TY - JOUR T1 - Prevalence and 30-Day Mortality in Hospitalized Patients With Covid-19 and Prior Lung Diseases JO - Archivos de Bronconeumología T2 - AU - Signes-Costa,Jaime AU - Núñez-Gil,Iván J. AU - Soriano,Joan B. AU - Arroyo-Espliguero,Ramón AU - Eid,Charbel Maroun AU - Romero,Rodolfo AU - Uribarri,Aitor AU - Fernández-Rozas,Inmaculada AU - Aguado,Marcos García AU - Becerra-Muñoz,Víctor Manuel AU - Huang,Jia AU - Pepe,Martino AU - Cerrato,Enrico AU - Raposeiras,Sergio AU - Gonzalez,Adelina AU - Franco-Leon,Francisco AU - Wang,Lin AU - Alfonso,Emilio AU - Ugo,Fabrizio AU - García-Prieto,Juan Fortunato AU - Feltes,Gisela AU - Abumayyaleh,Mohammad AU - Espejo-Paeres,Carolina AU - Jativa,Jorge AU - Masjuan,Alvaro López AU - Macaya,Carlos AU - Carbonell Asíns,Juan A. AU - Estrada,Vicente SN - 03002896 M3 - 10.1016/j.arbres.2020.11.012 DO - 10.1016/j.arbres.2020.11.012 UR - https://www.archbronconeumol.org/en-prevalence-30-day-mortality-in-hospitalized-articulo-S0300289620305354 AB - IntroductionPatients with pre-existing respiratory diseases in the setting of COVID-19 may have a greater risk of severe complications and even death. MethodsA retrospective, multicenter, cohort study with 5847 COVID-19 patients admitted to hospitals. Patients were separated in two groups, with/without previous lung disease. Evaluation of factors associated with survival and secondary composite end-point such as ICU admission and respiratory support, were explored. Results1,271 patients (22%) had a previous lung disease, mostly COPD. All-cause mortality occurred in 376 patients with lung disease (29.5%) and in 819 patients without (17.9%) (p<0.001). Kaplan–Meier curves showed that patients with lung diseases had a worse 30-day survival (HR=1.78; 95%C.I. 1.58–2.01; p<0.001) and COPD had almost 40% mortality. Multivariable Cox regression showed that prior lung disease remained a risk factor for mortality (HR, 1.21; 95%C.I. 1.02–1.44; p=0.02). Variables independently associated with all-cause mortality risk in patients with lung diseases were oxygen saturation less than 92% on admission (HR, 4.35; 95% CI 3.08–6.15) and elevated D-dimer (HR, 1.84; 95% CI 1.27–2.67). Age younger than 60 years (HR 0.37; 95% CI 0.21–0.65) was associated with decreased risk of death. ConclusionsPrevious lung disease is a risk factor for mortality in patients with COVID-19. Older age, male gender, home oxygen therapy, and respiratory failure on admission were associated with an increased mortality. Efforts must be done to identify respiratory patients to set measures to improve their clinical outcomes. ER -