Curriculum in CardiologySystematic review of studies of the effect of hyperoxia on coronary blood flow
Section snippets
Search strategy
To identify all studies that investigated the effect of oxygen therapy on coronary blood flow, a search using the terms “oxygen” and “coronary blood flow” as well as “hyperoxia” and “coronary circulation” was conducted from Medline, Cochrane Database of Systematic Reviews, EMBASE, and CINHAL in December 2007. The reference lists of all relevant studies were also examined. Particular attention was given to searching for studies before 1950, which would not be included in the electronic reference
Description of studies
Figure 1 shows the QUOROM statement for the search, which identified 2,072 potential publications. There were 4 publications with 6 studies that met the criteria for inclusion in this analysis (Table I).26, 27, 28, 29 Two of the publications reported data on separate subject groups, based on the presence or absence of cardiac disease as follows: Ganz et al26 studied patients with coronary artery disease and those with normal coronary arteries, and Mak et al27 studied patients with stable
Discussion
This systematic review has identified that hyperoxia secondary to high-concentration oxygen therapy results in a marked reduction in coronary blood flow due to an increase in coronary vascular resistance. Hyperoxia also caused a reduction in myocardial oxygen consumption in both healthy subjects and subjects with cardiac disorders including coronary artery disease and congestive heart failure. These physiologic effects, together with the well-recognized reduction in heart rate and cardiac
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2022, Seminars in NephrologyCitation Excerpt :In addition, organ-specific vascular changes induced by hyperoxia may paradoxically increase an individual organ's risk of hypoxia. The vascular beds of the heart,52 skeletal muscle,53 and brain54 have increased vasoconstrictive responses to hyperoxia, leading to decreased local blood flow. Although it has been suggested that pulmonary and renal vessels have limited response to hyperoxic vascular effects,55 high arterial oxygen impairs renal circulation in patients with pulmonary or cardiac pathologies.56