Elsevier

Journal of Magnetic Resonance

Volume 229, April 2013, Pages 173-186
Journal of Magnetic Resonance

Perspectives of hyperpolarized noble gas MRI beyond 3He

https://doi.org/10.1016/j.jmr.2012.11.014Get rights and content
Under a Creative Commons license
open access

Abstract

Nuclear Magnetic Resonance (NMR) studies with hyperpolarized (hp) noble gases are at an exciting interface between physics, chemistry, materials science and biomedical sciences. This paper intends to provide a brief overview and outlook of magnetic resonance imaging (MRI) with hp noble gases other than hp 3He. A particular focus are the many intriguing experiments with 129Xe, some of which have already matured to useful MRI protocols, while others display high potential for future MRI applications. Quite naturally for MRI applications the major usage so far has been for biomedical research but perspectives for engineering and materials science studies are also provided. In addition, the prospects for surface sensitive contrast with hp 83Kr MRI is discussed.

Highlights

► Advances in hyperpolarization have reduced the SNR gap between 3He and 129Xe. ► 129Xe offers additional information useful in materials and biomedical sciences. ► Non-invasive techniques with 129Xe probe lung morphometry and offer new biomarkers. ► 83Kr with a nuclear electric quadrupole moment provides surface sensitive contrast.

Keywords

129Xe
Xenon-129
Xe-129
83Kr
Krypton-83
Kr-83
Hyperpolarization
Hyperpolarized
Spin polarization
Spin-exchange optical pumping
Chemical shift selective
Nuclear electric quadrupole moment
Quadrupolar relaxation
NMR spectroscopy
Pulmonary MRI
Lung pathology
Biosensor
Molecular imaging
Remote detection
Flow
Diffusion
Gas phase
Transport weighted
Combustion
Surface sensitive
MRI contrast
Porous materials

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