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Vol. 46. Issue 5.
Pages 238-243 (May 2010)
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Vol. 46. Issue 5.
Pages 238-243 (May 2010)
Original Article
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Use of Positron Emission Tomography in Assessing Hidden Extrathoracic Metastasis in Non Small Cell Lung Cancer
Utilidad de la tomografía por emisión de positrones en la detección de metástasis ocultas extratorácicas en el carcinoma broncogénico no células pequeñas
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Rodrigo Alonso Moralejoa,
Corresponding author
ralonsomoralejo@gmail.com

Corresponding author.
, Javier Sayas Catalána, Ricardo García Lujána, Mónica Coronado Poggiob, Eduard Monsó Molasc, Ángel López Encuentraa
a Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain
b Servicio de Medicina Nuclear, Hospital Universitario La Paz, Madrid, Spain
c Servicio de Neumología, Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
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Abstract
Introduction

Positron emission tomography combined with computed axial tomography (PET/CT) is used for staging non small cell lung cancer (NSCLC). This study aims to describe PET/CT findings of unsuspected extrathoracic metastasis when used in mediastinal evaluation of patients with apparently resectable NSCLC.

Patients and method

Prospective and concurrent study including all NSCLC patients between June 2004 and November 2006 who underwent PET/CT after considering them as candidates for surgery, with resectable disease after bronchoscopy, thorax and abdominal CT, brain CT and bone gammagraphy evaluation, if metastasis at these locations were suspected. Metastasis were confirmed histopathologically or assumed when they had a compatible evolution.

Results

A total of 91 patients with NSCLC underwent PET/CT. In 24 of them (26%) at least one suspicious extrathoracic uptake was seen. In 7 patients (7.7%) those uptakes were NSCLC extrathoracic metastasis hidden from conventional staging. In 3 of these cases (13.1%) extrathoracic uptakes corresponded to metacrhonous tumours or pre-malignant conditions. Benign lesions were found in 12 patients (13.1%), and in 2 cases (2.2%) the uptake origins were undetermined.

Conclusions

PET/CT is a complementary diagnosis method for assessing hidden metastases which could modify the therapeutical approach in patients otherwise suitable for surgery.

Keywords:
Bronchogenic carcinoma
Positron emission tomography
Clinical staging
Hidden metastases
Resumen
Introducción

La tomografía de emisión de positrones asociada a la tomografía axial computerizada (PET/ TC) se utiliza en la estadificación del carcinoma broncogénico no microcítico (CBNM). El objetivo de este trabajo es describir la utilidad de la PET/TC en la estadificación clínica del CBNM para la detección de metástasis extratorácicas insospechadas en una población operable con un tumor aparentemente resecable antes de la evaluación ganglionar mediastínica pretoracotomí.

Pacientes y método

Estudio prospectivo y concurrente de todos los casos de CBNM recogidos entre junio 2004 y noviembre 2006, a los que se realizó una PET/TC tras considerar al paciente operable y al tumor resecable tras realizar broncoscopia, TC toracoabdominal, y TC cerebral o gammagrafía ósea si hubiesen datos clínicos sugerentes de metástasis a esos niveles. La metástasis fueron confirmadas por evidencia citohistológica o por la evolución.

Resultados

Se realizó una PET/TC a 91 pacientes con CBNM. En 24 pacientes (26%) se objetivó la existencia de, al menos, una captación extratorácica. En 7 pacientes (7,7%) la captación correspondió a una metástasis extratorácica del CBNM, oculta a la estadificacion convencional. En 3 casos (3,2%) la captación extratorácica correspondió a lesiones premalignas o a un segundo tumor primario. En 12 pacientes (13,1%) el hallazgo correspondía a lesiones benignas, y finalmente en 2 casos (2,2%) no se pudo determinar el origen de la captación.

Conclusiones

La PET/TC indicada en pacientes operables con CBNM potencialmente resecables supone un elemento diagnóstico de utilidad en la detección de metástasis ocultas que afecta a la toma de decisiones terapéuticas.

Palabras clave:
Carcinoma broncogénico
Tomografía de emisión de positrones
Estadificación clínica
Metástasis ocultas
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