Journal of the American Academy of Dermatology
Case ReportHenoch-Schönlein purpura associated with malignancy in adults
Section snippets
Case 1
A 71-year-old white man with a history of prostate and renal cell carcinoma and hypertension presented with the sudden onset of progressive palpable purpura on his lower extremities, diffuse abdominal pain, and constipation. His medical history included papillary renal cell carcinoma diagnosed 2 months before admission, which was treated with a left partial nephrectomy demonstrating negative margins. He also was diagnosed with Gleason score 7 prostate cancer 1 month before admission for which
Discussion
Neoplasia is a well-documented cause of vasculitis. The incidence of vasculitis in patients with malignancy is estimated to be 2.5% to 5%.2, 6, 8, 9, 10, 11, 12 Although myeloproliferative and lymphoproliferative malignancies were 3 to 5 times more common than solid tumors in all types of vasculitis, solid tumors were more common in association with HSP.11, 12, 13, 14 To date, there have been only 31 reported patients with HSP and coexisting malignancy in the world literature (Table I).8, 13, 14
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