Elsevier

Respiratory Medicine

Volume 99, Issue 10, October 2005, Pages 1213-1216
Respiratory Medicine

Helicobacter pylori seroprevalence in patients with chronic bronchitis

https://doi.org/10.1016/j.rmed.2005.02.036Get rights and content
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Summary

Aim

A high rate of seropositivity for antibodies against Helicobacter pylori has been found in many extragastrointestinal diseases. In addition, it has been reported that the risk of chronic bronchitis may be increased in subjects infected with H. pylori. This study was designed to determine the H. pylori seroprevalence in patients with and without chronic bronchitis.

Materials and methods

This study enrolled 68 patients with chronic bronchitis (40 men and 28 women, aged 50.5±16.2 years (mean±standard deviation) and 95 control subjects (60 men and 35 women, aged 51.8±15.9 years) matched for age and sex. An enzyme-linked immunosorbent assay immunoglobulin (Ig) G test for H. pylori diagnosis was performed on all enrolled subjects (those with chronic bronchitis and controls).

Results

Forty-five of 68 patients with chronic bronchitis (66.1%) and 48 of 95 subjects in the control group (57.7%) tested positive for H. pylori (P=0.008). Rates of H. pylori infection are higher in patients with chronic bronchitis than in the control group.

Conclusion

The main conclusion of this study is that H. pylori infection is associated with an increased prevalence chronic bronchitis. Further studies should be planned to understand the potential pathogenetic mechanisms that might underlie this association.

KEYWORDS

Helicobacter pylori
Chronic bronchitis

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