Original articleGeneral thoracicLung Retransplantation for Chronic Rejection: A Single-Center Experience
Section snippets
Study Population
This study was approved by the Institutional Review Board at St. Joseph’s Hospital and Medical Center. We reviewed the charts of patients who underwent LTx between March 1, 2010, and May 31, 2016, at Norton Thoracic Institute at St. Joseph’s Hospital and Medical Center in Phoenix, Arizona. All 419 patients who received LTx during this time period were included in the study. Patients were separated into one of two groups: primary LTx or lung retransplantation. Patient selection for primary LTx
Patient Characteristics
In total, 419 patients underwent LTx during the study period. Of these, 390 patients (93.1%) underwent primary LTx; 29 patients (6.9%) underwent retransplantation (Table 1). The indication for all 29 retransplantations was CLAD. Median time to retransplantation after initial LTx was 1,163 days (range: 304 to 3971 days). Most LTx procedures were bilateral—27 of 29 in the retransplantation group (93.1%) and 374 of 390 in the primary LTx group (95.9%). Patients who underwent retransplantation were
Comment
This report is a single-center review describing outcomes of lung retransplantation in 29 patients. Because of the reported poor outcomes after lung retransplantation for acute graft failure and airway complications 1, 3, 4, 9, we instituted a policy to perform retransplantation only for CLAD. The outcomes for lung retransplantation were then compared with the outcomes for primary LTx at our center.
Lung retransplantation procedures increased in frequency after the introduction of the LAS system
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