Elsevier

Journal of Cystic Fibrosis

Volume 12, Issue 5, September 2013, Pages 454-460
Journal of Cystic Fibrosis

Original Article
Exhaled molecular profiles in the assessment of cystic fibrosis and primary ciliary dyskinesia

https://doi.org/10.1016/j.jcf.2012.12.010Get rights and content
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Abstract

Background

Early diagnosis and monitoring of disease activity are essential in cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). We aimed to establish exhaled molecular profiles as the first step in assessing the potential of breath analysis.

Methods

Exhaled breath was analyzed by electronic nose in 25 children with CF, 25 with PCD and 23 controls. Principle component reduction and canonical discriminant analysis were used to construct internally cross-validated ROC curves.

Results

CF and PCD patients had significantly different breath profiles when compared to healthy controls (CF: sensitivity 84%, specificity 65%; PCD: sensitivity 88%, specificity 52%) and from each other (sensitivity 84%, specificity 60%). Patients with and without exacerbations had significantly different breath profiles (CF: sensitivity 89%, specificity 56%; PCD: sensitivity 100%, specificity 90%).

Conclusion

Exhaled molecular profiles significantly differ between patients with CF, PCD and controls. The eNose may have potential in disease monitoring based on the influence of exacerbations on the VOC-profile.

Keywords

Cystic fibrosis
Primary ciliary dyskinesia
Exhaled breath
Volatile Organic Compounds
Electronic nose

Cited by (0)

There are no conflicts of interest to disclose. The abstract was submitted to the American Thoracic Society conference 18–23th May 2012, San Francisco.

1

Both authors contributed equally to this manuscript.