Editorial
Thirdhand Smoke: A Ubiquitous Hidden Threat in Pandemic Times
Humo de tercera mano: una amenaza oculta ubicua en tiempos de pandemia
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"idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Thirdhand Smoke: A Ubiquitous Hidden Threat in Pandemic Times" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "569" "paginaFinal" => "570" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Noelia Ramírez González" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Noelia" "apellidos" => "Ramírez González" "email" => array:1 [ 0 => "noelia.ramirez@urv.cat" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Institut d’Investigació Sanitària Pere Virgili, Tarragona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Universitat Rovira i Virgili, DEEEiA, Tarragona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Humo de tercera mano: una amenaza oculta ubicua en tiempos de pandemia" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The COVID-19 pandemic has enforced unprecedent social isolation and worldwide lockdown measures, which lead to a vast increase of the time that we expend at home and, therefore, to our exposure to indoor air pollutants, including tobacco smoke toxicants. The harmful effects associated with passive exposure to tobacco smoke, also known as secondhand smoke (SHS), are widely recognised by society in general. Proof of this awareness is the smoke-free policies in public and workplaces implemented worldwide in the last few decades, following the recommendation of the Framework Convention on Tobacco Control in 2003.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Considered carcinogen to humans by the International Agency for Research on Cancer, the health effects associated with SHS exposure include rhinitis, allergic reactions, asthma, respiratory infections, and heart disease, as well as lung cancer, among others.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> Although exposure to SHS has globally decreased by more than 22% since 1990, the number of deaths attributable to SHS exposure were estimated to 900 thousand deaths in 2016, of which 6% were children under 5 years old,<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> numbers that cannot be neglected.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Nevertheless, exposure to tobacco smoke toxicants goes beyond SHS exposure, as most of the SHS gases and particles deposit, age, and remain for long periods of time on fabrics, surfaces, in airborne particles, and settled dust forming the so-called thirdhand smoke (THS), a less studied source of exposure to tobacco smoke toxicants.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> THS can be perceived as the characteristic tobacco smoke smell in clothes and hair after being exposed to SHS or inside rooms and cars where smoking is permitted.</p><p id="par0015" class="elsevierStylePara elsevierViewall">But why should THS be considered a new pathway of passive smoking? Firstly, these residual chemicals accumulate over time on indoor surfaces, remain for months after the last cigarette was consumed, and cannot be easily eliminated by cleaning or ventilation, adding to tobacco smoke exposure a long-lasting dimension not included in SHS.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a> Secondly, THS toxicants attached to surfaces as well as airborne and settled particles can be re-suspended, re-emitted into the gas phase, or even react with oxidants and other atmospheric compounds to yield secondary contaminants, some of them with increased toxicity.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> This is the case of the tobacco-specific nitrosamines (TSNAs), a leading class of carcinogens, whose concentrations could increase after the smoke was deposited indoors.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> A third reason is THS ubiquity. Recent studies have demonstrated the ubiquitous presence of tobacco-specific contaminants either in outdoor<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> and in indoor environments, including those with strict non-smoking bans.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> This fact gives tobacco smoke a dimension of active and complex environmental contaminant, whose regulation and health effects have been generally overlooked to date. Finally, the main pathways of exposure to THS toxicants are non-dietary ingestion and dermal absorption, which make young children especially susceptible owing to their hand-to-mouth behaviour and immature metabolism, among other causes.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The World Health Organisation (WHO) estimates that 40% of children are exposed to SHS,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> but this data does not include THS exposure and, therefore, underestimates the real exposure of tobacco smoke toxicants on children. After two decades of smoking-free laws, domestic environments have become the main sources of tobacco smoke exposure. The cancer risk associated with the exposure to carcinogen N-nitrosamines and TSNAs in THS accumulated in house dust from smokers’ homes was estimated to exceed the United States Environmental Protection Agency and WHO recommendations for children under 6 years old.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Considering the lack of awareness of THS risks by society in general and the fact that parents who smoke more than 10 cigarettes per day are less likely to believe that THS exposure is harmful to their children and, therefore, to implement strict smoking bans at home,<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> THS exposure of children cannot be overlooked. This latter statement has been particularly relevant during the stay-at-home period due to the COVID-19 pandemic that in many countries has led to an increase in smoking at home<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> and, therefore, to the inherent increase of THS exposure.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In the past decade, many studies have presented evidence of THS harm in animal models and human cell lines, recently reviewed by Jacob et al.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> THS health effects include the induction of oxidative DNA damage in human cell lines; and significant damage in the liver and lungs, poor wound healing, increased oxidative stress and inflammation, insulin resistance, or hyperactivity in mice exposed to THS, under conditions that mimic exposure of humans.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Given this evidence, it is urgent to investigate the effects of THS in children's health and the specific contribution of THS exposure in the occurrence of tobacco-related illnesses.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Hence, exposure to THS is a public health issue of global concern. Although awareness of the dangers of THS exposure increases every year, it is still generally omitted in health and environmental policies. To overcome this, future research must focus on filling the gaps in our current understanding of THS chemistry, toxicology, and, especially, on unravelling the health effects of this exposure on vulnerable populations. The need to respond to these challenges has become more urgent in the context of the current pandemic times since air pollution has been demonstrated as a risk factor of covid-19 adverse outcomes<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and THS exposure might have a relevant role in the occurrence, transmission and progression of covid-19 in vulnerable populations.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The COVID-19 pandemic has put smoking habits in the public eye decreasing the social acceptability of smoking in public and private places. It is our responsibility to take this unique opportunity to strengthen tobacco policies and increase general public awareness of the extensive impact of their smoking behaviour to protect the most susceptible population: children.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The author declares no conflict of interests.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of Interests" ] 1 => array:2 [ "identificador" => "xack552924" "titulo" => "Acknowledgements" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Word Health Organization Framework Convention on Tobacco Control (WHO FCTC)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "WHO" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "World Health Organization, Geneve." "fecha" => "2003" "paginaInicial" => "2003" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Oberg" 1 => "M.S. Jaakkola" 2 => "A. Woodward" 3 => "A. Peruga" 4 => "A. Prüss-Ustün" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(10)61388-8" "Revista" => array:6 [ "tituloSerie" => "Lancet." "fecha" => "2011" "volumen" => "377" "paginaInicial" => "139" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21112082" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "International Agency fo Research on Cancer (IARC). IARC Monograph Vol. 83. Tobacco Smoke and Involuntary Smoking. 2004. Available from: https://monographs.iarc.fr/iarc-monographs-on-the-evaluation-of-carcinogenic-risks-to-humans-38/." ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burden of disease attributable to second-hand smoke exposure: A systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Carreras" 1 => "A. Lugo" 2 => "S. Gallus" 3 => "B. Cortini" 4 => "E. Fernández" 5 => "M.J. López" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ypmed.2019.105833" "Revista" => array:4 [ "tituloSerie" => "Prev Med." "fecha" => "2019" "paginaInicial" => "129" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29337068" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Stanaway" 1 => "A. Afshin" 2 => "E. Gakidou" 3 => "S.S. Lim" 4 => "D. Abate" 5 => "K.H. Abate" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(18)32225-6" "Revista" => array:6 [ "tituloSerie" => "Lancet." "fecha" => "2018" "volumen" => "392" "paginaInicial" => "1923" "paginaFinal" => "1994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30496105" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimated Worldwide Mortality Attributed to Secondhand Tobacco Smoke Exposure, 1990-2016" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Yousuf" 1 => "M. Hofstra" 2 => "J. Tijssen" 3 => "B. Leenen" 4 => "J.W. Lindemans" 5 => "A. van Rossum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamanetworkopen.2020.1177" "Revista" => array:4 [ "tituloSerie" => "JAMA Netw Open." "fecha" => "2020" "volumen" => "3" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33030549" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thirdhand Smoke: New Evidence, Challenges, and Future Directions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Jacob" 1 => "N.L. Benowitz" 2 => "H. Destaillats" 3 => "L. Gundel" 4 => "B. Hang" 5 => "M. Martins-Green" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1021/acs.chemrestox.6b00343" "Revista" => array:6 [ "tituloSerie" => "Chem Res Toxicol." "fecha" => "2017" "volumen" => "30" "paginaInicial" => "270" "paginaFinal" => "294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28001376" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemical changes in thirdhand smoke associated with remediation using an ozone generator" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "X. Tang" 1 => "N. Ramírez" 2 => "M.L. Russell" 3 => "R.L. Maddalena" 4 => "L.A. Gundel" 5 => "H. Destaillats" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.envres.2020.110462" "Revista" => array:3 [ "tituloSerie" => "Environ Res." "fecha" => "2020" "paginaInicial" => "110462" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Formation of carcinogens indoors by surface-mediated reactions of nicotine with nitrous acid, leading to potential thirdhand smoke hazards" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Sleiman" 1 => "L.A. Gundel" 2 => "J.F. Pankow" 3 => "P. Jacob III" 4 => "B.C. Singer" 5 => "H. Destaillats" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.0912820107" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci USA." "fecha" => "2010" "volumen" => "107" "paginaInicial" => "6576" "paginaFinal" => "6581" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20142504" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimated Exposure Risks from Carcinogenic Nitrosamines in Urban Airborne Particulate Matter" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N.J. Farren" 1 => "N. Ramírez" 2 => "J.D. Lee" 3 => "E. Finessi" 4 => "A.C. Lewis" 5 => "J.F. Hamilton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1021/acs.est.5b01620" "Revista" => array:6 [ "tituloSerie" => "Environ Sci Technol." "fecha" => "2015" "volumen" => "49" "paginaInicial" => "9648" "paginaFinal" => "9656" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26207531" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposure to nitrosamines in thirdhand tobacco smoke increases cancer risk in non-smokers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Ramírez" 1 => "M.Z. Özel" 2 => "A.C. Lewis" 3 => "R.M. Marcé" 4 => "F. Borrull" 5 => "J.F. Hamilton" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.envint.2014.06.012" "Revista" => array:6 [ "tituloSerie" => "Environ Int." "fecha" => "2014" "volumen" => "71" "paginaInicial" => "139" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25036615" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pediatrician Interventions and Thirdhand Smoke Beliefs of Parents" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.E. Drehmer" 1 => "D.J. Ossip" 2 => "N.A. Rigotti" 3 => "E. Nabi-Burza" 4 => "H. Woo" 5 => "R.C. Wasserman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amepre.2012.07.020" "Revista" => array:6 [ "tituloSerie" => "Am J Prev Med." "fecha" => "2012" "volumen" => "43" "paginaInicial" => "533" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23079177" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tobacco Use Patterns in Five Countries During the COVID-19 Lockdown" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Yach" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ntr/ntaa097" "Revista" => array:5 [ "tituloSerie" => "Nicotine Tobacco Res." "fecha" => "2020" "volumen" => "22" "paginaInicial" => "1671" "paginaFinal" => "1672" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Air pollution and COVID-19 mortality in the United States: Strengths and limitations of an ecological regression analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "X. Wu" 1 => "R.C. Nethery" 2 => "M.B. Sabath" 3 => "D. Braun" 4 => "F. Dominici" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1126/sciadv.abd4049" "Revista" => array:4 [ "tituloSerie" => "Sci Adv." "fecha" => "2020" "volumen" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33277251" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Letter to the Editor Regarding: “An Imperative Need for Research on the Role of Environmental Factors in Transmission of Novel Coronavirus (COVID-19)”-Secondhand and Thirdhand Smoke As Potential Sources of COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.M. Mahabee-Gittens" 1 => "A.L. Merianos" 2 => "G.E. Matt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1021/acs.est.0c02041" "Revista" => array:6 [ "tituloSerie" => "Environ Sci Technol." "fecha" => "2020" "volumen" => "54" "paginaInicial" => "5309" "paginaFinal" => "5310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32319756" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack552924" "titulo" => "Acknowledgements" "texto" => "<p id="par0045" class="elsevierStylePara elsevierViewall">NRG's research is funded by a Miguel Servet contract (CP19/00060) from the Instituto de Salud Carlos III, co-financed by the European Union through Fondo Europeo de Desarrollo Regional (FEDER); “La Caixa” foundation under the grant agreement SR0074/2019.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03002896/0000005700000009/v1_202109020750/S0300289621000302/v1_202109020750/en/main.assets" "Apartado" => array:4 [ "identificador" => "14517" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorials / Editoriales" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000005700000009/v1_202109020750/S0300289621000302/v1_202109020750/en/main.pdf?idApp=UINPBA00003Z&text.app=https://www.archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289621000302?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 45 | 28 | 73 |
| 2024 September | 60 | 18 | 78 |
| 2024 August | 91 | 34 | 125 |
| 2024 July | 51 | 18 | 69 |
| 2024 June | 62 | 27 | 89 |
| 2024 May | 74 | 31 | 105 |
| 2024 April | 55 | 25 | 80 |
| 2024 March | 52 | 16 | 68 |
| 2024 February | 44 | 27 | 71 |
| 2024 January | 58 | 27 | 85 |
| 2023 December | 47 | 23 | 70 |
| 2023 November | 81 | 17 | 98 |
| 2023 October | 72 | 27 | 99 |
| 2023 September | 66 | 28 | 94 |
| 2023 August | 54 | 34 | 88 |
| 2023 July | 57 | 23 | 80 |
| 2023 June | 44 | 11 | 55 |
| 2023 May | 69 | 17 | 86 |
| 2023 April | 62 | 22 | 84 |
| 2023 March | 115 | 40 | 155 |
| 2023 February | 79 | 19 | 98 |
| 2023 January | 55 | 29 | 84 |
| 2022 December | 109 | 28 | 137 |
| 2022 November | 116 | 40 | 156 |
| 2022 October | 81 | 37 | 118 |
| 2022 September | 62 | 28 | 90 |
| 2022 August | 59 | 51 | 110 |
| 2022 July | 67 | 39 | 106 |
| 2022 June | 54 | 39 | 93 |
| 2022 May | 53 | 30 | 83 |
| 2022 April | 73 | 27 | 100 |
| 2022 March | 98 | 37 | 135 |
| 2022 February | 40 | 25 | 65 |
| 2022 January | 1 | 0 | 1 |
| 2021 December | 2 | 2 | 4 |
| 2021 November | 2 | 0 | 2 |
| 2021 October | 3 | 2 | 5 |
| 2021 September | 41 | 16 | 57 |
| 2021 August | 1 | 2 | 3 |
| 2021 April | 3 | 0 | 3 |
| 2021 March | 1 | 2 | 3 |
| 2021 February | 1 | 4 | 5 |
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