TY - JOUR T1 - Effect of Sex Differences on Computed Tomography Findings in Adults With Cystic Fibrosis: A Multicenter Study JO - Archivos de Bronconeumología T2 - AU - Diab Cáceres,Layla AU - Girón Moreno,Rosa María AU - García Castillo,Elena AU - Pastor Sanz,Maria Teresa AU - Olveira,Casilda AU - García Clemente,Marta AU - Nieto Royo,Rosa AU - Prados Sánchez,Concepción AU - Caballero Sánchez,Paloma AU - Olivera Serrano,Maria Jose AU - Padilla Galo,Alicia AU - Nava Tomas,Encarnación AU - Esteban Peris,Amparo AU - Fernández Velilla,Maria AU - Torres,Maria Isabel AU - Ancochea Bermúdez,Julio SN - 03002896 M3 - 10.1016/j.arbres.2019.12.028 DO - 10.1016/j.arbres.2019.12.028 UR - https://www.archbronconeumol.org/en-effect-sex-differences-on-computed-articulo-S0300289620300156 AB - BackgroundThe survival of women with cystic fibrosis (CF) is lower than that of men by approximately 5 years. While various factors have been put forward to account for this discrepancy, no specific reasons have been established. Our hypothesis was that anatomical-structural involvement is more pronounced in women with CF than in men and that this is reflected in thoracic HRCT findings. Material and methodsWe performed a prospective multicentre study, in which adult patients were consecutively included over 18 months. Chest HRCT was performed, and findings were scored by 2 thoracic radiologists using the modified Bhalla system. We also studied respiratory function, applied the CFQR 14+ questionnaire, and collected clinical variables. ResultsOf the 360 patients followed up in the participating units, 160 were eventually included. Mean age was 28 years, and 47.5% were women. The mean±SD global score on the modified Bhalla score was 13.7±3.8 in women and 15.2±3.8 in men (p=0.024). The highest scores were observed for sacculations, bronchial generations, and air trapping in women. Women had lower BMI, %FEV1, %FVC, and %DLCO. Similarly, the results for the respiratory domain in CFQR 14+ were worse in women, who also had more annual exacerbations. ConclusionsThis is the first study to provide evidence of the implication of sex differences in HRCT findings in patients with CF. Women with CF present a more severe form of the disease that results in more frequent exacerbations, poorer functional and nutritional outcomes, deterioration of quality of life, and greater structural damage. ER -