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Vol. 55. Issue 7.
Pages 378 (July 2019)
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Vol. 55. Issue 7.
Pages 378 (July 2019)
Clinical Image
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Multiple Pulmonary and Hepatic Arteriovenous Malformations in a Patient With Rendu-Osler-Weber Disease
Malformaciones arteriovenosas pulmonares y hepáticas múltiples en un paciente con enfermedad de Rendu-Osler-Weber
Emine Izgi, Fadime Guven, Hayri Ogul
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Department of Radiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey
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A 63-year-old female presented with shortness of breath. Thoracoabdominal computed tomography (CT) angiography demonstrated multiple pulmonary and hepatic arteriovenous malformations (Fig. 1). Rendu-Osler-Weber disease is characterized by multiple mucocutaneous telangiectasias and visceral arteriovenous malformations.

Fig. 1.

Coronal MIP image (A) and anterior view volume rendering 3D (B) thoracoabdominal CT angiographies showing multiple pulmonary (arrows) and hepatic arteriovenous malformations (between brackets).


Osler-Weber-Rendu is an autosomal dominant disease. It is characterized by multiple mucocutaneous telangiectasias, recurrent epistaxis, and visceral arteriovenous malformations. Vascular structures of the lung and gastrointestinal tract frequently involve.1 With the advent of multidetector CT, hepatic and pulmonary involvement with Rendu-Osler-Weber is commonly recognized.1

In liver involvement of Rendu-Osler-Weber disease, there is shunting from the hepatic artery to the portal or hepatic veins.2 These vascular anastomoses can diagnosed by CT or catheter angiography. Transcatheter embolization of hepatic or pulmonary arteries can perform in lung or liver involvement of patients with Rendu-Osler-Weber disease. Transplantation can perform in patients with liver or pulmonary insufficiency.3

H. Ogul, Y. Aydın, M. Ozgokce, E. Orsal, M. Kantarci, A. Eroglu.
Pulmonary arteriovenous malformations and hepatic involvement in a patient with Osler-Rendu-Weber disease.
Ann Thorac Surg, 94 (2012), pp. e155
G. Garcia-Tsao, J.R. Korzenik, L. Young, K.J. Henderson, D. Jain, B. Byrd, et al.
Liver disease in patients with hereditary hemorrhagic telangiectasia.
N Engl J Med, 343 (2000), pp. 931-936
P. Lacombe, A. Lacout, P.Y. Marcy, S. Binsse, J. Sellier, M. Bensalah, et al.
Diagnosis and treatment of pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: an overview.
Diagn Interv Imaging, 94 (2013), pp. 835-848
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