Asthma and lower airway diseaseDiagnostic properties of inhaled mannitol in the diagnosis of asthma: A population study
Section snippets
Study design
The study is a cross-sectional population study performed at the Respiratory Research Unit, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark. An unselected sample of 1000 young adults between the ages of 14 and 24 years was randomly drawn from the civil registration list. All subjects received a validated self-administered asthma and rhinitis screening questionnaire, with 20 questions adopted from the American College of Allergy, Asthma & Immunology screening program extended with
Population characteristics
Of the 978 subjects possible to contact, 448 (45.8%) responded by returning the screening questionnaire. Among these, 238 (24.3%) volunteered to participate in the study and completed the examination.
There were no differences between participants and nonparticipants regarding the prevalence of self-reported asthma; age; familial predisposition to asthma, allergic disease, or both; and smoking habits. The ratio between male and female subjects, however, was different in the 2 groups (Table I).
Response to mannitol
Discussion
Recently, a new BPT for asthma with inhalation of mannitol powder was introduced. Unlike the current tests available, the mannitol test has only 1 operating standard and protocol. The inconveniencies of comparing test results from one study with those from another because of differences in protocols have remained a major weak spot in AHR research. One operating standard is therefore an absolute advantage.
It was the objective of this study to uncover the distinctive qualities of the mannitol
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Airway Hyperresponsiveness to Inhaled Mannitol Identifies a Cluster of Noneosinophilic Asthma Patients with High Symptom Burden
2021, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :For this purpose, we pooled 6 well-characterized asthma cohorts and applied a hierarchical cluster analysis that group patients based on a principle of minimum within cluster variance. Data from 6 cohorts of asthma patients were merged.9-14 Eligible patients were those with an objectively confirmed diagnosis of asthma (provocation dose causing 15% decline in forced expiratory volume in 1 s [FEV1] [PD15] to mannitol < 635 mg or provocation dose causing a 20% decline in FEV1 [PD20] to methacholine < 8.0 mmol or reversibility in FEV1 to short-acting beta 2 agonist of at least 12% and 200 mL or day-to-day peak-flow variability of at least 20%) who also had a mannitol test, blood eosinophils, and Asthma Control Questionnaire (ACQ) measured.
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The Danish Agency for Science, Technology and Innovation, an institution under the Danish Ministry of Science, Technology and Innovation, granted a 1-year scholarship. Pharmaxis provided the research team with an unrestricted grant, with which one of the research assistants was employed. Moreover, parts of the Mannitol kits were delivered at no cost by Pharmaxis.
Disclosure of potential conflict of interest: V. Backer has received research support from Pharmaxis. The rest of the authors have declared that they have no conflict of interest.