array:23 [
  "pii" => "S0300289620301071"
  "issn" => "03002896"
  "doi" => "10.1016/j.arbres.2020.03.026"
  "estado" => "S300"
  "fechaPublicacion" => "2021-02-01"
  "aid" => "2457"
  "copyright" => "SEPAR"
  "copyrightAnyo" => "2020"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2021;57:101-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0300289620301393"
    "issn" => "03002896"
    "doi" => "10.1016/j.arbres.2020.04.020"
    "estado" => "S300"
    "fechaPublicacion" => "2021-02-01"
    "aid" => "2488"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2021;57:107-14"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Diferencias de g&#233;nero en las publicaciones originales de <span class="elsevierStyleItalic">Archivos de Bronconeumolog&#237;a</span> en el periodo 2001-2018"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:3 [
        0 => "es"
        1 => "es"
        2 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "107"
          "paginaFinal" => "114"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Gender Differences in Original <span class="elsevierStyleItalic">Archivos de Bronconeumolog&#237;a</span> Publications&#44; 2001-2018"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0035"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 1085
              "Ancho" => 837
              "Tamanyo" => 76163
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Daniel L&#243;pez-Padilla, Francisco Garc&#237;a-R&#237;o, Adolfo Alonso-Arroyo, Nuria Arenas Valls, Alicia Cerezo Lajas, Marta Corral Blanco, Virginia Gallo Gonz&#225;lez, Milagros Llanos Flores, Mar&#237;a Mart&#237;nez Redondo, Natalia Martos Gisbert, Elena Ojeda Castillejo, Marta Padilla Bern&#225;ldez, Marta P&#233;rez Gall&#225;n, Vania Prudencio Ribera, Luis Puente Maestu, Beatriz Recio Moreno, Elena Rodr&#237;guez Jimeno, Ana S&#225;nchez Azofra, Gonzalo Segrelles-Calvo, Jos&#233; Rafael Ter&#225;n Tinedo, Perla Valenzuela Reyes, Jos&#233; Ignacio de Granda-Orive"
          "autores" => array:22 [
            0 => array:2 [
              "nombre" => "Daniel"
              "apellidos" => "L&#243;pez-Padilla"
            ]
            1 => array:2 [
              "nombre" => "Francisco"
              "apellidos" => "Garc&#237;a-R&#237;o"
            ]
            2 => array:2 [
              "nombre" => "Adolfo"
              "apellidos" => "Alonso-Arroyo"
            ]
            3 => array:2 [
              "nombre" => "Nuria"
              "apellidos" => "Arenas Valls"
            ]
            4 => array:2 [
              "nombre" => "Alicia"
              "apellidos" => "Cerezo Lajas"
            ]
            5 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Corral Blanco"
            ]
            6 => array:2 [
              "nombre" => "Virginia"
              "apellidos" => "Gallo Gonz&#225;lez"
            ]
            7 => array:2 [
              "nombre" => "Milagros"
              "apellidos" => "Llanos Flores"
            ]
            8 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Mart&#237;nez Redondo"
            ]
            9 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Martos Gisbert"
            ]
            10 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Ojeda Castillejo"
            ]
            11 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "Padilla Bern&#225;ldez"
            ]
            12 => array:2 [
              "nombre" => "Marta"
              "apellidos" => "P&#233;rez Gall&#225;n"
            ]
            13 => array:2 [
              "nombre" => "Vania"
              "apellidos" => "Prudencio Ribera"
            ]
            14 => array:2 [
              "nombre" => "Luis"
              "apellidos" => "Puente Maestu"
            ]
            15 => array:2 [
              "nombre" => "Beatriz"
              "apellidos" => "Recio Moreno"
            ]
            16 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Rodr&#237;guez Jimeno"
            ]
            17 => array:2 [
              "nombre" => "Ana"
              "apellidos" => "S&#225;nchez Azofra"
            ]
            18 => array:2 [
              "nombre" => "Gonzalo"
              "apellidos" => "Segrelles-Calvo"
            ]
            19 => array:2 [
              "nombre" => "Jos&#233; Rafael"
              "apellidos" => "Ter&#225;n Tinedo"
            ]
            20 => array:2 [
              "nombre" => "Perla"
              "apellidos" => "Valenzuela Reyes"
            ]
            21 => array:2 [
              "nombre" => "Jos&#233; Ignacio"
              "apellidos" => "de Granda-Orive"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0035"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1579212920303694"
        "doi" => "10.1016/j.arbr.2020.04.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920303694?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620301393?idApp=UINPBA00003Z"
    "url" => "/03002896/0000005700000002/v1_202102021106/S0300289620301393/v1_202102021106/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0300289620300120"
    "issn" => "03002896"
    "doi" => "10.1016/j.arbres.2019.12.025"
    "estado" => "S300"
    "fechaPublicacion" => "2021-02-01"
    "aid" => "2382"
    "copyright" => "SEPAR"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2021;57:94-100"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Manejo cl&#237;nico de la EPOC en situaci&#243;n de vida real&#46; An&#225;lisis a partir de <span class="elsevierStyleItalic">big data</span>"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:3 [
        0 => "es"
        1 => "es"
        2 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "94"
          "paginaFinal" => "100"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Clinical Management of COPD in a Real-World Setting&#46; A Big Data Analysis"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0020"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 799
              "Ancho" => 1333
              "Tamanyo" => 77899
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Jos&#233; Luis Izquierdo, Diego Morena, Yolanda Gonz&#225;lez, Jos&#233; Manuel Paredero, Bernardino P&#233;rez, Desir&#233;e Graziani, Matilde Guti&#233;rrez, Jos&#233; Miguel Rodr&#237;guez"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "Izquierdo"
            ]
            1 => array:2 [
              "nombre" => "Diego"
              "apellidos" => "Morena"
            ]
            2 => array:2 [
              "nombre" => "Yolanda"
              "apellidos" => "Gonz&#225;lez"
            ]
            3 => array:2 [
              "nombre" => "Jos&#233; Manuel"
              "apellidos" => "Paredero"
            ]
            4 => array:2 [
              "nombre" => "Bernardino"
              "apellidos" => "P&#233;rez"
            ]
            5 => array:2 [
              "nombre" => "Desir&#233;e"
              "apellidos" => "Graziani"
            ]
            6 => array:2 [
              "nombre" => "Matilde"
              "apellidos" => "Guti&#233;rrez"
            ]
            7 => array:2 [
              "nombre" => "Jos&#233; Miguel"
              "apellidos" => "Rodr&#237;guez"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0020"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1579212920303931"
        "doi" => "10.1016/j.arbr.2019.12.023"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920303931?idApp=UINPBA00003Z"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300120?idApp=UINPBA00003Z"
    "url" => "/03002896/0000005700000002/v1_202102021106/S0300289620300120/v1_202102021106/es/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
    "titulo" => "Surgical Outcomes in a Lung Cancer-Screening Program Using Low Dose Computed Tomography"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "101"
        "paginaFinal" => "106"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "M&#46; Mesa-Guzm&#225;n, J&#46; Gonz&#225;lez, A&#46;B&#46; Alcaide, J&#46; Bert&#243;, J&#46;P&#46; de-Torres, A&#46; Campo, L&#46;M&#46; Seijo, M&#46;M&#46; Oc&#243;n, J&#46;C&#46; Pueyo, G&#46; Bastarrika, M&#46;D&#46; Lozano, R&#46; P&#237;o, L&#46;M&#46; Montuenga, M&#46; Garc&#237;a-Granero, J&#46; Zulueta"
        "autores" => array:15 [
          0 => array:4 [
            "nombre" => "M&#46;"
            "apellidos" => "Mesa-Guzm&#225;n"
            "email" => array:1 [
              0 => "mmesag@unav.es"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Gonz&#225;lez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "A&#46;B&#46;"
            "apellidos" => "Alcaide"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Bert&#243;"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "J&#46;P&#46;"
            "apellidos" => "de-Torres"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Campo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "L&#46;M&#46;"
            "apellidos" => "Seijo"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">j</span>"
                "identificador" => "aff0050"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "M&#46;M&#46;"
            "apellidos" => "Oc&#243;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "J&#46;C&#46;"
            "apellidos" => "Pueyo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Bastarrika"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "M&#46;D&#46;"
            "apellidos" => "Lozano"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "P&#237;o"
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              3 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "L&#46;M&#46;"
            "apellidos" => "Montuenga"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Garc&#237;a-Granero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          14 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Zulueta"
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">i</span>"
                "identificador" => "aff0045"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:10 [
          0 => array:3 [
            "entidad" => "Departamento de Cirug&#237;a Tor&#225;cica&#44; Cl&#237;nica Universidad de Navarra&#44; Pamplona&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Neumolog&#237;a&#44; Cl&#237;nica Universidad de Navarra&#44; Pamplona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Neumolog&#237;a&#44; Cl&#237;nica Universidad de Navarra&#44; Madrid&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Departamento de Radiolog&#237;a&#44; Cl&#237;nica Universidad de Navarra&#44; Pamplona&#44; Spain"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Departamento de Anatom&#237;a Patol&#243;gica&#44; Cl&#237;nica Universidad de Navarra&#44; Pamplona&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n de Medicina Aplicada &#8211; CIMA&#44; Universidad de Navarra&#44; Pamplona&#44; Spain"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Departamento de Bioqu&#237;mica y Gen&#233;tica&#44; Universidad de Navarra&#44; Pamplona&#44; Spain"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n Biom&#233;dica en Red de C&#225;ncer &#40;CIBERONC&#41;&#44; Madrid&#44; Spain"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
          8 => array:3 [
            "entidad" => "Instituto de Investigaci&#243;n Sanitaria de Navarra &#40;IdiSNA&#41;&#44; Pamplona&#44; Spain"
            "etiqueta" => "i"
            "identificador" => "aff0045"
          ]
          9 => array:3 [
            "entidad" => "Centro de Investigaci&#243;n Biom&#233;dica en Red de Enfermedades Respiratorias &#40;CIBERES&#41;&#44; Madrid&#44; Spain"
            "etiqueta" => "j"
            "identificador" => "aff0050"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Resultados quir&#250;rgicos de un programa de cribado de c&#225;ncer de pulm&#243;n utilizando tomograf&#237;a computarizada de baja dosis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 1
      "multimedia" => array:5 [
        "identificador" => "fig0015"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 687
            "Ancho" => 1333
            "Tamanyo" => 78736
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Lung cancer &#40;LC&#41; is the leading cause of cancer-related deaths worldwide&#44; with 1&#46;8 million lung cancer deaths each year&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">1</span></a> Overall survival has not changed significantly in decades despite improvements in surgical treatment&#44; chemotherapy&#44; and radiotherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">2</span></a> The poor survival rates are mainly a result of advanced stage at diagnosis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Lung cancer screening &#40;LCS&#41; with the use of low dose computed tomography &#40;LDCT&#41; is effective in detecting LC in early stages and reducing mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">3&#8211;6</span></a> The International Early Lung Cancer Action Program &#40;I-ELCAP&#41;&#44; showed in 2006 that 85&#37; of LC cases diagnosed by LDCT were in stage I with an estimated survival of 88&#37; at 10 years&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">In 2011 the National Lung Screening Trial &#40;NLST&#41;&#44; a randomized controlled trial&#44; showed that LCS with LDCT reduces mortality in a high-risk population by 20&#37; compared to screening with chest X-ray&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">8</span></a> The United Stated Preventive Services Task Force recommends screening with LDCT for individuals meeting NLST inclusion criteria since 2013&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Implementation of LCS guidelines in the United States is ongoing&#46; Widespread screening in Europe <a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">10</span></a> was precluded until the result of the Dutch-Belgian NELSON study were published&#46; This publication has now finally been published <a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">11</span></a> reported that LCS can significantly reduce deaths from lung cancer at 10 years by 24&#37; in men and up to 33&#37; in women compared to control&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Despite such promising results&#44; screening skeptics continue to argue that LCS may cause harm by leading to invasive procedures in asymptomatic individuals with false positive screening findings&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">12</span></a> Our group has published several papers analyzing different aspects related to this lung cancer screening cohort&#46;<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">13&#8211;16</span></a> The work presented here is an analysis from a surgical point of view of the longest running lung cancer screening program in Europe&#44; at the Cl&#237;nica Universidad de Navarra&#44; a program that is part of the I-ELCAP consortium since its inception in 1999&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">3&#44;15</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Materials and Methods</span><p id="par0030" class="elsevierStylePara elsevierViewall">This is a retrospective descriptive analysis of a prospectively recruited cohort&#46; Study subjects enrolled in the Pamplona International Program for Early Detection of Lung Cancer with LDCT &#40;P-ELCAP&#41;&#46; Patients undergoing surgery based on screening findings are included in this study&#46; Recruitment began in September of 2000 and is ongoing&#46; Patient follow up is based on the I-ELCAP protocol&#44; details of which are available online at <a href="http://www.ielcap.org/">www&#46;ielcap&#46;org</a>&#46; Inclusion criteria at our center include age<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>40&#44; and a smoking history of &#8805;10 pack-years&#46; Subjects must be asymptomatic&#46; Those with a history of cancer diagnosed within the previous 5 years are excluded&#46; Baseline LDCT and spirometry are performed in all cases&#44; and periodic follow up with LDCT is recommended thereafter&#46; Subjects with abnormal LDCT findings are managed according to the I-ELCAP protocol&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">17</span></a> Briefly&#44; for positive results on the baseline LDCT &#40;noncalcified nodules &#8805;5<span class="elsevierStyleHsp" style=""></span>mm&#41; additional diagnostic studies are recommended depending on the size and characteristics of a given nodule&#44; and may include PET-CT scanning&#44; antibiotic treatment with follow up LDCT at 1&#8211;3 months&#44; bronchoscopy&#44; transthoracic fine needle aspiration&#44; or surgical biopsy&#46; Subjects with a negative LDCT &#40;without pulmonary nodules or with non-calcified nodules &#60;5<span class="elsevierStyleHsp" style=""></span>mm&#41; are scheduled for an annual visit&#46; Annual LDCT is considered abnormal when a new nodule of any size is found or when a previously identified nodule grows&#44; prompting ancillary studies&#46; Prior to pulmonary resection&#44; the mediastinum was further assessed&#44; endobronchial ultrasound &#40;EBUS&#41;&#44; through endoscopic ultrasound &#40;EUS&#41; or mediastinoscopy&#46; In all cases&#44; a multidisciplinary team made up of pathologists&#44; oncologists&#44; pulmonologists&#44; radiologists and thoracic surgeons decided whether surgical or oncological interventions were required&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">For the purpose of the current study&#44; the following parameters were considered&#58; demographics&#44; preoperative tests&#44; surgical approach&#44; type of lung resection&#44; immediate and late post-surgical complications&#44; anatomopathological results&#44; stages&#44; and survival&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Respiratory health status was determined by smoking status and the presence or absence of chronic obstructive pulmonary disease &#40;COPD&#41;&#44; defined as postbronchodilator FEV1&#47;FVC<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>70&#37;&#44; the presence of emphysema on LDCT&#44; or both&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Staging of LC and definition of a metachronous tumor were defined according to the 8th edition of the international TNM classification&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">18</span></a> Mediastinal nodal dissection &#40;MLND&#41; was performed according to the European Society of Thoracic Surgeons guidelines&#44;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">19</span></a> i&#46;e&#46;&#44; at least three mediastinal nodal stations&#44; including the subcarinal lymph node&#44; were excised&#46; Mediastinal lymph node sampling &#40;MLNS&#41; was defined just as the removal of one or more lymph nodes&#44; guided by preoperative or intraoperative findings at the surgeon&#39;s discretion&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A false positive of the screening process was considered when a patient underwent surgery after all pre-surgical diagnostic tests &#40;including LDCTs&#41; could not rule out lung cancer&#44; and the pathology of the resected lesion was consistent with a benign diagnosis&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Data Analysis</span><p id="par0055" class="elsevierStylePara elsevierViewall">Quantitative data are presented as mean and standard deviation &#40;SD&#41;&#46; Categorical data were described using absolute and relative frequencies&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Lung cancer prevalence and incidence rates were calculated according to whether the diagnosis was based on the results of the baseline evaluation or on one of the follow-up screening rounds&#44; respectively&#46; Operative mortality included patients who died within 30 days&#46; Medical records were reviewed to obtain mortality data on patients with lung cancer&#44; and a Kaplan&#8211;Meier survival curve was constructed&#46; All statistical analyses were performed using Stata&#47;IC 12&#46;1 &#40;StataCorp&#46; 2011&#46; Stata Statistical Software&#58; Release 12&#46; College Station&#44; TX&#58; StataCorp LP&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Ethics Approval</span><p id="par0065" class="elsevierStylePara elsevierViewall">The University of Navarra&#39;s ethics committee approved the study protocol and all subjects signed an informed consent prior to enrollment in LCS&#46;</p></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Result</span><p id="par0070" class="elsevierStylePara elsevierViewall">Between September 2000 to December 2019&#44; 97 LC &#40;2&#46;5&#37;&#41; were diagnosed in 3825 participants screened&#46; Twenty patients had no surgery due to advanced stage or small cell histology and were referred to chemo-radiotherapy or SBRT&#46; Eighty-seven surgeries were performed in 75 patients for suspected LC&#46; When a pre-operative biopsy was not feasible&#44; we used wedge resection and frozen section as diagnostic tools&#46; In case of lung cancer&#44; the resection was performed during the same procedure&#44; except in three patients&#44; who had a wedge resection followed by a second surgery to complete the resection&#44; due to an uncertain intraoperative diagnosis&#44; once the definitive pathology results were known&#46; Only 14 patients had a non-surgical preoperative diagnosis of LC obtained by CT-guided fine needle aspiration cytology &#40;FNAC&#41; &#40;7&#41;&#44; bronchoscopy &#40;4&#41;&#44; EBUS &#40;1&#41;&#44; and EUS &#40;2&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">Nine patients underwent a second operation for a metachronous primary lung cancer&#46; One patient had a synchronous tumor resected in the same lobe&#46; Eight &#40;9&#46;2&#37;&#41; patients were false positive of the screening process and all of them had diagnostic wedge resections &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; One individual had 2 surgeries for a LC and a benign lesion&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">To maintain data independence&#44; only the therapeutic surgeries and the first surgery of the metachronous cases &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>67&#41; were taken into consideration for descriptive and statistical analysis in LC patients&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Fifty-seven &#40;85&#37;&#41; patients were male with a mean age of 67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;1 years&#46; Mean tumor size was 15&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;6&#46; Seven patients &#40;10&#46;5&#37;&#41; had COPD&#44; 21 &#40;31&#46;3&#37;&#41; had emphysema&#44; 28 &#40;41&#46;8&#37;&#41; had both&#44; and 11 &#40;16&#46;4&#37;&#41; had neither of those key respiratory comorbidities &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Surgical approaches included 44 posterolateral &#40;65&#46;7&#37;&#41;&#44; 4 anterolateral &#40;6&#37;&#41;&#44; and 3 axillary thoracotomies &#40;4&#46;5&#37;&#41;&#44; 1 robotic-assisted thoracic surgery &#40;RATS&#41; &#40;1&#46;5&#37;&#41;&#44; and 15 video-assisted thoracoscopic surgeries &#40;VATS&#41; &#40;22&#46;4&#37;&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Surgical lobectomy was performed in 56 cases &#40;83&#46;6&#37;&#41;&#46; Sublobar resections included&#59; 3 anatomical segmentectomies &#40;4&#46;5&#37;&#41; for tumors measuring less than 1<span class="elsevierStyleHsp" style=""></span>cm and clinical stage IA in which margins were confirmed intraoperatively to be &#62;1<span class="elsevierStyleHsp" style=""></span>cm&#44; and 7 &#40;10&#46;5&#37;&#41; wedge resections in patients with limited lung function&#46; One pneumonectomy &#40;1&#46;5&#37;&#41; was performed for a central tumor&#46; Thirty-seven &#40;55&#46;2&#37;&#41; patients underwent MLND and 30 &#40;44&#46;8&#37;&#41; had MLNS&#46; Adenocarcinoma &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#44; 58&#46;2&#37;&#41; was the most frequent histological type followed by squamous cell carcinoma &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#44; 25&#46;7&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Sixteen complications were reported in 13 patients&#44; including&#59; persistent air leak &#40;5&#41;&#44; atrial fibrillation &#40;2&#41;&#44; and acute urinary retention &#40;4&#41;&#44; re-intervention due to bleeding &#40;3&#41;&#44; pneumonia &#40;1&#41;&#44; and empyema &#40;1&#41;&#46; There were no complications in the false positives of the screening process patients&#46; One patient &#40;1&#46;2&#37;&#41; died from postoperative acute respiratory distress syndrome following a second pulmonary resection surgery due to a confirmed contralateral Stage II metachronous tumor&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Of the 67 patients&#44; 40 &#40;59&#46;7&#37;&#41; were diagnosed in the baseline screening of which 87&#46;5&#37; were in stage I&#46; Twenty-seven &#40;40&#46;3&#37;&#41; patients were diagnosed in annual screenings&#44; 88&#46;9&#37; of which were in stage I &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Fifty-nine patients &#40;88&#46;1&#37;&#41; were diagnosed in Stage I&#44; 4 in Stage II &#40;6&#37;&#41; and another 4 in stage III &#40;6&#37;&#41;&#46; The estimated overall survival rates at 5 and 10 years were 88&#37; &#40;95&#37; CI&#58; 77&#37;&#8211;95&#37;&#41; and 80&#37; &#40;95&#37; CI&#58; 65&#37;&#8211;90&#37;&#41;&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#44; and the 5 and 10 year survival rates for stage I patients were 93&#37; &#40;95&#37; CI&#58; 79&#37;&#8211;98&#37;&#41; and 83&#37; &#40;95&#37; CI&#58; 65&#37;&#8211;92&#37;&#41;&#44; respectively &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Discussion</span><p id="par0115" class="elsevierStylePara elsevierViewall">Our study confirms previous findings regarding favorable surgical outcomes in the LCS setting&#44; with overall five and 10-year survival rates of 88&#37; and 80&#37;&#44; respectively&#46; The majority of subjects in this cohort underwent lobectomies via thoracotomy&#44; a surgical approach that may become obsolete as sublobar resections and minimal invasive techniques become more prevalent in the LCS setting&#46; Nevertheless&#44; the surgical treatment of lung cancer in early stages and the extent of lung resections&#44; with its implications for survival&#44; still requires extensive research&#46; In our series&#44; a lobectomy was considered the &#8220;gold standard&#8221; of pulmonary resection for patients with adequate lung function and a confirmed diagnosis of malignancy&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Most retrospective studies have shown that VATS segmentectomy may be a valid procedure lung cancer patients in clinical stage I&#44;<a class="elsevierStyleCrossRefs" href="#bib0335"><span class="elsevierStyleSup">20&#8211;23</span></a> with lower complication rates and shorter hospital stays&#44; and no differences in terms of overall survival&#46; Two randomized controlled trials in progress will attempt to answer these questions &#40;CALGB 140503 and JCOG0802&#47;WJOG4607L&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">24&#44;25</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Only 22&#46;4&#37; of the surgeries in our study were VATS&#44; mainly due to the slow implementation of VATS in our center&#46; It has been shown that&#44; as compared to open classical thoracotomy&#44; VATS is associated with a significant reduction in perioperative morbidity and mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">26</span></a> In a randomized trial&#44; Bendixen et al&#46; observed that when compared to antero-lateral thoracotomy&#44; VATS is associated with less postoperative pain and better quality of life during the first year after surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">27</span></a> Preliminary results of the VIOLET trial&#44;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">28</span></a> a randomized multicenter trial in the United Kingdom led by Dr&#46; Eric Lim comparing the performance and morbidity of VATS with open thoracotomy&#44; showed that patients who received VATS had a significant reduction in overall in-hospital complications and stayed in hospital one day less compared to patients who received open surgery&#46; That notwithstanding&#44; oncologic outcomes were similar&#46; Therefore&#44; it appears that minimal invasive approaches may well become the surgery of choice for LC resections and even moreso in the context of LCS&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">In our series&#44; 55&#46;2&#37; of the subjects underwent systematic lymph node dissection&#46; Controversy persists regarding the optimal extent of lymph node dissection in early stage LC&#46; European Thoracic Surgery Society guidelines recommended a systematic dissection of nodes at all stages in 2006 to ensure complete resection and adequate staging&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">19</span></a> Lobe specific nodal dissection is considered acceptable for peripheral T1 lesions if hilar and interlobar nodes are negative at intra operative frozen section&#46; A similar recommendation was proposed in 2010 by the British Thoracic Society&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">29</span></a> Subsequently&#44; in a randomized controlled trial comparing mediastinal lymph node dissection &#40;MLND&#41; vs&#46; sampling after negative side-specific hilar and mediastinal lymph node sampling&#44; Darling et al&#46; demonstrated that MLND did not improve survival nor did it decrease the incidence of local or regional recurrence of patients with early-stage non small cell LC&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">30</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">In our cohort&#44; an overall positive effect on survival rates was observed in the MLND group &#40;log-rank-test <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;04&#41;&#46; However&#44; when we split the data set according to early &#40;I&#41; and more advanced stages &#40;II and III&#41;&#44; the difference between MLND and MLNS only held true for the former&#46; There is inconsistency among published reports in early stage NSCLC&#44; which could be related to tumor size&#46;<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">31&#44;32</span></a> Lymphadenectomy and the extent of lung resection in LCS early stage disease should benefit from further prospective studies and larger sample sizes&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Ongoing studies&#44; like IELCART &#40;Initiative for Early Lung Cancer Research on Treatment&#41;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">33</span></a> in which our institution participates&#44; aim to advance knowledge regarding the optimal surgical treatment of patients with early stage LC&#46; Key variables include&#59; the type of resection&#44; standardization of margin measurements&#44; extent of lymphadenectomy&#44; and alternative therapeutic approaches &#40;SBRT or watchful waiting&#41;&#44; as well as the impact on quality of life&#44; recurrence rates&#44; and long-term survival&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Interestingly&#44; after the diagnosis and surgical treatment of a first LC we found a significant number of patients with a second metachronic primary tumor that met the Martini-Melamed and the IASLC criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">18</span></a> This raises an important issue&#46; Patients with lung cancer are at a very high risk of developing additional lung cancers&#46; In our cohort&#44; 9 patients had more than one metachronous cancer&#46; Since most patients with lung cancer also have co-existing lung disease&#44; such as COPD and emphysema&#44;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">34</span></a> a conservative lung-sparing surgical approach may be important since additional resections may be in store for a given LCS patient&#46; In addition&#44; this increased risk for subsequent lung cancers underlines the need for continuing lung cancer screening in patients who undergo resection&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">35</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">On the other hand&#44; one of the main obstacles of LCS is the very nature of an early detection program&#44; in which the suspicious lesions are almost always small&#46; They may not be anatomically located in peripheral or accessible areas and&#47;or have a partially solid consistency&#44; which would make it difficult&#44; or even impossible&#44; to obtain a preoperative diagnosis via transthoracic or endoscopic needle aspiration&#46; Therefore&#44; it is not unusual for surgery to be both diagnostic and therapeutic in this setting&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Our series demonstrated certain limitations to obtain a preoperative diagnosis with only 16&#37; of surgical patients&#46; Those indeterminate cases&#44; which require diagnostic surgery&#44; demand a biopsy of the suspicious lesion in order to allow an adequate intraoperative diagnosis and by consequence&#44; the definition of the extent of the curative pulmonary resection&#46; The reason why most nodules are undiagnosed prior to surgery is likely the small size and location&#46; This also entails difficulties for intraoperative diagnosis due to the limitations for the surgeon to see and feel the lesions in the context of minimal invasive surgery&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Therefore&#44; identifying and locating these lesions has become a veritable challenge&#44; which has created a surge in different preoperative marking alternatives&#46; This is why preoperative marking of lesions is a tool which every LCS Program must count on&#46;<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">36&#44;37</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Having a high proportion of undiagnosed patients making it to the operating room&#44; together with the false-positive rate described&#44; suggests that proper risk assessment&#44; compliance with a correct diagnostic algorithm&#44; and a consensus decision by an expert multidisciplinary committee are key in LCS&#46; Unnecessary invasive procedures must be limited in order for LCS to succeed&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The results in this cohort&#44; with 9&#46;2&#37; of false positives of the screening process that underwent surgery&#44; coincide with the results of I-ELCAP&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Several strategies have been suggested to decrease it&#46; Firstly&#44; a better selection of the inclusion criteria&#44; which would lead to a more precise definition of high-risk candidates&#44; should be considered&#46; Standardized and structured reporting systems such as Lung-RADS<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">38</span></a> or the I-ELCAP management system<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">17</span></a> should be used&#46; Refined diagnostic algorithms determined under consensus and scientific evidence should be adapted&#44; and prediction tools for risk analysis should be established&#46;<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">39&#44;40</span></a> Finally&#44; well validated radiological techniques&#44; such as the volumetric study of indeterminate pulmonary nodules&#44;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">41</span></a> artificial intelligence and radiomic lung nodules prediction models&#44;<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">42&#44;43</span></a> should all be encouraged&#46; These&#44; together with the management by an expert multidisciplinary team&#44; have demonstrated their effectiveness in minimizing surgical intervention for benign disease&#44; minimizing the number of missed curable LC&#46; Even so&#44; false positives would be difficult to avoid completely&#46; The evidence of surgical procedures for benign disease in LCS with LDCT varies from 0&#37; to 33&#37;&#44; with an average of 18&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">44</span></a> Wilson and colleagues evaluated 3642 participants in the PLUSS <a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">45</span></a> study using an internal protocol&#46; Eighty-two &#40;2&#46;3&#37;&#41; underwent surgical procedures&#44; 28 of which &#40;34&#37;&#41; had benign disease&#46; The study investigators cited &#8220;an apparent generalized bias toward aggressive intervention&#8221; for indeterminate pulmonary nodules&#46; The DLCTS &#40;Danish Lung Cancer Screening Trial&#41; group reported 12&#37; of false-positive surgeries&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">36</span></a> Our results show that following validated management protocols&#44; such as that of IELCAP&#44; can minimize the number of individuals who undergo surgery for a benign lesion&#46; Albeit&#44; of those who unfortunately still underwent surgery&#44; none showed any consequential complications&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">We agree with current European guidelines suggesting that LCS should guarantee comprehensive quality of care and be led by an expert multidisciplinary team that provides high quality&#44; timely&#44; continuous and comprehensive information on the benefits and risks of screening&#46; Informed decision-making eliminates misperceptions and reduces the psychological burden related to diagnostic and therapeutic interventions&#46; The multidisciplinary team should include surgeons with experience in minimally invasive procedures and should be equipped with technical and&#47;or technological tools that allow for intra-operative localization of small nodules&#46; Furthermore&#44; we must not forget that every LCS program must include smoking cessation and should emphasize the importance of adherence to the program with a commitment to annual screening even in the face of prior negative results&#44; a limitation already described by programs like ours&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">15&#44;46&#44;47</span></a></p><p id="par0185" class="elsevierStylePara elsevierViewall">One potential limitation of this study is that it is based on data from a single center&#59; therefore&#44; our population&#44; resources&#44; and staffing characteristics may limit the generalizability of our results&#46; However&#44; we believe that surgery for lung cancer is quite standardized across Centers and that similar results will probably be achieved by others&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">In summary&#44; our results show that lung cancer screening is effective in detecting lung cancer at early stages&#44; and that the majority of patients achieve long term survival after surgical resection&#46; Ongoing research trials will help determine what the optimal surgical approach is for these patients&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Funding Source</span><p id="par0195" class="elsevierStylePara elsevierViewall">The authors received no specific funding for this work&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conflict of Interests</span><p id="par0200" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interests&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:13 [
        0 => array:3 [
          "identificador" => "xres1458550"
          "titulo" => "Graphical abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:3 [
          "identificador" => "xres1458551"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        2 => array:2 [
          "identificador" => "xpalclavsec1329604"
          "titulo" => "Keywords"
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1329605"
          "titulo" => "Abbreviations"
        ]
        4 => array:3 [
          "identificador" => "xres1458552"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        5 => array:2 [
          "identificador" => "xpalclavsec1329603"
          "titulo" => "Palabras clave"
        ]
        6 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        7 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Materials and Methods"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Data Analysis"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Ethics Approval"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Result"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Discussion"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Funding Source"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Conflict of Interests"
        ]
        12 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2020-01-25"
    "fechaAceptado" => "2020-03-21"
    "PalabrasClave" => array:2 [
      "en" => array:2 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1329604"
          "palabras" => array:6 [
            0 => "Lung cancer"
            1 => "Screening"
            2 => "Surgery"
            3 => "Survival"
            4 => "Low-dose CT"
            5 => "P-IELCAP"
          ]
        ]
        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
          "identificador" => "xpalclavsec1329605"
          "palabras" => array:18 [
            0 => "LC"
            1 => "LCS"
            2 => "LDCT"
            3 => "I-ELCAP"
            4 => "NLST"
            5 => "NELSON"
            6 => "P-ELCAP"
            7 => "EBUS"
            8 => "EUS"
            9 => "COPD"
            10 => "MLND"
            11 => "MLNS"
            12 => "SBRT"
            13 => "FNAC"
            14 => "VATS"
            15 => "RATS"
            16 => "CI"
            17 => "SD"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1329603"
          "palabras" => array:6 [
            0 => "C&#225;ncer de pulm&#243;n"
            1 => "Cribado"
            2 => "Cirug&#237;a"
            3 => "Supervivencia"
            4 => "Tomograf&#237;a computarizada de baja dosis"
            5 => "P-IELCAP"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Lung cancer &#40;LC&#41; is the leading cause of death from cancer worldwide&#46; More than 27&#44;000 LCs are diagnosed annually in Spain&#44; and most are unresectable&#46; Early detection and treatment reduce LC mortality&#46; This study describes surgical outcomes in a longstanding LC screening cohort in Spain&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We conducted a retrospective study of surgical outcomes in a LC screening &#40;LCS&#41; program using low dose computed tomography &#40;LDCT&#41; since the year 2000&#46; A descriptive analysis of clinical and radiological parameters&#44; presence or absence of a preoperative diagnosis&#44; pathological staging&#44; morbidity&#44; mortality&#44; and survival was performed&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Ninety-seven &#40;2&#46;5&#37;&#41; LC were diagnosed in 3825 screened&#46; Twenty individuals with LC had no surgery due to advanced stage or small cell histology&#46; Eighty-seven surgical procedures were carried out for suspected or biopsy proven LC&#44; detected by LDCT&#46; Most operated patients were male &#40;57&#91;85&#37;&#93;&#41; aged 64<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#46;1 years&#46; Nine patients underwent a second operation for a metachronous primary lung cancer&#46; Mean tumor size was 15&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;6<span class="elsevierStyleHsp" style=""></span>mm&#46; Eight nodules were benign &#40;9&#46;2&#37;&#41;&#46; Lobectomy was performed in 56 cases &#40;83&#46;6&#37;&#41;&#46; Adenocarcinoma &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#59; 58&#46;2&#37;&#41; was the most frequent histological type followed by squamous cell carcinoma &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#59; 25&#46;4&#37;&#41;&#46; Fifty-nine &#40;88&#37;&#41; tumors were in Stage I&#46; Thirteen patients &#40;15&#46;4&#37;&#41; had 16 complications&#46; The estimated survival rates at 5 and 10 years for stage I were 93&#37; &#40;95&#37; CI&#58; 79&#37;&#8211;98&#37;&#41; and 83&#37; &#40;95&#37; CI&#58; 65&#37;&#8211;92&#37;&#41;&#44; respectively&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Lung cancer screening was associated with excellent surgical outcomes with 5 and 10-year survival rates exceeding 90 and 80&#37;&#44; respectively&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Objetivo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El c&#225;ncer de pulm&#243;n &#40;CP&#41; es la principal causa de muerte por c&#225;ncer en todo el mundo&#46; En Espa&#241;a se diagnostican anualmente m&#225;s de 27&#46;000 CP y la mayor&#237;a son irresecables&#46; La detecci&#243;n y el tratamiento tempranos reducen la mortalidad por CP&#46; Este estudio describe los resultados quir&#250;rgicos en una cohorte de cribado de CP de larga duraci&#243;n en Espa&#241;a&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">M&#233;todos</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Llevamos a cabo un estudio retrospectivo de los resultados quir&#250;rgicos de un programa de cribado de CP &#40;CCP&#41; usando tomograf&#237;a computarizada de baja dosis &#40;LDCT&#44; por sus siglas en ingl&#233;s&#41; en marcha desde el a&#241;o 2000&#46; Se realiz&#243; un an&#225;lisis descriptivo de los par&#225;metros cl&#237;nicos y radiol&#243;gicos&#44; presencia o ausencia de un diagn&#243;stico preoperatorio&#44; estadificaci&#243;n patol&#243;gica&#44; morbilidad&#44; mortalidad y supervivencia&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se diagnosticaron 97 &#40;2&#44;5&#37;&#41; CP entre 3&#46;825 sujetos cribados&#46; Veinte personas con CP no se sometieron a cirug&#237;a debido a un estado avanzado de la enfermedad o a una histolog&#237;a de c&#233;lulas peque&#241;as&#46; Se llevaron a cabo 87 procedimientos quir&#250;rgicos por sospecha de CP o CP demostrado mediante biopsia&#44; detectados en la LDCT&#46; La mayor&#237;a de los pacientes operados fueron varones &#40;57 &#91;85&#37;&#93;&#41; de 64 a&#241;os<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9&#44;1 a&#241;os&#46; Nueve pacientes se sometieron a una segunda operaci&#243;n por un c&#225;ncer de pulm&#243;n primario metacr&#243;nico&#46; El tama&#241;o medio del tumor fue de 15&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;6<span class="elsevierStyleHsp" style=""></span>mm&#46; Ocho n&#243;dulos fueron benignos &#40;9&#44;2&#37;&#41;&#46; Se realiz&#243; lobectom&#237;a en 56 casos &#40;83&#44;6&#37;&#41;&#46; El adenocarcinoma &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39&#59; 58&#44;2&#37;&#41; fue el tipo histol&#243;gico m&#225;s frecuente seguido por el carcinoma de c&#233;lulas escamosas &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#59; 25&#44;4&#37;&#41;&#59; 59 &#40;88&#37;&#41; tumores se encontraban en estadio I&#46; Trece pacientes &#40;15&#44;4&#37;&#41; tuvieron 16 complicaciones&#46; Las tasas de supervivencia estimadas a los 5 y 10 a&#241;os para el estadio I fueron del 93&#37; &#40;IC 95&#37;&#58; 79 al 98&#37;&#41; y del 83&#37; &#40;IC 95&#37;&#58; 65 al 92&#37;&#41;&#44; respectivamente&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusi&#243;n</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El CCP se asoci&#243; con excelentes resultados quir&#250;rgicos y con tasas de supervivencia a los 5 y 10 a&#241;os superiores al 90 y al 80&#37;&#44; respectivamente&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "apendice" => array:1 [
      0 => array:1 [
        "seccion" => array:1 [
          0 => array:4 [
            "apendice" => "<p id="par0210" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Supplementary data"
            "identificador" => "sec0050"
          ]
        ]
      ]
    ]
    "multimedia" => array:9 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1093
            "Ancho" => 1500
            "Tamanyo" => 100298
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier overall survival curve&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1098
            "Ancho" => 1508
            "Tamanyo" => 102987
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Kaplan&#8211;Meier survival curve for all patients diagnosed as pathologic stage I&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Surgical Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cases &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Preoperative pathological diagnosis obtained by&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;19&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CT guided FNAC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bronchoscopy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EBUS &#40;Endobronchial ultrasound&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">EUS &#40;Endoscopic ultrasound&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Surgical wedge resection<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2509578.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Biopsy without curative resection due to absence of definitive intraoperative diagnosis&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Preoperative Diagnosis Technique&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Benign Lesions&#47;Screening Process False Positives&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cases &#40;<span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Histopathology&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;9&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pulmonary fibrosis&#58; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;37&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lymph node&#58; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sclerosing haemangioma&#58; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atypical adenomatous hyperplasia&#58; <span class="elsevierStyleItalic">N</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chronic inflammatory process&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2509574.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Confirmed Surgical Benign Diagnosis&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Patients Characteristics&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Males&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57 &#40;85&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Females&#44; n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;15&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Age&#44; Mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">BMI&#44; Mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;9 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pack&#47;years&#44; Mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FVC&#44; Mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;9 &#40;0&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FEV1&#44; Mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;6 &#40;31&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FEV1&#47;FVC&#44; Mean &#40;SD&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;9&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Health status&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No COPD nor emphysema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;16&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD &#40;only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;10&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Emphysema &#40;only&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#40;31&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>COPD and emphysema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;41&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2509576.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Patient Characteristics&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Method of resection&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Posterolateral thoracotomy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;65&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Anterolateral thoracotomy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Axillary thoracotomy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Video-assisted thoracoscopic surgery</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;22&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Robotic-assisted thoracic surgery</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Type of resection&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Sublobar</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Segmentectomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;4&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Wedge resection&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;10&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Lobectomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;83&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Pneumonectomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Lymph node resection&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mediastinal lymph node dissection</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;55&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mediastinal lymph node sampling</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;44&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Histopathology&#44;</span><span class="elsevierStyleItalic"><span class="elsevierStyleBold">n</span></span><span class="elsevierStyleBold">&#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Adenocarcinoma</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39 &#40;58&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Squamous</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;25&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Large cell</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;11&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Small cell</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Typical carcinoid</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Atypical carcinoid</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2509575.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Surgical Lung Cancer Patients&#8217; Characteristics&#46;</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0025"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at5"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Surgical Lung Cancer Patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline LDCT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Annual LDCT &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Stage</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;87&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;88&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59 &#40;88&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;7&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;59&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;40&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2509577.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Pathological Staging of Surgical Patients From Baseline and Annual LDCT&#46;</p>"
        ]
      ]
      7 => array:5 [
        "identificador" => "upi0005"
        "tipo" => "MULTIMEDIAECOMPONENTE"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "Ecomponente" => array:2 [
          "fichero" => "mmc1.mp3"
          "ficheroTamanyo" => 11348983
        ]
      ]
      8 => array:5 [
        "identificador" => "fig0015"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 687
            "Ancho" => 1333
            "Tamanyo" => 78736
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:47 [
            0 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer incidence and mortality worldwide&#58; Sources&#44; methods and major patterns in GLOBOCAN 2012"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46; Ferlay"
                            1 => "I&#46; Soerjomataram"
                            2 => "R&#46; Dikshit"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ijc.29210"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Cancer"
                        "fecha" => "2015"
                        "volumen" => "136"
                        "paginaInicial" => "E359"
                        "paginaFinal" => "E386"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25220842"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cancer statistics&#44; 2015"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;L&#46; Siegel"
                            1 => "K&#46;D&#46; Miller"
                            2 => "A&#46; Jemal"
                            3 => "R&#46;L&#46; Siegel"
                            4 => "K&#46;D&#46;J&#46;A&#46; Miller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3322/caac.21254"
                      "Revista" => array:7 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2015"
                        "volumen" => "65"
                        "paginaInicial" => "5"
                        "paginaFinal" => "29"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25559415"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0034935617301160"
                          "estado" => "S300"
                          "issn" => "00349356"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early lung cancer action project&#58; overall design and findings from baseline screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "C&#46;I&#46; Henschke"
                            1 => "D&#46;I&#46; McCauley"
                            2 => "D&#46;F&#46; Yankelevitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(99)06093-6"
                      "Revista" => array:5 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1999"
                        "volumen" => "354"
                        "paginaInicial" => "99"
                        "paginaFinal" => "105"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for early lung cancer with low-dose spiral computed tomography&#58; results of annual follow-up examinations in asymptomatic smokers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Diederich"
                            1 => "M&#46; Thomas"
                            2 => "M&#46; Semik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00330-003-2200-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2004"
                        "volumen" => "14"
                        "paginaInicial" => "691"
                        "paginaFinal" => "702"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14727146"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "S&#46; Sone"
                            1 => "F&#46; Li"
                            2 => "Z&#46;G&#46; Yang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1054/bjoc.2000.1531"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2001"
                        "volumen" => "84"
                        "paginaInicial" => "25"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11139308"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0196070915000630"
                          "estado" => "S300"
                          "issn" => "01960709"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for lung cancer with low-dose helical computed tomography&#58; anti-lung cancer association project"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "T&#46; Sobue"
                            1 => "N&#46; Moriyama"
                            2 => "M&#46; Kaneko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1200/JCO.2002.20.4.911"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Oncol"
                        "fecha" => "2002"
                        "volumen" => "20"
                        "paginaInicial" => "911"
                        "paginaFinal" => "920"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11844811"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "International Early Lung Cancer Action Program Investigators&#44; Henschke CI&#44; Yankelevitz DF&#44; et al&#46; Survival of patients with stage I lung cancer detected on CT screening&#46; N Engl J Med&#46; 2006&#59;355&#58;1763&#8211;71&#44; <a target="_blank" href="https://doi.org/10.1056/NEJMoa060476">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1056&#47;NEJMoa060476</a>"
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "NLST Team&#44; Aberle DR&#44; Adams AM BC&#44; Black WC&#44; Clapp JD&#44; Fagerstrom RM&#44; et al&#46; Reduced lung-cancer mortality with low-dose computed tomographic screening &#8211; the national lung screening trial research team&#46; N Engl J Med&#46; 2011&#59; 365&#58;395&#8211;409&#44; <a target="_blank" href="https://doi.org/10.1056/NEJMoa1102873.Reduced">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1056&#47;NEJMoa1102873&#46;Reduced</a>"
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening for lung cancer with low-dose computed tomography&#58; a systematic review to update the US Preventive services task force recommendation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "L&#46;L&#46; Humphrey"
                            1 => "M&#46; Deffebach"
                            2 => "M&#46; Pappas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-159-6-201309170-00690"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2013"
                        "volumen" => "159"
                        "paginaInicial" => "411"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23897166"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "European position statement on lung cancer screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46; Oudkerk"
                            1 => "A&#46; Devaraj"
                            2 => "R&#46; Vliegenthart"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1470-2045(17)30861-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Oncol"
                        "fecha" => "2017"
                        "volumen" => "18"
                        "paginaInicial" => "e754"
                        "paginaFinal" => "e766"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29208441"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reduced lung-cancer mortality with volume CT screening in a randomized trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;J&#46; de Koning"
                            1 => "C&#46;M&#46; van der Aalst"
                            2 => "P&#46;A&#46; de Jong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa1911793"
                      "Revista" => array:5 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2020"
                        "volumen" => "382"
                        "paginaInicial" => "503"
                        "paginaFinal" => "513"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cribado de c&#225;ncer de pulm&#243;n con tomograf&#237;a computarizada de baja dosis despu&#233;s del National Lung Screening Trial&#46; El debate contin&#250;a abierto"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Ruano-Ravina"
                            1 => "M&#46; P&#233;rez R&#237;os"
                            2 => "A&#46; Fern&#225;ndez-Villar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbres.2012.10.003"
                      "Revista" => array:2 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Early lung cancer detection using spiral computed tomography and positron emission tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Bastarrika"
                            1 => "M&#46;J&#46; Garc&#237;a-Velloso"
                            2 => "M&#46;D&#46; Lozano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200411-1479OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2005"
                        "volumen" => "171"
                        "paginaInicial" => "1378"
                        "paginaFinal" => "1383"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15790860"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of COPD patients at high risk for lung cancer mortality using the COPD-LUCSS-DLCO"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; de-Torres"
                            1 => "J&#46;M&#46; Mar&#237;n"
                            2 => "C&#46; Casanova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.15-1868"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2016"
                        "volumen" => "149"
                        "paginaInicial" => "936"
                        "paginaFinal" => "942"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26513409"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cribado de c&#225;ncer de pulm&#243;n&#58; catorce a&#241;os de experiencia del Programa Internacional de Detecci&#243;n Precoz de C&#225;ncer de Pulm&#243;n con TBDR de Pamplona &#40;P-IELCAP&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Sanchez-Salcedo"
                            1 => "J&#46; Berto"
                            2 => "J&#46;P&#46; De-Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.arbr.2015.02.015"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2015"
                        "volumen" => "51"
                        "paginaInicial" => "169"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25641356"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Improving selection criteria for lung cancer screening&#58; the potential role of emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46; Sanchez-Salcedo"
                            1 => "D&#46;O&#46; Wilson"
                            2 => "J&#46;P&#46; De-Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201410-1848OC"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2015"
                        "volumen" => "191"
                        "paginaInicial" => "924"
                        "paginaFinal" => "931"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25668622"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Henschke CI&#46; International early lung cancer action program protocol&#46; Cornell University&#44; <a target="_blank" href="https://doi.org/10.1097/01.JTO.0000283043.57906.f3">https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1097&#47;01&#46;JTO&#46;0000283043&#46;57906&#46;f3</a>"
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Rami-Porta R &#40;International A for the S of LC&#41;&#46; <span class="elsevierStyleItalic">Staging Manual in Thoracic Oncology &#8211; IASLC</span>&#46;"
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46; Lardinois"
                            1 => "P&#46; De Leyn"
                            2 => "P&#46; Van Schil"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejcts.2006.08.008"
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Cardio-thoracic Surg"
                        "fecha" => "2006"
                        "volumen" => "30"
                        "paginaInicial" => "787"
                        "paginaFinal" => "792"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Video-assisted thoracoscopic surgery is a safe and effective alternative to thoracotomy for anatomical segmentectomy in patients with clinical stage i non-small cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46; Ghaly"
                            1 => "M&#46; Kamel"
                            2 => "A&#46; Nasar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2015.06.112"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2016"
                        "volumen" => "101"
                        "paginaInicial" => "465"
                        "paginaFinal" => "472"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26391692"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In patients with resectable non-small-cell lung cancer&#44; is video-assisted thoracoscopic segmentectomy an appropriate alternative to video-assisted thoracoscopic lobectomy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;R&#46; Lex"
                            1 => "B&#46; Naidu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/icvts/ivw202"
                      "Revista" => array:6 [
                        "tituloSerie" => "Interact Cardiovasc Thorac Surg"
                        "fecha" => "2016"
                        "volumen" => "23"
                        "paginaInicial" => "826"
                        "paginaFinal" => "831"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27401084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thoracoscopic segmentectomy compares favorably with thoracoscopic lobectomy for patients with small stage I lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Shapiro"
                            1 => "T&#46;S&#46; Weiser"
                            2 => "J&#46;P&#46; Wisnivesky"
                            3 => "C&#46; Chin"
                            4 => "M&#46; Arustamyan"
                            5 => "S&#46;J&#46; Swanson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2009.02.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2009"
                        "volumen" => "137"
                        "paginaInicial" => "1388"
                        "paginaFinal" => "1393"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19464454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative intention-to-treat analysis of the video-assisted thoracoscopic surgery approach to pulmonary segmentectomy for lung carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Witte"
                            1 => "C&#46; Stenz"
                            2 => "C&#46;F&#46; Vahl"
                            3 => "M&#46; Huertgen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/icvts/ivv143"
                      "Revista" => array:6 [
                        "tituloSerie" => "Interact Cardiovasc Thorac Surg"
                        "fecha" => "2015"
                        "volumen" => "21"
                        "paginaInicial" => "276"
                        "paginaFinal" => "283"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26063694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer&#58; post-hoc analysis of an international&#44; randomised&#44; phase 3 trial &#40;CALGB&#47;Alliance 140503&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "N&#46;K&#46; Altorki"
                            1 => "X&#46; Wang"
                            2 => "D&#46; Wigle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(18)30411-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Respir Med"
                        "fecha" => "2018"
                        "volumen" => "6"
                        "paginaInicial" => "915"
                        "paginaFinal" => "924"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30442588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A Phase III randomized trial of lobectomy versus limited resection for small-sized peripheral non-small cell lung cancer &#40;JCOG0802&#47;WJOG4607L&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "K&#46; Nakamura"
                            1 => "H&#46; Saji"
                            2 => "R&#46; Nakajima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jjco/hyp156"
                      "Revista" => array:6 [
                        "tituloSerie" => "Jpn J Clin Oncol"
                        "fecha" => "2009"
                        "volumen" => "40"
                        "paginaInicial" => "271"
                        "paginaFinal" => "274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19933688"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Balancing curability and unnecessary surgery in the context of computed tomography screening for lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Flores"
                            1 => "T&#46; Bauer"
                            2 => "R&#46; Aye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2013.11.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2014"
                        "volumen" => "147"
                        "paginaInicial" => "1619"
                        "paginaFinal" => "1626"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24332102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer&#58; a randomised controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Bendixen"
                            1 => "O&#46;D&#46; J&#248;rgensen"
                            2 => "C&#46; Kronborg"
                            3 => "C&#46; Andersen"
                            4 => "P&#46;B&#46; Licht"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1470-2045(16)00173-X"
                      "Revista" => array:7 [
                        "tituloSerie" => "Lancet Oncol"
                        "fecha" => "2016"
                        "volumen" => "17"
                        "paginaInicial" => "836"
                        "paginaFinal" => "844"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27160473"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1808869415307151"
                          "estado" => "S300"
                          "issn" => "18088694"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Study protocol for VIdeo assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer&#44; a UK multicentre randomised controlled trial with an internal pilot &#40;the VIOLET study&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Lim"
                            1 => "T&#46; Batchelor"
                            2 => "M&#46; Shackcloth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmjopen-2019-029507"
                      "Revista" => array:4 [
                        "tituloSerie" => "BMJ Open"
                        "fecha" => "2019"
                        "volumen" => "9"
                        "paginaInicial" => "e029507"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines on the radical management of patients with lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "E&#46; Lim"
                            1 => "D&#46; Baldwin"
                            2 => "M&#46; Beckles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/thx.2010.145938"
                      "Revista" => array:7 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "2010"
                        "volumen" => "65"
                        "numero" => "Suppl&#46; III"
                        "paginaInicial" => "iii1"
                        "paginaFinal" => "iii27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20940263"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 &#40;less than hilar&#41; non-small cell carcinoma&#58; results of the American College of Surgery Oncology Group Z0030 Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "G&#46;E&#46; Darling"
                            1 => "M&#46;S&#46; Allen"
                            2 => "P&#46;A&#46; Decker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2010.11.008"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2011"
                        "volumen" => "141"
                        "paginaInicial" => "662"
                        "paginaFinal" => "670"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lymph node dissection and survival in patients with early stage nonsmall cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "Y&#46; Shen-Tu"
                            1 => "F&#46; Mao"
                            2 => "Y&#46; Pan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MD.0000000000008356"
                      "Revista" => array:3 [
                        "tituloSerie" => "Med &#40;United States&#41;"
                        "fecha" => "2017"
                        "volumen" => "96"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Does lymph node count influence survival in surgically resected non-small cell lung cancer&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;A&#46; David"
                            1 => "D&#46;T&#46; Cooke"
                            2 => "Y&#46; Chen"
                            3 => "K&#46; Nijar"
                            4 => "R&#46;J&#46; Canter"
                            5 => "R&#46;D&#46; Cress"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2016.05.018"
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2017"
                        "volumen" => "103"
                        "paginaInicial" => "226"
                        "paginaFinal" => "235"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Initiative for early lung cancer research on treatment&#58; development of study design and pilot implementation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Flores"
                            1 => "E&#46; Taioli"
                            2 => "D&#46;F&#46; Yankelevitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtho.2018.03.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Oncol"
                        "fecha" => "2018"
                        "volumen" => "13"
                        "paginaInicial" => "946"
                        "paginaFinal" => "957"
                        "itemHostRev" => array:3 [
                          "pii" => "S0196070916306093"
                          "estado" => "S300"
                          "issn" => "01960709"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer in COPD patients&#58; development and validation of the COPD LUng Cancer Screening Score &#40;COPD-LUCSS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "J&#46;P&#46; de-Torres"
                            1 => "D&#46;O&#46; Wilson"
                            2 => "P&#46; Sanchez-Salcedo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.201407-1210OC"
                      "Revista" => array:3 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2015"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19797159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer survivors need lung cancer screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46;M&#46; Flores"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2014.09.115"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2015"
                        "volumen" => "149"
                        "paginaInicial" => "53"
                        "paginaFinal" => "54"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25451497"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0034935612003039"
                          "estado" => "S300"
                          "issn" => "00349356"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer screening and video-assisted thoracic surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;H&#46; Petersen"
                            1 => "H&#46;J&#46; Hansen"
                            2 => "A&#46; Dirksen"
                            3 => "J&#46;H&#46; Pedersen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/JTO.0b013e31824fe942"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Oncol"
                        "fecha" => "2012"
                        "volumen" => "7"
                        "paginaInicial" => "1026"
                        "paginaFinal" => "1031"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22588154"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1808869415001317"
                          "estado" => "S300"
                          "issn" => "18088694"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In patients undergoing video-assisted thoracoscopic surgery excision&#44; what is the best way to locate a subcentimetre solitary pulmonary nodule in order to achieve successful excision&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Zaman"
                            1 => "H&#46; Bilal"
                            2 => "C&#46;Y&#46; Woo"
                            3 => "A&#46; Tang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/icvts/ivs068"
                      "Revista" => array:6 [
                        "tituloSerie" => "Interact Cardiovasc Thorac Surg"
                        "fecha" => "2012"
                        "volumen" => "15"
                        "paginaInicial" => "266"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22572410"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Performance of lung-RADS in the national lung screening trial&#58; a retrospective assessment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "P&#46;F&#46; Pinsky"
                            1 => "D&#46;S&#46; Gierada"
                            2 => "W&#46; Black"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/M14-2086"
                      "Revista" => array:2 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2015"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The probability of malignancy in solitary pulmonary nodules&#46; Application to small radiologically indeterminate nodules"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;J&#46; Swensen"
                            1 => "M&#46;D&#46; Silverstein"
                            2 => "D&#46;M&#46; Ilstrup"
                            3 => "C&#46;D&#46; Schleck"
                            4 => "E&#46;S&#46; Edell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "1997"
                        "volumen" => "157"
                        "paginaInicial" => "849"
                        "paginaFinal" => "855"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9129544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;pubmed&#47;9129544"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive accuracy of the pancan lung cancer risk prediction model-external validation based on CT from the danish lung cancer screening trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "M&#46;M&#46; Winkler Wille"
                            1 => "S&#46;J&#46; van Riel"
                            2 => "Z&#46; Saghir"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00330-015-3689-0"
                      "Revista" => array:2 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2015"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The utility of nodule volume in the context of malignancy prediction for small pulmonary nodules"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "H&#46;J&#46; Mehta"
                            1 => "J&#46;G&#46; Ravenel"
                            2 => "S&#46;R&#46; Shaftman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.13-0708"
                      "Revista" => array:3 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2014"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11115464"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of an AI-powered lung nodule algorithm for detection and 3D segmentation of primary lung tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "T&#46; Weikert"
                            1 => "T&#46; Akinci D&#8217;Antonoli"
                            2 => "J&#46; Bremerich"
                            3 => "B&#46; Stieltjes"
                            4 => "G&#46; Sommer"
                            5 => "A&#46;W&#46; Sauter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2019/1545747"
                      "Revista" => array:5 [
                        "tituloSerie" => "Contrast Media Mol Imaging"
                        "fecha" => "2019"
                        "volumen" => "2019"
                        "paginaInicial" => "1"
                        "paginaFinal" => "10"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiomics analysis of pulmonary nodules in low-dose CT for early detection of lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "W&#46; Choi"
                            1 => "J&#46;H&#46; Oh"
                            2 => "S&#46; Riyahi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/mp.12820"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Phys"
                        "fecha" => "2018"
                        "volumen" => "45"
                        "paginaInicial" => "1537"
                        "paginaFinal" => "1549"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29457229"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lung cancer screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "U&#46; Pastorino"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.bjc.6605660"
                      "Revista" => array:2 [
                        "tituloSerie" => "Br J Cancer"
                        "fecha" => "2010"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The Pittsburgh Lung Screening Study &#40;PLuSS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "D&#46;O&#46; Wilson"
                            1 => "J&#46;L&#46; Weissfeld"
                            2 => "C&#46;R&#46; Fuhrman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/rccm.200802-336oc"
                      "Revista" => array:3 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2008"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19797159"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "American Cancer Society lung cancer screening guidelines"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:3 [
                            0 => "R&#46; Wender"
                            1 => "E&#46;T&#46;H&#46; Fontham"
                            2 => "E&#46; Barrera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3322/caac.21172"
                      "Revista" => array:5 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2013"
                        "volumen" => "63"
                        "paginaInicial" => "106"
                        "paginaFinal" => "117"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Factors determining early adherence to a lung cancer screening protocol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "U&#46; Montes"
                            1 => "L&#46;M&#46; Seijo"
                            2 => "A&#46; Campo"
                            3 => "A&#46;B&#46; Alcaide"
                            4 => "G&#46; Bastarrika"
                            5 => "J&#46;J&#46; Zulueta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00143206"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2007"
                        "volumen" => "30"
                        "paginaInicial" => "532"
                        "paginaFinal" => "537"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17567671"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/03002896/0000005700000002/v1_202102021106/S0300289620301071/v1_202102021106/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "45423"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Original Articles / Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005700000002/v1_202102021106/S0300289620301071/v1_202102021106/en/main.pdf?idApp=UINPBA00003Z&text.app=https://www.archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620301071?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 57. Issue 2.
Pages 101-106 (February 2021)
Share
Share
Download PDF
More article options
Visits
4276
Vol. 57. Issue 2.
Pages 101-106 (February 2021)
Original Article
Full text access
Surgical Outcomes in a Lung Cancer-Screening Program Using Low Dose Computed Tomography
Resultados quirúrgicos de un programa de cribado de cáncer de pulmón utilizando tomografía computarizada de baja dosis
Visits
4276
M. Mesa-Guzmána,
Corresponding author
mmesag@unav.es

Corresponding author.
, J. Gonzálezb, A.B. Alcaideb, J. Bertób, J.P. de-Torresb, A. Campob, L.M. Seijoc,j, M.M. Ocónb, J.C. Pueyod, G. Bastarrikad, M.D. Lozanoe,h,i, R. Píof,g,h,i, L.M. Montuengaf,h,i, M. García-Granerog, J. Zuluetab,h,i
a Departamento de Cirugía Torácica, Clínica Universidad de Navarra, Pamplona, Spain