Original ArticlesRespiratory Compliance in Late Preterm Infants (340/7-346/7 Weeks) after Antenatal Steroid Therapy
Section snippets
Methods
This prospective cohort study was done in the Neonatal Intensive Care Unit at Oregon Health and Science University in Portland, Oregon. The study was approved by the Institutional Review Board of the hospital and informed consent was obtained from the parents. Patients were enrolled between September 2009 and March 2010. Inclusion criteria for the study group included (1) infants born at a gestational age 340/7-346/7 weeks treated with antenatal steroids as part of clinical care; (2) maternal
Results
The primary reason for preterm delivery in both groups was preterm labor, followed by hypertension/preeclampsia and antepartum hemorrhage (Table I). The antenatal steroids-treated group included 7 sets of twins and the untreated group included 5 sets of twins. Both groups had the same percent of Caucasian and female infants, and similar birth weights. The mean gestational age of the treated group was 34.1 vs 34.3 weeks in the untreated group. This was statistically different because of the very
Discussion
This prospective cohort study demonstrates that late preterm infants (340/7-34 6/7 weeks of gestation) treated with antenatal steroids as part of clinical care prior to delivery had significantly increased Crs (25% higher) compared with matched infants who did not receive antenatal steroid therapy. This increased Crs also correlated with improved clinical respiratory outcomes, as significantly less of the infants treated with antenatal steroids required any CPAP and significantly less required
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Cited by (8)
Development of Lung Function in Preterm Infants During the First Two Years of Life
2022, Archivos de BronconeumologiaCitation Excerpt :At T2, term infants also showed some degree of catch-up in tidal volume (higher than preterms) and V’max FRC (lower than preterms). At 6 months, the lower LF observed in the preterm infants with a normal lung size (normal FVC), is in concordance with previous studies.7,8,10,27,28 The lower respiratory compliance (Crs) has also been previously reported.7,8,10
Pulmonary Function Tests in Very Low Birth Weight Infants Screened for Pulmonary Hypertension: A Pilot Study
2021, Journal of PediatricsCitation Excerpt :The infants with pulmonary hypertension had significantly higher levels of NT-proBNP at the time of pulmonary hypertension screening and required significantly more days of mechanical ventilation and oxygen supplementation, although this difference, at least in part, might have been secondary to the treatment of their pulmonary hypertension. The major strengths of our study are the application of consensus screening guidelines for VLBW infants at risk for pulmonary hypertension, the performance of standardized neonatal PFTs by an experienced research team,25-27 and the review of Echos by a single pediatric cardiologist experienced in pulmonary hypertension. Our guidelines were based on published consensus recommendations and a critical review of available literature supporting the early screening of VLBW infants who continued to require respiratory support.6,9
End points for therapeutic trials for BPD
2020, Tantalizing Therapeutics in Bronchopulmonary DysplasiaLate preterm antenatal steroid use and infant outcomes in a single center
2024, Journal of PerinatologyLate Preterm Antenatal Steroid Use and Infant Outcomes in a Single Center
2023, Research SquareContemporary Classics in Neonatal Respiratory Care
2022, Manual of Neonatal Respiratory Care, Fifth Edition
Supported by National Center for Advancing Translational Sciences/National Institutes of Health (NIH; UL1TR000128), NIH/NHLBI (K23 HL080231 and R01 HL105447), Office of Dietary Supplement, and American Lung Association to CTM. The authors declare no conflicts of interest.