Journal Information
Vol. 45. Issue 6.
Pages 304-305 (June 2009)
Share
Share
Download PDF
More article options
Vol. 45. Issue 6.
Pages 304-305 (June 2009)
Case Report
Full text access
Hypersensitivity Pneumonitis Caused by Trichoderma viride
Neumonitis por hipersensibilidad causada por Trichoderma viride
Visits
5261
Alicia Enríquez-Matasa,
Corresponding author
aenriquezmatas@hotmail.com

Corresponding author.
, Santiago Quircea, Noelia Cuberob, Joaquín Sastrea, Rosario Melchorb
a Departamento de Alergia, Fundación Jiménez Díaz, Madrid, Spain
b Departamento de Neumología, Fundación Jiménez Díaz, Madrid, Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Abstract

Hypersensitivity pneumonitis (HP) can be induced by exposure to indoor molds contaminating humidifiers and heating or ventilation systems. A 54-year-old woman with dyspnea, cough, chest pain, and fever was seen in the emergency room. A chest radiograph revealed interstitial infiltrates and blood tests showed leukocytosis with neutrophilia and severe hypoxemia. A diagnosis of HP was made by a combination of clinical, radiologic, physiologic, and immunologic studies. Trichoderma viride was isolated in cultures of water samples from an ultrasonic humidifier installed in the patient's home a year earlier. Precipitating immunoglobulin G antibodies to T viride were detected in the patient's serum by enzyme-linked immunosorbent assay. The patient remained symptom free after the humidifier was removed from her home. Our findings strongly suggest that the patient developed HP due to T viride from the humidifier. To our knowledge, this is the first report of such a case.

Key words:
Fungi
Hypersensitivity pneumonitis
Trichoderma viride
Ultrasonic humidifiers
Resumen

Las neumonitis por hipersensibilidad (NH) pueden producirse debido a la exposición a hongos ambientales por contaminación de humidificadores y sistemas de calefacción. Describimos el caso de una paciente que acudió a urgencias por disnea, tos, dolor torácico y fiebre. Presentaba infiltrados intersticiales en la radiografía de tórax y leucocitosis con neutrofilia e hipoxemia grave en la analítica sanguínea. La combinación de exploraciones clínicas, radiológicas, fisiológicas e inmunológicas llevó al diagnóstico de NH. Tenía un humidificador doméstico en casa desde hacía un año. En el cultivo de las muestras de agua del humidificador creció Trichoderma viride. Se detectaron anticuerpos precipitantes inmunoglobulina G anti T. viride mediante enzimoinmunoanálisis en el suero de la paciente. Tras retirar el humidificador la paciente permaneció asintomática. El resultado de los estudios indica que desarrolló NH causada por T. viride que contaminaba el agua del humidificador. Según nuestro conocimiento, éste es el primer caso descrito de NH por T. viride.

Palabras clave:
Hongos
Neumonitis por hipersensibilidad
Trichoderma viride
Humidificadores ultrasónicos
Full text is only aviable in PDF
References
[1.]
T. Sugita, R. Ikeda, A. Nishikawa.
Analysis of Trichosporon isolates obtained from the houses of patients with summer-type hypersensitivity pneumonitis.
J Clin Microbiol, 42 (2004), pp. 5467-5471
[2.]
R.K. Bush, J.M. Portnoy, A. Saxon, A.I. Terr, R.A. Wood.
The medical effects of mold exposure.
J Allergy Clin Immunol, 117 (2006), pp. 326-333
[3.]
J.A. Álvarez-Fernández, S. Quirce, J.L. Calleja, M. Cuevas, E. Losada.
Hypersensitivity pneumonitis due to an ultrasonic humidifier.
Allergy, 53 (1998), pp. 210-212
[4.]
T. Chouaki, V. Lavarde, L. Lachaud, C.P. Raccurt, C. Hennequin.
Invasive Infections due to Trichoderma species: report of 2 cases, findings of in vitro susceptibility testing, and review of the literature.
Cin Infect Dis, 35 (2002), pp. 1360-1367
[5.]
S. Imokawa, A. Sato, M. Taniguchi, M. Imamura, T. Shirai, T. Suda, et al.
Two cases of acute eosinophilic pneumonia with precipitating antibody against Trichosporon cutaneum and Trichoderma viride.
Nihon Kyobu Shikkan Gakkai Zasshi, 31 (1993), pp. 352-359
[6.]
S.J. Vesper, C. McKinstry, C. Yang, R.A. Haugland, C.M. Kercsmar, I. Yike, et al.
Specific molds associated with asthma in water-damaged homes.
J Occup Environ Med, 48 (2006), pp. 852-858
Copyright © 2009. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?