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Vol. 59. Issue 2.
Pages 113 (February 2023)
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Vol. 59. Issue 2.
Pages 113 (February 2023)
Case report
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Spontaneous Bacterial Empyema Due to Enterococcus faecalis
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Carlos Cabanillas Díez-Madroñeroa,
Corresponding author
, Andrés Briones Gómezb, Cristina Luna Pardob
a Servicio de Neumología, Hospital Universitario Doctor Josep Trueta, Gerona, Spain
b Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Table 1. Sample characteristics.
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Hepatic hydrothorax is a type of pleural effusion that appears in cirrhotic patients with no evidence of cardiopulmonary disease. Spontaneous bacterial empyema is defined as hepatic hydrothorax infection and may or may not be accompanied by ascites.1 The diagnostic criteria are as follows:

  • 1.

    Positive pleural fluid culture and >250neutrophils/mL or negative culture and >500neutrophils/mL.

  • 2.

    a. Concomitant lung infection ruled out.b. Pleural effusion prior to the infectious episode or showing features of transudate during the infectious process.2

Treatment is usually based on antibiotic therapy; a chest tube is not required.2

We report the case of a 65-year-old man with a history of atrial fibrillation, chronic kidney disease, and liver cirrhosis due to alcoholism that required liver transplantation in 2006. He subsequently developed cirrhosis of the graft.

He was admitted for increased baseline dyspnea, pain in the right hemithorax, and dry cough, but no febrile symptoms. A computed tomography scan of the chest and abdomen showed moderate pleural effusion and moderate ascites. No consolidations were identified in the pulmonary parenchyma. Thoracentesis was performed, and the sample described in Table 1 was obtained.

Table 1.

Sample characteristics.

Appearance  Serous 
pH  7.29 
Glucose  113mg/dL 
WBC  5382/μL 
Neutrophils  88% 
Lymphocytes  4% 
Proteins  2.6g/dL 
LDH  980U/L 
Pleural fluid culture  Enterococcus faecalis 

Given the growth of Enterococcus faecalis in the pleural fluid culture of a patient with no clinical signs of infectious disease and a personal history of cirrhosis and ascites, we diagnosed spontaneous bacterial empyema and administered a 14-day course of antibiotic treatment with linezolid (guided by antimicrobial susceptibility testing) with good clinical progress.

Nevertheless, the pleural effusion persisted, so thoracentesis was repeated after 2 weeks. The pleural fluid obtained showed similar biochemical characteristics, but fewer leukocytes and polymorphonuclear neutrophils (PMN) (leukocytes 393/μL, 23% PMNs). Cultures this time were sterile.

This complication is uncommon, occurring in 2.4% of patients with cirrhosis3 and in 19.03% of patients with hydrothorax.4

Enterobacteriaceae are the causative agents most often identified in spontaneous bacterial empyema (Escherichia coli and Klebsiella pneumoniae),5 while enterococci have been isolated in 8.3% of patients in some series.2

Despite its low frequency, it is important that spontaneous bacterial empyema is included in the differential diagnosis of pleural effusion in cirrhotic patients. Thoracentesis is required for the analysis and culture of pleural fluid and early initiation of treatment.

References
[1]
A. Mohamed, M. Atef, A. Alsebaey, M.M. Elhabshy, M. Salama.
Combined spontaneous bacterial empyema and peritonitis in cirrhotic patients with ascites and hepatic hydrothorax.
Arab J Gastroenterol, 18 (2017), pp. 104-107
[2]
X. Xiol, J.M. Castellví, J. Guardiola, E. Sesé, J. Castellote, A. Perelló, et al.
Spontaneous bacterial empyema in cirrhotic patients: a prospective study.
Hepatology, 23 (1996), pp. 719-723
[3]
C.H. Chen, C.M. Shih, J.W. Chou, Y.H. Liu.
Outcome predictors of cirrhotic patients with spontaneous bacterial empyema.
[4]
K.T. Osman, N. Mehta, C. Spencer, A.A. Qamar.
Spontaneous bacterial empyema: a tertiary care center experience and a systematic review.
Expert Rev Gastroenterol Hepatol, 16 (2022), pp. 487-492
[5]
S. Soin, S. Nehan, N. Saleem.
Spontaneous bacterial empyema: an elusive diagnosis in a patient with cirrhosis.
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