibited a halo of ground-glass attenuation, or “halo sign” (Fig. 1 – left). In the clinical context, these findings corresponded to hemorrhagic infarcts and were highly suggestive of angioinvasive aspergillosis. Nevertheless, other much less common entities, such as Mucor and Candida, herpes simplex and cytomegalovirus, Wegener granulomatosis, Kaposi sarcoma and hemorrhagic metastases may present with similar findings on CT.1

Fig. 1.

Initial CT scan (left image) showing ill-defined nodules (arrow) with upper lobe predominance. Follow-up CT scan (right image) performed 3 weeks after starting treatment showing cavitation of known nodules.


Antifungal therapy for aspergillosis was administered and the patient made good progress. A follow-up CT performed after 3 weeks of treatment showed cavitation within the nodules, with a small solid component. This is called the “air crescent sign” (Fig. 1 – right), and appears in 50% of the cases.2 When it is seen after the “halo sign”, it reaffirms the diagnosis of aspergillosis and represents the separation of necrotic and healthy parenchyma.1

T. Franquet, N.L. Müller, A. Giménez, P. Guembe, J. de La Torre, S. Bagué.
Spectrum of pulmonary aspergillosis: histologic, clinical, and radiologic findings.
A. Prasad, K. Agarwal, D. Deepak, S.S. Atwal.
Pulmonary aspergillosis: what CT can offer before it is too late!.

Please cite this article as: Sánchez VV, García AG, Garmendia FS. Un caso de aspergilosis angioinvasiva. Arch Bronconeumol. 2017;53:273.

Copyright © 2016. SEPAR
Archivos de Bronconeumología

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