TY - JOUR T1 - Mid- and Long-term Efficacy of Non-invasive Ventilation in Obesity Hypoventilation Syndrome: The Pickwick's Study JO - Archivos de Bronconeumología T2 - AU - López-Jiménez,María J. AU - Masa,Juan F. AU - Corral,Jaime AU - Terán,Joaquín AU - Ordaz,Estrella AU - Troncoso,Maria F. AU - González-Mangado,Nicolás AU - González,Mónica AU - Lopez-Martínez,Soledad AU - De Lucas,Pilar AU - Marín,José M. AU - Martí,Sergi AU - Díaz-Cambriles,Trinidad AU - Díaz-de-Atauri,Josefa AU - Chiner,Eusebi AU - Aizpuru,Felipe AU - Egea,Carlos AU - Romero,Auxiliadora AU - Benítez,José M. AU - Sánchez-Gómez,Jesús AU - Golpe,Rafael AU - Santiago-Recuerda,Ana AU - Gómez,Silvia AU - Barbe,Ferrán AU - Bengoa,Mónica SN - 15792129 M3 - 10.1016/j.arbr.2016.01.012 DO - 10.1016/j.arbr.2016.01.012 UR - https://www.archbronconeumol.org/en-mid-long-term-efficacy-non-invasive-ventilation-articulo-S1579212916000136 AB - The Pickwick project is a prospective, randomized and controlled study, which addresses the issue of obesity hypoventilation syndrome (OHS), a growing problem in developed countries. OHS patients were divided according to apnea–hypopnea index (AHI) ≥30 and <30 determined by polysomnography. The group with AHI≥30 was randomized to intervention with lifestyle changes, noninvasive ventilation (NIV) or continuous positive airway pressure (CPAP); the group with AHI <30 received NIV or lifestyle changes.The aim of the study was to evaluate the efficacy of NIV treatment, CPAP and lifestyle changes (control) in the medium and long-term management of patients with OHS. The primary variables were PaCO2 and days of hospitalization, and operating variables were the percentage of dropouts for medical reasons and mortality.Secondary medium-term objectives were: (1) to evaluate clinical–functional effectiveness on quality of life, echocardiographic and polysomnographic variables; (2) to investigate the importance of apneic events and leptin in the pathogenesis of daytime alveolar hypoventilation and change according to the different treatments; (3) to investigate whether metabolic, biochemical and vascular endothelial dysfunction disorders depend on the presence of apneas and hypopneas and (4) changes in inflammatory markers and endothelial damage according to treatment.Secondary long-term objectives are to evaluate: (1) clinical and functional effectiveness and quality of life with NIV and CPAP; (2) changes in leptin, inflammatory markers and endothelial damage according to treatment; (3) changes in pulmonary hypertension and other echocardiographic variables, as well as blood pressure and incidence of cardiovascular events, and (4) dropout rate and mortality. ER -