Original articleGeneral thoracicLongitudinal Follow-Up of Six-Minute Walk Distance After Pulmonary Endarterectomy
Section snippets
Patients and Methods
The research protocol for this study was approved by the local Institutional Review Board, and the study was conducted in accordance with the principles of the Declaration of Helsinki. On inclusion, all patients were asked to consent to collection of their data. However, because the analyses performed for the present study used anonymized data that had been registered for research purposes, the need for informed consent was waived.
Patient Characteristics
Between January 2003 and January 2009, 96 patients with CTEPH underwent PEA in our hospital. Most of the 85 patients with pulmonary arterial hypertension at rest had moderate to severe pulmonary hypertension, with a mean mPAP of 43.7 ± 10.9 mm Hg and a mean total pulmonary resistance (TPR) of 806 ± 387 dynes · s · cm−5. Eleven additional patients with exercise-induced pulmonary hypertension presented with disabling impairment of exercise tolerance and had angiographic evidence for proximal
Comment
We assessed the longitudinal postoperative functional recovery of patients with CTEPH up to 5 years after PEA. Although NYHA functional class and sPAP improved within the first 3 months after PEA and remained constant thereafter, the 6-MWD showed a gradual improvement over a 2-year follow-up period. Interestingly, patients with residual pulmonary hypertension after PEA showed more improvement in both 6-MWD and hemodynamics, despite their worse absolute outcome.
As hypothesized, restoration of
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