Archivos de Bronconeumología Archivos de Bronconeumología
Arch Bronconeumol. 2012;48(Supl.2):2-6 - Vol. 48 Núm.Supl.2 DOI: 10.1016/S0300-2896(12)70044-3

La célula epitelial como factor etiopatogénico de la fibrosis pulmonar

Anna Serrano-Mollarabc,

a Centro de investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES)
b Departamento de Patología Experimental, Institut d’Investigacions Biomèdiques de Barcelona, España
c Consejo Superior de Investigaciones Científicas (IIBB-CSIC), Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, España

Palabras clave

Fibrosis. Células alveolares. Apoptosis. Regeneración alveolar.

Resumen

La fibrosis pulmonar idiopática se caracteriza por una acumulación progresiva de matriz extracelular y un desequilibrio entre mediadores profibróticos y antifibróticos. Durante los últimos años se ha avanzado mucho en el conocimiento de los mecanismos de la biología de la fibrosis pulmonar idiopática. En este sentido, uno de los hallazgos más significativo es el descubrimiento de que la lesión de las células del epitelio alveolar juega un papel importante en la patogénesis de esta enfermedad. En la presente revisión se describen algunos de los mecanismos por los cuales las lesiones en las células alveolares pueden contribuir al desarrollo de la fibrosis pulmonar idiopática.

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