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Vol. 26. Issue 1.
Pages 12-16 (January - February 1990)
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Vol. 26. Issue 1.
Pages 12-16 (January - February 1990)
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Carcinoides bronquiales: estudio clínico, histopatológico e inmunohistoquímico
Bronchial carcinoid: a clinical, histopathological and immunohistochemical study
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...
R. Rami Porta, R. Ledo Andión, M. Corbal Mosteiro, G. Calzadilla Martín
Servicios de Cirugía Torácica. Hospital General de Galicia-Clínico Universitario. Santiago de Compostela
M. Fraga Rodríguez*, M. Couce Matovelle*, M. Berdugo Oviedo**, E. Pérez Becerra*
* Servicios de Anatomía Patológica. Hospital General de Galicia-Clínico Universitario. Santiago de Compostela
** Servicios de Neumología. Hospital General de Galicia-Clínico Universitario. Santiago de Compostela
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Arch Bronconeumol. 1990;26:27610.1016/S0300-2896(15)31596-9
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Diez mujeres y 9 varones entre 18 y 65 años de edad fueron intervenidos por carcinoide broncopulmonar entre enero de 1978 y diciembre de 1988 en el Hospital General de Galicia. Se practicaron 13 lobectomías, 3 neumonectomías, 2 broncotomías con tumorectomía y una bilobectomía inferior y media. Los patrones histológicos fueron: mixto insular-trabecular (8), trabecular (7), insular (2) y mixto trabecular-glandular (2). Se realizó estudio inmunohistoquímico en 16 de los 19 carcinoides con anticuerpos dirigidos contra enolasa neuronal específica, cromogranina y LEU 7 (panmarcadores neuroendocrinos). Hubo tres hidroneumotórax residuales postoperatorios que requirieron drenaje. Un paciente fue perdido de seguimiento tras el alta hospitalaria y los restantes fueron seguidos entre un mes y 10 años (media, 3,2 años) y todos se encontraban vivos y sin signos de recidiva tumoral. Por tanto, a pesar de las características anatomopatológicas de malignidad, el carcinoide broncopulmonar tiene, tras la cirugía, una evolución favorable. No se ha observado ninguna diferencia en el comportamiento biológico del tumor según el patrón histopatológico exhibido. La inmunohistoquímica confirma la naturaleza neuroendocrina de estos tumores.

Ten females and 9 males aged 18-65 years underwent operation for bronchopulmonary carcinoid in the Hospital General de Galicia between January 1978 and December 1988; 13 lobectomies, 3 pneumectomies, 2 bronchotomies with tumorectomy and one mean and inferior bilobectomy «ere carried out. The histological patterns were: mixed insular-trabecular (8), trabecular (7), insular (2), and mixed trabecular-glandular (2). Immunohistochemical study was carried out in 16 of the 19 carcinoids with antibodies against neuore specifíc enolase, chromogramine and LEU 7 (panendocrine markers). There were three patients with residual postoperative hydropneumothorax required drainage. One patient was lost to follow up after hospital discharge, and the remaining patients were followed up for 1 month-10 years (mean 3, 2 years). All were alive and free from tumor relapse. Therefore, in spite the malignant pathological features, bronchopulmonary carcinoid has a good outcome after surgery. No difference in the biological behavior of the tumor was found between the different pathological behavior of the tumor was found between the different pathological patterns. Immunohistochemical study confirmed the neuroendocrine character of these tumors.

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Copyright © 1990. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología

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