Lung transplantationOutcomeResults of Lung Transplantation in Patients With Cystic Fibrosis
Section snippets
Patients and Methods
Between October 1993 and October 2007, we performed 259 consecutive LTs in 250 patients to treat various end-stage pulmonary conditions, including CF in 78 patients, idiopathic pulmonary fibrosis in 76, chronic obstructive pulmonary disease in 64, bronchiectasis in 11, alfa-1-antitrypsin deficit in 5, primary pulmonary hypertension in 4, bronchiolitis obliterans syndrome (BOS) in 4, and other indications in 11. Our study group comprised 78 patients (30.11%) who had been diagnosed with CF
Results
Seventy-eight LTs were performed in patients with CF, most of whom were ambulatory. Twenty-three patients (29.5%) received transplants under an urgency code because of onset of an irreversible respiratory crisis that required mechanical ventilation; giving them priority over the remaing patients who were on the active waiting list for a lung. In most patients (91%), bipulmonary LT was performed. The mean (SD) ischemia time for the first and second lungs was 337 (56) minutes (range, 230–450 min
Discussion
Lung transplantation is the only available therapy for patients with CF with end-stage lung disease. Several series have shown that the predominant operative approach is bilateral LT. The 1-year survival rate after LT has improved dramatically to 79% to 84%.4, 5 In our series, we observed significant differences in actuarial survival between the CFLT and the OILT groups, though perioperative mortality was similar in both groups. Ventilator dependence has traditionally been considered a relative
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Cited by (6)
Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis
2014, Free Radical Biology and MedicineCitation Excerpt :Conventional CVD risk factors and immunosuppressive regimes, including glucocorticoid use, may contribute to the vasculopathy and accelerated CVD development post-lung transplant [296,297]. In patients with CF, the overall 5-year post-lung transplant survival rate is around 70% and is associated with both CVD and non-CVD posttransplant comorbidities [298–301]. One study specifically and retrospectively analyzed CVD risk factors pre- and post-lung transplant in adults with CF. Posttransplant, 32% had significantly elevated total cholesterol and 42% elevated triglycerides, compared to the infrequent elevations of these lipids pretransplant [302].
Lung transplantation in patients with cystic fibrosis
2013, Transplantation ProceedingsCitation Excerpt :The incidence of PGD was only 10% among our cohort. The overall 30-day mortality rate was 10%, corresponding to the range observed in previous case series, namely, 3.5%–19.2%.7–14 Although infection was one of the major concerns after lung transplantation, none of our patients died due to sepsis after the procedure.
Guidelines for the Selection of Lung Transplantation Candidates
2011, Archivos de BronconeumologiaCitation Excerpt :In addition, the multisystemic affectation of CF makes this population peculiar. Despite all these added problems, it should be stated that the survival of CF transplanted patients is very good, in adults as well as in children.4,31–39 The infections by germs that are resistant to antibiotics can increase the risk of LT for these patients although this fact does not constitute an absolute contraindication for LT. It has been reported that the colonization by pan-resistant Pseudomonas aeruginosa does not influence the short-term results of LT.37,40–42 Nor are the colonizations by resistant Staphylococcus aureus meticilin, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans or Aspergillus fumigatus2 considered contraindications.
Cystic Fibrosis–Associated Liver Disease in Lung Transplant Recipients
2019, Liver TransplantationLung transplantation for cystic fibrosis: A single center experience of 100 consecutive cases
2012, European Journal of Cardio-thoracic SurgeryShould the bronchiectasis treatment given to cystic fibrosis patients be extrapolated to those with bronchiectasis from other causes?
2010, Jornal Brasileiro de Pneumologia