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Vol. 45. Issue 11.
Pages 550-555 (November 2009)
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Vol. 45. Issue 11.
Pages 550-555 (November 2009)
Original article
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Incidence and Characteristics of Asthma Exacerbations in Barcelona (ASMAB II)
Incidencia y características de las agudizaciones asmáticas en Barcelona (ASMAB II)
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Ferran Morella,
Corresponding author
fmorell@vhebron.net

Corresponding author.
, Ferran Morellb, Teresa Genoverb, Teresa Genoverc, Esther Benaqued, César Picadob, César Picadoe, Xavier Muñoza, Xavier Muñozb, María Jesús Cruza, María Jesús Cruzb
a Servei de Pneumologia, Hospital Universitari Vall d’Hebron, Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain
b CIBER de Enfermedades Respiratorias (CibeRes)
c Centro de Asistencia Primaria Sant Rafael, Barcelona, Spain
d Centro de Asistencia Primaria Río de Janeiro, SAP Muntanya, Institut Català de la Salut, Barcelona, Spain
e Servei de Pneumologia i Al lèrgia Respiratoria, Hospital Clínic, IDIBAPS, Departament de Medicina, Universitat de Barcelona, Barcelona, Spain
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Abstract
Introduction

A study has been carried out on the incidence and clinical characteristics of asthma exacerbations (AE) seen in hospital accident and emergency departments (HA&ED) and domiciliary services (DS) in Barcelona.

Patients and methods

AEs were identified over a 56-day-period during the October and November 2003 and the patients seen in university hospitals were interviewed.

Results

A total of 262 AE were identified, 188 in hospital accident and emergency departments and 82 in domiciliary care, which was a mean of 4.6 AE/day, giving an incidence of 0.37 AE/105 inhabitants. This incidence was no different from that obtained in the same months in 2002 (P > 0.05). The mean age (±standard deviation) of the143 cases of AE seen in university hospitals was 41±17 years; 87/143 (60%) were women and 57/138 (41%) smokers. In 36/61 (59%) the AE started in the home; in 88/132 (61%) it began 24 hours before arriving at the hospital centre. In 78/123 cases (63%) slow onset of nasal cold was noted before the AE and a viral infection was suspected. Inhaled corticosteroids were administered to 45/112 patients (40%), and only one was also given oral corticosteroids 12 hours before admission. The AEs were mild in 38/75 cases (51%), moderate in 28/75 (37%), severe in 8/75 (11%) and almost fatal in one patient (1.3%). Around 10% (13/137) of patients (10%) were readmitted.

Conclusions

The daily incidence of AE is 0.37/105 inhabitants. More than half of the exacerbations started after nasal cold and 11% of the AEs were severe.

Keywords:
Bronchial asthma
Asthma exacerbations
Epidemiology of asthma
Resumen
Introducción

Se ha estudiado la tasa de agudizaciones asmáticas (AA) atendidas en los servicios de urgencias hospitalarios (SUH) y domiciliarios (SEM), así como sus características clínicas.

Pacientes y métodos

Durante los meses de octubre y noviembre de 2003 se identificaron durante 56 días las AA y se entrevistó a los pacientes atendidos en los hospitales universitarios.

Resultados

Se identificaron 262 AA, 188 en los servicios de urgencias hospitalarios y 82 en los domiciliarios, es decir, una media de 4,6 AA/día, lo que significa una tasa de 0,37 AA/105 habitantes, incidencia no diferente de la obtenida en los mismos meses de 2002 (p > 0,05). La edad media (± desviación estándar) de los 143 casos de AA atendidas en los hospitales universitarios era de 41 ± 17 años; 87/143 (60%) eran mujeres y 57/138 (41%), fumadores. En 36/61 (59%) la AA se inició en el domicilio; en 88/132 (61%) comenzó 24 h antes de la llegada al centro hospitalario. En 78/123 casos (63%) se registró catarro nasal de instauración lenta antes de la AA y se sospechó una infección vírica. Recibían corticosteroides inhalados 45/112 pacientes (40%), y únicamente uno añadió corticosteroides orales en las 12h previas al ingreso. La AA era leve en 38/75 casos (51%), moderada en 28/75 (37%), grave en 8/75 (11%) y casi fatal en un paciente (1,3%). Fueron readmitidos 13/137 pacientes (10%).

Conclusiones

La incidencia diaria de AA es de 0,37/105 habitantes. Más de la mitad de las agudizaciones se habían iniciado tras un catarro nasal. Un 11% de las AA eran graves.

Palabras clave:
Asma bronquial
Exacerbaciones del asma
Epidemiología del asma
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References
[1.]
K.F. Rabe, P.A. Vermeire, J.B. Soriano, W.C. Maier.
Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study.
Eur Respir J, 16 (2000), pp. 802-807
[2.]
Global Initiative for Asthma (GINA). Available at: www.ginasthma.com. p. 85.
[3.]
J. Serra-Batlles, V. Plaza, E. Morejon, A. Comella, J. Bugues.
Cost of asthma according to the degree of severity.
Eur Respir J, 12 (1998), pp. 1322-1326
[4.]
F. Morell, T. Genover, X. Muñoz, J. Garcia-Aymerich, J. Ferrer, M.J. Cruz.
Rate and characteristics of asthma exacerbations: the ASMAB I study.
Arch Bronconeumol, 44 (2008), pp. 303-311
[5.]
S. Salmeron, R. Liard, D. Elkharrat, J. Muir, F. Neukirch, A. Ellrodt.
Asthma severity and adequacy of management in accident and emergency departments in Fran a prospective study.
Lancet, 358 (2001), pp. 629-635
[6.]
Global Initiative for Asthma (GINA). Available at: www.ginasthma.com. p. 68.
[7.]
Departament d’Estadística. Ajuntament de Barcelona. Available at: www.bcn.es/estadistica/.
[8.]
Grupo Español del Estudio Europeo del Asma.
Estudio Europeo del Asma. Prevalencia de síntomas relacionados con el asma en cinco áreas españolas.
Med Clin (Barc), 104 (1995), pp. 487-492
[9.]
G.J. Rodrigo, C. Rodrigo, J.B. Hall.
Acute asthma in adult.
Chest, 125 (2004), pp. 1081-1102
[10.]
V. Plaza, J. Serrano, C. Picado, J. Sanchis, High Risk Asthma Research Group.
Frequency and clinical characteristics of rapid-onset fatal and near-fatal asthma.
Eur Respir J, 19 (2002), pp. 846-852
[11.]
R.G. Barr, P.G. Woodruff, S. Clark, C.A. Camargo.
Sudden-onset asthma exacerbations: clinical features response to therapy, and 2-week follow-up.
Eur Respir J, 15 (2000), pp. 266-273
[12.]
Global Initiative for Asthma (GINA), 2002. Available at: www.ginasthma.com. p. 134.
[13.]
M. Charlson, T.P. Szatrowski, J. Peterson, J. Gold.
Validation of a combined comorbidity index.
J Clin Epidemiol, 47 (1994), pp. 1245-1251
[14.]
G.B. Marks, J.R. Colquhoun, S.T. Girgis, M.H. Koski, A.B. Treloar, P. Hansen, et al.
Thunderstorm outflows preceding epidemics of asthma during spring and summer.
Thorax, 56 (2001), pp. 468-471
[15.]
J.M. Antó, J. Sunyer, C.E. Reed, J. Sabria, F. Martínez, F. Morell, et al.
Preventing asthma epidemics due to soybeans by dust-control measures.
N Engl J Med, 329 (1993), pp. 1760-1763
[16.]
C.S. Murray, A. Simpson, A. Custovic.
Allergens, viruses, and asthma exacerbations.
Proc Am Thorac Soc, 1 (2004), pp. 99-104
[17.]
K.G. Nicholson, J. Kent, D.C. Ireland.
Respiratory virus and exacerbations of asthma in adults.
BMJ, 307 (1993), pp. 982-986
[18.]
M. Medina-Ramón, J.P. Zock, M. Kogevinas, J. Sunyer, X. Basagaña, J. Schwartz, et al.
Short-term respiratory effects of cleaning exposures in female domestic cleaners.
Eur Respir J, 27 (2006), pp. 1196-1203
[19.]
Bellido-Casado J, Plaza V, Rodrigo GJ, Neffen H, Bazús MT, Levy G, et al (en representación de las Áreas de Asma de ALAT y SEPAR). Agudización grave de asma y prescripción previa de corticosteroides inhalados en España y Latinoamérica: Proyecto EAGLE. 40.° Congreso Nacional de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR). Barcelona, 1–4 de junio de 2007. Arch Bronconeumol. 2007;43 Especial Congreso: 2.
[20.]
G.J. Rodrigo.
Rapid effects of inhaled corticosteroids in acute asthma: an evidencebased evaluation.
Chest, 130 (2006), pp. 1301-1311
[21.]
K. Parameswaran, J. Belda, B.H. Rowe.
Addition of intravenous aminophylline to beta2-agonists in adults with acute asthma.
Cochrane Database Syst Rev, (2000),
[22.]
Grupo Español para el Manejo del Asma (GEMA). Guía española para el manejo del asma. 2009. Available at: www.gemasma.com.
[23.]
Global Initiative for Asthma (GINA). Disponible en: www.ginasthma.com.
[24.]
G. Rodríguez-Trigo, V. Plaza, C. Picado, J. Sanchis.
Management according to the Global Initiative for Asthma guidelines of patients with near-fatal asthma reduces morbidity and mortality.
Arch Bronconeumol, 44 (2008), pp. 192-196
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