New methodsClinical endoscopyA pilot study of endoscopically inserted biodegradable biliary stents in the treatment of benign biliary strictures and cystic duct leaks
Section snippets
Methods
Altogether, 13 patients with either postcholecystectomy cystic duct leak or BBS were prospectively recruited between 2014 and 2016 at Tampere University Hospital, Finland. Patients with surgically altered duodenal anatomy or considered noncompliant with follow-up protocol or incompatible with magnetic resonance imaging (MRI) were not recruited. The diagnosis of bile leak was based on clinical features, CT scan, and bilirubin content in drain output. In BBSs malignancy was excluded with CT and
Results
Data on 13 patients treated with BDBSs for postcholecystectomy bile leak or BBS are presented in Table 1. Endoscopic stent insertion was successful in all cases (Figs. 1 and 3). Data on clinical outcome, repeated MRIs, and liver function tests from both groups are presented in Table 2. One patient was lost from follow-up in each group. In all patients during the first 30 days there were altogether 4 readmissions (31%), of which 2 were for pain after stent insertion, 1 (8%) for mild cholangitis,
Discussion
This pilot study evaluated the long-term clinical utility of endoscopically inserted BDBSs in postcholecystectomy bile leaks and BBSs. The biocompatibility and degradation profiles have been demonstrated in several studies.7, 8, 9 Furthermore, the largest study on BDBSs yielded an encouraging long-term success rate of 82% in the percutaneous management of refractory postoperative or chronic pancreatitis–related strictures.4 Our main result was that the endoscopic insertion of BDBSs was highly
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Management of Benign Biliary Stricture in Chronic Pancreatitis
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2022, Colloids and Surfaces B: BiointerfacesCitation Excerpt :Thus, the biodegradable biliary stents are receiving great attention due to it can overcome defects of the metallic and none-degradable plastic biliary stents [35,36]. Some materials with biodegradation profiles have been used to preparation of biodegradable biliary stents, such as polydioxanone, polylactic acid based polymers, polycaprolactone and biodegradable magnesium alloy [34, 35, 37–39]. In addition, a number of new multifunctional biliary stents have emerged in recent years, such as radioactive particle stents.
A review on biodegradable biliary stents: materials and future trends
2022, Bioactive MaterialsCitation Excerpt :However, 25% of the patients developed mild cholangitis during stent indwelling, while 17% of the patients developed restenosis. Factors such as slow degradation and rupturing of the stent may have caused intermittent obstruction of bile flow and resulted in acute cholangitis [19]. In their previous esophageal studies, PDX stent implantation were considered to be associated with secondary epithelial hyperplasia and stricture [20].
DISCLOSURE: All authors disclosed no financial relationships relevant to this publication. Research support for this study was provided by the Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital, Tampere, Finland.
If you would like to chat with an author of this article, you may contact Dr Siiki at [email protected].