TY - JOUR T1 - Combined Hepatic and Pulmonary Metastasectomies From Colorectal Carcinoma. Data From the Prospective Spanish Registry 2008–2010 JO - Archivos de Bronconeumología T2 - AU - Jarabo,Jose R. AU - Gómez,Ana M. AU - Calatayud,Joaquín AU - Fraile,Carlos A. AU - Fernández,Elena AU - Pajuelo,Nuria AU - Embún,Raul AU - Molins,Laureano AU - Rivas,Juan J. AU - Hernando,Florentino SN - 03002896 M3 - 10.1016/j.arbres.2017.10.003 DO - 10.1016/j.arbres.2017.10.003 UR - https://www.archbronconeumol.org/en-combined-hepatic-pulmonary-metastasectomies-from-articulo-S0300289617303927 AB - IntroductionResection of both liver and lung metastases from colorectal carcinoma (CRC) is a standard of care in selected patients with oligometastatic disease. We present here the analysis of the subgroup of patients undergoing combined surgery from the Spanish Group of Surgery of Pulmonary Metastases (PM) from Colorectal Carcinoma (GECMP-CCR-SEPAR). MethodsWe analyze characteristics, survival and prognostic factors of patients undergoing combined resection from March-2008 to February-2010 and followed-up during at least 3 years, from the prospective multicenter Spanish Registry. ResultsA total of 138 patients from a whole series of 543 cases from 32 thoracic surgery units underwent both procedures. Seventy-seven (43.8%) resected liver metastases were synchronic with colorectal tumor. Median disease specific survival (DSS) from first pulmonary metastasectomy was 48.9 months, being three and 5-year DSS 65.1% and 41.7%, respectively. From CRC-surgery median DSS was 97.2 months, with 3 and 5-year DSS rates of 96.7% and 77%, respectively. Five-year DSS from pulmonary metastasectomy was 41.7% for patients with combined resection and 52.4% for those without hepatic involvement (P=.04). Differences disappeared when considering DSS from colorectal surgery. Carcinoembrionary antigen (CEA) before lung surgery over 10mg/dl and bilateral PM were independent prognostic factors for survival (hazard ratio 2.4 and 2.5, respectively). ConclusionsPatients with resection of PM of CRC with history of resected hepatic metastases presented significantly lower disease specific survival rates than those undergoing pulmonary metastasectomy alone. CEA before lung surgery and bilateral PM associated worse prognosis. ER -