Evolving technology/basic scienceTreatment with placenta-derived mesenchymal stem cells mitigates development of bronchiolitis obliterans in a murine model
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Abbreviations and Acronyms
BO
bronchiolitis obliterans
DAPI
4,6-diamidine-2-phenylindole dihydrochloride
G-CSF
granulocyte colony-stimulating factor
GM-CSF
granulocyte macrophage colony-stimulating factor
H&E
hematoxylin and eosin
HPF
high-power field
HTT
heterotopic tracheal transplant
IL
interleukin
IL-1RA
interleukin 1 receptor antagonist
MSC
mesenchymal stem cells
PBS
phosphate-buffered saline
PMSC
placenta-derived human mesenchymal stem cells
PMSCCM
PMSC-conditioned medium
TNF
tumor necrosis factor
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C.L.L. is supported by a grant sponsored by the National Heart, Lung, and Blood Institute (1K08HL094704) and matching funds from the Thoracic Surgery Foundation for Research and Education. I.L.K. is supported by a grant sponsored by the National Institute of Health (5RO1HL092953). J.R.G. and is supported by a training grant under I.L.K sponsored by the National Institute of Health (NIH T32HL007849).
Disclosures: Authors have nothing to disclose with regard to commercial support.
Published by Mosby, Inc.