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Vol. 46. Issue 9.
Pages 479-488 (July 2010)
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Vol. 46. Issue 9.
Pages 479-488 (July 2010)
Review Article
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Sleep Apnea-Hypopnea Syndrome in the Elderly
El síndrome de apneas-hipopneas durante el sueño en edades avanzadas
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Miguel Ángel Martínez-Garcíaa,d,
Corresponding author
miangel@comv.es

Corresponding author.
, Joaquín Durán-Cantollab,d, José María Montserratc,d
a Unidad de Neumología, Hospital General de Requena, Valencia, Spain
b Unidad de Trastornos de Sueño, Hospital de Txagorritxu, Vitoria, Spain
c Unidad de Sueño Multidisciplinaria, Servei de Pneumologia, Institut del Tórax, Hospital Clínic de Barcelona, Barcelona, Spain
d CIBER de enfermedades respiratorias, CIBERES, Spain
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Abstract

The population pyramid is changing due to the increasing longevity of the population, making it a priority to have better knowledge of those diseases that have an increasingly major impact in advanced age. Sleep apnoea-hypopnea syndrome (SAHS) affects 15-20% of individuals over 65 years. Despite this high prevalence and the fact that one in four Spanish sleep studies are conducted on the elderly and that more 60% of these were treated with CPAP, there are few specific studies in this age group on the diagnosis and management of this syndrome. Over time, physiological increase in the number of sleep respiratory disorders may be the biggest obstacle when defining, diagnosing and treating SAHS in the elderly. In any case and while more solid scientific evidence is obtained, the Spanish SAHS Consensus, as well as the Guidelines on the diagnosis and treatment of SAHS, recommend that, within logical limits, age should not be an obstacle to offering the elderly diagnostic help and treatment similar to that offered to the rest of the population.

Keywords:
Sleep apnoea-hypopnea syndrome
SAHS
Epidemiology
Elderly
Advanced age
Diagnosis
Treatment
Impact
Continuous positive airway pressure
CPAP
Resumen

La pirámide de población está cambiando como consecuencia de la cada vez mayor longevidad de la población por lo que se hace prioritario conocer en profundidad aquellas enfermedades que impactan con mayor frecuencia en edades avanzadas. El síndrome de apneas-hipopneas durante el sueño (SAHS) afecta al 15-20% de los individuos mayores de 65 años. Sin embargo, y a pesar de esta elevada prevalencia y que en nuestro país uno de 4 estudios de sueño se realiza en ancianos y que más del 60% de estos serán tratados con CPAP, apenas existen estudios específicos para este grupo de edad sobre el diagnóstico y manejo de esta enfermedad. Probablemente el incremento fisiológico con el paso del tiempo del número de trastornos respiratorios durante el sueño sea el mayor obstáculo a la hora de definir, diagnosticar y tratar el SAHS en los ancianos. En cualquier caso y mientras llegan evidencias científicas más sólidas tanto el Consenso Nacional de SAHS como las Normativas sobre el diagnóstico y tratamiento del SAHS recomiendan que, dentro de límites lógicos, la edad por sí misma no sea un obstáculo para ofrecer a los ancianos un trato diagnóstico y terapéutico semejante al ofrecido al resto de la población.

Palabras clave:
Síndrome de apnea-hipopnea del sueño
SAHS
Epidemiología
Ancianos
Edad avanzada
Diagnóstico
Tratamiento
Impacto
Presión positiva continua de la vía aérea
CPAP
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References
[1.]
K. Christensen, G. Doblhammer, R. Rau, J.W. Vaupel.
Ageing populations: the challenges ahead.
Lancet, 374 (2009), pp. 1196-1208
[2.]
Instituto Nacional de Estadística (INE) 2008. Available from: www.ine.es. Última visita. Diciembre 2009.
[3.]
C.R. Schubert, M.S. Karen, K.J. Cruickshanks, D.S. Dalton, B.E.K. Klein, R. Klein, et al.
Prevalence of sleep problems and quality of life in an older population.
Sleep, 25 (2002), pp. 48-52
[4.]
S. Redline, H.L. Kirchner, S.F. Quan.
The effect of age, sex, etnicity, and sleep-disordered breathing on sleep architecture.
Arch Intern Med, 164 (2004), pp. 406-418
[5.]
A.N. Vgontzas, E.O. Bixler, T. Wittman.
Middle aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications.
J Clin Endocrinol Metab, 86 (2001), pp. 1489-1495
[6.]
P.N. Prinz, K.E. Moe, E.M. Dulberg.
Higher plasma IGF-1 levels are associated with increased delta sleep in healthy older men.
J Gerontol A Biol Sci Med Sci, 50A (1995), pp. 222-226
[7.]
E. Van Cauter, R. Leproult, L. Plat.
Age-related changed in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men.
JAMA, 284 (2000), pp. 861-868
[8.]
E. Mignot, G.J. Lammers, B. Ripley.
The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias.
Arch Neurol, 59 (2002), pp. 1553-1562
[9.]
A.N. Vgontzas, M. Zoumakis, E.O. Bixler.
Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels. Physiologic and therapeutics implications.
J Clin Endocrinol Metab, 88 (2003), pp. 2087-2095
[10.]
P.J. Shiromani, J. Lu, D. Wagner.
Compensatory sleep response to 12h wakefulness in young and old rats.
Am J Physiol Regul Integr Comp Physiol, 278 (2000), pp. 125-133
[11.]
R. Basheer, P.J. Shiromani.
Effets of prolonged wakefulness on c-fos and AP1 activity in young and old rats.
Brain Res Mol Brain Res, 89 (2001), pp. 153-157
[12.]
A.R. Kendall, A.J. Lewy, R.L. Sack.
Effects of aging on the intrinsic circadian period of totally blind humans.
J Biol Rhythms, 16 (2001), pp. 87-95
[13.]
J.F. Duffy, J.M. Zeitzner, D.W. Rimmer.
Peak of circadian melatonin rhythm occurs later within the sleep of older subjects.
Am J Physiol Endocrinol Metab, 282 (2002), pp. e297-e303
[14.]
N.A. Collop.
The significance of sleep-disordered breathing and obstructive sleep apnea in the elderly.
Chest, 112 (1997), pp. 867-868
[15.]
M.A. Martínez-García, J.J. Soler-Cataluña, P. Román-Sánchez, V. González, C. Amorós, J.M. Montserrat.
Obstructive sleep apnea has little impact on quality of life in the elderly.
Sleep Med, 10 (2009), pp. 104-111
[16.]
S.H. Launois, J.L. Pépin, P. Lévy.
Sleep apnea in the elderly: A specific entity?.
Sleep Med Rev, 11 (2007), pp. 87-97
[17.]
H.G. Bloom, I. Ahmed, C.A. Alessi, S. Ancoli-Israel, D.J. Buysse, M.H. Kryger, et al.
Evidence-based recommendations for the assessment and management of sleep disorders in older persons.
J Am Geriatr Soc, 57 (2009), pp. 761-789
[18.]
D.P. White, R.M. Lombard, R.J. Cadieux, C.W. Zwillich.
Pharyngeal resistance in normal humans: influence of gender, age, and obesity.
J Appl Physiol, 58 (1985), pp. 365-371
[19.]
M. Eikermann, A.S. Jordan, N.L. Chamberlin, S. Gautam, A. Wellman, Y.L. Lo.
The influence of aging on pharingeal collapsibility during sleep.
Chest, 131 (2007), pp. 1702-1709
[20.]
J.J. Harrington, T. Lee-Chong.
Sleep and older adults.
Clin Chest Med, 28 (2007), pp. 673-684
[21.]
D.L. Bliwise.
Normal aging.
Principles and Practice of Sleep Medicine, 3rd ed., pp. 26-42
[22.]
T. Young, E. Shahar, F.J. Nieto, S. Redline, A.B. Newman, D.J. Gottlieb, et al.
Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study.
Arch Intern Med, 162 (2002), pp. 893-900
[23.]
Duran J, Esnaola S, Rubio R, De La Torre G, Solles J, Goicolea A, et al. Prevalence of obstructive sleep apnoea-hypopnoea and related clinical features in the elderly. A population based-study in the general population aged 71–100. WFSRS. World Conference Sleep odyssey 2001. Punta del Este. Uruguay.
[24.]
C.C. Hoch, C.F. Reynolds, T.H. Monk, D.J. Buysse, A.L. Yeager, P.R. Houck, et al.
Comparison of sleep-disordered breathing among healthy elderly in the seventh, eight, and ninth decades of life.
Sleep, 13 (1990), pp. 501-511
[25.]
E.O. Bixler, A.N. Vgontzas, T.T. Have, K. Tyson, A. Kales.
Effects of age on sleep apnea in men. Prevalencia and severity.
Am Respir J Crit Care Med, 157 (1998), pp. 144-148
[26.]
S. Ancoli-Israel, D.F. Kripke, M.R. Klauber, W.J. Mason, R. Fel, O. Kaplan.
Sleep-disordered breathing in community-dwelling elderly.
Sleep, 14 (1991), pp. 486-495
[27.]
C. Zamarrón, F. Gude, Y. Otero, J.M. Álvarez, A. Golpe, J.R. Rodríguez.
Prevalence of sleep disordered breathing and sleep apnea in 50 to 70 year old individuals. A survey.
Respiration, 66 (1999), pp. 317-322
[28.]
F. Campos-Rodríguez, A. Fernández Palacín, N. Reyes Núñez, A. Reina González.
Características clínicas y polisomnográficas del síndrome de apneas durante el sueño localizado en la fase REM.
Arch Bronconeumol, 45 (2009), pp. 330-334
[29.]
P. Levy, J.L. Pepin, D. Malauzat, J.P. Emeriau, J.M. Legar.
Is sleep apnea syndrome in the elderly a specific entity?.
Sleep, 19 (1996), pp. s29-s38
[30.]
M.A. Martínez-García, J. Amilibia, E. Chiner, C. Queipo, J. Díaz de Atauri, C. Carmona- Bernal, et al.
Apnea del sueño en individuos de edad avanzada. Actividad asistencial (2002–2008) en España.
Arch Bronconeumol, (2010),
[31.]
E.O. Bixler, A.N. Vgontzas, H.M. Lin, S.L. Calhoun, A. Vela-Bueno, A. Kales.
Excessive daytime sleepiness in a general population simple: the role of sleep apnea, age, obesity, diabetes, and depresión.
J Clin Endocrinol Metab, 90 (2005), pp. 4510-4515
[32.]
C.W. Whitney, P.L. Enroght, B. Newman, W. Bonekat, D. Foley, S.F. Quan.
Correlates of daytime sleepiness in 4578 elderly persons: the Cardiovascular Health Study.
Sleep, 21 (1998), pp. 27-36
[33.]
N.A. Collop.
The significance of sleep-disordered breathing and obstructive sleep apnea in the elderly.
Chest, 112 (1997), pp. 867-868
[34.]
N. Roure, O. Mediano, J. Durán-Cantolla, F. García Río, M. de la Peña, F. Capote, et al.
Influencia del sexo en las variables clínicas y polisomnográficas del síndrome de apnea del sueño.
Arch Bronconeumol, 44 (2008), pp. 685-688
[35.]
E. Chiner, J. Arriero, J. Signes-Costa, J. Marco, I. Fuentes.
Validación de la versión española del test de somnolencia Epworth en pacientes con síndrome de apnea de sueño.
Arch Bronconeumol, 35 (1999), pp. 422-427
[36.]
C. Hernández.
Síndrome de apneas-hipopneas durante el sueño sin somnolencia.
Arch Bronconeumol, 45 (2009), pp. 240-244
[37.]
P.L. Enright, A.B. Newman, P.W. Wahl, T.A. Manolio, E.F. Haponik, P.J. Boyle.
Prevalence and correlates of snoring and observed apneas in 5201 older adults.
Sleep, 19 (1996), pp. 531-538
[38.]
T. Saunamaki, M. Jehkonen.
Depression and anxiety in obstructive sleep apnea syndrome: a review.
Acta Neurol Scand, 116 (2007), pp. 277-288
[39.]
M. Annette, Chihorek, B. Abou-Khalil, B.A. Malow.
Obstructve sleep apnea is associated with seizure occurrence in older adults with epilepsy.
[40.]
H. Abdal, J.J. Pizzimenti, C.C. Purvis.
The eye in sleep apnea síndrome.
Sleep Med, 7 (2006), pp. 107-115
[41.]
Y.W. Endershaw, T.M. Jonson, M.H. Kutner, J.G. Ouslander, D.L. Bliwise.
Sleep-disordered breathing and nocturna in older adulys.
J Am Geriatr Soc, 52 (2004), pp. 957-960
[42.]
G.S. Brassington, A.C. King, D.L. Bliwise.
Sleep problems as a risk factor for falls in a sample of community-dwelling adulys aged 64–99 years.
J Am Geriatr Soc, 48 (2000), pp. 1234-1240
[43.]
H. Kadotani, T. Kadotani, T. Young, P.E. Peppard, L. Finn, I.M. Colrain, et al.
Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults.
JAMA, 285 (2001), pp. 2888-2890
[44.]
D.J. Gottlieb, A.L. DeStefano, D.J. Foley, E. Mignot, S. Redline, R.J. Givelber, et al.
APOE epsilon4 is associated with obstructive sleep apnea/hypopnea: The Sleep Heart Health Study.
Neurology, 63 (2004), pp. 664-668
[45.]
M.A. Martínez-García, J.J. Soler-Cataluña, L. Ejarque-Martínez, Y. Soriano, P. Román- Sánchez, F.B. Illa, et al.
Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study.
Am J Respir Crit Care Med, 180 (2009), pp. 36-41
[46.]
M.A. Martínez-García, R. Galiano-Blancart, P. Román-Sánchez, J.J. Soler-Cataluña, L. Cabero-Salt, E. Salcedo-Maiques.
Continuous positive airway pressure in sleep apnea prevents new vascular events after ischemic stroke.
Chest, 128 (2005), pp. 2123-2129
[47.]
O. Parra, A. Arboix, S. Bechich, L. Garcia-Eroles, J.M. Montserrat, J.A. López, et al.
Time course of sleep related breathing disorders in first-ever stroke or transient ischemic attack.
Am J Respir Crit Care Med, 161 (2000), pp. 375-380
[48.]
R. Muñoz, J. Durán-Cantolla, E. Martínez-Vila, J. Gallego, R. Rubio, F. Aizpuru, et al.
Severe sleep apnea and risk of ischemic stroke in the elderly.
[49.]
Consenso Nacional sobre el Síndrome de apneas-hipopneas durante el sueño. Arch Bronconeumol. 2005; 41(Suppl 4):1-110.
[50.]
C.A. Cusida, M.R. Littner, T. Morgenthaler, C.A. Alessi, D. Bailey, J. Colemen, et al.
Practice parameters for the indications for polysomnography and related procedures: an update for 2005.
Sleep, 28 (2005), pp. 499-521
[51.]
C. Hernández, J. Durán-Cantolla, P. Lloberes, M. González.
Novedades en la epidemiología, la historia natural, el diagnostico y el tratamiento del síndrome de apneas-hipopneas durante el sueno.
Arch Bronconeumol, 45 (2009), pp. 3-10
[52.]
A. Camarasa, D. Gonzalez Vergara, J.C. Serrano Rebollo, F. Barbe.
El síndrome de apnea-hipopnea del sueño en 2009.
Arch Bronconeumol, 45 (2009), pp. 14-21
[53.]
S. Misra, B.A. Malow.
Evaluation of sleep disturbances in older adults.
Clin Geriatr Med, 24 (2008), pp. 15-26
[54.]
D. Norman, J.S. Loredo.
Obstructive sleep apnea in older adults.
Clin Geriatr Med, 24 (2008), pp. 151-165
[55.]
S.S. Mosko, M.J. Dickel, T. Paul, T. LaTour, S. Dhillon, A. Granim, et al.
Sleep apnea and sleep-related periodic leg movements in community resident seniors.
J Am Geriatr Soc, 36 (1988), pp. 502-508
[56.]
S.S. Mosko, M.J. Dickel, J. Ashurst.
Night-to-night variability in sleep apnea and sleep-related periodic leg movements in the elderly.
Sleep, 11 (1998), pp. 340-348
[57.]
C. Stepnowsky, S. Johnson, J. Dimsdale, S. Ancoli-Israel.
Sleep apnea and health-related quality of life in African-American elderly.
Ann Behav Med, 22 (2000), pp. 116-120
[58.]
C.M. Baldwin, K.A. Griffith, J. Nieto, G.T. O’Connor, J.A. Walsleben, S. Redline.
The association of sleep-disordered breathing and sleep symptoms with quality of life in the Sleep Heart Health Study.
Sleep, 24 (2001), pp. 96-105
[59.]
E.J. Kezirian, S.L. Harrison, S. Ancoli-Israel, S. Redline, K. Ensrud, A.N. Goldberg, et al.
Behavioral correlates of sleep-disordered breathing in older men.
Sleep, 32 (2009), pp. 253-261
[60.]
S. Chung, I.Y. Yoon, Y.K. Shin, C.H. Lee, J.W. Kim, H.J. Ahn.
Endotelial dysfunction and inflammatory reactions of elderly and middle-aged men with obstructive sleep apnea síndrome.
Sleep Breath, 13 (2009), pp. 11-17
[61.]
P.W. Wilson, M. Pencina, P. Jacques, J. Selhub, R. D’Agostino, C.J. O’Donnell.
C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study.
Circ Cardiovasc Qual Outcomes, 1 (2008), pp. 92-97
[62.]
F. Roche, J.M. Gaspoz, V. Pichot, M. Picard-Kossovsky, D. Maudoux, A. Garcin, et al.
Association between C-reactive protein and unrecognised sleep-disordered breathing in the elderly.
Eur Respir J, 33 (2009), pp. 797-803
[63.]
F.J. Nieto, D.M. Herrington, S. Redline, E.J. Benjamin, J.A. Robbins.
Sleep apnea and markers of vascular endothelial function in a large community sample of older adults.
Am J Respir Crit Care Med, 169 (2004), pp. 354-360
[64.]
P. Lavie, L. Lavie, P. Herer.
All cause mortality in men with sleep apnea syndrome: declining mortality rates with age.
Eur Respir J, 27 (2005), pp. 1-7
[65.]
L. Lavie, P. Lavie.
Ischemic preconditioning as a possible explanation for the age decline relative mortality in sleep apnea.
Med Hypotheses, 66 (2006), pp. 1069-1073
[66.]
G. Bianchi, C. Di Giulio, C. Rapino, M. Rapino, A. Antonucci, A. Cataldi.
P53 and p66 proteins compete for hipoxia-inducible factor 1 alpha stabilization in young and old rat hearts exposed to intermittent hypoxia.
Gerontology, 52 (2006), pp. 17-23
[67.]
R. Mehra, K.L. Stone, P.D. Varosy, A.R. Hoffman, G.M. Marcus, T. Blackwell, et al.
Nocturnal arrhythmias across a spectrum of obstructive and central sleep-disordered breathing in older men: outcomes of sleep disorders in older men (MrOS sleep) study.
Arch Intern Med, 169 (2009), pp. 1147-1155
[68.]
P. Johansson, U. Alehagen, E. Svanborg, U. Dahlström, A. Broström.
Sleep disordered breathing in an elderly community-living population: Relationship to cardiac function, insomnia symptoms and daytime sleepiness.
Sleep Med, 10 (2009), pp. 1005-1011
[69.]
Y.W. Endeshaw, W.B. White, M. Kutner, J.G. Ouslander, D.L. Bliwise.
Sleep-disordered breathing and 24-hour blood pressure pattern among older adults.
J Gerontol A Biol Sci Med Sci, 64 (2009), pp. 280-285
[70.]
J.M. Marin, S.J. Carrizo, E. Vicente, A.G. Agusti.
Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study.
Lancet, 365 (2005), pp. 1046-1053
[71.]
N.J. Butchner, B.M. Sanner, J. Borgel, L.C. Rup.
Continuous positive airway pressure treatment of mild to moderate obstructive sleep apnea reduces cardiovascular risk.
Am J Respir Crit Care Med, 176 (2007), pp. 1274-1280
[72.]
F.J. Nieto, T.B. Young, B.K. Lind, E. Shahar, J.M. Famet, S. Redline, et al.
Assocition of sleep-disordered breathing, sleep apnea, and hipertensión in a large community-based study. Sleep Heart Health Study.
JAMA, 283 (2000), pp. 1829-1836
[73.]
P. Lavie.
Mortality in sleep apnoea syndrome: a review of the evidence.
Eur Respir Rev, 16 (2007), pp. 203-210
[74.]
H.K. Yaggi, J. Concato, W.N. Kernan, J.H. Lichtman, L.M. Brass, V. Monhesin.
Obstructive sleep apnea as a risk factor for stroke and death.
N Engl J Med, 353 (2005), pp. 2034-2041
[75.]
O. Parra, A. Arboix, S. Bechich, L. Garcia-Eroles, J.M. Montserrat, J.A. López, et al.
Time course of sleep related breathing disorders in first-ever stroke or transient ischemic attack.
Am J Respir Crit Care Med, 161 (2000), pp. 375-380
[76.]
C.L. Bassetti, M. Milanova, M. Gugger.
Sleep-disordered breathing and acute stroke: diagnosis, risk factors, treatment, evolution and long-term clinical outcome.
[77.]
B.A. Phillips, D.T. Berry, T.C. Lipke-Molby.
Sleep-disordered breathing in healthy, aged persons. Fifth and final year follow-up.
Chest, 110 (1996), pp. 654-658
[78.]
P.L. Enright, A.B. Newman, P.W. Wahl, T.A. Manolio, E.F. Haponik, P.J. Oyle.
Prevalence and correlates of snoring and observed apneas in 5201 older adults.
Sleep, 19 (1996), pp. 531-538
[79.]
D.C. Haas, G.L. Foster, F.J. Nieto, S. Redline, H.E. Resnick, J.A. Robbins, et al.
Age-dependent associations between sleep-disordered breathing and hypertension: importance of discriminating between systolic/diastolic hypertension and isolated systolic hypertension in the Sleep Heart Health Study.
Circulation, 111 (2005), pp. 614-621
[80.]
N.S. Marshall, K.K.H. Wong, P.Y. Lui, S.R.J. Cullen, M.W. Knuiman, R.R. Grustein.
Sleep apnea as an independent risk factor for all-cause mortality: The Busselton Health Study.
Sleep, 31 (2008), pp. 1079-1085
[81.]
T. Young, L. Finn, P.E. Peppard, M. Szklo-Coxe, D. Austin, J. Nieto, et al.
Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisonsin Sleep Cohort.
Sleep, 31 (2008), pp. 1071-1078
[82.]
J. He, M.H. Kryger, F.J. Zorich, W. Conway, T. Roth.
Mortality and apnea index in obstructive sleep apnea: experience in 385 male patients.
Chest, 94 (1988), pp. 9-14
[83.]
S. Martí, G. Sampol, X. Muñoz, F. Torres, A. Roca, P. Lloberes, et al.
Mortality in severe sleep apnoea/hipopnoea syndrome patients: impact of treatment.
Eur Respir J, 20 (2002), pp. 1511-1518
[84.]
F. Campos-Rodriguez, N. Peña-Griñan, N. Reyes-Nuñez, I. De La Cruz-Morón, J. Pérez- Ronchel, F. De La Vega-Gallardo, et al.
Mortality in obstructive sleep apneahypopnea syndrome treated with positive airway pressure.
Chest, 128 (2005), pp. 624-633
[85.]
S. Ancoli-Israel, D.F. Kripke, M.R. Klauber, R. Fell, C. Stepnowsky, E. Estline, et al.
Morbidity, mortality and sleep disordered breathing in community dwelling elderly.
Sleep, 19 (1996), pp. 277-282
[86.]
O. Parra, A. Arboix, J.M. Montserrat, L. Quintó, S. Bechich, L. García-Eroles.
Sleep-related breathing disorders: impact on mortality of cerebrovascular disease.
Eur Respir J, 24 (2004), pp. 267-272
[87.]
L. Ferini-Strambi, C. Baietto, M.R. Di Gioia.
Cognitive dysfunction in patients with obstructive sleep apnea: partial reversibility after continuous positive airway pressure.
Brain Res Bull, 61 (2003), pp. 87-92
[88.]
E. Sforza, J. Haba-Rubio, F. De Bilbao, T. Rochat, V. Ibanez.
Performance vigilance task and sleepiness in patients with sleep-disordered breathing.
Eur Respir J, 24 (2004), pp. 279-285
[89.]
B.A. Phillips, D.T. Berry, F.A. Schmitt, L.K. Magan, D.C. Gerhardstein, Y.R. Cook.
Sleep-disordered breathing in the healthy elderly.
Chest, 101 (1992), pp. 345-349
[90.]
B.A. Phillips, D.T. Berry, F.A. Schmitt, L. Harbison, T. Lipke-Molby.
Sleep-disordered breathing in healthy aged persons: two- and three-year follow-up.
Sleep, 17 (1994), pp. 411-415
[91.]
M. Cohen-Zion, C. Stepnowsky, S. Johnson, M. Marler, J.E. Dimsdale, S. Ancoli-Israel.
Cognitive changes and sleep disordered breathing in eldery: differences in race.
J Psychosom Res, 56 (2004), pp. 549-553
[92.]
S. Ancoli-Israel, M.R. Klauber, N. Butters, L. Parker, D.F. Kripke.
Dementia in institutionalized elderly: relation to sleep apnea.
J Am Geriatr Soc, 39 (1991), pp. 258-263
[93.]
S. Ancoli-Israel, T. Coy.
Are breathing disturbances in elderly equivalent to sleep apnea syndrome?.
Sleep, 17 (1994), pp. 77-83
[94.]
P.R. Gehrman, J.L. Martin, T. Shochat, S. Nolan, J. Corey-Bloom, S. Ancoli-Israel.
Sleep-disordered breathing and agitation in institutionalized adults with Alzheimer disease.
Am J Geriatr Psychiatry, 11 (2003), pp. 426-433
[95.]
A.P. Spira, T. Blackwell, K.L. Stone, S. Redline, J.A. Cauley, S. Ancoli-Israel, et al.
Sleep-disordered breathing and cognition in older women.
J Am Geriatr Soc, 56 (2008), pp. 45-50
[96.]
C.C. Hoch, C.F. Reynolds III, R.D. Nebes, D.J. Kupfer, S.R. Berman, D. Campbell.
Clinical significance of sleep-disordered breathing in Alzheimer's disease.
J Am Geriatr Soc, 37 (1989), pp. 138-144
[97.]
T. Erkinjuntti, M. Partinen, R. Sulkava, T. Telakivi, T. Salmi, R. Tilvis.
Sleep apnea in multiinfart dementia and Alzheimer's disease.
Sleep, 10 (1987), pp. 419-425
[98.]
R. O’Hara, C.M. Schröder, H.C. Kraemer.
Nocturnal sleep apnea-hypopnea is associated with lower memory performance in APOE epsolin4 carriers.
[99.]
M. Harris, N. Glozier, R. Ratnavadivel, R.R. Grunstein.
Obstructive sleep apnea and depression.
Sleep Med Rev, 13 (2009), pp. 437-444
[100.]
C.C. Hoch, C.F. Reynolds, D.J. Kupfer, P.R. Houck, S.R. berman, J.A. Stack.
Sleep-disordered breathing in normal and pathologic aging.
J Clin Psychiatry, 47 (1986), pp. 499-503
[101.]
A. Tarasiuk, S. greenberg-Dotan, T. Simon-Tuval, A. Oksenberg, H. Reuveni.
The effect of obstructive sleep apnea on morbidity and health care utilization of middle-aged and older adults.
JAGS, 56 (2008), pp. 247-254
[102.]
T.E. Weaver, E.R. Chasens.
Continuous positive airway pressure treatment for sleep apnea in older adults.
Sleep Med Rev, 11 (2007), pp. 99-111
[103.]
M. Barnes, D. Houston, C.J. Worsnop, A.M. Neill, I.J. Mykytyn, A. Kay, et al.
A randomized controlled trial of continuous positive airway pressure in mild obstructive sleep apnea.
Am J Respir Crit Care Med, 165 (2002), pp. 773-780
[104.]
M. Barnes, R.D. McEvoy, S. Banks, N. Tarquinio, C.G. Murray, N. Vowles, et al.
Efficacy of positive airway pressure and oral appliance in mild to moderate obstructive sleep apnea.
Am J Respir Crit Care Med, 170 (2004), pp. 656-664
[105.]
H.M. Engleman, S.E. Martin, I.J. Deary, N.J. Douglas.
Effect of continuous positive airway pressure treatment on daytime function in sleep apnoea/hypopnoea syndrome.
Lancet, 343 (1994), pp. 572-575
[106.]
H.M. Engleman, S.E. Martin, I.J. Deary, N.J. Douglas.
Effect of CPAP therapy on daytime function in patients with mild sleep apnoea/hypopnoea syndrome.
Thorax, 52 (1997), pp. 114-119
[107.]
H.M. Engleman, S.E. Martin, R.N. Kingshott, T.W. Mackay, I.J. Deary, N.J. Douglas.
Randomised placebo controlled trial of daytime function after continuous positive airway pressure (CPAP) therapy for the sleep apnoea/hypopnoea syndrome.
Thorax, 53 (1998), pp. 341-345
[108.]
J.F. Faccenda, T.W. Mackay, N.A. Boon, N.J. Douglas.
Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome.
Am J Respir Crit Care Med, 163 (2001), pp. 344-348
[109.]
N. McArdle, N.J. Douglas.
Effect of continuous positive airway pressure on sleep architecture in the sleep apnea-hypopnea syndrome: a randomized controlled trial.
Am J Respir Crit Care Med, 164 (2001), pp. 1459-1463
[110.]
E. Ballester, J.R. Badia, L. Hernandez, E. Carrasco, J. de Pablo, C. Fornas, et al.
Evidence of the effectiveness of continuous positive airway pressure in the treatment of sleep apnea/hypopnea syndrome.
Am J Respir Crit Care Med, 159 (1999), pp. 495-501
[111.]
F. Barbe, L.R. Mayoralas, J. Duran, J.F. Masa, A. Maimo, J.M. Montserrat, et al.
Treatment with continuous positive airway pressure is not effective in patients with sleep apnea but no daytime sleepiness a randomized controlled trial.
Ann Intern Med, 134 (2001), pp. 1015-1023
[112.]
H.F. Becker, A. Jerrentrup, T. Ploch, L. Grote, T. Penzel, C.E. Sullivan, et al.
Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea.
Circulation, 107 (2003), pp. 68-73
[113.]
Chong M, Ayalon L, Marler M, Loredo J, Corey-Bloom J, Palmer B, et al. Continuous positive airway pressure reduces subjective daytime sleepiness in mild-moderate Alzheimer's disease patients with sleep disordered breathing. Journal of Geriatric Society of America (in press).
[114.]
M. Hack, R.J. Davies, R. Mullins, S.J. Choi, S. Ramdassingh-Dow, C. Jenkinson, et al.
Randomised prospective parallel trial of therapeutic versus subtherapeutic nasal continuous positive airway pressure on simulated steering performance in patients with obstructive sleep apnoea.
Thorax, 55 (2000), pp. 224-231
[115.]
K.G. Henke, J.J. Grady, S.T. Kuna.
Effect of nasal continuous positive airway pressure on neuropsychological function in sleep apnea-hypopnea syndrome A randomized placebo-controlled trial.
Am J Respir Crit Care Med, 163 (2001), pp. 911-917
[116.]
C. Jenkinson, R.J.O. Davies, R. Mullins, J.R. Stradling.
Comparison of therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised prospective parallel trial.
Lancet, 353 (1999), pp. 2100-2105
[117.]
J.M. Montserrat, M. Ferrer, L. Hernandez, R. Farre, G. Vilagut, D. Navajas, et al.
Effectiveness of CPAP treatment in daytime function in sleep apnea syndrome: a randomized controlled study with an optimized placebo.
Am J Respir Crit Care Med, 164 (2001), pp. 608-613
[118.]
R.A. Nelesen, H. Yu, M.G. Ziegler, P.J. Mills, J.L. Clausen, J.E. Dimsdale.
Continuous positive airway pressure normalizes cardiac autonomic and hemodynamic responses to a laboratory stressor in apneic patients.
Chest, 119 (2001), pp. 1092-1101
[119.]
J.C. Pepperell, S. Ramdassingh-Dow, N. Crosthwaite, R. Mullins, C. Jenkinson, J.R. Stradling, et al.
Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial.
[120.]
J. Profant, S. Ancoli-Israel, J.E. Dimsdale.
A randomized controlled trial of 1 week of continuous positive airway pressure treatment on quality of life.
Heart Lung, 32 (2003), pp. 52-58
[121.]
S. Redline, N. Adams, M.E. Strauss, T. Roebuck, M. Winters, C. Rosenberg.
Improvement of mild sleep-disordered breathing with CPAP compared with conservative therapy.
Am J Respir Crit Care Med, 157 (1998), pp. 858-865
[122.]
X. Zhang, K. Yin, H. Wang, M. Su, Y. Yang.
Effect of continuous positive airway pressure treatment on elderly Chinese patients with obstructive sleep apnea in the prethrombotic state.
Chin Med J (Engl), 116 (2003), pp. 1426-1428
[123.]
M.G. Ziegler, P.J. Mills, J.S. Loredo, S. Ancoli-Israel, J.E. Dimsdale.
Effect of continuous positive airway pressure and placebo treatment on sympathetic nervous activity in patients with obstructive sleep apnea.
Chest, 120 (2001), pp. 887-893
[124.]
S. Kajaste, P.E. Brander, T. Telakivi, M. Partinen, P. Mustajoki.
A cognitive-behavioral weight reduction program in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study.
Sleep Med, 5 (2004), pp. 125-131
[125.]
C. Monasterio, S. Vidal, J. Duran, M. Ferrer, C. Carmona, F. Barbe, et al.
Effectiveness of continuous positive airway pressure in mild sleep apnea-hypopnea syndrome.
Am J Respir Crit Care Med, 164 (2001), pp. 939-943
[126.]
G.V. Robinson, J.C. Pepperell, H.C. Segal, R.J. Davies, J.R. Stradling.
Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials.
Thorax, 5 (2004), pp. 777-782
[127.]
G.V. Robinson, D.M. Smith, B.A. Langford, R.J. Davies, J.R. Stradling.
CPAP does not reduce blood pressure in non-sleepy hypertensive OSA patients.
Eur Respir J, 27 (2006), pp. 234-238
[128.]
H.M. Engleman, R.N. Kingshott, P.K. Wraith, T.W. Mackay, I.J. Deary, N.J. Douglas.
Randomized placebo-controlled crossover trial of continuous positive airway pressure for mild sleep Apnea/Hypopnea syndrome.
Am J Respir Crit Care Med, 159 (1999), pp. 461-467
[129.]
M. Kohler, J.C. Pepperell, B. Casadei, S. Craig, N. Crosthwaite, J.R. Stradling, et al.
CPAP and measures of cardiovascular risk in males with OSAS.
Eur Respir J, 32 (2008), pp. 1488-1496
[130.]
P. Ruttanaumpawan, M.P. Gilman, K. Usui, J.S. Floras, T.D. Bradley.
Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea.
J Hypertens, 26 (2008), pp. 1163-1168
[131.]
A. Noda, S. Nakata, Y. Koike, S. Miyata, K. Kitaichi, T. Nishizawa, et al.
Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea syndrome.
Hypertens Res, 30 (2007), pp. 669-676
[132.]
W. Lim, W.A. Bardwell, J.S. Loredo, E.J. Kim, S. Ancoli-Israel, E.E. Morgan, et al.
Neuropsychological effects of 2-week continuous positive airway pressure treatment and supplemental oxygen in patients with obstructive sleep apnea: a randomized placebo-controlled study.
J Clin Sleep Med, 3 (2007), pp. 380-386
[133.]
S.D. West, D.J. Nicoll, T.M. Wallace, D.R. Matthews, J.R. Stradling.
Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes.
Thorax, 62 (2007), pp. 969-974
[134.]
A. Haensel, D. Norman, L. Natarajan, W.A. Bardwell, S. Ancoli-Israel, J.E. Dimsdale.
Effect of a 2 week CPAP treatment on mood states in patients with obstructive sleep apnea: a double-blind trial.
Sleep Breath, 11 (2007), pp. 239-244
[135.]
F. Campos-Rodriguez, A. Grilo-Reina, J. Perez-Ronchel, M. Merino-Sanchez, M.A. Gonzalez-Benitez, M. Beltran-Robles, et al.
Effect of continuous positive airway pressure on ambulatory BP in patients with sleep apnea and hypertension: a placebo-controlled trial.
Chest, 129 (2006), pp. 1459-1467
[136.]
K.W. To, W.C. Chan, K.L. Choo, W.K. Lam, K.K. Wong, D.S. Hui.
A randomized cross-over study of auto-continuous positive airway pressure versus fixed-continuous positive airway pressure in patients with obstructive sleep apnoea.
[137.]
F. Barbe, J. Duran-Cantolla, F. Capote, M. de la Peña, E. Chiner, J.F. Masa, et al.
Long- Term Effect of Continuous Positive Airway Pressure in Hypertensive Patients With Sleep Apnea.
Am J Respir Crit Care Med, 181 (2010), pp. 18-26
[138.]
Durán-Cantolla J, Aizpuru F, Martínez-Null C, Rubio R, Terán J, Alonso M, et al. Efficacy of continuous positive airway pressure (CPAP) on Patients with recently diagnosed of systemic hipertensión (SH) and obstructive sleep apnea-hypopnea (OSAH). American Thoracic Society Internation Conference 2008; 177: A805 May 16–21 Toronto, Ontario, Canada.
[139.]
O. Parra, M.A. Sánchez-Armengol, M. Bonnin, A. Arboix, A. Gil Peralta, F. Campos, et al.
Utilidad del tratamiento con CPAP nasal en pacientes con primer episodio de ictus y síndrome de apneas obstructivas del sueño (SAOS). Estudio multicéntrico (PII de sueño). Resultados preliminares.
Arch Bronconeumol, 44 (2008), pp. 206
[140.]
S. Ancoli-Israel, B.W. Palmer, J.R. Cooke, J. Corey-Bloom, L. Florentino, L. Natarajan, et al.
Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: A randomized controlled study.
J Am Geriatr Soc, 56 (2008), pp. 2076-2081
[141.]
M.S. Aloia, N. Ilniczky, P. Di Dio.
Neuropsychological changes and treatment compliance in older adults with sleep apnea.
J Psychosom Res, 56 (2003), pp. 549-553
[142.]
K.E. Lewis, L. Seale, I.E. Bartle, A.J. Watkins, P. Veden.
Early predictors of CPAP use for the treatment of obstructive sleep apnea.
Sleep, 27 (2004), pp. 134-138
[143.]
K. Kotsikas, H.A.K. Browne, R. Ghiassi, L. Adams, A.K. Simonds, M.J. Morrell.
The determinants of therapeutic levels of continuous positive airway pressure in elderly sleep apnea patients.
Respir Med, 100 (2006), pp. 1216-1225
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