Notice: Undefined index: tieneTextoCompleto in /var/www/html/bronco/controladores/procedimientos-especificos.php on line 26

Notice: Undefined index: textoCompleto in /var/www/html/bronco/controladores/procedimientos-especificos.php on line 26
La célula epitelial como factor etiopatogénico de la fibrosis pulmonar | Archivos de Bronconeumología
Archivos de Bronconeumología Archivos de Bronconeumología
Arch Bronconeumol 2012;48 Supl 2:2-6 - Vol. 48 DOI: 10.1016/S0300-2896(12)70044-3
Actualización en fibrosis pulmonar idiopática
La célula epitelial como factor etiopatogénico de la fibrosis pulmonar
Alveolar epithelial cell injury as an etiopathogenic factor in pulmonary fibrosisa
Anna Serrano-Mollar
Departamento de Patología Experimental, Institut d’Investigacions Biomèdiques de Barcelona, España
Consejo Superior de Investigaciones Científicas (IIBB-CSIC), Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, España
Centro de investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES)
Resumen

La fibrosis pulmonar idiopática se caracteriza por una acumulación progresiva de matriz extracelular y un desequilibrio entre mediadores profibróticos y antifibróticos. Durante los últimos años se ha avanzado mucho en el conocimiento de los mecanismos de la biología de la fibrosis pulmonar idiopática. En este sentido, uno de los hallazgos más significativo es el descubrimiento de que la lesión de las células del epitelio alveolar juega un papel importante en la patogénesis de esta enfermedad. En la presente revisión se describen algunos de los mecanismos por los cuales las lesiones en las células alveolares pueden contribuir al desarrollo de la fibrosis pulmonar idiopática.

Abstract

Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive accumulation of extracellular matrix and an imbalance between profibrotic and antifibrotic mediators. In the last few years, understanding of the mechanisms of the biology of IPF has increased. One of the most significant discoveries is the finding that alveolar epithelial cell injury plays an important role in the pathogenesis of this disease. In this review, we describe some of the mechanisms involved in alveolar cell injury and their contribution to the development of IPF.

Keywords
Fibrosis, Alveolar cells, Apoptosis, Alveolar regeneration
Palabras clave
Fibrosis, Células alveolares, Apoptosis, Regeneración alveolar
El Texto completo solo esta disponible en PDF
Bibliografía
1.
G. Raghu,H.R. Collard,J.J. Egan,F.J. Martínez,J. Behr,K.K. Brown
An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management
Am J Respir Crit Care Med, 183 (2011), pp. 788-824
2.
B. Corrin,A. Dewar,R. Rodríguez-Roisín,M. Turner-Warwick
Fine structural changes in cryptogenic fibrosing alveolitis and asbestosis
J Pathol, 147 (1985), pp. 107-119
3.
J.L. Myers,A.L. Katzenstein
Epithelial necrosis and alveolar collapse in the pathogenesis of usual interstitial pneumonia
Chest, 94 (1988), pp. 1309-1311
4.
T.H. Sisson,M. Méndez,K. Choi,N. Subbotina,A. Courey,A. Cunningham
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
Am J Respir Crit Care Med, 181 (2010), pp. 254-263
5.
M. Korfei,C. Ruppert,P. Mahavadi,I. Henneke,P. Markart,M. Koch
Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
Am J Respir Crit Care Med, 178 (2008), pp. 838-846
6.
J.D. Crapo,B.E. Barry,P. Gehr,M. Bachofen,E.R. Weibel
Cell numbers and cell characteristics of the normal human lung
Am Rev Respir Dis, 126 (1982), pp. 332-337
7.
Y. Sibille,H.Y. Reynols
Macrophages and polymorphonuclear neutrophils in lung defense and injury
Am Rev Respir Dis, 141 (1990), pp. 471-501
8.
J. Pérez-Gil
Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions
Biochim Biophys Acta, 1778 (2008), pp. 1676-1695
9.
Z.C. Chroneos,Z. Sever-Chroneos,V.L. Shepherd
Pulmonary surfactant: an immunological perspective
Cell Physiol Biochem, 25 (2010), pp. 13-26
10.
D.F. Zoz,W.E. Lawson,T.S. Blackwell
Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction
Am J Med Sci, 341 (2011), pp. 435-438
11.
T.H. Sisson,M. Méndez,K. Choi,N. Subbotina,A. Courey,A. Cunningham
Targeted injury of type II alveolar epithelial cells induces pulmonary fibrosis
Am J Respir Crit Care Med, 181 (2010), pp. 254-263
12.
M. Korfei,C. Ruppert,P. Mahavadi,I. Henneke,P. Markart,M. Koch
Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
Am J Respir Crit Care Med, 178 (2008), pp. 838-846
13.
J.V. Barbas-Filho,M.A. Ferreira,A. Sesso,R.A. Kairalla,C.R. Carvalho,V.L. Capelozzi
Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP)
J Clin Pathol, 54 (2001), pp. 132-138
14.
B.D. Uhal,I. Joshi,W.F. Hughes,C. Ramos,A. Pardo,M. Selman
Alveolar epithelial cell death adjacent to underlying myofibroblasts in advanced fibrotic human lung
Am J Physiol Lung Cell Mol Physiol, 275 (1998), pp. L1192-L1199
15.
F. Drakopanagiotakis,A. Xifteri,V. Polychronopoulos,D. Bouros
Apoptosis in lung injury and fibrosis
Eur Respir J, 32 (2008), pp. 1631-1638
16.
S.M. Frisch,R.A. Screaton
Anoikis mechanisms
Curr Opin Cell Biol, 13 (2001), pp. 555-562
17.
A.J. Valentijn,N. Zouq,A.P. Gilmore
Anoikis. Biochem Soc Trans, 32 (2004), pp. 421-425
18.
T.M. Maher,A.U. Wells,G.J. Laurent
Idiopathic pulmonary fibrosis: multiple causes and multiple mechanisms?
Eur Respir J, 30 (2007), pp. 835-839
19.
W. Dröge
Free radicals in the physiological control of cell function
Physiol Rev, 82 (2002), pp. 47-95
20.
X. Wang,J.L. Martindale,Y. Liu,N.J. Holbrook
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival
Biochem J, 333 (1998), pp. 291-300
21.
M. Waghray,Z. Cui,J.C. Horowitz,I.M. Subramanian,F.J. Martínez,G.B. Toews
Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
FASEB J, 19 (2005), pp. 854-856
22.
N. Hagimoto,K. Kuwano,I. Inoshima,M. Yoshimi,N. Nakamura,M. Fujita
TGF-b1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
J Immunol, 168 (2002), pp. 6470-6478
23.
S.J. Chen,W. Yuan,Y. Mori,A. Levenson,M. Trojanowska,J. Varga
Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3
J Invest Dermatol, 112 (1999), pp. 49-57
24.
A. Desmoulière,A. Geinoz,F. Gabbiani,G. Gabbiani
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
J Cell Biol, 122 (1993), pp. 103-111
25.
V.J. Thannickal,J.C. Horowitz
Evolving concepts of apoptosis in idiopathic pulmonary fibrosis
Proc Am Thorac Soc, 3 (2006), pp. 350-356
26.
Y.P. Moodley,P. Caterina,A.K. Scaffidi,N.L. Misso,J.M. Papadimitriou,R.J. McAnulty
Comparison of the morphological and biochemical changes in normal human lung fibroblasts and fibroblasts derived from lungs of patients with idiopathic pulmonary fibrosis during FasL-induced apoptosis
J Pathol, 202 (2004), pp. 486-495
27.
C. Ramos,M. Montano,J. García-Álvarez,V. Ruiz,B.D. Uhal,M. Selman
Fibroblasts from idiopathic pulmonary fibrosis and normal lungs differ in growth rate, apoptosis, and tissue inhibitor of metalloproteinases expression
Am J Respir Cell Mol Biol, 24 (2001), pp. 591-598
28.
M. Korfei,C. Ruppert,P. Mahavadi,I. Henneke,P. Markart,M. Koch
Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis
Am J Respir Crit Care Med, 178 (2008), pp. 838-846
29.
W.E. Lawson,P.F. Crossno,V.V. Polosukhin,J. Roldan,D.S. Cheng,K.B. Lane
Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection
Am J Physiol Lung Cell Mol Physiol, 294 (2008), pp. L1119-L1126
30.
Y. Ma,L.M. Hendershot
The role of the unfolded protein response in tumour development: friend or foe?
Nat Rev Cancer, 4 (2004), pp. 966-977
31.
M. Schroder,R.J. Kaufman
The mammalian unfolded protein response
Annu Rev Biochem, 74 (2005), pp. 739-789
32.
J. Shang
Quantitative measurement of events in the mammalian unfolded protein response
Methods, 35 (2005), pp. 390-394
33.
L.M. Nogee,A.E. Dunbar 3rd,S.E. Wert,F. Askin,A. Hamvas,J.A. Whitsett
A mutation in the surfactant protein C gene associated with familial interstitial lung disease
N Engl J Med, 344 (2001), pp. 573-579
34.
K.K. Kim,M.C. Kugler,P.J. Wolters,L. Robillard,M.G. Gálvez,A.N. Brumwell
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
Proc Natl Acad Sci USA, 103 (2006), pp. 13180-13185
35.
B.C. Willis,J.M. Liebler,K. Luby-Phelps,A.G. Nicholson,E.D. Crandall,R.M. Du Bois
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis
Am J Pathol, 166 (2005), pp. 1321-1332
36.
C.J. Scotton,R.C. Chambers
Molecular targets in pulmonary fibrosis: the myofibroblast in focus
Chest, 132 (2007), pp. 1311-1321
Copyright © 2012. Sociedad Española de Neumología y Cirugía Torácica
Arch Bronconeumol 2012;48 Supl 2:2-6 - Vol. 48 DOI: 10.1016/S0300-2896(12)70044-3