A novel polymorphism of the CYP2J2 gene is associated with coronary artery disease in Uygur population in China
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Graphical abstract
Schematic of EET interactions with cardiovascularion channels.
A: In the cardiac myocyte, EETs activate sarcolemmal or mitochondrial KATP channels.
B: In the vasculature, EETs activate endothelial small (SKCa) or intermediate (IKCa) conductance calcium-activated channels to cause hyperpolarization, which can be transmitted to the vascular smooth muscle via myoendothelial gap junctions. EETs also activate TRPV4 channels to activate Ca2 + influx. In the vascular smooth muscle, EETs activate large conductance, calcium-activated (BKCa) channels through a G-protein-coupled event.
C: In platelets, EETs activate BKCa channels
Keywords
CYP2J2
Single nucleotide polymorphism
Coronary artery disease
Case–control study
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These authors contributed equally to this work.
Copyright © 2013 The Authors. Published by Elsevier Inc.