Review
LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

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Abstract

LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on the regulation of NF-κB by LUBAC and the diseases associated with this process are the focus of this review.

Keywords

Ubiquitin
NF-κB
Inflammation
Cytokine
Immunity
Apoptosis

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