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Vol. 55. Issue 7.
Pages 373-377 (July 2019)
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Vol. 55. Issue 7.
Pages 373-377 (July 2019)
Review article
How Far Are we Away From an Improved Vaccine For Tuberculosis? Current Efforts and Future Prospects
¿Estamos lejos de una mejor vacuna para la tuberculosis? Investigaciones actuales y perspectivas de futuro
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Cristina Vilaplanaa,b,
Corresponding author
, Pere-Joan Cardonaa,b
a Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Universitat Autònoma de Barcelona (UAB), Can Ruti Campus, Badalona, Catalonia, Spain
b Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain
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Table 1. Vaccine candidates in clinical development.
Abstract

Tuberculosis still is a major public health problem worldwide, and vaccines may play a major role in its eradication. However, despite 20 years of intensive research, we still do not have a better vaccine than the Bacille Calmette-Guérin vaccine, which has been used since 1921 but exhibits only limited efficacy in the field. This effort has not, however, been entirely in vain as our understanding of TB vaccinology has been substantially expanded and there are currently 17 vaccine candidates in clinical development and several more in preclinical trials. This manuscript reviews the most important recent advances, concerns raised and future prospects in the TB vaccinology field.

Keywords:
Tuberculosis
Vaccine
Clinical trials
Bacille Calmette-Guérin
Resumen

La tuberculosis (TB) continúa siendo un importante problema de salud pública a nivel mundial, para cuya erradicación las vacunas pueden jugar un papel relevante. Sin embargo, a pesar de 20 años de intensa investigación, todavía no se dispone de una mejor alternativa que la vacuna del bacilo Calmette-Guérin, que se utiliza desde 1921 pero cuya efectividad es limitada en el campo. Sin embargo, este esfuerzo no ha sido en vano, porque nuestro conocimiento sobre la vacunología de la TB ha aumentado sustancialmente, haciendo que actualmente haya 17 vacunas candidatas en estudios clínicos y algunas más en fase preclínica. Este artículo revisa los avances más importantes, problemas y perspectivas de futuro en el campo de la vacunología de la TB.

Palabras clave:
Tuberculosis
Vacuna
Ensayos clínicos
Bacilo Calmette-Guérin

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