TY - JOUR T1 - Hypercapnia Response in Patients With Obesity-Hypoventilation Syndrome Treated With Non-Invasive Ventilation at Home JO - Archivos de Bronconeumología T2 - AU - Fernández Álvarez,Ramón AU - Rubinos Cuadrado,Gemma AU - Ruiz Alvarez,Ines AU - Hermida Valverde,Tamara AU - Iscar Urrutia,Marta AU - Vázquez Lopez,María José AU - Casan Clara,Pere SN - 15792129 M3 - 10.1016/j.arbr.2018.07.009 DO - 10.1016/j.arbr.2018.07.009 UR - https://www.archbronconeumol.org/en-hypercapnia-response-in-patients-with-articulo-S1579212918302386 AB - IntroductionRespiratory center (RC) dysfunction has been implicated in the pathogenesis of obesity-hypoventilation syndrome (OHS), and often requires treatment with home non-invasive ventilation (NIV). Our objective was to measure the effect of NIV on RC function in patients with OHS, and the factors that determine such an effect. MethodsWe performed a prospective, repeated measures study to evaluate hypercapnia response (HR) by determining the p01/pEtCO2 ratio slope at baseline and after 6months of treatment with NIV in a group of OHS patients. A threshold of 0.22cmH2O/mmHg had previously been established in a control group, in order to differentiate optimal RC response from suboptimal RC response. ResultsA total of 36 cases were included, 19 men (52%) aged 65 (SD 9) years, 63% of whom had p01/pEtCO2 below the reference value. Baseline p01/pEtCO2 was 0.17 (SD: 0.14)cmH2O/mmHg and, after 6 months of NIV, 0.30 (SD: 0.22)cm H2O/mmHg (P=0.011). After 6months of treatment with NIV, depressed RC function persisted in 12 cases (33%). ConclusionIn total, 63% of OHS patients had RC dysfunction. The application of NIV improves RC function but not in all cases. ER -