Clinical lung and heart/lung transplantationTrue Survival Benefit of Lung Transplantation for Cystic Fibrosis Patients: The Zurich Experience
Section snippets
Study Population
In this study we included all pediatric and adult CF patients undergoing primary lung transplantation at the University Hospital Zurich, Switzerland, between November 1992 and November 2007. Transplant recipients were followed-up until August 2008. Patients' demographic data were collected. Pre-transplant clinical data included forced expiratory volume in 1 second (FEV1), body mass index (BMI), diagnosis of CF-related diabetes mellitus (CFDM) and bone mineral density at the hip/femoral neck
Study Population
Two hundred thirty lung transplant operations have been performed in our program since its establishment in 1992 up to November 2007. Of this cohort, 80 (34.5%) transplant recipients had CF, all of whom were included in this study (13.8% were <18 years of age). All except 1 patient underwent double-lung transplantation. One patient with additional congenital heart disease had a heart–lung transplant operation performed. Two CF patients were chronically infected with Burkholderia cepacia
Discussion
This observational study demonstrates a true survival benefit for CF patients with end-stage lung disease undergoing lung transplantation at our center. Estimated 5-year survival without transplantation in our cohort was 33% compared with a 5-year survival after transplantation of 67%. Moreover, the 1-year post-transplant survival in the recent era (since 2000) improved to >90% in CF transplant recipients, and for 3-year survival was >80%. Furthermore, pediatric age had no negative impact on
References (29)
- et al.
Registry of the International Society for Heart and Lung Transplantation: twenty-fifth official adult lung and heart–lung transplantation report—2008
J Heart Lung Transplant
(2008) - et al.
Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria
J Heart Lung Transplant
(2002) - et al.
Lung transplantation and life extension in children with cystic fibrosis
Lancet
(1999) - et al.
Quality of life after lung transplantation: a cross-sectional study
J Heart Lung Transplant
(2005) - et al.
Registry of the International Society for Heart and Lung Transplantation: eleventh official pediatric lung and heart–lung transplantation report —2008
J Heart Lung Transplant
(2008) - et al.
Post-operative infections in cystic fibrosis and non–cystic fibrosis patients after lung transplantation
J Heart Lung Transplant
(2007) - et al.
Health-related quality of life in 280 lung transplant recipients
J Heart Lung Transplant
(2005) - et al.
A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation
J Heart Lung Transplant
(2007) Update on cystic fibrosis: selected aspects related to lung transplantation
Swiss Med Wkly
(2003)- et al.
Survival following lung transplantation of cystic fibrosis patients colonized with Burkholderia cepacia
Am J Respir Crit Care Med
(2000)