Journal Information
Vol. 57. Issue 9.
Pages 590 (September 2021)
Download PDF
More article options
Vol. 57. Issue 9.
Pages 590 (September 2021)
Clinical Image
Full text access
Paracoccidioidomycosis: Endobronchial Involvement in a Rare Disease in Europe
Paracoccidioidomicosis: aspectos endobronquiales de una enfermedad rara en Europa
Cláudia Sousaa,
Corresponding author

Corresponding author.
, José Alvesb, Michelle Cordeiroc
a Pulmonology Department, Hospital Central do Funchal, Portugal
b Clinical Pathology Department, Hospital Central do Funchal, Portugal
c Anatomical Pathology Department, Hospital Central do Funchal, Portuga
This item has received
Article information
Full Text
Download PDF
Figures (1)
Full Text

We report the case of a 64 years old man, a former farmer in Venezuela, with heavy alcoholic and tobacco smoking habits with no immunosuppressive status.

As he presented hemoptoic sputum, a computed tomographic study was performed, showing multiple calcifications, fibro-cicatricial lesions scattered in both lungs, along with emphysema and bronchiectasis. Bronchofibroscopy documented an exuberant inflammatory process, with nacreous plaques, hemorrhagic areas and ulceration of the lower third of tracheal mucosa and both bronchial trees. Histology of bronchial biopsies revealed a necrotizing granulomatous inflammatory process with polymorphonuclear cells and macrophages. Histochemical study revealed the presence of fungus in Grocott and PAS coloration stains (Fig. 1). No mycobacteria or neoplastic cells were detected.

Fig. 1.

Computed tomographic image of the patient thorax (a) and endobronchial aspects of disease at the distal third of patient's trachea (b); Histochemical detection of fungal forms in PAS coloration (c) and Grocott coloration (d).


A second bronchofibroscopy was executed to collect samples to mycological evaluation in a National Center, were PCR for detection of fungal DNA identified the fungus Paracoccidioides brasiliensis.

Paracoccidioidomycosis is endemic in South America, mainly Brazil (80%), Argentina, Colombia and Venezuela1,2. Although pulmonary involvement is frequent, endobronchial lesions solely rarely have been described2 and in this case were initially misinterpreted as suggestive of neoplasm, what was excluded in histological studies. This patient presented clinical, imagiological and endoscopic improvement after treatment with itraconazole 200mg for eighteen months.

S.A. Marques.
Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating.
An. Bras. Dermatol., 88 (2013), pp. 700-711
M.M. Barreto, E. Marchiori, V.B. Amorim, G. Zanetti, T.C. Takayassu, D.L. Escuissato.
Thoracic paracoccidioidomycosis: radiographic and CT findings.
Radiographics, 32 (2012), pp. 71-84
Copyright © 2020. SEPAR
Archivos de Bronconeumología
Article options

Are you a health professional able to prescribe or dispense drugs?